[go: up one dir, main page]

DK0747357T3 - Dihydropyridin som NPY-antagonister: piperidinderivater - Google Patents

Dihydropyridin som NPY-antagonister: piperidinderivater

Info

Publication number
DK0747357T3
DK0747357T3 DK96109043T DK96109043T DK0747357T3 DK 0747357 T3 DK0747357 T3 DK 0747357T3 DK 96109043 T DK96109043 T DK 96109043T DK 96109043 T DK96109043 T DK 96109043T DK 0747357 T3 DK0747357 T3 DK 0747357T3
Authority
DK
Denmark
Prior art keywords
dihydropyridine
npy
antagonists
piperidine derivatives
npy antagonists
Prior art date
Application number
DK96109043T
Other languages
English (en)
Inventor
Marc Bruce
Graham Johnson
Karen Leboulluec
Charles P Sloan
Graham S Poindexter
Original Assignee
Bristol Myers Squibb Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bristol Myers Squibb Co filed Critical Bristol Myers Squibb Co
Application granted granted Critical
Publication of DK0747357T3 publication Critical patent/DK0747357T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/26—Psychostimulants, e.g. nicotine, cocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/80—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D211/84—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen directly attached to ring carbon atoms
    • C07D211/90—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Psychiatry (AREA)
  • Anesthesiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Pain & Pain Management (AREA)
  • Child & Adolescent Psychology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Hydrogenated Pyridines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
DK96109043T 1995-06-07 1996-06-05 Dihydropyridin som NPY-antagonister: piperidinderivater DK0747357T3 (da)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US48235395A 1995-06-07 1995-06-07

Publications (1)

Publication Number Publication Date
DK0747357T3 true DK0747357T3 (da) 2002-04-29

Family

ID=23915711

Family Applications (1)

Application Number Title Priority Date Filing Date
DK96109043T DK0747357T3 (da) 1995-06-07 1996-06-05 Dihydropyridin som NPY-antagonister: piperidinderivater

Country Status (10)

Country Link
US (1) US5668151A (da)
EP (1) EP0747357B1 (da)
JP (1) JPH093045A (da)
AT (1) ATE211733T1 (da)
AU (1) AU720923B2 (da)
CA (1) CA2177110A1 (da)
DE (1) DE69618383T2 (da)
DK (1) DK0747357T3 (da)
ES (1) ES2169774T3 (da)
PT (1) PT747357E (da)

