[go: up one dir, main page]

DK0629210T3 - Peptidforbindelsesenhed, der omfatter methylenphosphinsyre - Google Patents

Peptidforbindelsesenhed, der omfatter methylenphosphinsyre

Info

Publication number
DK0629210T3
DK0629210T3 DK93903068T DK93903068T DK0629210T3 DK 0629210 T3 DK0629210 T3 DK 0629210T3 DK 93903068 T DK93903068 T DK 93903068T DK 93903068 T DK93903068 T DK 93903068T DK 0629210 T3 DK0629210 T3 DK 0629210T3
Authority
DK
Denmark
Prior art keywords
peptide
pct
linkage
aspartic proteinase
methylene
Prior art date
Application number
DK93903068T
Other languages
English (en)
Inventor
Kim D Janda
Peter Wirsching
Shoji Ikeda
Original Assignee
Scripps Research Inst
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Scripps Research Inst filed Critical Scripps Research Inst
Application granted granted Critical
Publication of DK0629210T3 publication Critical patent/DK0629210T3/da

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K7/00Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/02Linear peptides containing at least one abnormal peptide link
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07FACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02Phosphorus compounds
    • C07F9/28Phosphorus compounds with one or more P—C bonds
    • C07F9/30Phosphinic acids [R2P(=O)(OH)]; Thiophosphinic acids ; [R2P(=X1)(X2H) (X1, X2 are each independently O, S or Se)]
    • C07F9/301Acyclic saturated acids which can have further substituents on alkyl
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07FACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02Phosphorus compounds
    • C07F9/28Phosphorus compounds with one or more P—C bonds
    • C07F9/30Phosphinic acids [R2P(=O)(OH)]; Thiophosphinic acids ; [R2P(=X1)(X2H) (X1, X2 are each independently O, S or Se)]
    • C07F9/32Esters thereof
    • C07F9/3205Esters thereof the acid moiety containing a substituent or a structure which is considered as characteristic
    • C07F9/3241Esters of arylalkanephosphinic acids
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K5/00Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/02Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
    • C07K5/021Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -NH-(X)n-C(=0)-, n being 5 or 6; for n > 6, classification in C07K5/06 - C07K5/10, according to the moiety having normal peptide bonds
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B60VEHICLES IN GENERAL
    • B60WCONJOINT CONTROL OF VEHICLE SUB-UNITS OF DIFFERENT TYPE OR DIFFERENT FUNCTION; CONTROL SYSTEMS SPECIALLY ADAPTED FOR HYBRID VEHICLES; ROAD VEHICLE DRIVE CONTROL SYSTEMS FOR PURPOSES NOT RELATED TO THE CONTROL OF A PARTICULAR SUB-UNIT
    • B60W40/00Estimation or calculation of non-directly measurable driving parameters for road vehicle drive control systems not related to the control of a particular sub unit, e.g. by using mathematical models
    • B60W40/08Estimation or calculation of non-directly measurable driving parameters for road vehicle drive control systems not related to the control of a particular sub unit, e.g. by using mathematical models related to drivers or passengers
    • B60W40/09Driving style or behaviour
    • FMECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F16ENGINEERING ELEMENTS AND UNITS; GENERAL MEASURES FOR PRODUCING AND MAINTAINING EFFECTIVE FUNCTIONING OF MACHINES OR INSTALLATIONS; THERMAL INSULATION IN GENERAL
    • F16HGEARING
    • F16H59/00Control inputs to control units of change-speed- or reversing-gearings for conveying rotary motion
    • F16H2059/003Detecting or using driving style of a driver, e.g. for adapting shift schedules
    • FMECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F16ENGINEERING ELEMENTS AND UNITS; GENERAL MEASURES FOR PRODUCING AND MAINTAINING EFFECTIVE FUNCTIONING OF MACHINES OR INSTALLATIONS; THERMAL INSULATION IN GENERAL
    • F16HGEARING
    • F16H2312/00Driving activities
    • F16H2312/02Driving off

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
DK93903068T 1992-01-09 1993-01-11 Peptidforbindelsesenhed, der omfatter methylenphosphinsyre DK0629210T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US81935692A 1992-01-09 1992-01-09
PCT/US1993/000228 WO1993014114A1 (en) 1992-01-09 1993-01-11 Peptide linkage unit comprising methylene phosphinic acid

Publications (1)

Publication Number Publication Date
DK0629210T3 true DK0629210T3 (da) 1998-10-12

Family

ID=25227921

Family Applications (1)

