DK0844241T3 - Inhibitor af narkotisk analgetisk afhængighed/resistensudvikling - Google Patents
Inhibitor af narkotisk analgetisk afhængighed/resistensudviklingInfo
- Publication number
- DK0844241T3 DK0844241T3 DK96926004T DK96926004T DK0844241T3 DK 0844241 T3 DK0844241 T3 DK 0844241T3 DK 96926004 T DK96926004 T DK 96926004T DK 96926004 T DK96926004 T DK 96926004T DK 0844241 T3 DK0844241 T3 DK 0844241T3
- Authority
- DK
- Denmark
- Prior art keywords
- narcotic analgesic
- inhibitor
- resistance development
- development
- substituted
- Prior art date
Links
- 239000004084 narcotic analgesic agent Substances 0.000 title abstract 3
- 239000003112 inhibitor Substances 0.000 title 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 2
- 125000004076 pyridyl group Chemical group 0.000 abstract 2
- -1 2-oxo-1-pyrrolidinyl group Chemical group 0.000 abstract 1
- 239000004480 active ingredient Substances 0.000 abstract 1
- 230000000202 analgesic effect Effects 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/4015—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil having oxo groups directly attached to the heterocyclic ring, e.g. piracetam, ethosuximide
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/402—1-aryl substituted, e.g. piretanide
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/485—Morphinan derivatives, e.g. morphine, codeine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
- C07D207/22—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D207/24—Oxygen or sulfur atoms
- C07D207/26—2-Pyrrolidones
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Epidemiology (AREA)
- Emergency Medicine (AREA)
- Neurology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Psychiatry (AREA)
- Addiction (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP20076395 | 1995-08-07 | ||
| PCT/JP1996/002207 WO1997006139A1 (en) | 1995-08-07 | 1996-08-06 | Inhibitor for narcotic analgetic dependence/resistance acquisition |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK0844241T3 true DK0844241T3 (da) | 2003-05-12 |
Family
ID=16429771
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK96926004T DK0844241T3 (da) | 1995-08-07 | 1996-08-06 | Inhibitor af narkotisk analgetisk afhængighed/resistensudvikling |
Country Status (13)
| Country | Link |
|---|---|
| US (1) | US6107330A (da) |
| EP (1) | EP0844241B1 (da) |
| KR (1) | KR19990036248A (da) |
| CN (1) | CN1085979C (da) |
| AT (1) | ATE231491T1 (da) |
| AU (1) | AU6631396A (da) |
| CA (1) | CA2228813A1 (da) |
| DE (1) | DE69625913T2 (da) |
| DK (1) | DK0844241T3 (da) |
| ES (1) | ES2191763T3 (da) |
| NO (1) | NO315078B1 (da) |
| TW (1) | TW457087B (da) |
| WO (1) | WO1997006139A1 (da) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1998014213A1 (en) * | 1996-10-01 | 1998-04-09 | Daiichi Pharmaceutical Co., Ltd. | Mitochondrial membrane stabilizer |
| US6281242B1 (en) * | 1997-07-15 | 2001-08-28 | Daiichi Pharmaceutical Co., Ltd. | Prophylactic or therapeutic agent for amnesia |
| US6890951B2 (en) | 1998-08-05 | 2005-05-10 | Brookhaven Science Associates Llc | Treatment of addiction and addiction-related behavior |
| US20040077709A1 (en) * | 1999-05-31 | 2004-04-22 | Daiichi Pharmaceutical Co., Ltd. | Neuronal death inhibitors |
| US6423739B1 (en) | 2000-02-23 | 2002-07-23 | Daiichi Pharmaceutical Co., Ltd. | Method for aiding cerebral recovery following neurodegeneration |
| US6348489B1 (en) * | 2000-04-11 | 2002-02-19 | Daiichi Pharmaceutical Co., Ltd. | Method of treating traumatic brain injury and other neuronal disorders |
| JPWO2002053153A1 (ja) * | 2000-12-28 | 2004-04-30 | 第一製薬株式会社 | 神経因性疼痛治療及び予防薬 |
| WO2004039372A1 (en) | 2002-10-29 | 2004-05-13 | Sungkyunkwan University | Medicament component of berberine for the use of prevention and treatment of psycological dependence on and analgesic tolerance to morphine |
