DK0712862T3 - Selektiv acylering af epsilon-aminogrupper i insulin - Google Patents

Selektiv acylering af epsilon-aminogrupper i insulin

Info

Publication number: DK0712862T3
Authority: DK; Denmark
Prior art keywords: insulin; amino groups; epsilon amino; selective acylation; acylation
Prior art date: 1994-11-17

Application number

DK95308167T

Other languages

Danish (da)

English (en)

Inventor

Jeffrey Clayton Baker

Brian Allen Moser

Jose Michael Hanquier

Robert Theodore Shuman

Victor John Chen

Aidas Vladas Kriauciunas

Original Assignee

Lilly Co Eli

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1994-11-17

Filing date

1995-11-14

Publication date

2006-09-25

1995-11-14 Application filed by Lilly Co Eli filed Critical Lilly Co Eli

2006-09-25 Application granted granted Critical

2006-09-25 Publication of DK0712862T3 publication Critical patent/DK0712862T3/da

Links

NOESYZHRGYRDHS-UHFFFAOYSA-N insulin Chemical compound N1C(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(NC(=O)CN)C(C)CC)CSSCC(C(NC(CO)C(=O)NC(CC(C)C)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CCC(N)=O)C(=O)NC(CC(C)C)C(=O)NC(CCC(O)=O)C(=O)NC(CC(N)=O)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CSSCC(NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2C=CC(O)=CC=2)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2NC=NC=2)NC(=O)C(CO)NC(=O)CNC2=O)C(=O)NCC(=O)NC(CCC(O)=O)C(=O)NC(CCCNC(N)=N)C(=O)NCC(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC(O)=CC=3)C(=O)NC(C(C)O)C(=O)N3C(CCC3)C(=O)NC(CCCCN)C(=O)NC(C)C(O)=O)C(=O)NC(CC(N)=O)C(O)=O)=O)NC(=O)C(C(C)CC)NC(=O)C(CO)NC(=O)C(C(C)O)NC(=O)C1CSSCC2NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(N)CC=1C=CC=CC=1)C(C)C)CC1=CN=CN1 NOESYZHRGYRDHS-UHFFFAOYSA-N 0.000 title 2
102000004877 Insulin Human genes 0.000 title 1
108090001061 Insulin Proteins 0.000 title 1
230000010933 acylation Effects 0.000 title 1
238000005917 acylation reaction Methods 0.000 title 1
125000003277 amino group Chemical group 0.000 title 1
229940125396 insulin Drugs 0.000 title 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/62—Insulins
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/107—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides
- C07K1/1072—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides by covalent attachment of residues or functional groups
- C07K1/1077—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides by covalent attachment of residues or functional groups by covalent attachment of residues other than amino acids or peptide residues, e.g. sugars, polyols, fatty acids

Landscapes

Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Medicinal Chemistry (AREA)
Molecular Biology (AREA)
Biochemistry (AREA)
Biophysics (AREA)
General Health & Medical Sciences (AREA)
Genetics & Genomics (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Analytical Chemistry (AREA)
Diabetes (AREA)
Endocrinology (AREA)
Toxicology (AREA)
Zoology (AREA)
Gastroenterology & Hepatology (AREA)
Peptides Or Proteins (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)

DK95308167T 1994-11-17 1995-11-14 Selektiv acylering af epsilon-aminogrupper i insulin DK0712862T3 (da)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US08/341,231 US5646242A (en)	1994-11-17	1994-11-17	Selective acylation of epsilon-amino groups

Publications (1)

Publication Number	Publication Date
DK0712862T3 true DK0712862T3 (da)	2006-09-25

Family

ID=23336740

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK95308167T DK0712862T3 (da)	1994-11-17	1995-11-14	Selektiv acylering af epsilon-aminogrupper i insulin

Country Status (27)

Country	Link
US (2)	US5646242A (fr)
EP (2)	EP1227107A1 (fr)
JP (1)	JP4312828B2 (fr)
CN (1)	CN1171742A (fr)
AR (1)	AR003915A1 (fr)
AT (1)	ATE328902T1 (fr)
AU (2)	AU691066B2 (fr)
BR (1)	BR9509652A (fr)
CA (1)	CA2205061A1 (fr)
CO (1)	CO4520285A1 (fr)
CZ (1)	CZ287731B6 (fr)
DE (1)	DE69535031T2 (fr)
DK (1)	DK0712862T3 (fr)
ES (1)	ES2264124T3 (fr)
HU (2)	HU217585B (fr)
IL (1)	IL115972A (fr)
IN (1)	IN179820B (fr)
NO (1)	NO972185L (fr)
NZ (1)	NZ297256A (fr)
PL (1)	PL320556A1 (fr)
PT (1)	PT712862E (fr)
RU (1)	RU2155773C2 (fr)
SI (1)	SI0712862T1 (fr)
TR (1)	TR199501421A2 (fr)
WO (1)	WO1996015803A1 (fr)
YU (1)	YU71495A (fr)
ZA (1)	ZA959680B (fr)

