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DK0726899T3 - New pyrazinecarboxamide derivatives, their preparation and their use in pharmaceuticals - Google Patents

New pyrazinecarboxamide derivatives, their preparation and their use in pharmaceuticals

Info

Publication number
DK0726899T3
DK0726899T3 DK94931018T DK94931018T DK0726899T3 DK 0726899 T3 DK0726899 T3 DK 0726899T3 DK 94931018 T DK94931018 T DK 94931018T DK 94931018 T DK94931018 T DK 94931018T DK 0726899 T3 DK0726899 T3 DK 0726899T3
Authority
DK
Denmark
Prior art keywords
pharmaceuticals
preparation
new
pyrazinecarboxamide derivatives
pyrazinecarboxamide
Prior art date
Application number
DK94931018T
Other languages
Danish (da)
Inventor
Dietrich Arndts
Otto Roos
Georg Speck
Walter Lisel
Wolf-Dietrich Bechtel
Original Assignee
Boehringer Ingelheim Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boehringer Ingelheim Pharma filed Critical Boehringer Ingelheim Pharma
Application granted granted Critical
Publication of DK0726899T3 publication Critical patent/DK0726899T3/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/10—Expectorants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/10—Antioedematous agents; Diuretics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Pulmonology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)

Abstract

The novel compounds of formula (I), which is explained in the description, can be conventionally produced and used as medical substances.
DK94931018T 1993-11-04 1994-10-31 New pyrazinecarboxamide derivatives, their preparation and their use in pharmaceuticals DK0726899T3 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE4337609A DE4337609A1 (en) 1993-11-04 1993-11-04 Novel pyrazinecarboxamide derivatives, their preparation and their use in medicines
PCT/EP1994/003580 WO1995012592A1 (en) 1993-11-04 1994-10-31 Novel pyrazine carboxamide derivatives, their production and their use in medicaments

Publications (1)

Publication Number Publication Date
DK0726899T3 true DK0726899T3 (en) 2000-06-26

Family

ID=6501757

Family Applications (1)

Application Number Title Priority Date Filing Date
DK94931018T DK0726899T3 (en) 1993-11-04 1994-10-31 New pyrazinecarboxamide derivatives, their preparation and their use in pharmaceuticals

Country Status (17)

Country Link
EP (1) EP0726899B1 (en)
JP (1) JPH09505035A (en)
KR (1) KR960705815A (en)
CN (1) CN1134151A (en)
AT (1) ATE188965T1 (en)
AU (1) AU690588B2 (en)
CA (1) CA2175837A1 (en)
CO (1) CO4290432A1 (en)
DE (2) DE4337609A1 (en)
DK (1) DK0726899T3 (en)
ES (1) ES2140565T3 (en)
GR (1) GR3033034T3 (en)
NZ (1) NZ274848A (en)
PL (1) PL314187A1 (en)
PT (1) PT726899E (en)
WO (1) WO1995012592A1 (en)
ZA (1) ZA948669B (en)

Families Citing this family (28)

