DK0733046T3 - Benzoylguanidiner, deres fremstilling og anvendelse i medikamenter - Google Patents
Benzoylguanidiner, deres fremstilling og anvendelse i medikamenterInfo
- Publication number
- DK0733046T3 DK0733046T3 DK94931019T DK94931019T DK0733046T3 DK 0733046 T3 DK0733046 T3 DK 0733046T3 DK 94931019 T DK94931019 T DK 94931019T DK 94931019 T DK94931019 T DK 94931019T DK 0733046 T3 DK0733046 T3 DK 0733046T3
- Authority
- DK
- Denmark
- Prior art keywords
- pct
- benzoylguanidines
- drugs
- preparation
- date
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/72—Nitrogen atoms
- C07D213/74—Amino or imino radicals substituted by hydrocarbon or substituted hydrocarbon radicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/10—Antioedematous agents; Diuretics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
- C07D239/72—Quinazolines; Hydrogenated quinazolines
- C07D239/95—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in positions 2 and 4
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Urology & Nephrology (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Vascular Medicine (AREA)
- Endocrinology (AREA)
- Reproductive Health (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE4337611A DE4337611A1 (de) | 1993-11-04 | 1993-11-04 | Neue Benzoylguanidine, ihre Herstellung und ihre Verwendung in Arzneimitteln |
| PCT/EP1994/003581 WO1995012584A1 (fr) | 1993-11-04 | 1994-10-31 | Nouvelles benzoylguanidines, leur preparation et leur utilisation dans des medicaments |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK0733046T3 true DK0733046T3 (da) | 2001-09-03 |
Family
ID=6501758
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK94931019T DK0733046T3 (da) | 1993-11-04 | 1994-10-31 | Benzoylguanidiner, deres fremstilling og anvendelse i medikamenter |
Country Status (20)
| Country | Link |
|---|---|
| US (1) | US5783576A (fr) |
| EP (1) | EP0733046B1 (fr) |
| JP (1) | JPH09504535A (fr) |
| KR (1) | KR100359676B1 (fr) |
| CN (1) | CN1056609C (fr) |
| AT (1) | ATE202563T1 (fr) |
| AU (1) | AU687911B2 (fr) |
| CA (1) | CA2175838A1 (fr) |
| CO (1) | CO4290417A1 (fr) |
| DE (2) | DE4337611A1 (fr) |
| DK (1) | DK0733046T3 (fr) |
| ES (1) | ES2157993T3 (fr) |
| GR (1) | GR3036642T3 (fr) |
| NZ (1) | NZ274849A (fr) |
| PL (1) | PL180302B1 (fr) |
| PT (1) | PT733046E (fr) |
| RU (1) | RU2136659C1 (fr) |
| TW (1) | TW400319B (fr) |
| WO (1) | WO1995012584A1 (fr) |
| ZA (1) | ZA948670B (fr) |
Families Citing this family (32)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ZA9610687B (en) * | 1995-12-22 | 1997-09-29 | Smithkline Beecham Corp | Novel synthesis. |
| DE19601303A1 (de) * | 1996-01-16 | 1997-07-17 | Boehringer Ingelheim Kg | Neuartige Benzoylguanidin-Derivate, Verfahren zu ihrer Herstellung und ihre Verwendung bei der Herstellung von Arzneimitteln |
| EP1080075B1 (fr) * | 1998-03-23 | 2004-08-11 | Aventis Pharmaceuticals Inc. | Derives de piperididinyle et n-amidinopiperidinyle |
| US6239279B1 (en) * | 1998-12-16 | 2001-05-29 | Smithkline Beecham Corporation | Synthesis for 4-aryl-5-pyrimidine imidazole substituted derivatives |
| WO2000075115A1 (fr) | 1999-06-03 | 2000-12-14 | Takeda Chemical Industries, Ltd. | Preparations s'administrant par voie nasale |
| US6156758A (en) * | 1999-09-08 | 2000-12-05 | Isis Pharmaceuticals, Inc. | Antibacterial quinazoline compounds |
| IL164703A0 (en) * | 2002-04-19 | 2005-12-18 | Cellular Genomics Inc | ImidazoÄ1,2-AÜpyrazin-8-ylamines method of making and method of use thereof |
