DK0864092T3 - Kompleks-bundne inhibitorer af aktiverbare stofskifteenzymer som molekylære markører til diagnosticering og terapiovervågning - Google Patents

Kompleks-bundne inhibitorer af aktiverbare stofskifteenzymer som molekylære markører til diagnosticering og terapiovervågning

Info

Publication number: DK0864092T3
Authority: DK; Denmark
Prior art keywords: diagnosis; activatable; therapy monitoring; pct; complex
Prior art date: 1995-09-13

Application number

DK96927067T

Other languages

English (en)

Inventor

Goetz Nowak

Elke Bucha

Verena Baldinger

Original Assignee

Max Planck Gesellschaft

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1995-09-13

Filing date

1996-08-01

Publication date

2002-02-11

1996-08-01 Application filed by Max Planck Gesellschaft filed Critical Max Planck Gesellschaft

2002-02-11 Application granted granted Critical

2002-02-11 Publication of DK0864092T3 publication Critical patent/DK0864092T3/da

Links

108090000790 Enzymes Proteins 0.000 title abstract 4
102000004190 Enzymes Human genes 0.000 title abstract 4
238000003745 diagnosis Methods 0.000 title abstract 4
239000003112 inhibitor Substances 0.000 title abstract 3
238000012544 monitoring process Methods 0.000 title abstract 3
238000002560 therapeutic procedure Methods 0.000 title abstract 3
230000002503 metabolic effect Effects 0.000 title abstract 2
206010053567 Coagulopathies Diseases 0.000 abstract 3
230000035602 clotting Effects 0.000 abstract 3
229940088598 enzyme Drugs 0.000 abstract 3
239000003147 molecular marker Substances 0.000 abstract 3
230000004913 activation Effects 0.000 abstract 2
229940006607 hirudin Drugs 0.000 abstract 2
102000007625 Hirudins Human genes 0.000 abstract 1
108010007267 Hirudins Proteins 0.000 abstract 1
101000712605 Theromyzon tessulatum Theromin Proteins 0.000 abstract 1
229940122388 Thrombin inhibitor Drugs 0.000 abstract 1
WQPDUTSPKFMPDP-OUMQNGNKSA-N hirudin Chemical compound C([C@@H](C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC=1C=CC(OS(O)(=O)=O)=CC=1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(O)=O)NC(=O)[C@H](CC(O)=O)NC(=O)CNC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC=1NC=NC=1)NC(=O)[C@H](CO)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H]1N(CCC1)C(=O)[C@H](CCCCN)NC(=O)[C@H]1N(CCC1)C(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)CNC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H]1NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCC(O)=O)NC(=O)CNC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)CNC(=O)[C@H](CC(C)C)NC(=O)[C@H]([C@@H](C)CC)NC(=O)[C@@H]2CSSC[C@@H](C(=O)N[C@@H](CCC(O)=O)C(=O)NCC(=O)N[C@@H](CO)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@H](C(=O)N[C@H](C(NCC(=O)N[C@@H](CCC(N)=O)C(=O)NCC(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCCCN)C(=O)N2)=O)CSSC1)C(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H]1NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)CNC(=O)[C@H](CO)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@@H](NC(=O)[C@H](CC=2C=CC(O)=CC=2)NC(=O)[C@@H](NC(=O)[C@@H](N)C(C)C)C(C)C)[C@@H](C)O)CSSC1)C(C)C)[C@@H](C)O)[C@@H](C)O)C1=CC=CC=C1 WQPDUTSPKFMPDP-OUMQNGNKSA-N 0.000 abstract 1
239000003868 thrombin inhibitor Substances 0.000 abstract 1

Classifications

- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/86—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving blood coagulating time or factors, or their receptors
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/81—Protease inhibitors
- G01N2333/8107—Endopeptidase (E.C. 3.4.21-99) inhibitors
- G01N2333/811—Serine protease (E.C. 3.4.21) inhibitors
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/81—Protease inhibitors
- G01N2333/8107—Endopeptidase (E.C. 3.4.21-99) inhibitors
- G01N2333/811—Serine protease (E.C. 3.4.21) inhibitors
- G01N2333/8121—Serpins
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/81—Protease inhibitors
- G01N2333/8107—Endopeptidase (E.C. 3.4.21-99) inhibitors
- G01N2333/811—Serine protease (E.C. 3.4.21) inhibitors
- G01N2333/8121—Serpins
- G01N2333/8132—Plasminogen activator inhibitors
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/81—Protease inhibitors
- G01N2333/815—Protease inhibitors from leeches, e.g. hirudin, eglin