Families Citing this family (55)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU729590B2 (en) * 1996-10-23 2001-02-08 Sanofi-Aventis Cosmetic composition containing a neuropeptide Y receptor antagonist
US6245817B1 (en) 1997-02-14 2001-06-12 Bayer Corporation NPY5 receptor antagonists and methods for using same
US6048900A (en) * 1998-02-13 2000-04-11 Bayer Corporation Amide derivatives and methods for using the same as selective neuropeptide Y receptor antagonists
EP0910565A1 (en) * 1997-02-14 1999-04-28 Bayer Corporation Amide derivatives as selective neuropeptide y receptor antagonists
US6001836A (en) * 1997-05-28 1999-12-14 Bristol-Myers Squibb Company Dihydropyridine NPY antagonists: cyanoguanidine derivatives
US6605623B1 (en) 1998-12-18 2003-08-12 Bristol-Myers Squibb Pharma Co. N-ureidoalkyl-piperidines as modulators of chemokine receptor activity
WO2000035454A1 (en) 1998-12-18 2000-06-22 Du Pont Pharmaceuticals Company N-ureidoalkyl-piperidines as modulators of chemokine receptor activity
US6331541B1 (en) 1998-12-18 2001-12-18 Soo S. Ko N-ureidoalkyl-piperidines as modulators of chemokine receptor activity
WO2000035877A1 (en) 1998-12-18 2000-06-22 Du Pont Pharmaceuticals Company Heterocyclic piperidines as modulators of chemokine receptor activity
US6444686B1 (en) 1998-12-18 2002-09-03 Brsitol-Myers Squibb Pharma Company N-ureidoalkyl-piperidines as modulators of chemokine receptor activity
CA2347769A1 (en) 1998-12-18 2000-06-22 Dean A. Wacker 2-substituted-4-nitrogen heterocycles as modulators of chemokine receptor activity
ATE302606T1 (de) 1998-12-18 2005-09-15 Bristol Myers Squibb Pharma Co N-ureidoalkylpiperidine als modulatoren der aktivität der chemokinrezeptoren
EP1140086A4 (en) * 1998-12-18 2002-04-03 Du Pont Pharm Co N-UREIDOALKYL-PIPERIDINES FOR USE AS MODULATORS OF THE ACTIVITY OF CHIMIOKIN RECEPTORS
CA2346933A1 (en) * 1998-12-18 2000-06-22 Dupont Pharmaceuticals Company N-ureidoalkyl-piperidines as modulators of chemokine receptor activity
US6525069B1 (en) 1998-12-18 2003-02-25 Bristol-Myers Squibb Pharma Co. N-ureidoalkyl-piperidines as modulators of chemokine receptor activity
EP1177188B1 (en) 1999-05-12 2005-10-12 Ortho-McNeil Pharmaceutical, Inc. Pyrazole carboxamides useful for the treatment of obesity and other disorders
GB9912415D0 (en) * 1999-05-28 1999-07-28 Pfizer Ltd Compounds useful in therapy
CA2377698A1 (en) * 1999-06-21 2000-12-28 Bristol-Myers Squibb Company Dihydropyrazine derivatives as npy antagonists
EP1219605B1 (en) 1999-10-05 2006-05-10 Takeda Pharmaceutical Company Limited Urea compounds, process for producing the same and use thereof
EP1220840A2 (en) 1999-10-15 2002-07-10 Bristol-Myers Squibb Pharma Company Bicyclic and tricyclic amines as modulators of chemokine receptor activity
CA2384240A1 (en) * 1999-10-15 2001-04-26 Dean A. Wacker Benzylcycloalkyl amines as modulators of chemokine receptor activity
US6784200B2 (en) * 2000-10-13 2004-08-31 Bristol-Myers Squibb Pharma Company Bicyclic and tricyclic amines as modulators of chemokine receptor activity
US6897234B2 (en) * 1999-12-17 2005-05-24 Bristol-Myers Squibb Pharma Company N-ureidoalkyl-piperidines as modulators of chemokine receptor activity
AU2001232900A1 (en) * 2000-01-20 2001-07-31 Michael Amling Methods and compositions for control of bone formation via modulation of neuropeptide y activity
US6531478B2 (en) 2000-02-24 2003-03-11 Cheryl P. Kordik Amino pyrazole derivatives useful for the treatment of obesity and other disorders
US6479482B2 (en) 2000-05-10 2002-11-12 Bristol-Myers Squibb Company Alkylamine derivatives of dihydropyridine NPY antagonists
US6444675B2 (en) * 2000-05-10 2002-09-03 Bristol-Myers Squibb Company 4-alkyl and 4-cycloalkyl derivatives of dihydropyridine NPY antagonists
US6432960B2 (en) 2000-05-10 2002-08-13 Bristol-Myers Squibb Company Squarate derivatives of dihydropyridine NPY antagonists
US6391881B2 (en) * 2000-05-19 2002-05-21 Bristol-Myers Squibb Company Thiourea derivatives of dihydropyridine NPY antagonists
EP1296949A2 (en) * 2000-06-21 2003-04-02 Bristol-Myers Squibb Pharma Company Piperidine amides as modulators of chemokine receptor activity
EP1296978A2 (en) 2000-06-30 2003-04-02 Bristol-Myers Squibb Company N-ureidoheterocycloaklyl-piperidines as modulators of chemokine receptor activity
US6596724B2 (en) 2000-07-07 2003-07-22 Bristol-Myers Squibb Company Oxadiazole and thiadiazole derivatives of dihydropyridine NPY antagonists
WO2003024401A2 (en) * 2001-09-18 2003-03-27 Bristol-Myers Squibb Company Piperizinones as modulators of chemokine receptor activity
NZ532427A (en) 2001-09-24 2008-07-31 Imp Innovations Ltd Modification of feeding behavior using PYY (peptide YY) and its agonists such as NPY (neuropeptide Y)
JP2005516001A (ja) 2001-12-05 2005-06-02 ベイラー カレッジ オブ メディスン 交感神経活動状態の調節による骨形成の制御のための方法及び組成物
TW200409630A (en) * 2002-09-12 2004-06-16 Bristol Myers Squibb Co N-ureidoalkyl-piperidines as modulators of chemokine receptor activity
US6919356B2 (en) * 2002-09-26 2005-07-19 Bristol Myers Squibb Company N-substituted heterocyclic amines as modulators of chemokine receptor activity
US20040152769A1 (en) * 2002-11-09 2004-08-05 Ekwuribe Nnochiri Nkem Modified carbamate-containing prodrugs and methods of synthesizing same
US7371871B2 (en) 2003-05-05 2008-05-13 Probiodrug Ag Inhibitors of glutaminyl cyclase
CA2544573A1 (en) 2003-11-03 2005-06-02 Probiodrug Ag Combinations useful for the treatment of neuronal disorders
US7291744B2 (en) * 2003-11-13 2007-11-06 Bristol-Myers Squibb Company N-ureidoalkyl-amino compounds as modulators of chemokine receptor activity
DE602004022704D1 (de) * 2003-11-26 2009-10-01 Novartis Ag 4-phenylpiperidinderivate als renininhibitoren
US7498346B2 (en) 2003-12-11 2009-03-03 Genzyme Corporation Chemokine receptor binding compounds
CA2548393A1 (en) 2003-12-11 2005-06-30 Anormed Inc. Chemokine receptor binding compounds
KR101099206B1 (ko) 2004-02-05 2011-12-27 프로비오드룩 아게 신규한 글루타미닐 시클라제 저해제
WO2008055945A1 (en) 2006-11-09 2008-05-15 Probiodrug Ag 3-hydr0xy-1,5-dihydr0-pyrr0l-2-one derivatives as inhibitors of glutaminyl cyclase for the treatment of ulcer, cancer and other diseases
EP2091948B1 (en) 2006-11-30 2012-04-18 Probiodrug AG Novel inhibitors of glutaminyl cyclase
CN101668525A (zh) 2007-03-01 2010-03-10 前体生物药物股份公司 谷氨酰胺酰环化酶抑制剂的新用途
US9656991B2 (en) 2007-04-18 2017-05-23 Probiodrug Ag Inhibitors of glutaminyl cyclase
ES2548913T3 (es) 2009-09-11 2015-10-21 Probiodrug Ag Derivados heterocíclicos como inhibidores de glutaminil ciclasa
WO2011107530A2 (en) 2010-03-03 2011-09-09 Probiodrug Ag Novel inhibitors
CA2789440C (en) 2010-03-10 2020-03-24 Probiodrug Ag Heterocyclic inhibitors of glutaminyl cyclase (qc, ec 2.3.2.5)
JP5945532B2 (ja) 2010-04-21 2016-07-05 プロビオドルグ エージー グルタミニルシクラーゼの阻害剤としてのベンゾイミダゾール誘導体
US8530670B2 (en) 2011-03-16 2013-09-10 Probiodrug Ag Inhibitors
EP3461819B1 (en) 2017-09-29 2020-05-27 Probiodrug AG Inhibitors of glutaminyl cyclase

