DK0854867T3 - Tetrahydroquinoliner som NMDA-antagonister - Google Patents

Tetrahydroquinoliner som NMDA-antagonister

Info

Publication number: DK0854867T3
Authority: DK; Denmark
Prior art keywords: tetrahydroquinolines; nmda antagonists; nmda; antagonists
Prior art date: 1995-09-29

Application number

DK96933399T

Other languages

Danish (da)

English (en)

Inventor

Fabio Romano Di

Simone Giacobbe

Barbara Bertani

Fabrizio Micheli

Original Assignee

Glaxosmithkline Spa

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1995-09-29

Filing date

1996-09-26

Publication date

2002-12-02

1995-09-29 Priority claimed from GBGB9519893.3A external-priority patent/GB9519893D0/en

1996-08-17 Priority claimed from GBGB9617306.7A external-priority patent/GB9617306D0/en

1996-09-26 Application filed by Glaxosmithkline Spa filed Critical Glaxosmithkline Spa

2002-12-02 Application granted granted Critical

2002-12-02 Publication of DK0854867T3 publication Critical patent/DK0854867T3/da

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/48—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Animal Behavior & Ethology (AREA)
Pharmacology & Pharmacy (AREA)
Chemical Kinetics & Catalysis (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Neurosurgery (AREA)
Neurology (AREA)
Biomedical Technology (AREA)
Psychiatry (AREA)
Hospice & Palliative Care (AREA)
Virology (AREA)
Communicable Diseases (AREA)
AIDS & HIV (AREA)
Addiction (AREA)
Heart & Thoracic Surgery (AREA)
Molecular Biology (AREA)
Tropical Medicine & Parasitology (AREA)
Cardiology (AREA)
Oncology (AREA)
Pain & Pain Management (AREA)
Otolaryngology (AREA)
Epidemiology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Peptides Or Proteins (AREA)

DK96933399T 1995-09-29 1996-09-26 Tetrahydroquinoliner som NMDA-antagonister DK0854867T3 (da)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
GBGB9519893.3A GB9519893D0 (en)	1995-09-29	1995-09-29	Heterocyclic compounds
GBGB9617306.7A GB9617306D0 (en)	1996-08-17	1996-08-17	Heterocyclic compounds
PCT/EP1996/004206 WO1997012870A1 (fr)	1995-09-29	1996-09-26	Tetrahydroquinolines utiles en tant qu'antagonistes du nmda (n-methyl-d-aspartate)

Publications (1)

Publication Number	Publication Date
DK0854867T3 true DK0854867T3 (da)	2002-12-02

Family

ID=26307841

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK96933399T DK0854867T3 (da)	1995-09-29	1996-09-26	Tetrahydroquinoliner som NMDA-antagonister

Country Status (28)

