DK0788373T3 - Nye komplekser af taxol eller taxotere og farmaceutiske sammensætninger deraf - Google Patents
Nye komplekser af taxol eller taxotere og farmaceutiske sammensætninger derafInfo
- Publication number
- DK0788373T3 DK0788373T3 DK95936697T DK95936697T DK0788373T3 DK 0788373 T3 DK0788373 T3 DK 0788373T3 DK 95936697 T DK95936697 T DK 95936697T DK 95936697 T DK95936697 T DK 95936697T DK 0788373 T3 DK0788373 T3 DK 0788373T3
- Authority
- DK
- Denmark
- Prior art keywords
- taxol
- cyclodextrin
- taxotere
- beta
- taxus
- Prior art date
Links
- ZDZOTLJHXYCWBA-VCVYQWHSSA-N N-debenzoyl-N-(tert-butoxycarbonyl)-10-deacetyltaxol Chemical compound O([C@H]1[C@H]2[C@@](C([C@H](O)C3=C(C)[C@@H](OC(=O)[C@H](O)[C@@H](NC(=O)OC(C)(C)C)C=4C=CC=CC=4)C[C@]1(O)C3(C)C)=O)(C)[C@@H](O)C[C@H]1OC[C@]12OC(=O)C)C(=O)C1=CC=CC=C1 ZDZOTLJHXYCWBA-VCVYQWHSSA-N 0.000 title abstract 4
- 229930012538 Paclitaxel Natural products 0.000 title abstract 4
- 229960001592 paclitaxel Drugs 0.000 title abstract 4
- RCINICONZNJXQF-MZXODVADSA-N taxol Chemical compound O([C@@H]1[C@@]2(C[C@@H](C(C)=C(C2(C)C)[C@H](C([C@]2(C)[C@@H](O)C[C@H]3OC[C@]3([C@H]21)OC(C)=O)=O)OC(=O)C)OC(=O)[C@H](O)[C@@H](NC(=O)C=1C=CC=CC=1)C=1C=CC=CC=1)O)C(=O)C1=CC=CC=C1 RCINICONZNJXQF-MZXODVADSA-N 0.000 title abstract 4
- 229940063683 taxotere Drugs 0.000 title abstract 4
- 239000008194 pharmaceutical composition Substances 0.000 title abstract 3
- 239000006184 cosolvent Substances 0.000 abstract 3
- 239000000284 extract Substances 0.000 abstract 3
- HFHDHCJBZVLPGP-UHFFFAOYSA-N schardinger α-dextrin Chemical class O1C(C(C2O)O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC(C(O)C2O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC2C(O)C(O)C1OC2CO HFHDHCJBZVLPGP-UHFFFAOYSA-N 0.000 abstract 3
- 229920000858 Cyclodextrin Polymers 0.000 abstract 2
- 239000001116 FEMA 4028 Substances 0.000 abstract 2
- 241001116500 Taxus Species 0.000 abstract 2
- 229960004853 betadex Drugs 0.000 abstract 2
- 241000202349 Taxus brevifolia Species 0.000 abstract 1
- 239000004480 active ingredient Substances 0.000 abstract 1
- WHGYBXFWUBPSRW-FOUAGVGXSA-N beta-cyclodextrin Chemical class OC[C@H]([C@H]([C@@H]([C@H]1O)O)O[C@H]2O[C@@H]([C@@H](O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O3)[C@H](O)[C@H]2O)CO)O[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@@H]3O[C@@H]1CO WHGYBXFWUBPSRW-FOUAGVGXSA-N 0.000 abstract 1
- 238000007865 diluting Methods 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
Classifications
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B82—NANOTECHNOLOGY
- B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
- B82Y5/00—Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/69—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit
- A61K47/6949—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit inclusion complexes, e.g. clathrates, cavitates or fullerenes
- A61K47/6951—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit inclusion complexes, e.g. clathrates, cavitates or fullerenes using cyclodextrin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D305/00—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms
- C07D305/14—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms condensed with carbocyclic rings or ring systems