| AU2003270489A1 (en) * | 2002-09-09 | 2004-03-29 | Cellular Genomics, Inc. | 6-ARYL-IMIDAZO(1,2-a)PYRAZIN-8-YLAMINES, METHOD OF MAKING, AND METHOD OF USE THEREOF |
| US7160885B2 (en) * | 2003-02-10 | 2007-01-09 | Cgi Pharmaceuticals, Inc. | Certain 6, 8-(heteroaryl or aryl) disubstituted imidazo[1,2-a]pyrazines as modulators of Hsp90 complex activity |
| WO2005014599A1 (fr) * | 2003-06-04 | 2005-02-17 | Cellular Genomics, Inc. | Imidazo[1,2-a]pyrazin-8-ylamines et methodes d'inhibition de la tyrosine kinase de bruton par de tels composes |
| US20060183746A1 (en) * | 2003-06-04 | 2006-08-17 | Currie Kevin S | Certain imidazo[1,2-a]pyrazin-8-ylamines and method of inhibition of Bruton's tyrosine kinase by such compounds |
| US7393848B2 (en) * | 2003-06-30 | 2008-07-01 | Cgi Pharmaceuticals, Inc. | Certain heterocyclic substituted imidazo[1,2-A]pyrazin-8-ylamines and methods of inhibition of Bruton's tyrosine kinase by such compounds |
| US7259164B2 (en) * | 2003-08-11 | 2007-08-21 | Cgi Pharmaceuticals, Inc. | Certain substituted imidazo[1,2-a]pyrazines, as modulators of kinase activity |
| WO2005030776A1 (fr) * | 2003-09-23 | 2005-04-07 | Vertex Pharmaceuticals Incorporated | Derives de pyrazolopyrrole utilises en tant qu'inhibiteurs de proteines kinases |
| EP2397478A1 (fr) * | 2005-01-14 | 2011-12-21 | CGI Pharmaceuticals, Inc. | Urées 1,3-diaryl substituées en tant que modulateurs d'activité de kinase |
| WO2007024294A2 (fr) * | 2005-05-03 | 2007-03-01 | Cgi Pharmaceuticals, Inc. | Certains urees substitues, modulateurs de l'activite des kinases |
| JP2009507032A (ja) | 2005-09-02 | 2009-02-19 | アボット・ラボラトリーズ | 新規なイミダゾ系複素環 |
| US20090221612A1 (en) | 2008-02-13 | 2009-09-03 | Mitchell Scott A | Certain substituted amides, method of making, and method of use thereof |
| MX2011006094A (es) | 2008-12-08 | 2011-11-29 | Gilead Connecticut Inc | Inhibidores de imidazopirazina syk. |
| US8450321B2 (en) | 2008-12-08 | 2013-05-28 | Gilead Connecticut, Inc. | 6-(1H-indazol-6-yl)-N-[4-(morpholin-4-yl)phenyl]imidazo-[1,2-A]pyrazin-8-amine, or a pharmaceutically acceptable salt thereof, as a SYK inhibitor |
| KR101745732B1 (ko) | 2008-12-08 | 2017-06-12 | 질레드 코네티컷 인코포레이티드 | 이미다조피라진 syk 억제제 |
| TW201200518A (en) * | 2010-03-10 | 2012-01-01 | Kalypsys Inc | Heterocyclic inhibitors of histamine receptors for the treatment of disease |
| BR112012022943A2 (pt) | 2010-03-11 | 2018-06-05 | Gilead Connecticut Inc | inibidores de syk de imidazopiridnas |
| PT3027171T (pt) | 2013-07-30 | 2020-06-18 | Gilead Connecticut Inc | Formulação de inibidores da syk |
| MX2016001304A (es) | 2013-07-30 | 2016-04-07 | Gilead Connecticut Inc | Polimorfo de inhibidores de syk. |
| SG11201603050TA (en) | 2013-12-04 | 2016-05-30 | Gilead Sciences Inc | Methods for treating cancers |
| US9290505B2 (en) | 2013-12-23 | 2016-03-22 | Gilead Sciences, Inc. | Substituted imidazo[1,2-a]pyrazines as Syk inhibitors |
| TWI735853B (zh) | 2013-12-23 | 2021-08-11 | 美商克洛諾斯生技有限公司 | 脾酪胺酸激酶抑制劑 |
| MX2017000610A (es) | 2014-07-14 | 2017-04-27 | Gilead Sciences Inc | Metodos combinados para tratar canceres. |
| CN115028640A (zh) | 2017-08-25 | 2022-09-09 | 吉利德科学公司 | Syk抑制剂的多晶型物 |
| KR20210131372A (ko) | 2019-02-22 | 2021-11-02 | 크로노스 바이오, 인코포레이티드 | Syk 억제제로서의 축합된 피라진의 고체 형태 |
| WO2024086790A1 (fr) * | 2022-10-21 | 2024-04-25 | Exelixis, Inc. | Composés de 4,5,6,7-tétrahydro-1h-pyrazolo[4,3-c]pyridine et dérivés utilisés en tant qu'inhibiteurs de usp1 |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3953476A (en) * | 1971-12-27 | 1976-04-27 | Merck & Co., Inc. | 3-Amino-5-sulfonylbenzoic acids |
