[go: up one dir, main page]

DK0782567T3 - Isothiourinstofderivater og fremgangsmåder til deres fremstilling - Google Patents

Isothiourinstofderivater og fremgangsmåder til deres fremstilling

Info

Publication number
DK0782567T3
DK0782567T3 DK95933007T DK95933007T DK0782567T3 DK 0782567 T3 DK0782567 T3 DK 0782567T3 DK 95933007 T DK95933007 T DK 95933007T DK 95933007 T DK95933007 T DK 95933007T DK 0782567 T3 DK0782567 T3 DK 0782567T3
Authority
DK
Denmark
Prior art keywords
pct
processes
preparation
sec
formula
Prior art date
Application number
DK95933007T
Other languages
English (en)
Inventor
James Edwin Macdonald
Original Assignee
Astra Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=10761604&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DK0782567(T3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Astra Ab filed Critical Astra Ab
Application granted granted Critical
Publication of DK0782567T3 publication Critical patent/DK0782567T3/da

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D217/00Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/02Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines
    • C07D217/04Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines with hydrocarbon or substituted hydrocarbon radicals attached to the ring nitrogen atom
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/04Centrally acting analgesics, e.g. opioids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/06Antimigraine agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/30Drugs for disorders of the nervous system for treating abuse or dependence
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C335/00Thioureas, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
    • C07C335/04Derivatives of thiourea
    • C07C335/16Derivatives of thiourea having nitrogen atoms of thiourea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
    • C07C335/20Derivatives of thiourea having nitrogen atoms of thiourea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton being further substituted by nitrogen atoms, not being part of nitro or nitroso groups
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C335/00Thioureas, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
    • C07C335/30Isothioureas
    • C07C335/32Isothioureas having sulfur atoms of isothiourea groups bound to acyclic carbon atoms

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Neurosurgery (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Neurology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biomedical Technology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Pain & Pain Management (AREA)
  • Addiction (AREA)
  • Psychiatry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Immobilizing And Processing Of Enzymes And Microorganisms (AREA)
  • Pyridine Compounds (AREA)
DK95933007T 1994-09-20 1995-09-20 Isothiourinstofderivater og fremgangsmåder til deres fremstilling DK0782567T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB9418912A GB9418912D0 (en) 1994-09-20 1994-09-20 Pharmaceutically active compounds
PCT/SE1995/001069 WO1996009286A1 (en) 1994-09-20 1995-09-20 Isothiourea derivatives as no synthase inhibitors

Publications (1)

Publication Number Publication Date
DK0782567T3 true DK0782567T3 (da) 1999-11-22

Family

ID=10761604

Family Applications (1)

Application Number Title Priority Date Filing Date
DK95933007T DK0782567T3 (da) 1994-09-20 1995-09-20 Isothiourinstofderivater og fremgangsmåder til deres fremstilling

Country Status (11)

Country Link
US (1) US5721247A (da)
EP (1) EP0782567B2 (da)
JP (1) JPH10505862A (da)
AT (1) ATE181731T1 (da)
AU (1) AU3582095A (da)
DE (1) DE69510553T3 (da)
DK (1) DK0782567T3 (da)
ES (1) ES2135769T3 (da)
GB (1) GB9418912D0 (da)
GR (1) GR3031321T3 (da)
WO (1) WO1996009286A1 (da)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2629795A (en) 1994-12-12 1996-07-03 Chugai Seiyaku Kabushiki Kaisha Aniline derivative having the effect of inhibiting nitrogen monoxide synthase
GB9708805D0 (en) 1997-05-01 1997-06-25 Smithkline Beecham Plc Compounds
US6028083A (en) * 1997-07-25 2000-02-22 Hoechst Marion Roussel, Inc. Esters of (+)-α-(2,3-dimethoxyphenyl)-1-[2-(4-fluorophenyl) ethyl]-4-piperidinemethanol
GB9810876D0 (en) 1998-05-20 1998-07-22 Smithkline Beecham Plc Compounds
EP1119563B1 (en) 1998-10-08 2006-02-01 SmithKline Beecham plc Tetrahydrobenzazepine derivatives useful as modulators of dopamine d3 receptors (antipsychotic agents)
AU5851400A (en) * 1999-07-09 2001-01-30 Chugai Seiyaku Kabushiki Kaisha Process for the preparation of aniline derivatives
BR0113698A (pt) 2000-09-05 2003-12-09 Meditor Pharmaceuticals Ltd Composições farmacêuticas para dor de cabeça, enxaqueca, náusea e emese
US8173642B2 (en) 2005-10-25 2012-05-08 Shionogi & Co., Ltd. Aminodihydrothiazine derivatives
MX2009011498A (es) 2007-04-24 2009-11-10 Shionogi & Co Derivados de aminodihidrotiazina sustituida con un grupo ciclico.
EP2151435A4 (en) 2007-04-24 2011-09-14 Shionogi & Co PHARMACEUTICAL COMPOSITION FOR THE TREATMENT OF ALZHEIMER'S DISEASE
KR101324426B1 (ko) 2008-06-13 2013-10-31 시오노기세야쿠 가부시키가이샤 β 세크레타제 저해 작용을 갖는 황 함유 복소환 유도체
EP2360155A4 (en) 2008-10-22 2012-06-20 Shionogi & Co 2-AMINOPYRIDIN-4-ON AND 2-AMINOPYRIDINE DERIVATIVE WITH BACE1-HEMDERING EFFECT
US20120015961A1 (en) * 2009-03-31 2012-01-19 Shionogi & Co., Ltd. Isothiourea derivatives or isourea derivatives having bace1 inhibitory activity
RU2012129168A (ru) 2009-12-11 2014-01-20 Сионоги Энд Ко. Лтд. Производные оксазина
JP5766198B2 (ja) 2010-10-29 2015-08-19 塩野義製薬株式会社 縮合アミノジヒドロピリミジン誘導体
CN103261199A (zh) 2010-10-29 2013-08-21 盐野义制药株式会社 萘啶衍生物
JPWO2012147763A1 (ja) 2011-04-26 2014-07-28 塩野義製薬株式会社 オキサジン誘導体およびそれを含有するbace1阻害剤
JP2016501827A (ja) 2012-10-24 2016-01-21 塩野義製薬株式会社 Bace1阻害作用を有するジヒドロオキサジンまたはオキサゼピン誘導体