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nanotechnology (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- General Engineering & Computer Science (AREA)
- Epidemiology (AREA)
- Biophysics (AREA)
- Biotechnology (AREA)
- Medical Informatics (AREA)
- Molecular Biology (AREA)
- Crystallography & Structural Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Epoxy Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| HU9403237A HUT73844A (en) | 1994-11-11 | 1994-11-11 | New taxol complexes and pharmaceutical compositions containing them |
| PCT/HU1995/000055 WO1996014872A1 (fr) | 1994-11-11 | 1995-11-02 | Nouveaux complexes et compositions les contenant |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK0788373T3 true DK0788373T3 (da) | 2003-08-11 |
Family
ID=10985749
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK95936697T DK0788373T3 (da) | 1994-11-11 | 1995-11-02 | Nye komplekser af taxol eller taxotere og farmaceutiske sammensætninger deraf |
Country Status (13)
| Country | Link |
|---|---|
| US (1) | US6432928B1 (fr) |
| EP (1) | EP0788373B1 (fr) |
| JP (1) | JPH10508836A (fr) |
| AT (1) | ATE238069T1 (fr) |
| AU (1) | AU716704B2 (fr) |
| CA (1) | CA2205019A1 (fr) |
| DE (1) | DE69530502T2 (fr) |
| DK (1) | DK0788373T3 (fr) |
| ES (1) | ES2201121T3 (fr) |
| HU (1) | HUT73844A (fr) |
| IL (1) | IL115917A0 (fr) |
| WO (1) | WO1996014872A1 (fr) |
| ZA (1) | ZA959567B (fr) |
Families Citing this family (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5439686A (en) * | 1993-02-22 | 1995-08-08 | Vivorx Pharmaceuticals, Inc. | Methods for in vivo delivery of substantially water insoluble pharmacologically active agents and compositions useful therefor |
| US8853260B2 (en) * | 1997-06-27 | 2014-10-07 | Abraxis Bioscience, Llc | Formulations of pharmacological agents, methods for the preparation thereof and methods for the use thereof |
| HUP9701945A3 (en) * | 1997-11-10 | 2000-04-28 | Hexal Ag | Pharmaceutical composition for injection containing cyclodextrin and taxoids |
| JP4644364B2 (ja) * | 1998-02-05 | 2011-03-02 | ノバルティス アーゲー | エポシロン組成物 |
| US5981564A (en) * | 1998-07-01 | 1999-11-09 | Universite Laval | Water-soluble derivatives of paclitaxel, method for producing same and uses thereof |
| JP4585074B2 (ja) * | 2000-03-28 | 2010-11-24 | ライオン株式会社 | 薬剤組成物の製造方法 |
| US6759058B1 (en) * | 2001-04-25 | 2004-07-06 | Western Center For Drug Development College Of Pharmacy Western University Of Health Sciences | Enteric-coated proliposomal formulations for poorly water soluble drugs |
| US8658202B2 (en) * | 2001-04-25 | 2014-02-25 | Western University Of Health Sciences | Coated drug delivery formulations |
| US7125833B2 (en) * | 2003-03-24 | 2006-10-24 | Wacker Chemie Ag | Cyclodextrin laundry detergent additive complexes and compositions containing same |
| EP1462512B1 (fr) * | 2003-03-24 | 2007-08-01 | The Procter & Gamble Company | Compositions comprenant complexes de cyclodextrine et au moins un additif pour traitement de lavage |
| US7157446B2 (en) * | 2003-05-02 | 2007-01-02 | Bristol Myers Squibb Company | Complex of ras-farnesyltransferase inhibitor, a cyclodextrin, and ethanol |
| US7266899B2 (en) * | 2004-08-18 | 2007-09-11 | Mark Sanders | Speed level |
