DK0727994T3 - Anvendelse af antipyretiske og analgetiske præparater indeholdende optisk rent R-etodolac - Google Patents
Anvendelse af antipyretiske og analgetiske præparater indeholdende optisk rent R-etodolacInfo
- Publication number
- DK0727994T3 DK0727994T3 DK93907465T DK93907465T DK0727994T3 DK 0727994 T3 DK0727994 T3 DK 0727994T3 DK 93907465 T DK93907465 T DK 93907465T DK 93907465 T DK93907465 T DK 93907465T DK 0727994 T3 DK0727994 T3 DK 0727994T3
- Authority
- DK
- Denmark
- Prior art keywords
- etodolac
- pain
- optically pure
- antipyretic
- preparations containing
- Prior art date
Links
- NNYBQONXHNTVIJ-QGZVFWFLSA-N (R)-etodolac Chemical compound C1CO[C@](CC)(CC(O)=O)C2=C1C(C=CC=C1CC)=C1N2 NNYBQONXHNTVIJ-QGZVFWFLSA-N 0.000 title abstract 3
- 230000000202 analgesic effect Effects 0.000 title 1
- 230000001754 anti-pyretic effect Effects 0.000 title 1
- 239000002221 antipyretic Substances 0.000 title 1
- 238000002360 preparation method Methods 0.000 title 1
- 208000002193 Pain Diseases 0.000 abstract 5
- 230000002411 adverse Effects 0.000 abstract 2
- 230000000694 effects Effects 0.000 abstract 2
- NNYBQONXHNTVIJ-UHFFFAOYSA-N etodolac Chemical compound C1COC(CC)(CC(O)=O)C2=C1C(C=CC=C1CC)=C1N2 NNYBQONXHNTVIJ-UHFFFAOYSA-N 0.000 abstract 2
- 229960005293 etodolac Drugs 0.000 abstract 2
- 239000000203 mixture Substances 0.000 abstract 2
- 208000006820 Arthralgia Diseases 0.000 abstract 1
- 206010019233 Headaches Diseases 0.000 abstract 1
- 206010037660 Pyrexia Diseases 0.000 abstract 1
- 208000010040 Sprains and Strains Diseases 0.000 abstract 1
- 230000027950 fever generation Effects 0.000 abstract 1
- 231100000869 headache Toxicity 0.000 abstract 1
- 208000004371 toothache Diseases 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Pain & Pain Management (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US85322292A | 1992-03-13 | 1992-03-13 | |
| US2983493A | 1993-03-11 | 1993-03-11 | |
| PCT/US1993/002282 WO1993017680A1 (fr) | 1992-03-13 | 1993-03-12 | Procedes et compositions antipyretiques et analgesiques contenant de l'acide etodolique r optiquement pur |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK0727994T3 true DK0727994T3 (da) | 2000-08-07 |
Family
ID=26705391
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK93907465T DK0727994T3 (da) | 1992-03-13 | 1993-03-12 | Anvendelse af antipyretiske og analgetiske præparater indeholdende optisk rent R-etodolac |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US5561151A (fr) |
| EP (1) | EP0727994B1 (fr) |
| JP (1) | JPH07506817A (fr) |
| AT (1) | ATE193648T1 (fr) |
| AU (2) | AU3806393A (fr) |
| CA (1) | CA2131992A1 (fr) |
| DE (1) | DE69328838T2 (fr) |
| DK (1) | DK0727994T3 (fr) |
| WO (1) | WO1993017680A1 (fr) |
Families Citing this family (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IN182040B (fr) * | 1995-06-13 | 1998-12-12 | American Home Prod | |
| JP4234907B2 (ja) * | 1998-05-15 | 2009-03-04 | わかもと製薬株式会社 | 抗炎症点眼剤 |
| AU767586B2 (en) | 1998-07-09 | 2003-11-20 | Cephalon, Inc. | Methods and compositions for the treatment of chronic lymphocytic leukemia |
| US7129262B2 (en) * | 1999-07-23 | 2006-10-31 | The Regents Of The University Of California | Indole compounds useful for the treatment of cancer |
| US7105560B1 (en) | 1999-07-23 | 2006-09-12 | The Regents Of The University Of California | Use of etodolac in the treatment of multiple myeloma |
| US6545034B1 (en) | 1999-07-23 | 2003-04-08 | The Regents Of The University Of California | Use of etodolac for the treatment of chronic lymphocytic leukemia |
| US7361680B2 (en) * | 1999-07-23 | 2008-04-22 | The Regents Of The University Of California | Indole compounds useful for the treatment of cancer |
| US7151100B1 (en) * | 1999-07-23 | 2006-12-19 | The Regents Of The University Of California | Indole compounds useful for the treatment of cancer |
| US20040152672A1 (en) * | 2000-08-09 | 2004-08-05 | Carson Dennis A. | Indole compounds useful for the treatment of cancer |
| US6534676B2 (en) * | 2001-01-31 | 2003-03-18 | The Arizona Board Of Regents On Behalf Of The University Of Arizona | Method to treat chronic heart failure and/or elevated cholesterol levels using 3,5-diiodothyropropionic acid and method to prepare same |