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3523950A (en) * 1967-12-13 1970-08-11 Robins Co Inc A H Certain 4 - phenyl - 1,2,3,6 - tetrahydropyridyl-n-lower alkylene-ureas and derivatives
DE3587851D1 (de) * 1984-09-28 1994-07-21 Byk Gulden Lomberg Chem Fab Neue Diarylverbindungen.
DE3500898A1 (de) * 1985-01-12 1986-07-17 Hoechst Ag, 6230 Frankfurt Neue propionsaeureamide mit saeuresekretionshemmender wirkung, verfahren zu ihrer herstellung, diese enthaltende mittel und ihre verwendung
HU196755B (en) * 1986-09-16 1989-01-30 Gyogyszerkutato Intezet Process for production of new substituated amilid derivatives and medical compositions containing them
EP0276552A1 (en) * 1986-12-08 1988-08-03 Yamanouchi Pharmaceutical Co. Ltd. 1,4-dihydropyridine derivatives and their production
JPH0449237A (ja) * 1990-06-15 1992-02-18 Yamanouchi Pharmaceut Co Ltd ホスホリパーゼａ↓２阻害剤
WO1993006082A1 (en) * 1991-09-13 1993-04-01 Merck & Co., Inc. Process for the preparation of 4-substituted-1,4-dihydropyridines
GB9119983D0 (en) * 1991-09-19 1991-11-06 Erba Carlo Spa Dihydropyridine derivatives useful in antitumor therapy
FR2701480B1 (fr) * 1993-02-15 1995-05-24 Sanofi Elf Composés à groupe sulfamoyle et amidino, leur procédé de préparation et les compositions pharmaceutiques les contenant.