| US20060105045A1 (en) * | 2004-11-08 | 2006-05-18 | Buchanan Charles M | Cyclodextrin solubilizers for liquid and semi-solid formulations |
| KR100917809B1 (ko) * | 2006-05-22 | 2009-09-18 | 에스케이케미칼주식회사 | 우수한 저장안정성을 갖는 도세탁셀 함유 주사제 조성물 |
| EP2371368A3 (fr) * | 2008-05-30 | 2012-08-22 | Novelix Pharmaceuticals, Inc. | Compositions et procédés pour le traitement de lésions inflammatoires et hyperkératosiques |
| DE102010023790A1 (de) | 2010-06-15 | 2011-12-15 | Heinrich-Heine-Universität Düsseldorf | Waschaktive Zusammensetzung |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| HU199444B (en) * | 1985-09-10 | 1990-02-28 | Chinoin Gyogyszer Es Vegyeszet | Process for producing 7-isopropoxy-isoflavone-cyclodextrene inclusion complex and pharmaceutical compositions therefrom |
| US5180716A (en) * | 1990-08-01 | 1993-01-19 | The Regents Of The University Of California | Cyclodextrin complexes for neuraxial administration of drugs |
| US5120720A (en) * | 1990-09-20 | 1992-06-09 | The United States Of America As Represented By The Secretary Of The Department Of Health & Human Services | Preparation of lipophile:hydroxypropylcyclodextrin complexes by a method using co-solubilizers |
| JPH06157330A (ja) * | 1992-11-27 | 1994-06-03 | Ensuiko Sugar Refining Co Ltd | タキソールのサイクロデキストリン包接物，その製造法と用途 |
| JPH0753396A (ja) | 1993-08-19 | 1995-02-28 | Ensuiko Sugar Refining Co Ltd | タキソールのサイクロデキストリン包接物，その製造法および用途 |
| HU213200B (en) * | 1993-05-12 | 1997-03-28 | Chinoin Gyogyszer Es Vegyeszet | The cyclodextrin or cyclodextrin derivative cluster complexes of taxol, taxotere, or taxus, pharmaceutical preparations containing them and process for their production |
-
1994
- 1994-11-11 HU HU9403237A patent/HUT73844A/hu unknown
-
1995
- 1995-11-02 US US08/836,390 patent/US6432928B1/en not_active Expired - Fee Related
- 1995-11-02 DK DK95936697T patent/DK0788373T3/da active
- 1995-11-02 WO PCT/HU1995/000055 patent/WO1996014872A1/fr not_active Ceased
- 1995-11-02 ES ES95936697T patent/ES2201121T3/es not_active Expired - Lifetime
- 1995-11-02 JP JP8515861A patent/JPH10508836A/ja active Pending
- 1995-11-02 CA CA002205019A patent/CA2205019A1/fr not_active Abandoned
- 1995-11-02 DE DE69530502T patent/DE69530502T2/de not_active Expired - Lifetime
- 1995-11-02 AU AU38540/95A patent/AU716704B2/en not_active Ceased
- 1995-11-02 AT AT95936697T patent/ATE238069T1/de active
- 1995-11-02 EP EP95936697A patent/EP0788373B1/fr not_active Expired - Lifetime
- 1995-11-08 IL IL11591795A patent/IL115917A0/xx unknown
- 1995-11-10 ZA ZA959567A patent/ZA959567B/xx unknown
Also Published As
| Publication number | Publication date |
|---|---|
| JPH10508836A (ja) | 1998-09-02 |
| ZA959567B (en) | 1996-05-28 |
| DE69530502T2 (de) | 2004-03-04 |
| EP0788373A1 (fr) | 1997-08-13 |
| CA2205019A1 (fr) | 1996-05-23 |
| AU716704B2 (en) | 2000-03-02 |
| ES2201121T3 (es) | 2004-03-16 |
| ATE238069T1 (de) | 2003-05-15 |
| HU9403237D0 (en) | 1995-01-30 |
| HUT73844A (en) | 1996-09-30 |
| IL115917A0 (en) | 1996-01-31 |
| AU3854095A (en) | 1996-06-06 |
| WO1996014872A1 (fr) | 1996-05-23 |
| US6432928B1 (en) | 2002-08-13 |
| DE69530502D1 (de) | 2003-05-28 |
| EP0788373B1 (fr) | 2003-04-23 |
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