DK0728148T3 - Forbedrede immunogene sammensætninger mod humant gastrin 17 - Google Patents

Forbedrede immunogene sammensætninger mod humant gastrin 17

Info

Publication number: DK0728148T3
Authority: DK; Denmark
Prior art keywords: pro; against human; glu; immunogenic compositions; human gastrin
Prior art date: 1993-11-12

Application number

DK95902570T

Other languages

English (en)

Inventor

Philip C Gevas

Stephen Grimes

Stephen L Karr

Dov Michaeli

Robert Scibienski

Original Assignee

Aphton Corp

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1993-11-12

Filing date

1994-11-10

Publication date

1999-09-27

1994-11-10 Application filed by Aphton Corp filed Critical Aphton Corp

1999-09-27 Application granted granted Critical

1999-09-27 Publication of DK0728148T3 publication Critical patent/DK0728148T3/da

Links

230000002163 immunogen Effects 0.000 title abstract 3
102400000921 Gastrin Human genes 0.000 title abstract 2
101001002317 Homo sapiens Gastrin Proteins 0.000 title abstract 2
GKDWRERMBNGKCZ-RNXBIMIWSA-N gastrin-17 Chemical compound C([C@@H](C(=O)NCC(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CC=1C=CC=CC=1)C(N)=O)NC(=O)[C@H](C)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC=1C2=CC=CC=C2NC=1)NC(=O)[C@H]1N(CCC1)C(=O)CNC(=O)[C@H]1NC(=O)CC1)C1=CC=C(O)C=C1 GKDWRERMBNGKCZ-RNXBIMIWSA-N 0.000 title abstract 2
239000000203 mixture Substances 0.000 title abstract 2
239000008194 pharmaceutical composition Substances 0.000 abstract 1
108090000765 processed proteins & peptides Proteins 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/595—Gastrins; Cholecystokinins [CCK]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
- Y10S530/827—Proteins from mammals or birds
- Y10S530/843—Digestive system
- Y10S530/844—Stomach; intestine

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Gastroenterology & Hepatology (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Molecular Biology (AREA)
Biophysics (AREA)
Biochemistry (AREA)
Genetics & Genomics (AREA)
Zoology (AREA)
Toxicology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Endocrinology (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Peptides Or Proteins (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

DK95902570T 1993-11-12 1994-11-10 Forbedrede immunogene sammensætninger mod humant gastrin 17 DK0728148T3 (da)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US08/151,219 US5468494A (en)	1993-11-12	1993-11-12	Immunogenic compositions against human gastrin 17
PCT/US1994/013205 WO1995013297A2 (en)	1993-11-12	1994-11-10	Improved immunogenic compositions against human gastrin 17

Publications (1)

Publication Number	Publication Date
DK0728148T3 true DK0728148T3 (da)	1999-09-27

Family

ID=22537815

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK95902570T DK0728148T3 (da)	1993-11-12	1994-11-10	Forbedrede immunogene sammensætninger mod humant gastrin 17

Country Status (10)

Country	Link
US (1)	US5468494A (da)
EP (1)	EP0728148B1 (da)
JP (1)	JP3694893B2 (da)
AT (1)	ATE177757T1 (da)
AU (1)	AU1179795A (da)
DE (1)	DE69417252T2 (da)
DK (1)	DK0728148T3 (da)
ES (1)	ES2130575T3 (da)
GR (1)	GR3029791T3 (da)
WO (1)	WO1995013297A2 (da)