Country	Link
US (1)	US5977136A (fr)
EP (1)	EP0854867B1 (fr)
JP (1)	JP4108123B2 (fr)
KR (1)	KR100464895B1 (fr)
CN (1)	CN1130346C (fr)
AP (1)	AP876A (fr)
AR (1)	AR005233A1 (fr)
AT (1)	ATE221520T1 (fr)
AU (1)	AU708148B2 (fr)
BR (1)	BR9610733A (fr)
CA (1)	CA2232509A1 (fr)
CZ (1)	CZ292379B6 (fr)
DE (1)	DE69622731T2 (fr)
DK (1)	DK0854867T3 (fr)
EA (1)	EA000875B1 (fr)
ES (1)	ES2180799T3 (fr)
HU (1)	HUP9900040A3 (fr)
IL (1)	IL123322A0 (fr)
IS (1)	IS4677A (fr)
MX (1)	MX9801967A (fr)
NO (1)	NO310355B1 (fr)
NZ (1)	NZ319596A (fr)
PL (1)	PL186781B1 (fr)
PT (1)	PT854867E (fr)
SI (1)	SI0854867T1 (fr)
TR (1)	TR199800531T1 (fr)
TW (1)	TW460465B (fr)
WO (1)	WO1997012870A1 (fr)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB9617305D0 (en) *	1996-08-17	1996-09-25	Glaxo Wellcome Spa	Heterocyclic compounds
GB9706294D0 (en) *	1997-03-26	1997-05-14	Glaxo Wellcome Spa	Heterocyclic compound
MY125037A (en) *	1998-06-10	2006-07-31	Glaxo Wellcome Spa	1,2,3,4 tetrahydroquinoline derivatives
TW555757B (en) *	1998-07-31	2003-10-01	Akzo Nobel Nv	Aminomethylcarboxylic acid derivatives
EP1103552A4 (fr) *	1998-08-07	2003-01-15	Takeda Chemical Industries Ltd	Derives de benzothiepine, leur procede de preparation et leurs utilisations
GB9929037D0 (en) *	1999-12-08	2000-02-02	Glaxo Wellcome Spa	Heterocyclic derivatives
WO2003057672A2 (fr) *	2001-12-28	2003-07-17	Acadia Pharmaceuticals, Inc.	Analogues de tetrahydroquinoline utiles comme agonistes muscariniques
DE10236910A1 (de) *	2002-08-12	2004-03-11	Grünenthal GmbH	Substituierte 1,2,3,4-Tetrahydrochinolinderivate
RU2451014C2 (ru) *	2005-07-22	2012-05-20	Мотида Фармасьютикал Ко., Лтд.	Новое производное гетероциклиден ацетамида
CA2616079C (fr) *	2005-07-22	2012-09-25	Mochida Pharmaceutical Co., Ltd.	Nouveau derive d'acetamide d'heterocyclidene
ATE520696T1 (de) *	2008-03-05	2011-09-15	Boehringer Ingelheim Int	Tricyclische pyridinderivate, solche verbindungen enthaltende medikamente, ihre verwendung und verfahren zu ihrer herstellung
EP2286808A1 (fr) *	2009-08-18	2011-02-23	Rheinische Friedrich-Wilhelms Universität	Inhibiteurs de la cytohésine
AU2011216950A1 (en)	2010-02-16	2012-08-23	Pfizer Inc.	(R)-4-((4-((4-(tetrahydrofuran-3-yloxy) benzo[d]isoxazol-3-yloxy)methyl)piperidin-1-yl)methyl)tetrahydro-2H-pyran-4-ol, a partial agonist of 5-HT4 receptors
MA34007B1 (fr)	2010-02-19	2013-02-01	Boehringer Ingelheim Int	Derives de pyridine tricycliques medicaments contenant ces composes leur utilisation et leur procede de preparation
US9150583B2 (en)	2011-08-17	2015-10-06	Boehringer Ingelheim International Gmbh	Furo[3,4-c]quinoline derivatives, medicaments containing such compounds, their use and process for their preparation
WO2016114655A1 (fr) *	2015-01-12	2016-07-21	Ry Pharma B.V.	Traitement de maladie neuromusculaire ou neurologique par réduction de la surstimulation des neurotransmetteurs inhibiteurs gabaergiques et/ou glycinergique
WO2017065602A1 (fr) *	2015-10-13	2017-04-20	Ry Pharma B.V.	Traitement de maladie neuromusculaire ou neurologique par réduction de la surstimulation des neurotransmetteurs inhibiteurs gabaergiques et/ou glycinergiques

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE69029668T2 (de) *	1989-03-08	1997-08-07	Merck Sharp & Dohme	Tetrahydroquinolin-Derivate, verwendbar bei neurodegenerativen Krankheiten

1996
- 1996-09-26 CZ CZ1998940A patent/CZ292379B6/cs not_active IP Right Cessation
- 1996-09-26 KR KR10-1998-0702321A patent/KR100464895B1/ko not_active Expired - Fee Related
- 1996-09-26 WO PCT/EP1996/004206 patent/WO1997012870A1/fr not_active Ceased
- 1996-09-26 EA EA199800230A patent/EA000875B1/ru not_active IP Right Cessation
- 1996-09-26 DK DK96933399T patent/DK0854867T3/da active
- 1996-09-26 AT AT96933399T patent/ATE221520T1/de not_active IP Right Cessation
- 1996-09-26 PL PL96325966A patent/PL186781B1/pl not_active IP Right Cessation
- 1996-09-26 DE DE69622731T patent/DE69622731T2/de not_active Expired - Lifetime
- 1996-09-26 HU HU9900040A patent/HUP9900040A3/hu unknown
- 1996-09-26 CN CN96198560A patent/CN1130346C/zh not_active Expired - Fee Related
- 1996-09-26 TR TR1998/00531T patent/TR199800531T1/xx unknown
- 1996-09-26 ES ES96933399T patent/ES2180799T3/es not_active Expired - Lifetime
- 1996-09-26 AU AU72148/96A patent/AU708148B2/en not_active Ceased
- 1996-09-26 EP EP96933399A patent/EP0854867B1/fr not_active Expired - Lifetime
- 1996-09-26 AP APAP/P/1998/001212A patent/AP876A/en active
- 1996-09-26 US US09/029,860 patent/US5977136A/en not_active Expired - Fee Related
- 1996-09-26 NZ NZ319596A patent/NZ319596A/en not_active IP Right Cessation
- 1996-09-26 CA CA002232509A patent/CA2232509A1/fr not_active Abandoned
- 1996-09-26 PT PT96933399T patent/PT854867E/pt unknown
- 1996-09-26 SI SI9630523T patent/SI0854867T1/xx unknown
- 1996-09-26 BR BR9610733A patent/BR9610733A/pt not_active IP Right Cessation
- 1996-09-26 JP JP51394797A patent/JP4108123B2/ja not_active Expired - Fee Related
- 1996-09-26 IL IL12332296A patent/IL123322A0/xx not_active IP Right Cessation
- 1996-09-30 AR ARP960104543A patent/AR005233A1/es active IP Right Grant
- 1996-10-04 TW TW085112168A patent/TW460465B/zh not_active IP Right Cessation
1998
- 1998-02-27 IS IS4677A patent/IS4677A/is unknown
- 1998-03-12 MX MX9801967A patent/MX9801967A/es not_active IP Right Cessation
- 1998-03-27 NO NO19981396A patent/NO310355B1/no not_active IP Right Cessation

