[go: up one dir, main page]

DK0782450T3 - Anvendelse af aromatasehæmmere til fremstilling af et lægemiddel til behandling af en relativ androgenmangel hos mænd - Google Patents

Anvendelse af aromatasehæmmere til fremstilling af et lægemiddel til behandling af en relativ androgenmangel hos mænd

Info

Publication number
DK0782450T3
DK0782450T3 DK95934094T DK95934094T DK0782450T3 DK 0782450 T3 DK0782450 T3 DK 0782450T3 DK 95934094 T DK95934094 T DK 95934094T DK 95934094 T DK95934094 T DK 95934094T DK 0782450 T3 DK0782450 T3 DK 0782450T3
Authority
DK
Denmark
Prior art keywords
men
pct
aromatase inhibitors
androgen deficiency
medicament
Prior art date
Application number
DK95934094T
Other languages
Danish (da)
English (en)
Inventor
Albert Radlmaier
Ursula-Friederike Habenicht
Friedmund Neumann
Original Assignee
Schering Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=6529877&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DK0782450(T3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Schering Ag filed Critical Schering Ag
Application granted granted Critical
Publication of DK0782450T3 publication Critical patent/DK0782450T3/da

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/565—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/565—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
    • A61K31/568—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol substituted in positions 10 and 13 by a chain having at least one carbon atom, e.g. androstanes, e.g. testosterone
    • A61K31/5685—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol substituted in positions 10 and 13 by a chain having at least one carbon atom, e.g. androstanes, e.g. testosterone having an oxo group in position 17, e.g. androsterone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4196—1,2,4-Triazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
    • A61P5/26—Androgens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
    • A61P5/32—Antioestrogens

Landscapes

  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Endocrinology (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Diabetes (AREA)
  • Gynecology & Obstetrics (AREA)
  • Reproductive Health (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicinal Preparation (AREA)
  • Medicines Containing Plant Substances (AREA)
DK95934094T 1994-09-22 1995-09-22 Anvendelse af aromatasehæmmere til fremstilling af et lægemiddel til behandling af en relativ androgenmangel hos mænd DK0782450T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE4435368A DE4435368A1 (de) 1994-09-22 1994-09-22 Verwendung von Aromatasehemmern zur Herstellung eines Arzneimittels zur Behandlung eines relativen Androgenmangels beim Mann
PCT/EP1995/003733 WO1996009057A1 (fr) 1994-09-22 1995-09-22 Utilisation d'inhibiteurs d'aromatase pour la production d'un medicament destine au traitement d'une deficience relative d'androgene chez l'homme

Publications (1)

Publication Number Publication Date
DK0782450T3 true DK0782450T3 (da) 2003-08-18

Family

ID=6529877

Family Applications (1)

Application Number Title Priority Date Filing Date
DK95934094T DK0782450T3 (da) 1994-09-22 1995-09-22 Anvendelse af aromatasehæmmere til fremstilling af et lægemiddel til behandling af en relativ androgenmangel hos mænd

Country Status (21)

Country Link
US (1) US5861389A (fr)
EP (1) EP0782450B1 (fr)
JP (1) JPH10505848A (fr)
KR (1) KR100387345B1 (fr)
CN (1) CN1104243C (fr)
AT (1) ATE241989T1 (fr)
AU (1) AU707997B2 (fr)
BR (1) BR9509155A (fr)
CA (1) CA2200195C (fr)
CZ (1) CZ76097A3 (fr)
DE (2) DE4435368A1 (fr)
DK (1) DK0782450T3 (fr)
ES (1) ES2199255T3 (fr)
FI (1) FI971207A0 (fr)
HU (1) HUT76981A (fr)
MX (1) MX9702170A (fr)
NO (1) NO971349L (fr)
PL (1) PL182909B1 (fr)
PT (1) PT782450E (fr)
SK (1) SK36397A3 (fr)
WO (1) WO1996009057A1 (fr)