* Cited by examiner, † Cited by third party
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DE19548812A1 (en) * 1995-12-27 1997-07-03 Hoechst Ag Use of inhibitors of the cellular Na · + · / H · + · exchanger (NHE) for the manufacture of a medicament for respiratory stimulation
DE19738604A1 (en) * 1997-09-04 1999-03-11 Hoechst Marion Roussel De Gmbh Use of Na<+>/H<+> exchange inhibitors
CA2375702A1 (en) 1999-06-03 2000-12-14 Takeda Chemical Industries, Ltd. Nasal preparations
US6156758A (en) * 1999-09-08 2000-12-05 Isis Pharmaceuticals, Inc. Antibacterial quinazoline compounds
EP1509526A2 (en) 2002-04-19 2005-03-02 Cellular Genomics Inc. Imidazo(1,2-a)pyrazin-8-ylamines, method of making, and method of use thereof
WO2004022562A1 (en) 2002-09-09 2004-03-18 Cellular Genomics, Inc. 6-ARYL-IMIDAZO[1,2-a]PYRAZIN-8-YLAMINES, METHOD OF MAKING, AND METHOD OF USE THEREOF
WO2004072080A1 (en) 2003-02-10 2004-08-26 Cellular Genomics, Inc. Certain 8-heteroaryl-6-phenyl-imidazo[1,2-a]pyrazines as modulators of hsp90 complex activity
WO2005014599A1 (en) 2003-06-04 2005-02-17 Cellular Genomics, Inc. Imidazo[1,2-a]pyrazin-8-ylamines and method of inhibition of bruton’s tyrosine kinase by such compounds
US7393848B2 (en) 2003-06-30 2008-07-01 Cgi Pharmaceuticals, Inc. Certain heterocyclic substituted imidazo[1,2-A]pyrazin-8-ylamines and methods of inhibition of Bruton's tyrosine kinase by such compounds
CN1845924A (en) 2003-07-02 2006-10-11 弗·哈夫曼-拉罗切有限公司 Arylamine-substituted quinazolinone compounds
WO2005019220A2 (en) 2003-08-11 2005-03-03 Cellular Genomics Inc. Substituted imidazo[1,2-a]pyrazines as modulators of kinase activity
WO2005030776A1 (en) 2003-09-23 2005-04-07 Vertex Pharmaceuticals Incorporated Pyrazolopyrrole derivatives as protein kinase inhibitors
US7777040B2 (en) 2005-05-03 2010-08-17 Cgi Pharmaceuticals, Inc. Certain substituted ureas, as modulators of kinase activity
US20090221612A1 (en) 2008-02-13 2009-09-03 Mitchell Scott A Certain substituted amides, method of making, and method of use thereof
US8450321B2 (en) 2008-12-08 2013-05-28 Gilead Connecticut, Inc. 6-(1H-indazol-6-yl)-N-[4-(morpholin-4-yl)phenyl]imidazo-[1,2-A]pyrazin-8-amine, or a pharmaceutically acceptable salt thereof, as a SYK inhibitor
WO2010068258A1 (en) 2008-12-08 2010-06-17 Cgi Pharmaceuticals, Inc. Imidazopyrazine syk inhibitors
LT2716157T (en) 2008-12-08 2016-09-12 Gilead Connecticut, Inc. Imidazopyrazine Syk inhibitors
MX350010B (en) 2010-03-11 2017-08-23 Gilead Connecticut Inc Imidazopyridines syk inhibitors.
HUE025873T2 (en) 2010-09-13 2016-05-30 Otsuka Pharma Co Ltd Heterocyclic compounds for treating or preventing disorders caused by reduced neurotransmission of serotonin, norephnephrine or dopamine.
NZ715776A (en) 2013-07-30 2017-04-28 Gilead Connecticut Inc Polymorph of syk inhibitors
JP6153667B2 (en) 2013-07-30 2017-06-28 ギリアード コネチカット， インコーポレイテッド Formulation of SKY inhibitor
CN103467392B (en) * 2013-10-09 2016-08-17 重庆工商大学 A kind of polyhalo pyrazinecarboxamide derivatives and its esters, preparation method and purposes
EP3076976B1 (en) 2013-12-04 2020-09-02 Gilead Sciences, Inc. Methods for treating cancers
US9290505B2 (en) 2013-12-23 2016-03-22 Gilead Sciences, Inc. Substituted imidazo[1,2-a]pyrazines as Syk inhibitors
TWI735853B (en) 2013-12-23 2021-08-11 美商克洛諾斯生技有限公司 Syk inhibitors
MX2017000610A (en) 2014-07-14 2017-04-27 Gilead Sciences Inc Combinations for treating cancers.
US11384082B2 (en) 2017-08-25 2022-07-12 Kronos Bio, Inc. Hydrates of polymorphs of 6-(1H-indazol-6-YL)-N-(4-morpholinophenyl)-2,3-dihydroimidazo[1,2-A]pyrazin-8-amine bisemsylate as Syk inhibitors
CN113950479A (en) 2019-02-22 2022-01-18 克洛诺斯生物股份有限公司 Solid forms of condensed pyrazines as SYK inhibitors

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL299931A (en) * 1962-10-30
TW213903B (en) * 1991-08-16 1993-10-01 Boehringer Ingelheim Kg

Also Published As

Publication number Publication date
PT726899E (en) 2000-04-28
NZ274848A (en) 1998-03-25
DE59409094D1 (en) 2000-02-24
ZA948669B (en) 1995-07-04
AU7993694A (en) 1995-05-23
ES2140565T3 (en) 2000-03-01
GR3033034T3 (en) 2000-08-31
WO1995012592A1 (en) 1995-05-11
KR960705815A (en) 1996-11-08
DE4337609A1 (en) 1995-05-11
AU690588B2 (en) 1998-04-30
CN1134151A (en) 1996-10-23
EP0726899A1 (en) 1996-08-21
JPH09505035A (en) 1997-05-20
CO4290432A1 (en) 1996-04-17
ATE188965T1 (en) 2000-02-15
CA2175837A1 (en) 1995-05-11
EP0726899B1 (en) 2000-01-19
PL314187A1 (en) 1996-09-02

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