Application Number Title Priority Date Filing Date
DK93903068T DK0629210T3 (da) 1992-01-09 1993-01-11 Peptidforbindelsesenhed, der omfatter methylenphosphinsyre

Country Status (12)

Country Link
US (1) US5563121A (da)
EP (1) EP0629210B1 (da)
JP (1) JP3547432B2 (da)
AT (1) ATE167194T1 (da)
AU (1) AU677949B2 (da)
CA (1) CA2127295A1 (da)
DE (1) DE69319101T2 (da)
DK (1) DK0629210T3 (da)
ES (1) ES2119888T3 (da)
FI (1) FI943282L (da)
NO (1) NO310919B1 (da)
WO (1) WO1993014114A1 (da)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2004078780A1 (en) * 2003-03-04 2004-09-16 Pepharm R&D Limited Pharmaceutical composition containing l-seryl-l-leucine
CN103525794A (zh) * 2012-07-06 2014-01-22 天津市国际生物医药联合研究院 在原核系统中分离纯化包涵体形式hiv-1蛋白酶的方法

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH634968A5 (de) * 1977-04-01 1983-03-15 Ciba Geigy Ag Herbizides und pflanzenwuchsregulierendes mittel enthaltend eine neue phosphinsaeure oder deren salze, ester, amide oder hydrazide sowie verwendung derselben.
ES2110404T3 (es) * 1989-12-16 1998-02-16 Hoechst Ag Inhibidores de proteasas retrovirales.

Also Published As

Publication number Publication date
JP3547432B2 (ja) 2004-07-28
JPH07503013A (ja) 1995-03-30
CA2127295A1 (en) 1993-07-22
FI943282A0 (fi) 1994-07-08
AU677949B2 (en) 1997-05-15
AU3441893A (en) 1993-08-03
US5563121A (en) 1996-10-08
ATE167194T1 (de) 1998-06-15
FI943282A7 (fi) 1994-09-08
ES2119888T3 (es) 1998-10-16
WO1993014114A1 (en) 1993-07-22
DE69319101T2 (de) 1998-11-05
DE69319101D1 (de) 1998-07-16
NO310919B1 (no) 2001-09-17
EP0629210B1 (en) 1998-06-10
NO942544D0 (no) 1994-07-06
NO942544L (no) 1994-08-19
FI943282L (fi) 1994-09-08
EP0629210A1 (en) 1994-12-21

Similar Documents

Publication Publication Date Title
WO2001000663A3 (en) Catalytically active recombinant memapsin and methods of use thereof
EP0387231A3 (en) Novel inhibitors of retroviral protease
EP0104041A1 (en) Enzyme inhibitors
ATE377006T1 (de) Aus d-aminosäuren abgeleitete cystein- und serinproteasehemmer
WO1994001451A3 (en) Method for modification of recombinant polypeptides
ATE279432T1 (de) Kininogen-inhibitoren
Folk 2 Carboxypeptidase B
EP0498784A3 (en) Inhibitors of retroviral protease
Wagner et al. Inhibitors of a rat brain enkephalin aminopeptidase
NZ294397A (en) Cloning of an insulin-dependent membrane aminopeptidase designated GTVap from GLUT-4 vesicles
ATE146188T1 (de) Substituierungsanaloge von magaininpeptiden
ES2153433T3 (es) Inhibidores de trombina bivalentes.
DK0629210T3 (da) Peptidforbindelsesenhed, der omfatter methylenphosphinsyre
ATE171950T1 (de) Faktor vii-peptide
KR910007960A (ko) 항응고성 펩티드
EP0837074A3 (en) Biologically active fibronectin fragment as cancer metastasis inhibitor
Benuck et al. Rat brain and kidney metalloendopeptidase: enkephalin heptapeptide conversion to form a cardioactive neuropeptide, Phe-Met-Arg-Phe-amide
GB2262528B (en) Further improvements relating to the radiolabelling of proteins
EP0934952A3 (en) Peptides containing an N-substituted glycine residue
WO1999001567A3 (en) Methods and compositions for a deubiquitinating enzyme and variants thereof
Hrušková-Heidingsfeldová et al. Substrates and inhibitors of human T-cell leukemia virus type 1 (HTLV-1) proteinase.
Yonezawa et al. Substrate specificity of honeydew melon protease D, a plant serine endopeptidase
EP0249445A3 (en) Substituted aminoalkanoylaminoalkyl phosphonate angiotensin converting enzyme inhibitors
Pozsgay et al. Investigations on new tripeptidyl-p-nitroanilide substrates for subtilisins
Zimmerman Role of proteinases from leukocytes in inflammation