Also Published As

Publication number	Publication date
HK1009133A1 (en)	1999-05-28
DE69622731T2 (de)	2003-02-20
IS4677A (is)	1998-02-27
PL325966A1 (en)	1998-08-17
JPH11512728A (ja)	1999-11-02
BR9610733A (pt)	1999-07-13
SI0854867T1 (en)	2003-02-28
MX9801967A (es)	1998-08-30
AP876A (en)	2000-09-27
ES2180799T3 (es)	2003-02-16
PT854867E (pt)	2002-12-31
CZ94098A3 (cs)	1998-07-15
NO310355B1 (no)	2001-06-25
EP0854867B1 (fr)	2002-07-31
TW460465B (en)	2001-10-21
JP4108123B2 (ja)	2008-06-25
EP0854867A1 (fr)	1998-07-29
PL186781B1 (pl)	2004-02-27
CN1202887A (zh)	1998-12-23
DE69622731D1 (de)	2002-09-05
NO981396D0 (no)	1998-03-27
EA199800230A1 (ru)	1998-10-29
AR005233A1 (es)	1999-04-28
CZ292379B6 (cs)	2003-09-17
AU7214896A (en)	1997-04-28
IL123322A0 (en)	1998-09-24
ATE221520T1 (de)	2002-08-15
TR199800531T1 (xx)	1998-06-22
HUP9900040A2 (hu)	1999-04-28
HUP9900040A3 (en)	2001-01-29
CA2232509A1 (fr)	1997-04-10
EA000875B1 (ru)	2000-06-26
US5977136A (en)	1999-11-02
KR19990063850A (ko)	1999-07-26
NO981396L (no)	1998-05-27
KR100464895B1 (ko)	2005-05-16
NZ319596A (en)	1999-09-29
WO1997012870A1 (fr)	1997-04-10
AP9801212A0 (en)	1998-03-31
CN1130346C (zh)	2003-12-10
AU708148B2 (en)	1999-07-29

Publication	Publication Date	Title
DK0802910T3 (da)	2002-05-21	Estrogenagonister/antagonister
EE9600186A (et)	1997-08-15	Neurokiniini (tahhüülkiniini) antagonistid
DK1009732T3 (da)	2003-09-22	1-Amino-alkylcyclohexan NMDA receptor antagonister
NO974463L (no)	1997-09-26	Anordninger for tele-arbeid
FI960516L (fi)	1996-08-07	Substituoituja bifenyylisulfonamidiendoteliiniantagonisteja
FI961628A0 (fi)	1996-04-12	Indolijohdannaisia NMDA-antagonisteina
DK0854867T3 (da)	2002-12-02	Tetrahydroquinoliner som NMDA-antagonister
DK0922034T3 (da)	2002-11-18	Tetrahydroquinolinderivater som EAA-antagonister
DK1068202T3 (da)	2009-03-16	1-(-heteroarylpropyl- eller -prop-2-enyl)-4benzylpipderidiner som NMDA-receptor-antagonister
NO974043L (no)	1997-11-03	Indolderivater som EAA-antagonister
DK0929521T3 (da)	2006-03-27	NMDA-antagonister (N-methyl-D-aspartat-antagnonister)
FI972862A7 (fi)	1997-09-03	Uudet stafylokinaasijohdannaiset
ATA46395A (de)	1999-03-15	Hängebahn
DK0770603T3 (da)	1999-06-14	Alkynylphenylaminosulfonylurinstoffer som herbicider
KR970702876A (ko)	1997-06-10	뉴로키닌 길항제(Neurokinine (tachykinine) antagonists)
EE03762B1 (et)	2002-06-17	Protsess NMDA antagonistide valmistamiseks
FI970143A0 (fi)	1997-01-14	Kinoliinijohdannaiset leukotrieeniantagonisteina
SE9502290D0 (sv)	1995-06-26	New Preparation
FI960434A0 (fi)	1996-01-30	Slaganordning som arbetar med hydrauliskt tryck
FI940181A0 (fi)	1994-01-14	Foerfarande foer aostadkommande av en masspektrometer som fungerar under lufttryck
FIU950183U0 (fi)	1995-04-10	Faerdiggraeddad matsporation avsedd att foertaeras som engaongsportion
SK1155U (sk)	1996-05-08	Rameno