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US20030082671A1 (en) *	2001-07-24	2003-05-01	Thomas Hoeg-Jensen	Method for making acylated polypeptides
PL367687A1 (en) *	2001-07-24	2005-03-07	Novo Nordisk A/S	Method for making acylated polypeptides
US7595172B2 (en)	2001-07-24	2009-09-29	Novo Nordisk A/S	Method for making acylated polypeptides
AU2002355160A1 (en) *	2001-07-24	2003-02-17	Novo Nordisk A/S	Method for making acylated polypeptides
US6913903B2 (en) *	2001-09-07	2005-07-05	Nobex Corporation	Methods of synthesizing insulin polypeptide-oligomer conjugates, and proinsulin polypeptide-oligomer conjugates and methods of synthesizing same
US7196059B2 (en)	2001-09-07	2007-03-27	Biocon Limited	Pharmaceutical compositions of insulin drug-oligomer conjugates and methods of treating diseases therewith
US6770625B2 (en)	2001-09-07	2004-08-03	Nobex Corporation	Pharmaceutical compositions of calcitonin drug-oligomer conjugates and methods of treating diseases therewith
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PT2203181T (pt)	2007-10-16	2018-05-10	Biocon Ltd	Uma composição farmacêutica sólida para administração por via oral e o seu processo de fabrico
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HRP20191793T1 (hr)	2010-10-27	2019-12-27	Novo Nordisk A/S	Liječenje dijabetesa melitusa injekcijama inzulina koje se primijenjuje u različitim intervalima injiciranja
EP2836508B1 (fr)	2012-04-11	2016-06-29	Novo Nordisk A/S	Formulations à base d'insuline
JP2016519127A (ja)	2013-04-30	2016-06-30	ノヴォノルディスクアー／エス	新規投与レジメン
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1994
- 1994-11-17 US US08/341,231 patent/US5646242A/en not_active Ceased
1995
- 1995-11-14 AR ARP950100165A patent/AR003915A1/es not_active Application Discontinuation
- 1995-11-14 ZA ZA959680A patent/ZA959680B/xx unknown
- 1995-11-14 CA CA002205061A patent/CA2205061A1/fr not_active Abandoned
- 1995-11-14 CN CN95197224A patent/CN1171742A/zh active Pending
- 1995-11-14 IL IL11597295A patent/IL115972A/xx unknown
- 1995-11-14 EP EP02000258A patent/EP1227107A1/fr not_active Ceased
- 1995-11-14 HU HU9800566A patent/HU217585B/hu not_active IP Right Cessation
- 1995-11-14 IN IN1452CA1995 patent/IN179820B/en unknown
- 1995-11-14 HU HU9903007A patent/HU9903007D0/hu unknown
- 1995-11-14 BR BR9509652A patent/BR9509652A/pt not_active Application Discontinuation
- 1995-11-14 EP EP95308167A patent/EP0712862B1/fr not_active Expired - Lifetime
- 1995-11-14 NZ NZ297256A patent/NZ297256A/xx active IP Right Revival
- 1995-11-14 DE DE69535031T patent/DE69535031T2/de not_active Expired - Lifetime
- 1995-11-14 CO CO95053590A patent/CO4520285A1/es unknown
- 1995-11-14 PL PL95320556A patent/PL320556A1/xx unknown
- 1995-11-14 JP JP51696396A patent/JP4312828B2/ja not_active Expired - Lifetime
- 1995-11-14 WO PCT/US1995/014872 patent/WO1996015803A1/fr not_active Ceased
- 1995-11-14 TR TR95/01421A patent/TR199501421A2/xx unknown
- 1995-11-14 YU YU71495A patent/YU71495A/sh unknown
- 1995-11-14 SI SI9530727T patent/SI0712862T1/sl unknown
- 1995-11-14 PT PT95308167T patent/PT712862E/pt unknown
- 1995-11-14 CZ CZ19971456A patent/CZ287731B6/cs not_active IP Right Cessation
- 1995-11-14 DK DK95308167T patent/DK0712862T3/da active
- 1995-11-14 ES ES95308167T patent/ES2264124T3/es not_active Expired - Lifetime
- 1995-11-14 AU AU42372/96A patent/AU691066B2/en not_active Revoked
- 1995-11-14 AT AT95308167T patent/ATE328902T1/de active
- 1995-11-14 RU RU97110075/04A patent/RU2155773C2/ru active
1997
- 1997-05-13 NO NO972185A patent/NO972185L/no not_active Application Discontinuation
1998
- 1998-08-07 AU AU78854/98A patent/AU720820B2/en not_active Ceased
1999
- 1999-07-08 US US09/351,103 patent/USRE37971E1/en not_active Expired - Lifetime