Families Citing this family (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19610645A1 (de) * 1996-03-06 1997-09-11 Schering Ag Kombination von Dehydroepiandrosteron und Aromatasehemmern und Verwendung dieser Kombination zur Herstellung eines Arzeimittels zur Behandlung eines relativen und absoluten Androgenmangels beim Mann
US5972921A (en) * 1997-12-12 1999-10-26 Hormos Medical Oy Ltd. Use of an aromatase inhibitor in the treatment of decreased androgen to estrogen ratio and detrusor urethral sphincter dyssynergia in men
WO2001091744A1 (fr) 2000-05-26 2001-12-06 Harry Fisch Methodes de traitement d'une carence androgenique chez des hommes au moyen d'anti-oestrogenes selectifs
US7067557B2 (en) * 2000-05-26 2006-06-27 Harry Fisch Methods of treating androgen deficiency in men using selective antiestrogens
US6607755B2 (en) * 2001-06-21 2003-08-19 Michael Donald Farley Anti-aromatase pharmaceutical composition for controlling testosterone/estrone ratios
CA2453337C (fr) * 2001-07-09 2012-08-28 Zonagen, Inc. Methodes et materiaux destines au traitement de la deficience en testosterone chez l'homme
US7173064B2 (en) * 2001-07-09 2007-02-06 Repros Therapeutics Inc. Methods and compositions with trans-clomiphene for treating wasting and lipodystrophy
US7737185B2 (en) * 2001-07-09 2010-06-15 Repros Therapeutics Inc. Methods and compositions with trans-clomiphene
IL162340A0 (en) * 2001-12-06 2005-11-20 Gtx Inc Treating muscle wasting with selective androgen receptor modulators
US6586417B1 (en) 2002-04-22 2003-07-01 Nutrisport Pharmacal, Inc. Ester and ether derivatives of 4-hydroxy 4-androstene-3,17-dione and a method for the regulation of athletic function in humans
AU2003203010A1 (en) * 2003-01-13 2004-08-13 Michael Donald Farley Improvements in or relating to anti-aromatase composition
WO2004064814A1 (fr) * 2003-01-13 2004-08-05 Michael Donald Farley Ameliorations apportees a une composition anti-aromatase
US20040248989A1 (en) 2003-06-05 2004-12-09 Risto Santti Method for the treatment or prevention of lower urinary tract symptoms
MX2007000050A (es) * 2004-07-14 2007-07-10 Repros Therapeutics Inc Trans-clomifeno para el tratamiento de hipertrofia de prostata benigna, cancer de prostata, hipogonadismo, trigliceridos elevados y colesterol elevado.
KR20070100811A (ko) * 2005-02-04 2007-10-11 레프로스 쎄라피우틱스 아이엔씨. 남성불임의 치료를 위한 트랜스―클로미펜을 이용한 물질과치료방법
NZ560551A (en) * 2005-03-22 2010-02-26 Repros Therapeutics Inc Dosing regimes for trans-clomiphene
KR101505884B1 (ko) * 2006-05-22 2015-03-25 호르모스 메디칼 리미티드 만성 비세균성 전립선염 치료용 선택적 에스트로겐 수용체 조절제 또는 아로마타아제 저해제
ES2718912T3 (es) 2007-10-16 2019-07-05 Repros Therapeutics Inc Trans-clomifeno para el tratamiento de la diabetes en hombres hipogonadales
CN102335219A (zh) * 2007-11-21 2012-02-01 客乐谐制药株式会社 芳香酶抑制剂
US20090215733A1 (en) * 2008-02-26 2009-08-27 Michael Charles Scally Therapy for the prophylaxis or treatment of adverse body composition changes and/or decreased muscle strength after androgen or gnrh analogue intake
US20090306031A1 (en) * 2009-08-07 2009-12-10 Kneller Bruce W 5alpha-ANDROSTANE-3,6,17-TRIONE (KNELLER'S TRIONE) AND METHODS OF USE THEREFOR
CA2673461C (fr) * 2009-08-07 2011-07-26 Bruce W. Kneller 5.alpha.-androstane-3,6,17-trione (tricetone de kneller) et methodes d'utilisation connexes
UA113291C2 (xx) 2011-08-04 2017-01-10 Метаболіти транскломіфену і їх застосування
CA2881604C (fr) * 2011-08-09 2021-09-14 Kenneth W. Adams Utilisation d'un inhibiteur de l'aromatase ou d'un anti-oestrogene pour accroitre la spermatogenese ou les niveaux de testosterone chez des sujets males
BR112014004879B1 (pt) * 2011-09-08 2020-01-28 Novartis Ag uso de inibidor de aromatase para tratamento de hipogonadismo e doenças relacionadas, composição farmacêutica oral, e kit
CN102641502A (zh) * 2012-04-25 2012-08-22 中国农业大学 芳香酶抑制剂的新用途
CN104994877A (zh) 2012-11-02 2015-10-21 利普生物药剂公司 用于癌症治疗的反式-克罗米芬

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4289762A (en) * 1980-06-27 1981-09-15 Merrell Dow Pharmaceuticals Inc. 10-(1,2-Propadienyl) steroids as irreversible aromatase inhibitors
US4322416A (en) * 1980-06-27 1982-03-30 Merrell Dow Pharmaceuticals Inc. 10-Alkynyl steroids
DE3362176D1 (en) * 1982-07-14 1986-03-27 Akzo Nv Novel 19-thio-androstane derivatives
DE3322285A1 (de) * 1983-06-18 1984-12-20 Schering AG, 1000 Berlin und 4709 Bergkamen 1-alkyl-androsta-1,4-dien-3,17-dione, verfahren zu deren herstellung und diese enthaltende pharmazeutische praeparate
DE3539244A1 (de) * 1985-11-01 1987-05-07 Schering Ag 1-methyl-15(alpha)-alkyl-androsta- 1,4-dien-3,17-dione, verfahren zu deren herstellung und diese enthaltende pharmazeutische praeparate
GB8531745D0 (en) * 1985-12-24 1986-02-05 Erba Farmitalia 10beta-alkynyl-4-9(11)-estradiene derivatives
GB8615092D0 (en) * 1986-06-20 1986-07-23 Erba Farmitalia Androst-4-ene-317-diones
DE3705990A1 (de) * 1987-02-20 1988-09-01 Schering Ag 1-methyl-15(alpha)-(1-oxyalkyl)-androsta-1,4-dien- 3,17-dione, verfahren zu deren herstellung und diese enthaltende pharmazeutische praeparate
DE3926365A1 (de) * 1989-08-04 1991-02-07 Schering Ag Cycloalkylenazole, verfahren zu deren herstellung, pharmazeutische praeparate, die diese enthalten sowie ihre verwendung zur herstellung von arzneimitteln
GB9226620D0 (en) * 1992-12-21 1993-02-17 Fujisawa Pharmaceutical Co A new compound fr 901537,production thereof and use thereof

