DK0626859T3 - Inhibering af nitrogenoxid medieret hypotension og septisk schock med jernholdig hæmoprotein - Google Patents
Inhibering af nitrogenoxid medieret hypotension og septisk schock med jernholdig hæmoproteinInfo
- Publication number
- DK0626859T3 DK0626859T3 DK93905917T DK93905917T DK0626859T3 DK 0626859 T3 DK0626859 T3 DK 0626859T3 DK 93905917 T DK93905917 T DK 93905917T DK 93905917 T DK93905917 T DK 93905917T DK 0626859 T3 DK0626859 T3 DK 0626859T3
- Authority
- DK
- Denmark
- Prior art keywords
- nitric oxide
- septic shock
- hemoprotein
- ferrous
- inhibition
- Prior art date
Links
- MWUXSHHQAYIFBG-UHFFFAOYSA-N Nitric oxide Chemical compound O=[N] MWUXSHHQAYIFBG-UHFFFAOYSA-N 0.000 title abstract 4
- 208000001953 Hypotension Diseases 0.000 title abstract 2
- 206010040070 Septic Shock Diseases 0.000 title abstract 2
- 230000036543 hypotension Effects 0.000 title abstract 2
- 230000036303 septic shock Effects 0.000 title abstract 2
- CWYNVVGOOAEACU-UHFFFAOYSA-N Fe2+ Chemical compound [Fe+2] CWYNVVGOOAEACU-UHFFFAOYSA-N 0.000 title 1
- 230000005764 inhibitory process Effects 0.000 title 1
- 230000001404 mediated effect Effects 0.000 title 1
- 238000000034 method Methods 0.000 abstract 2
- 238000011282 treatment Methods 0.000 abstract 2
- 102000004127 Cytokines Human genes 0.000 abstract 1
- 108090000695 Cytokines Proteins 0.000 abstract 1
- 230000008512 biological response Effects 0.000 abstract 1
- 230000002939 deleterious effect Effects 0.000 abstract 1
- 239000002158 endotoxin Substances 0.000 abstract 1
- 239000000367 immunologic factor Substances 0.000 abstract 1
- 239000003607 modifier Substances 0.000 abstract 1
- 230000001766 physiological effect Effects 0.000 abstract 1
- 238000011321 prophylaxis Methods 0.000 abstract 1
- 230000009885 systemic effect Effects 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/41—Porphyrin- or corrin-ring-containing peptides
- A61K38/42—Haemoglobins; Myoglobins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Immunology (AREA)
- General Chemical & Material Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Gastroenterology & Hepatology (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Epidemiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US07/838,603 US5296466A (en) | 1992-02-19 | 1992-02-19 | Inhibition of nitric oxide-mediated hypotension and septic shock with iron-containing hemoprotein |
| PCT/US1993/001288 WO1993016721A1 (en) | 1992-02-19 | 1993-02-16 | Inhibition of nitric oxide-mediated hypotension and septic shock with iron-containing hemoprotein |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK0626859T3 true DK0626859T3 (da) | 1998-09-21 |
Family
ID=25277557
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK93905917T DK0626859T3 (da) | 1992-02-19 | 1993-02-16 | Inhibering af nitrogenoxid medieret hypotension og septisk schock med jernholdig hæmoprotein |
Country Status (11)
| Country | Link |
|---|---|
| US (6) | US5296466A (da) |
| EP (1) | EP0626859B1 (da) |
| JP (1) | JPH07504193A (da) |
| AT (1) | ATE162722T1 (da) |
| AU (1) | AU657212B2 (da) |
| CA (1) | CA2117380C (da) |
| DE (1) | DE69316737T2 (da) |
| DK (1) | DK0626859T3 (da) |
| ES (1) | ES2115054T3 (da) |
| GR (1) | GR3026750T3 (da) |
| WO (1) | WO1993016721A1 (da) |
Families Citing this family (81)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5955581A (en) * | 1986-11-10 | 1999-09-21 | Biopure Corporation | Method for producing a stable polymerized hemoglobin blood-substitute |