| SU1114021A1 (ru) * | 1982-11-11 | 1995-12-20 | Институт Тонкой Органической Химии Им.А.Л.Мнджояна | 4-метоксибензилгуанидин или его сернокислая соль, оказывающие ингибирующее действие на моноаминоксидазу мозга |
| DE3929582A1 (de) * | 1989-09-06 | 1991-03-07 | Hoechst Ag | Benzoylguanidine, verfahren zu ihrer herstellung, ihre verwendung als medikament sowie sie enthaltendes medikament |
| DK0556674T3 (da) * | 1992-02-15 | 1996-10-14 | Hoechst Ag | 3,5-Substituerede benzoylguanidiner med antiarytmisk virkning og inhiberende virkning på celleproliferation |
| CZ284456B6 (cs) * | 1992-02-15 | 1998-12-16 | Hoechst Aktiengesellschaft | Aminosubstituované benzoylguanidiny, způsob jejich přípravy, jejich použití jako léčiv a léčivo, které je obsahuje |
| EP0589336B1 (fr) * | 1992-09-22 | 1997-01-08 | Hoechst Aktiengesellschaft | Benzoylguanidines, leur procédé de préparation et leur utilisation comme agents antiarrhythmiques |
| ATE151071T1 (de) * | 1992-12-16 | 1997-04-15 | Hoechst Ag | 3,5-substituierte aminobenzoylguanidine, verfahren zu ihrer herstellung, ihre verwendung als medikament oder diagnostikum sowie sie enthaltendes medikament |
-
1993
- 1993-11-04 DE DE4337611A patent/DE4337611A1/de not_active Ceased
-
1994
- 1994-10-31 PL PL94314188A patent/PL180302B1/pl unknown
- 1994-10-31 DE DE59409794T patent/DE59409794D1/de not_active Expired - Fee Related
- 1994-10-31 CN CN94194015A patent/CN1056609C/zh not_active Expired - Fee Related
- 1994-10-31 ES ES94931019T patent/ES2157993T3/es not_active Expired - Lifetime
- 1994-10-31 RU RU96112103A patent/RU2136659C1/ru not_active IP Right Cessation
- 1994-10-31 PT PT94931019T patent/PT733046E/pt unknown
- 1994-10-31 NZ NZ274849A patent/NZ274849A/en unknown
- 1994-10-31 KR KR1019960702300A patent/KR100359676B1/ko not_active Expired - Fee Related
- 1994-10-31 EP EP94931019A patent/EP0733046B1/fr not_active Expired - Lifetime
- 1994-10-31 US US08/649,614 patent/US5783576A/en not_active Expired - Lifetime
- 1994-10-31 AT AT94931019T patent/ATE202563T1/de not_active IP Right Cessation
- 1994-10-31 CA CA002175838A patent/CA2175838A1/fr not_active Abandoned
- 1994-10-31 JP JP7513011A patent/JPH09504535A/ja active Pending
- 1994-10-31 WO PCT/EP1994/003581 patent/WO1995012584A1/fr not_active Ceased
- 1994-10-31 AU AU79937/94A patent/AU687911B2/en not_active Ceased
- 1994-10-31 DK DK94931019T patent/DK0733046T3/da active
- 1994-11-02 CO CO94050176A patent/CO4290417A1/es unknown
- 1994-11-03 ZA ZA948670A patent/ZA948670B/xx unknown
- 1994-11-04 TW TW083110205A patent/TW400319B/zh active
-
2001
- 2001-09-18 GR GR20010401500T patent/GR3036642T3/el not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| GR3036642T3 (en) | 2001-12-31 |
| DE4337611A1 (de) | 1995-05-11 |
| US5783576A (en) | 1998-07-21 |
| RU2136659C1 (ru) | 1999-09-10 |
| CN1056609C (zh) | 2000-09-20 |
| PL180302B1 (pl) | 2001-01-31 |
| HK1010722A1 (en) | 1999-06-25 |
| AU7993794A (en) | 1995-05-23 |
| NZ274849A (en) | 1998-08-26 |
| ATE202563T1 (de) | 2001-07-15 |
| KR100359676B1 (ko) | 2003-04-16 |
| PL314188A1 (en) | 1996-09-02 |
| ZA948670B (en) | 1995-07-04 |
| CN1134146A (zh) | 1996-10-23 |
| TW400319B (en) | 2000-08-01 |
| PT733046E (pt) | 2001-10-30 |
| EP0733046B1 (fr) | 2001-06-27 |
| CA2175838A1 (fr) | 1995-05-11 |
| DE59409794D1 (de) | 2001-08-02 |
| AU687911B2 (en) | 1998-03-05 |
| CO4290417A1 (es) | 1996-04-17 |
| KR960705789A (ko) | 1996-11-08 |
| JPH09504535A (ja) | 1997-05-06 |
| WO1995012584A1 (fr) | 1995-05-11 |
| EP0733046A1 (fr) | 1996-09-25 |
| ES2157993T3 (es) | 2001-09-01 |
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