DK0793659T3 - Fremgangsmåde til fremstilling af 5-hydroxymethylthiazol - Google Patents
Fremgangsmåde til fremstilling af 5-hydroxymethylthiazolInfo
- Publication number
- DK0793659T3 DK0793659T3 DK95940008T DK95940008T DK0793659T3 DK 0793659 T3 DK0793659 T3 DK 0793659T3 DK 95940008 T DK95940008 T DK 95940008T DK 95940008 T DK95940008 T DK 95940008T DK 0793659 T3 DK0793659 T3 DK 0793659T3
- Authority
- DK
- Denmark
- Prior art keywords
- hydroxymethylthiazole
- preparation
- hydrolyzing
- optimally
- gives
- Prior art date
Links
- WKBQQWDVVHGWDB-UHFFFAOYSA-N 1,3-thiazol-5-ylmethanol Chemical compound OCC1=CN=CS1 WKBQQWDVVHGWDB-UHFFFAOYSA-N 0.000 title abstract 3
- 238000000034 method Methods 0.000 title abstract 2
- 150000001734 carboxylic acid salts Chemical class 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 238000006298 dechlorination reaction Methods 0.000 abstract 1
- 150000002148 esters Chemical class 0.000 abstract 1
- 230000003301 hydrolyzing effect Effects 0.000 abstract 1
- 150000003242 quaternary ammonium salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D277/22—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
- C07D277/24—Radicals substituted by oxygen atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Thiazole And Isothizaole Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US34369094A | 1994-11-22 | 1994-11-22 | |
| PCT/US1995/014930 WO1996016050A1 (fr) | 1994-11-22 | 1995-11-15 | Procede pour la preparation de 5-hydroxymethylthiazole |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK0793659T3 true DK0793659T3 (da) | 2001-06-11 |
Family
ID=23347195
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK95940008T DK0793659T3 (da) | 1994-11-22 | 1995-11-15 | Fremgangsmåde til fremstilling af 5-hydroxymethylthiazol |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US5712400A (fr) |
| EP (1) | EP0793659B1 (fr) |
| JP (1) | JPH10509177A (fr) |
| AT (1) | ATE199714T1 (fr) |
| DE (1) | DE69520368T2 (fr) |
| DK (1) | DK0793659T3 (fr) |
| ES (1) | ES2156955T3 (fr) |
| GR (1) | GR3035865T3 (fr) |
| MX (1) | MX9703766A (fr) |
| PT (1) | PT793659E (fr) |
| WO (1) | WO1996016050A1 (fr) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6265585B1 (en) | 1997-01-22 | 2001-07-24 | Syngenta Crop Protection, Inc. | Process for the preparation of thiazole derivatives |
| US5932736A (en) * | 1997-04-07 | 1999-08-03 | Reilly Industries, Inc. | Preparation of heterocycles using 1,3-dihalopropenes |
| WO1998045279A1 (fr) * | 1997-04-07 | 1998-10-15 | Reilly Industries, Inc. | Preparation de thiazoles utilisant des 1,3-dihalopropenes |
| US5959118A (en) * | 1997-08-29 | 1999-09-28 | Abbott Laboratories | Process for the preparation of 5-hydroxymethylthiazoles |
| US5773625A (en) * | 1997-10-02 | 1998-06-30 | Abbott Laboratories | Process for the preparation of disubstituted carbonates |
| US6765019B1 (en) | 1999-05-06 | 2004-07-20 | University Of Kentucky Research Foundation | Permeable, water soluble, non-irritating prodrugs of chemotherapeutic agents with oxaalkanoic acids |
| CN101260100A (zh) * | 2008-04-21 | 2008-09-10 | 湖南有色凯铂生物药业有限公司 | 一种5-羟甲基噻唑的制备方法 |
| CN101863853B (zh) * | 2009-12-28 | 2012-12-19 | 安徽贝克联合制药有限公司 | 一锅煮法制备5-羟甲基噻唑工艺 |
| BR112020008124A2 (pt) | 2017-10-27 | 2020-10-06 | Syngenta Participations Ag | composições de controle de vetores, métodos e produtos utilizando as mesmas |
| CN116375662B (zh) * | 2022-12-30 | 2024-07-23 | 新沂市砥研医药技术研究院有限公司 | 一种高效的5-羟甲基噻唑医药中间体的纯化工艺 |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4247464A (en) * | 1979-10-01 | 1981-01-27 | General Electric Company | Liquid extraction method for recovering aromatic bisimides |
| DE3631538A1 (de) * | 1986-09-17 | 1988-03-24 | Bayer Ag | Verfahren zur herstellung von 2-chlor-5-chlormethylthiazol |
| JPS63165334A (ja) * | 1986-12-27 | 1988-07-08 | Hodogaya Chem Co Ltd | ２，６−ジクロロベンジルアルコ−ルの製造法 |
| IE20010533A1 (en) * | 1990-11-20 | 2003-03-05 | Abbott Lab | Intermediates for preparing retroviral protease inhibiting compounds |
| EP1302468B1 (fr) * | 1992-12-29 | 2008-12-17 | Abbott Laboratories | Procédés et intermédiaires pour la préparation d'inhibiteurs de protéase rétrovirale |
-
1995
- 1995-11-15 PT PT95940008T patent/PT793659E/pt unknown
- 1995-11-15 JP JP8516978A patent/JPH10509177A/ja not_active Ceased
- 1995-11-15 AT AT95940008T patent/ATE199714T1/de not_active IP Right Cessation
- 1995-11-15 MX MX9703766A patent/MX9703766A/es unknown
- 1995-11-15 WO PCT/US1995/014930 patent/WO1996016050A1/fr not_active Ceased
- 1995-11-15 EP EP95940008A patent/EP0793659B1/fr not_active Expired - Lifetime
- 1995-11-15 DK DK95940008T patent/DK0793659T3/da active
- 1995-11-15 ES ES95940008T patent/ES2156955T3/es not_active Expired - Lifetime
- 1995-11-15 DE DE69520368T patent/DE69520368T2/de not_active Expired - Fee Related
-
1996
- 1996-05-22 US US08/651,439 patent/US5712400A/en not_active Expired - Fee Related
-
2001
- 2001-05-15 GR GR20010400716T patent/GR3035865T3/el not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| ES2156955T3 (es) | 2001-08-01 |
| PT793659E (pt) | 2001-07-31 |
| EP0793659B1 (fr) | 2001-03-14 |
| EP0793659A1 (fr) | 1997-09-10 |
| JPH10509177A (ja) | 1998-09-08 |
| DE69520368D1 (de) | 2001-04-19 |
| US5712400A (en) | 1998-01-27 |
| WO1996016050A1 (fr) | 1996-05-30 |
| MX9703766A (es) | 1997-08-30 |
| GR3035865T3 (en) | 2001-08-31 |
| ATE199714T1 (de) | 2001-03-15 |
| DE69520368T2 (de) | 2001-06-28 |
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