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DK0731838T3 - Bindende struktur rettet mod CA55.1 antigenet - Google Patents

Bindende struktur rettet mod CA55.1 antigenet

Info

Publication number
DK0731838T3
DK0731838T3 DK95902188T DK95902188T DK0731838T3 DK 0731838 T3 DK0731838 T3 DK 0731838T3 DK 95902188 T DK95902188 T DK 95902188T DK 95902188 T DK95902188 T DK 95902188T DK 0731838 T3 DK0731838 T3 DK 0731838T3
Authority
DK
Denmark
Prior art keywords
seq
antigen
binding structure
cdr2
cdr3
Prior art date
Application number
DK95902188T
Other languages
English (en)
Inventor
Susan Margaret Hall
Michael Samuel Rose
Christopher Boot
Clive Graham Copley
Douglas Stephen Paterson
Andrew Firmin Wright
David Charles Blakey
Original Assignee
Astrazeneca Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB939324819A external-priority patent/GB9324819D0/en
Priority claimed from GB9411089A external-priority patent/GB9411089D0/en
Application filed by Astrazeneca Ab filed Critical Astrazeneca Ab
Application granted granted Critical
Publication of DK0731838T3 publication Critical patent/DK0731838T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
    • C07K16/3046—Stomach, Intestines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Cell Biology (AREA)
  • Zoology (AREA)
  • Toxicology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Breeding Of Plants And Reproduction By Means Of Culturing (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
DK95902188T 1993-12-03 1994-11-29 Bindende struktur rettet mod CA55.1 antigenet DK0731838T3 (da)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB939324819A GB9324819D0 (en) 1993-12-03 1993-12-03 Proteins
GB9411089A GB9411089D0 (en) 1994-06-03 1994-06-03 Proteins
PCT/GB1994/002610 WO1995015382A1 (en) 1993-12-03 1994-11-29 Binding structures directed against the ca55.1 antigen

Publications (1)

Publication Number Publication Date
DK0731838T3 true DK0731838T3 (da) 2004-05-24

Family

ID=26303960

Family Applications (1)

Application Number Title Priority Date Filing Date
DK95902188T DK0731838T3 (da) 1993-12-03 1994-11-29 Bindende struktur rettet mod CA55.1 antigenet

Country Status (14)

Country Link
US (1) US5665357A (da)
EP (1) EP0731838B1 (da)
JP (1) JP3962087B2 (da)
AT (1) ATE259877T1 (da)
AU (1) AU684863B2 (da)
CA (1) CA2174972A1 (da)
DE (1) DE69433563T2 (da)
DK (1) DK0731838T3 (da)
ES (1) ES2214494T3 (da)
GB (1) GB9424108D0 (da)
IL (1) IL111748A0 (da)
NZ (1) NZ276745A (da)
PT (1) PT731838E (da)
WO (1) WO1995015382A1 (da)

Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20040117863A1 (en) * 1998-09-18 2004-06-17 Edge Michael D. Transgenically produced fusion proteins
EP1220864A4 (en) * 1999-09-17 2003-05-21 Genzyme Transgenics Corp TRANSGENICALLY PRODUCED FUSION PROTEINS
BR0014524A (pt) * 1999-09-17 2002-06-11 Genzyme Transgenics Corp Proteìnas de fusão otimizadas com subunidade
WO2003074704A1 (fr) * 2002-03-01 2003-09-12 Japan Envirochemicals, Ltd. Proteines capables de se lier aux hormones sexuelles feminines et procede de preparation
MX342007B (es) * 2003-05-14 2016-09-09 Immunogen Inc Composicion de farmaco conjugado.
US20110166319A1 (en) * 2005-02-11 2011-07-07 Immunogen, Inc. Process for preparing purified drug conjugates
WO2006086733A2 (en) 2005-02-11 2006-08-17 Immunogen, Inc. Process for preparing maytansinoid antibody conjugates
EA014513B1 (ru) * 2005-08-03 2010-12-30 Иммьюноджен, Инк. Композиция иммуноконъюгата
NZ595430A (en) 2005-08-24 2013-05-31 Immunogen Inc Process for preparing maytansinoid antibody conjugates
CN104524592B (zh) 2008-04-30 2018-06-05 伊缪诺金公司 交联剂和它们的用途
US8293101B2 (en) 2009-03-13 2012-10-23 Terrasep, Llc Methods and apparatus for centrifugal liquid chromatography
KR101947176B1 (ko) 2009-06-03 2019-02-12 이뮤노젠 아이엔씨 접합 방법
CA2780713A1 (en) * 2009-09-03 2011-03-10 Vancouver Biotech Ltd. Monoclonal antibodies against gonadotropin-releasing hormone receptor
JP2013506709A (ja) 2009-10-06 2013-02-28 イミュノジェン・インコーポレーテッド 有効なコンジュゲートおよび親水性リンカー
WO2012135517A2 (en) 2011-03-29 2012-10-04 Immunogen, Inc. Preparation of maytansinoid antibody conjugates by a one-step process
EA201991268A3 (ru) 2011-03-29 2020-01-31 Иммуноджен, Инк. Получение конъюгатов "майтансиноид-антитело" одностадийным способом
HK1213288A1 (zh) 2012-10-04 2016-06-30 Immunogen, Inc. 使用pvdf膜純化細胞結合劑細胞毒性劑綴合物
JP2016021883A (ja) * 2014-07-17 2016-02-08 日産化学工業株式会社 ヒト大腸癌細胞Ｃｏｌｏ２０５に特異的に結合する核酸
US9616114B1 (en) 2014-09-18 2017-04-11 David Gordon Bermudes Modified bacteria having improved pharmacokinetics and tumor colonization enhancing antitumor activity
CN107592813A (zh) 2014-11-19 2018-01-16 伊缪诺金公司 用于制备细胞结合剂‑细胞毒性剂缀合物的方法
US10676723B2 (en) 2015-05-11 2020-06-09 David Gordon Bermudes Chimeric protein toxins for expression by therapeutic bacteria
KR20180105233A (ko) 2016-02-05 2018-09-27 이뮤노젠 아이엔씨 세포 결합제-세포독성제 접합체를 제조하기 위한 효율적인 방법
US11180535B1 (en) 2016-12-07 2021-11-23 David Gordon Bermudes Saccharide binding, tumor penetration, and cytotoxic antitumor chimeric peptides from therapeutic bacteria
US11129906B1 (en) 2016-12-07 2021-09-28 David Gordon Bermudes Chimeric protein toxins for expression by therapeutic bacteria
EP3813878A4 (en) 2018-06-14 2022-03-16 2seventy bio, Inc. CAR ANTI-BCMA ANTIBODIES, CONJUGATES AND METHODS OF USE
US20230030085A1 (en) * 2019-12-16 2023-02-02 2Seventy Bio, Inc. Anti-bcma car antibodies, conjugates, and methods of use

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4867973A (en) * 1984-08-31 1989-09-19 Cytogen Corporation Antibody-therapeutic agent conjugates
EP0289400A3 (en) * 1987-04-30 1990-01-24 Fairchild Weston Systems Inc. High speed asynchronous data multiplexer/demultiplexer
HUT53672A (en) * 1988-02-25 1990-11-28 Gen Hospital Corp Quick immunoselective cloning process

Also Published As

Publication number Publication date
EP0731838A1 (en) 1996-09-18
JPH09506507A (ja) 1997-06-30
GB9424108D0 (en) 1995-01-18
WO1995015382A1 (en) 1995-06-08
DE69433563T2 (de) 2004-12-23
DE69433563D1 (de) 2004-03-25
PT731838E (pt) 2004-05-31
CA2174972A1 (en) 1995-06-08
AU684863B2 (en) 1998-01-08
AU1113095A (en) 1995-06-19
ES2214494T3 (es) 2004-09-16
ATE259877T1 (de) 2004-03-15
NZ276745A (en) 1998-02-26
EP0731838B1 (en) 2004-02-18
JP3962087B2 (ja) 2007-08-22
US5665357A (en) 1997-09-09
IL111748A0 (en) 1995-01-24

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