Also Published As

Publication number Publication date
CA2177110A1 (en) 1996-12-08
AU720923B2 (en) 2000-06-15
EP0747357B1 (en) 2002-01-09
US5668151A (en) 1997-09-16
DE69618383T2 (de) 2002-09-26
AU5475896A (en) 1996-12-19
ATE211733T1 (de) 2002-01-15
PT747357E (pt) 2002-06-28
JPH093045A (ja) 1997-01-07
ES2169774T3 (es) 2002-07-16
EP0747357A2 (en) 1996-12-11
DE69618383D1 (de) 2002-02-14
EP0747357A3 (en) 1998-12-16

Similar Documents

Publication Publication Date Title
DK0747357T3 (da) Dihydropyridin som NPY-antagonister: piperidinderivater
WO2001085098A3 (en) Squarate derivatives of dihydropyridine npy antagonists
SE8701348L (sv) Forbettringar av farmaceutiskt godtagabara salter
BR9811685A (pt) Derivados de piridina
DE69904302D1 (de) Farnesyltransferase-inhibitoren mit piperidinstruktur und verfahren zu ihrer herstellung
NL300006I2 (nl) Imidazolylalkeenzuurderivaten.
DE69915004D1 (de) 5-Oxo-pyrrolidine-2-Carbonsäure-Hydroxamidderivate
BR9913592A (pt) Compostos, processo de preparação dos compostos, e, composições farmacêuticas
NO20015365D0 (no) Piperidinderivater som er anvendbare som CCR5-antagonister
ATE211732T1 (de) N-benzylpiperidin- und tetrahydropyridin-derivate
NO991761L (no) Nye piperidin-kotokarbonsyre-derivater, deres fremstilling og anvendelse
PT1023267E (pt) Compostos de piridilo e composicoes farmaceuticas que os contem
DE69635996D1 (de) Pharmazeutische zusammensetzungen mit hydroximsäurederivaten
NO20005668D0 (no) Forbindelser med veksthormonfrigjörende egenskaper
DK135884D0 (da) 1,4-dihydropyridin-forbindelser og farmaceutisk acceptable syreadditionssalte deraf og deres anvendelse som anti-ischaemiske og antihypertensive midler
DE69616802D1 (de) 1-(1,2-disubstituierte piperidinyl)-4-(kondensierte imidazole)-piperidin derivate
TR28066A (tr) 1,4-disübstitüe piperidin derivatlari, bunlarin hazirlanisi ve fungisid olarak kullanimi.
PT992509E (pt) Novos derivados macrolidos
EP0152273A3 (en) A phenylpiperidine derivative, and its salts, their preparation, compositions containing them, and their therapeutic use
MX9302589A (es) Procedimiento mejorado para la preparacion de derivados de n-metoxi de 4-hidroxi-2,2,6,6-tetrametilpiperidina y 2,2,6,6-tetrametil-4-piperidona.
ATE147625T1 (de) Hydantoin- oder imidazolidintrionderivate zur vorbeugung oder behandlung von niereninsuffizienz
BG104232A (bg) Заместени 1,2,3,4,5,6-хексахидро-2,6-метано-3-бензазоцин- 10-оли, метод за тяхното получаване и приложението им като лекарствени средства
AU4692889A (en) New piperidin-2,6-diones used to prepare piperidines useful as medicaments
EA200000389A3 (ru) Новые замещенные пиридины или пиперидины, способ их получения и содержащие их фармацевтические композиции
NO180779B (no) Pyridinderivater, fremgangsmåte for deres fremstilling, anvendelse derav, sett omfattende slike, og utgangsforbindelse for fremgangsmåten