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Hematology (AREA)
Engineering & Computer Science (AREA)
Molecular Biology (AREA)
Biomedical Technology (AREA)
Chemical & Material Sciences (AREA)
Immunology (AREA)
Urology & Nephrology (AREA)
Biotechnology (AREA)
Biochemistry (AREA)
Cell Biology (AREA)
Food Science & Technology (AREA)
Medicinal Chemistry (AREA)
Physics & Mathematics (AREA)
Analytical Chemistry (AREA)
Microbiology (AREA)
General Health & Medical Sciences (AREA)
General Physics & Mathematics (AREA)
Pathology (AREA)
Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Investigating Or Analysing Biological Materials (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

DK96927067T 1995-09-13 1996-08-01 Kompleks-bundne inhibitorer af aktiverbare stofskifteenzymer som molekylære markører til diagnosticering og terapiovervågning DK0864092T3 (da)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
DE19533817A DE19533817C2 (de)	1995-09-13	1995-09-13	Komplex-gebundene Hemmstoffe aktivierbarer Stoffwechselenzyme als molekulare Marker zur Diagnostik und Therapieüberwachung
PCT/EP1996/003383 WO1997010509A1 (de)	1995-09-13	1996-08-01	Komplex-gebundene hemmstoffe aktivierbarer stoffwechselenzyme als molekulare marker zur diagnostik und therapieüberwachung

Publications (1)

Publication Number	Publication Date
DK0864092T3 true DK0864092T3 (da)	2002-02-11

Family

ID=7771988

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK96927067T DK0864092T3 (da)	1995-09-13	1996-08-01	Kompleks-bundne inhibitorer af aktiverbare stofskifteenzymer som molekylære markører til diagnosticering og terapiovervågning

Country Status (9)

Country	Link
US (1)	US6051390A (da)
EP (1)	EP0864092B1 (da)
JP (1)	JPH11514218A (da)
AT (1)	ATE208504T1 (da)
CA (1)	CA2231354A1 (da)
DE (2)	DE19533817C2 (da)
DK (1)	DK0864092T3 (da)
ES (1)	ES2165513T3 (da)
WO (1)	WO1997010509A1 (da)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE19904674A1 (de) *	1999-02-04	2000-08-31	Haemosys Gmbh	Verfahren zur Bestimmung der Konzentration von Thrombininhibitoren
DE102005008066A1 (de) *	2005-02-22	2006-08-24	Haemosys Gmbh	Verfahren zur Bestimmung der Gesamtgerinnungsaktivität einer Blut- oder Plasmaprobe
GB2492104A (en) *	2011-06-22	2012-12-26	Job Harenberg	Assay for direct thrombin inhibitors
CA3002250C (en) *	2014-10-23	2024-02-06	Q-Sera Pty Ltd	Improved clotting composition

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JPS5120597B2 (da) *	1973-05-02	1976-06-25
JPS5629365B2 (da) *	1974-08-10	1981-07-08
US4226775A (en) *	1979-06-01	1980-10-07	American Cyanamid Company	Substituted thio-substituted benzyl-propionyl-L-prolines
NL8501682A (nl) *	1985-06-11	1987-01-02	Tno	Nieuw, uit bloed geisoleerd eiwit, werkwijze ter bereiding van dit eiwit, antilichamen tegen het nieuwe eiwit en farmaceutische preparaten, die het eiwit of de antilichamen bevatten.
JP2643137B2 (ja) *	1987-02-27	1997-08-20	不二製油株式会社	蛋白質分解酵素阻害剤・デキストラン結合体
DE3819079A1 (de) *	1988-06-04	1989-12-07	Hoechst Ag	Hirudin-derivate mit verzoegerter wirkung
NL8902406A (nl) *	1989-09-27	1991-04-16	Hendrik Coenraad Hemker Prof D	Werkwijze voor het bepalen van de endogene trombinepotentiaal van plasma, en bloed alsmede een bij deze werkwijze te gebruiken kit.
ES2084149T3 (es) *	1989-12-01	1996-05-01	Basf Ag	Conjugados de hirudinpolialquilenglicol.
WO1992005749A1 (en) *	1990-10-04	1992-04-16	New England Deaconess Hospital Corporation	Soluble thrombogenesis inhibitor conjugates
FR2687681B1 (fr) *	1992-02-20	1995-10-13	Transgene Sa	Conjugues polyethyleneglycol-hirudine, leur procede de preparation et leur emploi pour le traitement des thromboses.
DE4342154A1 (de) *	1993-12-10	1995-06-14	Behringwerke Ag	Amidinophenylalaninderivate, Verfahren zu deren Herstellung, deren Verwendung und diese enthaltende Mittel als Antikoagulantien