| US20060241144A1 (en) * | 2005-04-20 | 2006-10-26 | Albert Cha | Method for treating apathy syndrome |
Family Cites Families (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5198317A (en) * | 1975-02-21 | 1976-08-30 | 22 okisopirorijin 11 iruasetamidochushaekinoseizoho | |
| US4212878A (en) * | 1978-01-26 | 1980-07-15 | The Upjohn Company | Phenylacetamide derivative analgesics |
| IT1141287B (it) * | 1979-06-13 | 1986-10-01 | Nattermann A & Cie | Ammidi di acidi pirrolidin-(2)-on-(1)-ilalchil-carbossilici,procedimento per la loro preparazione e prodotti medicinali che le contengono |
| US4490167A (en) * | 1979-08-06 | 1984-12-25 | Ciba-Geigy Corporation | Oxime derivatives of diphenyl ethers and their use in herbicidal compositions |
| BE893276A (fr) * | 1981-06-01 | 1982-11-24 | Sandoz Sa | Nouvelle application therapeutique d'un derive de l'acetamide |
| IL91451A0 (en) * | 1988-08-30 | 1990-04-29 | Bristol Myers Co | Pharmaceutical compositions comprising azapiron compounds and their use in the treatment of addiction |
| US5185329A (en) * | 1988-08-30 | 1993-02-09 | Bristol-Myers Squibb Company | Method for treatment of substance addiction |
| US5468749A (en) * | 1988-08-30 | 1995-11-21 | Gawin; Frank H. | Method for treatment of substance addiction |
| EP0415693A1 (en) * | 1989-08-28 | 1991-03-06 | Arizona Technology Development Corporation | Composition and method for selective enhancement of opiate activity and reduction of opiate tolerance and dependence |
| US5220018A (en) * | 1991-04-10 | 1993-06-15 | Merck & Co., Inc. | Cholecystokinin antagonists |
| IL101514A (en) * | 1991-04-10 | 1996-01-31 | Merck & Co Inc | Benzodiazepinone derivatives and cholecystokinin antagonist pharmaceutical compositions containing them |
| JPH0517421A (ja) * | 1991-07-10 | 1993-01-26 | Yamanouchi Pharmaceut Co Ltd | Ｎ−置換アミド誘導体 |
| US5461157A (en) * | 1992-06-19 | 1995-10-24 | Daiichi Pharmaceutical Co., Ltd. | Process for preparing pyrrolidinylacetamide derivatives |
| JPH0665197A (ja) * | 1992-06-19 | 1994-03-08 | Dai Ichi Seiyaku Co Ltd | ピロリジニルアセトアミド誘導体の製法 |
-
1995
- 1995-08-06 US US09/000,236 patent/US6107330A/en not_active Expired - Fee Related
-
1996
- 1996-08-06 ES ES96926004T patent/ES2191763T3/es not_active Expired - Lifetime
- 1996-08-06 DE DE69625913T patent/DE69625913T2/de not_active Expired - Fee Related
- 1996-08-06 TW TW085109475A patent/TW457087B/zh not_active IP Right Cessation
- 1996-08-06 WO PCT/JP1996/002207 patent/WO1997006139A1/ja not_active Ceased
- 1996-08-06 DK DK96926004T patent/DK0844241T3/da active
- 1996-08-06 KR KR1019980700916A patent/KR19990036248A/ko not_active Abandoned
- 1996-08-06 AU AU66313/96A patent/AU6631396A/en not_active Abandoned
- 1996-08-06 AT AT96926004T patent/ATE231491T1/de not_active IP Right Cessation
- 1996-08-06 CA CA002228813A patent/CA2228813A1/en not_active Abandoned
- 1996-08-06 EP EP96926004A patent/EP0844241B1/en not_active Expired - Lifetime
- 1996-08-06 CN CN96197355A patent/CN1085979C/zh not_active Expired - Fee Related
-
1998
- 1998-02-06 NO NO19980531A patent/NO315078B1/no unknown
Also Published As
| Publication number | Publication date |
|---|---|
| EP0844241A4 (en) | 1998-11-18 |
| US6107330A (en) | 2000-08-22 |
| DE69625913D1 (de) | 2003-02-27 |
| CN1085979C (zh) | 2002-06-05 |
| AU6631396A (en) | 1997-03-05 |
| CN1198738A (zh) | 1998-11-11 |
| ATE231491T1 (de) | 2003-02-15 |
| NO315078B1 (no) | 2003-07-07 |
| EP0844241A1 (en) | 1998-05-27 |
| KR19990036248A (ko) | 1999-05-25 |
| ES2191763T3 (es) | 2003-09-16 |
| WO1997006139A1 (en) | 1997-02-20 |
| NO980531L (no) | 1998-04-06 |
| DE69625913T2 (de) | 2003-11-27 |
| CA2228813A1 (en) | 1997-02-20 |
| TW457087B (en) | 2001-10-01 |
| NO980531D0 (no) | 1998-02-06 |
| EP0844241B1 (en) | 2003-01-22 |
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