DK0746551T3 - Optisk rene 4-aryl-2-hydroxytetronsyrer - Google Patents
Optisk rene 4-aryl-2-hydroxytetronsyrerInfo
- Publication number
- DK0746551T3 DK0746551T3 DK95911075T DK95911075T DK0746551T3 DK 0746551 T3 DK0746551 T3 DK 0746551T3 DK 95911075 T DK95911075 T DK 95911075T DK 95911075 T DK95911075 T DK 95911075T DK 0746551 T3 DK0746551 T3 DK 0746551T3
- Authority
- DK
- Denmark
- Prior art keywords
- optically pure
- aryl
- treatment
- cyclooxygenase
- hydroxytetronic acids
- Prior art date
Links
- 239000002253 acid Substances 0.000 title abstract 2
- 150000007513 acids Chemical class 0.000 title abstract 2
- 102000004005 Prostaglandin-endoperoxide synthases Human genes 0.000 abstract 2
- 108090000459 Prostaglandin-endoperoxide synthases Proteins 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- 239000003112 inhibitor Substances 0.000 abstract 2
- 102000001381 Arachidonate 5-Lipoxygenase Human genes 0.000 abstract 1
- 108010093579 Arachidonate 5-lipoxygenase Proteins 0.000 abstract 1
- 201000001320 Atherosclerosis Diseases 0.000 abstract 1
- 206010003246 arthritis Diseases 0.000 abstract 1
- 230000015572 biosynthetic process Effects 0.000 abstract 1
- 208000029078 coronary artery disease Diseases 0.000 abstract 1
- 230000002757 inflammatory effect Effects 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 230000007170 pathology Effects 0.000 abstract 1
- 230000003389 potentiating effect Effects 0.000 abstract 1
- 230000002265 prevention Effects 0.000 abstract 1
- 208000010110 spontaneous platelet aggregation Diseases 0.000 abstract 1
- 238000003786 synthesis reaction Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D339/00—Heterocyclic compounds containing rings having two sulfur atoms as the only ring hetero atoms
- C07D339/08—Six-membered rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/365—Lactones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
- C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D307/56—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D307/62—Three oxygen atoms, e.g. ascorbic acid
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Epidemiology (AREA)
- Diabetes (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Hematology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Furan Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US08/201,775 US5399721A (en) | 1990-01-12 | 1994-02-25 | Synthesis of optically pure 4-aryl-2-hydroxytetronic acids |
| US08/350,205 US5504108A (en) | 1990-01-12 | 1994-12-05 | Optically pure 4-aryl-2-hydroxytetronic acids |
| PCT/US1995/002183 WO1995023139A1 (en) | 1994-02-25 | 1995-02-22 | Optically pure 4-aryl-2-hydroxytetronic acids |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK0746551T3 true DK0746551T3 (da) | 2003-01-06 |
Family
ID=26897085
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK95911075T DK0746551T3 (da) | 1994-02-25 | 1995-02-22 | Optisk rene 4-aryl-2-hydroxytetronsyrer |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US5504108A (da) |
| EP (1) | EP0746551B1 (da) |
| JP (1) | JP3241735B2 (da) |
| AT (1) | ATE223395T1 (da) |
| CA (1) | CA2184068A1 (da) |
| DE (1) | DE69528044T2 (da) |
| DK (1) | DK0746551T3 (da) |
| ES (1) | ES2182890T3 (da) |
| PT (1) | PT746551E (da) |
| WO (1) | WO1995023139A1 (da) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6005000A (en) * | 1996-08-22 | 1999-12-21 | Oxis International, Inc. | 5,5-Disubstituted-3, 4-dihydroxy-2(5H)-furanones and methods of use therefor |
| AU1676300A (en) * | 1999-12-29 | 2001-07-16 | Oxis Isle Of Man, Limited | Methods for resolving racemic mixtures of 5-substituted 4-hydroxy-2-furanones |
| PT1303265E (pt) | 2000-07-20 | 2007-10-09 | Lauras As | ''utilização de inibidores da cox-2 como imuno-estimulantes, no tratamento do vih ou da sida'' |
| EP1449821B1 (en) * | 2001-11-30 | 2012-05-09 | Nippon Shokubai Co., Ltd. | Optically active mandelic acid and its derivative, and method for crystallization thereof |
| WO2003053916A1 (en) * | 2001-12-21 | 2003-07-03 | Ortho-Mcneil Pharmaceutical, Inc. | Process for preparing 2-(substituted phenyl) - 2 - hydroxy-ethyl carbamates |
| KR20100134082A (ko) * | 2001-12-21 | 2010-12-22 | 오르토-맥네일 파마슈티칼, 인코퍼레이티드 | 2-(치환된 페닐)-2-하이드록시-에틸 카바메이트의 제조방법 |
| MX2011011517A (es) | 2009-04-29 | 2012-06-19 | Amarin Corp Plc | Composiciones farmaceuticas que comprenden epa y un agente cardiovascular y metodos para utilizar el mismo. |
| GB2512863A (en) * | 2013-04-09 | 2014-10-15 | Pornthip Lattmann | Medicinal applications of arylated hydroxy-tetronic acids |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2830268B2 (ja) * | 1989-01-21 | 1998-12-02 | 武田薬品工業株式会社 | アスコルビン酸誘導体の製造法 |
| US5095126A (en) * | 1990-01-12 | 1992-03-10 | Ohio State University Research Foundation | Efficient synthesis for optically pure stereogenically labile 4-substituted-2-hydroxytetronic acids |
| US5071872A (en) * | 1990-08-14 | 1991-12-10 | The Ohio State University Research Foundation | Method for improving interleukin-2 activity using aci-reductone compounds |
-
1994
- 1994-12-05 US US08/350,205 patent/US5504108A/en not_active Expired - Fee Related
-
1995
- 1995-02-22 DK DK95911075T patent/DK0746551T3/da active
- 1995-02-22 AT AT95911075T patent/ATE223395T1/de not_active IP Right Cessation
- 1995-02-22 JP JP52242295A patent/JP3241735B2/ja not_active Expired - Fee Related
- 1995-02-22 CA CA002184068A patent/CA2184068A1/en not_active Abandoned
- 1995-02-22 ES ES95911075T patent/ES2182890T3/es not_active Expired - Lifetime
- 1995-02-22 EP EP95911075A patent/EP0746551B1/en not_active Expired - Lifetime
- 1995-02-22 PT PT95911075T patent/PT746551E/pt unknown
- 1995-02-22 WO PCT/US1995/002183 patent/WO1995023139A1/en not_active Ceased
- 1995-02-22 DE DE69528044T patent/DE69528044T2/de not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| PT746551E (pt) | 2003-01-31 |
| ATE223395T1 (de) | 2002-09-15 |
| CA2184068A1 (en) | 1995-08-31 |
| JPH10500663A (ja) | 1998-01-20 |
| DE69528044T2 (de) | 2003-04-17 |
| WO1995023139A1 (en) | 1995-08-31 |
| EP0746551A1 (en) | 1996-12-11 |
| US5504108A (en) | 1996-04-02 |
| ES2182890T3 (es) | 2003-03-16 |
| EP0746551B1 (en) | 2002-09-04 |
| DE69528044D1 (de) | 2002-10-10 |
| JP3241735B2 (ja) | 2001-12-25 |
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