Also Published As

Publication number Publication date
FI971207A7 (fi) 1997-03-21
KR100387345B1 (ko) 2003-08-30
EP0782450A1 (fr) 1997-07-09
DE59510714D1 (de) 2003-07-10
WO1996009057A1 (fr) 1996-03-28
EP0782450B1 (fr) 2003-06-04
NO971349D0 (no) 1997-03-21
DE4435368A1 (de) 1996-03-28
CN1104243C (zh) 2003-04-02
JPH10505848A (ja) 1998-06-09
NO971349L (no) 1997-05-16
MX9702170A (es) 1998-04-30
HUT76981A (hu) 1998-01-28
FI971207L (fi) 1997-03-21
SK36397A3 (en) 1997-08-06
ATE241989T1 (de) 2003-06-15
CA2200195C (fr) 2008-04-22
AU3651895A (en) 1996-04-09
FI971207A0 (fi) 1997-03-21
CZ76097A3 (en) 1997-07-16
US5861389A (en) 1999-01-19
PT782450E (pt) 2003-09-30
PL182909B1 (pl) 2002-04-30
CA2200195A1 (fr) 1996-03-28
ES2199255T3 (es) 2004-02-16
AU707997B2 (en) 1999-07-29
PL319299A1 (en) 1997-08-04
BR9509155A (pt) 1997-10-14
CN1158570A (zh) 1997-09-03
KR970706002A (ko) 1997-11-03

Similar Documents

Publication Publication Date Title
DK0782450T3 (da) Anvendelse af aromatasehæmmere til fremstilling af et lægemiddel til behandling af en relativ androgenmangel hos mænd
NO20003546L (no) Anvendelse av progestin og en farmasøytisk sammensetning samt et kit inneholdende disse
PL327146A1 (en) Antagonists of the gonadotrophin liberating hormone
SE9500422D0 (sv) New oral pharmaceutical dosage forms
ATE230757T1 (de) Verabreichung von peptidylheterocyclen zur behandlung von thrombin in zusammenhang stehenden krankheiten
SE9600073D0 (sv) Multiple unit dosage form
EP1935423A3 (fr) Composition pour le traitement et/ou la prophylaxie des tumeurs du sein
IL114446A (en) Pharmaceutical preparation for pain management and process for its preparation
DK1140016T3 (da) Præparat og kit til anvendelse ved intraoculær kirurgi
DE60129550D1 (de) Verwendung von niedrigen dosen estrogen in kombination mit immunotherapeutischen verbindungen zur behandlung von immunkrankheiten
NO951996L (no) Leveringsinnretning med innkapslede eksipienser
TNSN01169A1 (fr) Compositions comprenant des agonistes de gaba et des inhibiteurs de sorbitol-deshydrogenase.
DK0771217T3 (da) Faste lægemiddelformer, som indeholder clathrater af det steroide könshormon ethinylestadiol
BG105302A (en) Means for improving cognition
TW349865B (en) Therapeutic agent for hemorrhoidal diseases
IL159241A0 (en) Use of branched-chain fatty acids and derivatives thereof for the treatment of pain
ATE198707T1 (de) Prostaglandinanaloga zur oralen oder vaginalen verabreichung in der routinebehandlung des dritten stadiums der geburtswehen
LV10839A (lv) Arstniecibas lidzeklis lipidu un holesterina vielmainas traucejumu profilaksei un arstesanai so traucejumu profilakses un arstesanas panemiens
GR3035358T3 (en) Use of cyclooxygenase inhibitors for the manufacture of a medicament for enhancing uterine blood perfusion
HUP0101005A2 (hu) Szteroid aromatáz gátlót tartalmazó gyógyszer emlőrák megelőzésére és/vagy kezelésére
Hermus et al. Are the hypokalaemia and hypertension in Cushing's disease caused by apparent mineralocorticoid excess?
DK0648117T3 (da) Lægemiddel til at forebygge udvikling af tolerance ved behandling med benzodiazepin-receptor-bindende aktive forbindelser
BR0208968A (pt) Inibição de aromatase para aumentar a reprodução assistida
EA200200285A1 (ru) Мезопрогестины (модуляторы рецептора прогестерона) в качестве компонента композиций для заместительной гормональной терапии (згт)
Wolfsen Complications of systemic contraceptive agents: hypertension