| US6596686B2 (en) | 2001-03-12 | 2003-07-22 | International Flavors & Fragrances Inc. | Use of dihydropyrans as fragrance Material |
| US7601846B2 (en) * | 2001-06-26 | 2009-10-13 | The Regents Of The University Of California | Compounds having activity as inhibitors of apoptosis |
| US20030232794A1 (en) * | 2001-06-26 | 2003-12-18 | Cottam Howard B. | Use of STAT-6 inhibitors as therapeutic agents |
| US20030027867A1 (en) * | 2001-06-29 | 2003-02-06 | Myriad Genetics, Incorporated | Use of R-NSAID compounds for anti-HIV treatment |
| TW200400963A (en) * | 2002-05-21 | 2004-01-16 | Wyeth Corp | R-enantiomers of pyranoindole derivatives and the use thereof for the treatment of hepatitis C virus infection or disease |
| AU2003295336A1 (en) * | 2002-09-19 | 2004-04-08 | Dennis A. Carson | Use of etodoclac to treat hyperplasia |
| WO2005033112A2 (fr) * | 2003-10-02 | 2005-04-14 | Cephalon, Inc. | Derives d'indole substitues |
| ZA200701719B (en) | 2004-08-19 | 2008-05-28 | Igt Reno Nev | Gaming system having multiple gaming machines which provide bonus awards |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3904682A (en) * | 1967-01-13 | 1975-09-09 | Syntex Corp | 2-(6{40 -Methoxy-2{40 -naphthyl)acetic acid |
| NL170852C (nl) * | 1968-03-27 | 1983-01-03 | Ciba Geigy Ag | Werkwijze ter bereiding van farmaceutische preparaten en werkwijze ter bereiding van anti-inflammatoir werkzaam p-isoindolinylfenylazijnzuur en van derivaten hiervan. |
| FR2068425B1 (fr) * | 1969-11-12 | 1973-01-12 | Roussel Uclaf | |
| US3843681A (en) * | 1971-06-01 | 1974-10-22 | American Home Prod | 1-carboxamido pyrano(thiopyrano)(3,4-6)indole derivatives |
| US3896145A (en) * | 1972-07-24 | 1975-07-22 | Hoffmann La Roche | Carbazoles |
| US4501899A (en) * | 1983-08-16 | 1985-02-26 | American Home Products Corporation | Resolution of (+)-1,8-diethyl-1,3,4,9-tetrahydropyrano[3,4-b]indole-1-acetic acid using cholesteryl aniline |
| US4520203A (en) * | 1983-08-16 | 1985-05-28 | American Home Products Corporation | Resolution of (±)-1,8-diethyl-1,3,4,9-tetrahydropyrano[3,4-b]indole-1-acetic acid using cinchonine |
| US4515961A (en) * | 1983-08-16 | 1985-05-07 | American Home Products Corporation | Resolution of (±)-1,8-diethyl-1,3,4,9-tetrahydropyrano[3,4,-b] indole-1-acetic acid using enrichment crystallization |
| US4544757A (en) * | 1984-02-16 | 1985-10-01 | American Home Products Corporation | Process for the resolution of pyrano[3,4-b]indole-1-acetic acids |
| US4962124A (en) * | 1987-11-17 | 1990-10-09 | Analgesic Associates | Onset-hastened/enhanced antipyretic response |
| US4927854A (en) * | 1987-12-24 | 1990-05-22 | Analgesic Associates | Sustained/enhanced analgesia |
| DE3824353A1 (de) * | 1988-07-19 | 1990-01-25 | Paz Arzneimittelentwicklung | Verfahren zur trennung von gemischen enantiomerer arylpropionsaeuren |
-
1993
- 1993-03-12 WO PCT/US1993/002282 patent/WO1993017680A1/fr not_active Ceased
- 1993-03-12 AU AU38063/93A patent/AU3806393A/en not_active Abandoned
- 1993-03-12 EP EP93907465A patent/EP0727994B1/fr not_active Expired - Lifetime
- 1993-03-12 DK DK93907465T patent/DK0727994T3/da active
- 1993-03-12 CA CA002131992A patent/CA2131992A1/fr not_active Abandoned
- 1993-03-12 JP JP5516026A patent/JPH07506817A/ja active Pending
- 1993-03-12 AT AT93907465T patent/ATE193648T1/de not_active IP Right Cessation
- 1993-03-12 DE DE69328838T patent/DE69328838T2/de not_active Expired - Fee Related
-
1995
- 1995-01-04 US US08/368,735 patent/US5561151A/en not_active Expired - Fee Related
-
1997
- 1997-10-09 AU AU39992/97A patent/AU707780B2/en not_active Ceased
Also Published As
| Publication number | Publication date |
|---|---|
| EP0727994A4 (fr) | 1997-01-15 |
| EP0727994B1 (fr) | 2000-06-07 |
| DE69328838T2 (de) | 2000-10-12 |
| JPH07506817A (ja) | 1995-07-27 |
| EP0727994A1 (fr) | 1996-08-28 |
| AU3999297A (en) | 1997-12-18 |
| WO1993017680A1 (fr) | 1993-09-16 |
| US5561151A (en) | 1996-10-01 |
| DE69328838D1 (de) | 2000-07-13 |
| CA2131992A1 (fr) | 1993-09-16 |
| ATE193648T1 (de) | 2000-06-15 |
| AU707780B2 (en) | 1999-07-22 |
| AU3806393A (en) | 1993-10-05 |
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