Families Citing this family (33)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US6861510B1 (en) *	1989-01-24	2005-03-01	Aphton Corporation	Immunogenic compositions against gastrin peptides
ATE114160T1 (de) *	1989-01-24	1994-12-15	Aphton Corp	Immunogenische zusammensetzungen gegen gastrin- peptide.
CA2261433A1 (en) *	1993-12-09	1995-06-10	Belinda Sanchez Ramirez	Composition comprising autologous epidermal growth factor
US5688506A (en) *	1994-01-27	1997-11-18	Aphton Corp.	Immunogens against gonadotropin releasing hormone
EP0889735B1 (en) *	1996-02-08	2011-04-13	Cancer Advances, Inc.,	Immunological methods for the treatment of gastrointestinal cancer
NZ500748A (en)	1997-05-12	2001-06-29	Aphton Corp	Methods for the treatment of gastrin-dependent tumours comprising active or passive immunisation with an anti-CCK-B/gastrin receptor immunogen or anti-CCK-B/gastrin receptor antibodies
US20040001842A1 (en) *	1997-05-12	2004-01-01	Dov Michaeli	Immunogenic compositions to the CCK-B/gastrin receptor and methods for the treatment of tumors
US20030068326A1 (en) *	1998-05-15	2003-04-10	Aphton Corporation	Method for the treatment of gastroesophageal reflux disease
ATE300311T1 (de) *	1998-05-15	2005-08-15	Aphton Corp	Vorbereitung eines medikaments zur behandlung von refluxösophagitis
KR100699574B1 (ko) *	1998-05-15	2007-03-23	리셉터 바이오로직스 인크	종양 치료를 위한 조합 치료
AU4080399A (en) *	1998-05-15	1999-12-06	Aphton Corporation	Prevention and treatment of hypergastrinemia
AU770475B2 (en) *	1999-12-23	2004-02-19	Aphton Corporation	A stable immunogenic composition for frozen storage
US6783761B2 (en)	2000-05-05	2004-08-31	Aphton Corporation	Chimeric peptide immunogens
US20030091574A1 (en) *	2001-03-23	2003-05-15	Gevas Philip C.	Combination treatment of pancreatic cancer
CU22999A1 (es) *	2001-12-04	2004-10-12	Centro Inmunologia Molecular	Método de tratamiento de enfermedades malignas e infecciosas crónicas
US20090191232A1 (en) *	2001-05-04	2009-07-30	Gevas Philip C	Combination therapy for the treatment of tumors
CA2450898A1 (en) *	2001-07-09	2003-01-23	Aphton Corporation	Treatment and prevention of cancerous and pre-cancerous conditions of the liver, lung and esophagus
US20040247661A1 (en) *	2002-07-03	2004-12-09	Dov Michaeli	Liposomal vaccine
US20050169979A1 (en) *	2002-07-03	2005-08-04	Dov Michaeli	Liposomal vaccine
EP1528915A2 (en) *	2002-07-03	2005-05-11	Aphton Corporation	Liposomal vaccine
EP1608984A2 (en)	2003-03-28	2005-12-28	Aphton Corporation	Gastrin hormone immunoassays
JP2008513536A (ja)	2004-09-22	2008-05-01	レセプターバイオロジックスインコーポレイテッド	プロガストリンに対するモノクローナル抗体
CL2007002166A1 (es) *	2006-07-24	2008-01-25	Tetralogic Pharm Corp	Compuestos derivados de heterociclos de nitrogeno, antagonistas de los inhibidores de las proteinas de la apoptosis; sus composiciones farmaceuticas; y uso de dichos compuestos para el tratamiento del cancer.
JP5391071B2 (ja) *	2007-10-26	2014-01-15	株式会社先端生命科学研究所	ガストリン放出ペプチド前駆体に対する抗体及びその使用
CN102256620B (zh)	2008-08-07	2016-11-16	莫西亚药物公司	用于治疗阿尔茨海默氏病的免疫治疗组合物
US8283372B2 (en)	2009-07-02	2012-10-09	Tetralogic Pharmaceuticals Corp.	2-(1H-indol-3-ylmethyl)-pyrrolidine dimer as a SMAC mimetic
US8674064B2 (en) *	2010-03-03	2014-03-18	Onkologix Ltd	Immunogenic compositions against human progastrin peptides
CN101797382B (zh) *	2010-03-03	2013-11-20	戚胜美	抗人前胃液素多肽免疫组合物
GB201121571D0 (en)	2011-12-15	2012-01-25	Astrimmune Ltd	Compounds and uses thereof
EP2999485B1 (en)	2013-05-21	2018-01-31	Tyg Oncology Ltd.	Gastrin peptide immunogenic composition
AU2018283284B2 (en)	2017-06-15	2024-05-16	Cancer Advances Inc.	Compositions and methods for inducing humoral and cellular immunities against tumors and cancer
US12150978B2 (en)	2017-06-15	2024-11-26	Cancer Advances Inc.	Compositions and methods for preventing tumors and cancer
WO2022099128A1 (en) *	2020-11-06	2022-05-12	Cancer Advances Inc.	Compositions and methods for enhancing t cell penetration of tumors and cancers

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4691006A (en) *	1983-03-04	1987-09-01	Ohio State University	Antigenic modification of polypeptides
US4526716A (en) *	1981-11-20	1985-07-02	The Ohio State University	Antigenic modification of polypeptides
US4201770A (en) *	1973-05-07	1980-05-06	The Ohio State University	Antigenic modification of polypeptides
US4384995A (en) *	1980-01-16	1983-05-24	The Ohio State University	Antigenic modification of polypeptides
US4069313A (en) *	1974-11-19	1978-01-17	Merck & Co., Inc.	Water-in-oil adjuvant composition
US4894443A (en) *	1984-02-08	1990-01-16	Cetus Corporation	Toxin conjugates
ATE114160T1 (de) *	1989-01-24	1994-12-15	Aphton Corp	Immunogenische zusammensetzungen gegen gastrin- peptide.
US5023077A (en) *	1989-01-24	1991-06-11	Aphton Corporation	Immunogenic compositions and methods for the treatment and prevention of gastric and duodenal ulcer disease
US5120829A (en) *	1989-03-20	1992-06-09	La Jolla Cancer Research Foundation	Hydrophobic attachment site for adhesion peptides
US5256542A (en) *	1992-03-09	1993-10-26	Tanox Biosystems, Inc.	Selecting low frequency antigen-specific single B lymphocytes with correction for background noise