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE152027C (da) *
US2050557A (en) * 1930-10-09 1936-08-11 Winthrop Chem Co Inc New therapeutically active ureaand thiourea-derivatives
US2050552A (en) * 1932-08-29 1936-08-11 Dufaycolor Ltd Color photography
NL294924A (da) * 1963-07-05
GB1178242A (en) * 1966-02-05 1970-01-21 Wellcome Found Novel Biologically Active Bis-Isothioureas
US4008330A (en) * 1971-09-13 1977-02-15 Nippon Kayaku Kabushiki Kaisha Method for combatting rodents and rodenticidal compositions
US4211867A (en) * 1976-03-19 1980-07-08 Mcneil Laboratories, Incorporated Nitrogen heterocyclic carboximidamide compounds
DD208298A1 (de) * 1982-09-08 1984-05-02 Hackel Goetz Ruediger Verfahren zur herstellung von keratinfaserfaerbepraeparaten
FR2581063B1 (fr) * 1985-04-30 1987-07-17 Chauvin Blache Lab Amino-2 thiazoles n-substitues, leur procede de preparation et leur application en therapeutique
GB8903592D0 (en) * 1989-02-16 1989-04-05 Boots Co Plc Therapeutic agents
GB8908063D0 (en) * 1989-04-11 1989-05-24 Beecham Group Plc Novel compounds
US4988688A (en) * 1989-08-02 1991-01-29 Warner-Lambert Company 4-(N-substituted amino)-2-butynyl-1-ureas and thioureas and derivatives thereof as centrally acting muscarinic agents
JPH08503940A (ja) * 1992-11-27 1996-04-30 ザ ウエルカム ファウンデーション リミテッド 酵素阻害薬
DK0690851T3 (da) * 1993-03-23 1999-11-08 Astra Ab Guanidin-derivater, som er anvendelige til behandling
SK16396A3 (en) * 1993-08-12 1996-09-04 Astra Ab Amidine derivatives with nitric oxide synthetase activities
EP0723438A1 (en) * 1993-10-04 1996-07-31 The Wellcome Foundation Limited Substituted urea and isothiourea derivatives as no synthase inhibitors
AU2629795A (en) 1994-12-12 1996-07-03 Chugai Seiyaku Kabushiki Kaisha Aniline derivative having the effect of inhibiting nitrogen monoxide synthase

Also Published As

Publication number Publication date
US5721247A (en) 1998-02-24
DE69510553D1 (en) 1999-08-05
GR3031321T3 (en) 1999-12-31
EP0782567B1 (en) 1999-06-30
WO1996009286A1 (en) 1996-03-28
GB9418912D0 (en) 1994-11-09
ES2135769T3 (es) 1999-11-01
DE69510553T2 (de) 1999-12-23
EP0782567A1 (en) 1997-07-09
JPH10505862A (ja) 1998-06-09
EP0782567B2 (en) 2002-12-11
AU3582095A (en) 1996-04-09
DE69510553T3 (de) 2003-10-02
ATE181731T1 (de) 1999-07-15

Similar Documents

Publication Publication Date Title
DK0782567T3 (da) Isothiourinstofderivater og fremgangsmåder til deres fremstilling
DK0683780T3 (da) Imidazopyridiner og deres anvendelse til behandling af mave-tarm-sygdomme
NO952132D0 (no) Farmakologiske aktive pyridin-derivater og deres fremstilling
DK0711280T3 (da) Perhydroisoindolderivater, fremstilling af disse forbindelser og farmaceutiske præparater indeholdende disse forbindelser
ES2124424T3 (es) Azadioxacicloalquenos substituidos y su empleo como fungicidas.
NO962286D0 (no) N-substituerte azabicykloalkanderivater som neuroleptika etc.
ATE206123T1 (de) Phenylxanthin-derivate
DK0772604T3 (da) Trialzolforbindelser og deres anvendelse som dopamin-D3-ligander
NO965094L (no) [aÅ-annelerte pyrrolderivater og anvendelse av disse i farmasien
IL114241A0 (en) Thiazolidine derivatives their preparation and compositions containing them
ATE200672T1 (de) Alkoxyalkylcarbamate von imidazo(1,2-a)pyridinen
NO930143D0 (no) Piperidinforbindelser, deres fremstilling og bruk
NO962285L (no) N-substituerte azabicykloheptan-derivater anvendt for eksempel som neuroleptika
DK0646110T3 (da) N-substituerede 3-azabicyclo(3.2.0) heptanderivater som neuroleptika
ATE198887T1 (de) Substituierte arylthioalkylthiopyridine
DK0731801T3 (da) Substituerede aminoaylkylaminopyridiner
ZA955052B (en) Pyrrolidine derivatives their preparation and compositions containing them
ATE327235T1 (de) 1,2,5,10-tetrahydropyridazino 4,5-böchinolin-1, 0-dione und ihre anwendung in der behandlung von schmerzen