Also Published As

Publication number	Publication date
IN179820B (fr)	1997-12-13
EP1227107A1 (fr)	2002-07-31
CZ145697A3 (en)	1997-12-17
MX9703506A (es)	1997-07-31
NO972185D0 (no)	1997-05-13
CZ287731B6 (en)	2001-01-17
SI0712862T1 (sl)	2006-10-31
DE69535031T2 (de)	2006-12-28
PL320556A1 (en)	1997-10-13
CA2205061A1 (fr)	1996-05-30
YU71495A (sh)	1998-09-18
IL115972A0 (en)	1996-01-31
AU720820B2 (en)	2000-06-15
RU2155773C2 (ru)	2000-09-10
HUT77737A (hu)	1998-07-28
US5646242A (en)	1997-07-08
DE69535031D1 (de)	2006-07-20
ES2264124T3 (es)	2006-12-16
HU9903007D0 (en)	1999-11-29
ZA959680B (en)	1997-05-14
USRE37971E1 (en)	2003-01-28
AU7885498A (en)	1998-11-05
EP0712862A2 (fr)	1996-05-22
AU691066B2 (en)	1998-05-07
CO4520285A1 (es)	1997-10-15
NO972185L (no)	1997-05-13
EP0712862A3 (fr)	1998-03-04
BR9509652A (pt)	1997-09-16
AU4237296A (en)	1996-06-17
CN1171742A (zh)	1998-01-28
JPH10509176A (ja)	1998-09-08
JP4312828B2 (ja)	2009-08-12
TR199501421A2 (tr)	1996-06-21
AR003915A1 (es)	1998-09-30
EP0712862B1 (fr)	2006-06-07
IL115972A (en)	2000-09-28
ATE328902T1 (de)	2006-06-15
WO1996015803A1 (fr)	1996-05-30
NZ297256A (en)	2000-01-28
HU217585B (hu)	2000-02-28
HK1014007A1 (en)	1999-09-17
PT712862E (pt)	2006-08-31

Publication	Publication Date	Title
DK0712862T3 (da)	2006-09-25	Selektiv acylering af epsilon-aminogrupper i insulin
NO983987D0 (no)	1998-08-28	Optisk film med samkontinuelige faser
NO20001242L (no)	2000-05-11	April - et nytt protein med veksteffekter
DE69826007D1 (de)	2004-10-07	Tetrafluorethylencopolymer und dessen verwendung
FI950147L (fi)	1996-07-14	Uusia bioaktiivisia laseja ja niiden käytt
IS4491A (is)	1997-12-01	Interferon tengd efni
DE69510334D1 (de)	1999-07-22	Amino- und fluorogruppen enthaltende siloxane
DE69512125D1 (de)	1999-10-21	Herstellung von Löchern in polymerischen Materialien
DK0907358T3 (da)	2002-03-25	Behandling med ensartet afgivelse af lægemiddel
PL329466A1 (en)	1999-05-10	Increase in recativity of urethanic prepolymers of diisocyanatedipfenylmathanes modified with allophanianic groups
FI964312A7 (fi)	1996-12-20	Bentsosykloalkyyliatsolitionijohdannaiset
IT232096Y1 (it)	1999-08-16	Giostra di divertimento perfezionata
FI953639L (fi)	1996-01-30	Actinomaduran skylanaasisekvenssit ja käyttömenetelmät
BR9509641A (pt)	1997-09-16	Sequências de dna e seu uso
IT1276775B1 (it)	1997-11-03	Gruppi filtranti
IT1303761B1 (it)	2001-02-23	Filatoio con gruppi di sezioni
DE59704437D1 (de)	2001-10-04	Halteelement aus Kunststoff
KR950022491U (ko)	1995-08-18	자석 및 바이오 세라믹 처리를 한 가발
KR950031840U (ko)	1995-12-14	인공어초
KR960037640U (ko)	1996-12-18	인조석재
KR970047679U (ko)	1997-07-31	표면 탄성과 필터 지그
KR960003760U (ko)	1996-02-14	바이오 세라믹이 부착된 지갑
KR970049082U (ko)	1997-08-12	자석 및 세라믹이 부설된 치솔
KR960007311U (ko)	1996-03-13	인조대리석
KR970014796U (ko)	1997-04-28	바이오 안경