1993
- 1993-11-12 US US08/151,219 patent/US5468494A/en not_active Expired - Lifetime
1994
- 1994-11-10 JP JP51407395A patent/JP3694893B2/ja not_active Expired - Lifetime
- 1994-11-10 AT AT95902570T patent/ATE177757T1/de active
- 1994-11-10 DK DK95902570T patent/DK0728148T3/da active
- 1994-11-10 EP EP95902570A patent/EP0728148B1/en not_active Expired - Lifetime
- 1994-11-10 AU AU11797/95A patent/AU1179795A/en not_active Abandoned
- 1994-11-10 ES ES95902570T patent/ES2130575T3/es not_active Expired - Lifetime
- 1994-11-10 WO PCT/US1994/013205 patent/WO1995013297A2/en not_active Ceased
- 1994-11-10 DE DE69417252T patent/DE69417252T2/de not_active Expired - Lifetime
1999
- 1999-03-23 GR GR990400879T patent/GR3029791T3/el unknown

Also Published As

Publication number	Publication date
ES2130575T3 (es)	1999-07-01
WO1995013297A2 (en)	1995-05-18
DE69417252D1 (de)	1999-04-22
JP3694893B2 (ja)	2005-09-14
DE69417252T2 (de)	1999-07-08
EP0728148B1 (en)	1999-03-17
GR3029791T3 (en)	1999-06-30
WO1995013297A3 (en)	1995-06-15
EP0728148A1 (en)	1996-08-28
ATE177757T1 (de)	1999-04-15
US5468494A (en)	1995-11-21
AU1179795A (en)	1995-05-29
JPH09505056A (ja)	1997-05-20

Publication	Publication Date	Title
DK0728148T3 (da)	1999-09-27	Forbedrede immunogene sammensætninger mod humant gastrin 17
IL113812A0 (en)	1995-08-31	Copolymer-1, pharmaceutical compositions containing it and its use
GR3023233T3 (en)	1997-07-30	Inhibitors of dipeptidyl-aminopeptidase type iv
HUT75555A (en)	1997-05-28	Lactobacillus strains of human origin, their compositions and uses thereof
PH31059A (en)	1998-02-05	Pharmaceutical compositions comprising cyclosporins.
ATE146360T1 (de)	1997-01-15	Gonadotropin enthaltende gefriergetrocknete troepfen
GR3007385T3 (da)	1993-07-30
JO2034B1 (en)	1999-05-15	Isotopes of the hormone peptide its uses and the chemical compounds it contains
KR0180256B1 (en)	1999-04-01	Bpc peptides, their preparation and use
SE9101838D0 (sv)	1991-06-14	Novel peptides and their use
GR3024667T3 (en)	1997-12-31	Cosmetical or pharmaceutical compositions comprising deacylated glycerophospholipids for topical use.
BG103677A (en)	2000-06-30	Solid mixtures based on sulphonylcarbamides and adjuvants
AU1751892A (en)	1992-11-02	Novel peptide compositions and uses therefor
MY128260A (en)	2007-01-31	Cyclopentane-and-pentene-b-amino acids
ZA867887B (en)	1987-08-26	Peptides comprising,in sequence units selected from the aminoacid residues 17 to 24 of vip
MY106352A (en)	1995-05-30	Hemoregulatory peptides.
AU9731198A (en)	1999-05-17	Histogranin peptide and their analgesic use
OA09233A (en)	1992-06-30	Permanent waving process and compositions.
DE69524971D1 (de)	2002-02-14	Neue familie von proteaseinhibitoren und andere biologisch aktive substanzen
IL139604A (en)	2010-12-30	Fibrinogen-beta chain derived peptide, compositions comprising same and use thereof
CA2199624A1 (en)	1997-01-30	Polymerizable aromatic carboxylic acids and carboxyanhydrides with cyclic carbonate groups, as well as preparations containing these compounds
JO1992B1 (en)	1999-05-15	Fixed pharmaceutical compounds based on the derivatives of quinpristine and dalphopristine materials and their preparation process
ZA9710254B (en)	1998-05-28	LH-RH peptide analogues, their uses and pharmaceutical composition containing them.
EP0490383A3 (en)	1993-06-30	Peptides of the hiv-gag protein, their preparation and use
ES2013025A6 (es)	1990-04-16	Un metodo para preparar 24r-escimnol.