1995
- 1995-09-13 DE DE19533817A patent/DE19533817C2/de not_active Expired - Fee Related
1996
- 1996-08-01 WO PCT/EP1996/003383 patent/WO1997010509A1/de not_active Ceased
- 1996-08-01 ES ES96927067T patent/ES2165513T3/es not_active Expired - Lifetime
- 1996-08-01 AT AT96927067T patent/ATE208504T1/de not_active IP Right Cessation
- 1996-08-01 DE DE59608163T patent/DE59608163D1/de not_active Expired - Fee Related
- 1996-08-01 US US09/029,867 patent/US6051390A/en not_active Expired - Fee Related
- 1996-08-01 CA CA002231354A patent/CA2231354A1/en not_active Abandoned
- 1996-08-01 JP JP9511588A patent/JPH11514218A/ja active Pending
- 1996-08-01 EP EP96927067A patent/EP0864092B1/de not_active Expired - Lifetime
- 1996-08-01 DK DK96927067T patent/DK0864092T3/da active

Also Published As

Publication number	Publication date
EP0864092A1 (de)	1998-09-16
ES2165513T3 (es)	2002-03-16
US6051390A (en)	2000-04-18
CA2231354A1 (en)	1997-03-20
ATE208504T1 (de)	2001-11-15
JPH11514218A (ja)	1999-12-07
DE19533817C2 (de)	1999-12-09
EP0864092B1 (de)	2001-11-07
DE19533817A1 (de)	1997-03-20
WO1997010509A1 (de)	1997-03-20
DE59608163D1 (de)	2001-12-13

Publication	Publication Date	Title
NO990338L (no)	1999-03-25	Celleadhesjonsinhibitorer
BR9908280A (pt)	2000-10-31	Inibidores de enzimas de fosfolipase
DK1304327T3 (da)	2005-06-27	Glutamin-thiazolidider og -pyrrolidider samt anvendelsen af disse som dipeptidylpeptidase-IV-inhibitorer
ATE209191T1 (de)	2001-12-15	Parazinon thrombin inhibitoren
HU9603328D0 (en)	1997-01-28	Retroviral protease inhibitor combinations
FR2828206B1 (fr)	2004-09-24	Utilisation d'inhibiteurs des lysyl oxydases pour la culture cellulaire et le genie tissulaire
EP1027080A4 (en)	2004-07-14	METHOD FOR DETECTING A FIBRING ISLAND
DK0817622T3 (da)	2002-03-25	Transdermalt applicerbart lægemiddel med ACE-hæmmere
TR199900310T2 (xx)	1999-04-21	Trombin inhibit�rleri
ATE187651T1 (de)	2000-01-15	Zweikomponenten-fibrinkleber
ES2191830T3 (es)	2003-09-16	Inhibidores de trombina.
AU8178894A (en)	1995-07-06	Method for determining platelet aggregation
AR030718A1 (es)	2003-09-03	Proteinas de bacillus thuringiensis inhibidoras de insectos fusiones y metodos de uso de las mismas
WO2000068414A3 (en)	2001-05-17	Whole cell assay for cathepsin k
DK0864092T3 (da)	2002-02-11	Kompleks-bundne inhibitorer af aktiverbare stofskifteenzymer som molekylære markører til diagnosticering og terapiovervågning
ES2168816T3 (es)	2002-06-16	Cemento de inyeccion que contiene inhibidores de la corrosion.
DE69625230D1 (de)	2003-01-16	Thrombininhibitoren
AU6385498A (en)	1998-10-22	Reagent for determining aptt
DK1095032T3 (da)	2004-03-29	Hidtil ukendte fluorescerende CYP2D-assayreagenser
ATE323173T1 (de)	2006-04-15	Nährboden zum nachweis und/oder zur unterscheidung von enterokokken
ATE283370T1 (de)	2004-12-15	Nachweis und/oder unterscheidung der bakterien der gattung vibrio
ATE288081T1 (de)	2005-02-15	Verfahren zum selektieren von inhibitoren für enzyme
DE60034660D1 (de)	2007-06-14	Monoklonaler antikörper gegen protein c inhibitor
ATE290878T1 (de)	2005-04-15	Inhibierung von invasiver remodulierung
BR9607577A (pt)	1999-09-14	Método para inibir catepsina k