| US5854209A (en) * | 1995-03-23 | 1998-12-29 | Biopure Corporation | Method for oxygenating tissue having reduced red blood cell flow |
| US6022849A (en) * | 1987-05-16 | 2000-02-08 | Baxter Biotech Technology Saarl | Mutant recombinant hemoglobins containing heme pocket mutations |
| US6204009B1 (en) | 1988-05-16 | 2001-03-20 | BAXTER BIOTECH TECHNOLOGY SàRL | Nucleic acids encoding mutant recombinant hemoglobins containing heme pocket mutations |
| US5478806A (en) * | 1989-11-22 | 1995-12-26 | Enzon, Inc. | Enhancement of antitumor therapy with hemoglobin-based conjugates |
| US5374651A (en) * | 1991-09-27 | 1994-12-20 | Board Of Regents, The University Of Texas System | Methods and compositions for the treatment of hypotension with arginine free essential and essential amino acids and arginine derivatives |
| US5334706A (en) * | 1992-01-30 | 1994-08-02 | Baxter International | Administration of low dose hemoglobin to increase perfusion |
| US5296466A (en) * | 1992-02-19 | 1994-03-22 | Board Of Regents, The University Of Texas System | Inhibition of nitric oxide-mediated hypotension and septic shock with iron-containing hemoprotein |
| US7063844B2 (en) | 1992-12-10 | 2006-06-20 | The Brigham And Women's Hospital, Inc. | Presentation of hydrophobic antigens to T-cells by CD1 molecules |
| US6238676B1 (en) | 1992-12-10 | 2001-05-29 | Brigham And Women's Hospital | Presentation of hydrophobic antigens to T-cells by CD1 molecules |
| GB9309387D0 (en) * | 1993-05-06 | 1993-06-16 | Wellcome Found | Nitric oxide scavengers |
| US5686436A (en) * | 1993-05-13 | 1997-11-11 | Hiv Diagnostics, Inc. | Multi-faceted method to repress reproduction of latent viruses in humans and animals |
| US5554638A (en) * | 1993-05-24 | 1996-09-10 | Duke University | Methods for improving therapeutic effectiveness of agents for the treatment of solid tumors and other disorders |
| US5612310A (en) * | 1993-05-24 | 1997-03-18 | Duke University | Methods for improving therapeutic effectiveness of agents for the treatment of solid tumors and other disorders |
| US5424447A (en) * | 1993-07-07 | 1995-06-13 | The Medical College Of Wisconsin Research Foundation, Inc. | Heme binding compounds and use thereof |
| DE69431194T2 (de) * | 1993-10-21 | 2002-12-12 | G.D. Searle & Co., Chicago | Amidino-derivate nützlich als no synthase-hemmer |
| JPH09504028A (ja) * | 1993-10-21 | 1997-04-22 | ジー.ディー.サール アンド カンパニー | 酸化窒素シンターゼ抑制剤として有用なアミジノ誘導体 |
| US5364881A (en) * | 1993-11-15 | 1994-11-15 | The Medical College Of Wisconsin Research Foundation, Inc. | S-alkyl-isothioureido-amino acids and use thereof |
| DE4338812A1 (de) * | 1993-11-15 | 1995-05-18 | Braun Melsungen Ag | Verwendung von Lösungen von vernetztem Hämoglobin zur Bekämpfung des septischen und hämorrhagischen Schocks bei Säugetieren |
| PT749418E (pt) * | 1994-03-10 | 2001-01-31 | Searle & Co | Derivados de l-n6-(1-iminoetil)lisina uteis como inibidores de oxido nitrico sintetase |
| US6245758B1 (en) | 1994-05-13 | 2001-06-12 | Michael K. Stern | Methods of use for peroxynitrite decomposition catalysts, pharmaceutical compositions therefor |
| PL317192A1 (en) * | 1994-05-13 | 1997-03-17 | Monsanto Co | Methods of using pernitrite decomposition catalyst and their pharmaceutic compositions |
| US5767103A (en) * | 1994-05-17 | 1998-06-16 | Research Corporation Tech., Inc. | Nitric oxide sequestrant |
| US5583101A (en) * | 1994-07-15 | 1996-12-10 | Harvard College | Use of nitrogen oxide species and adducts to inhibit skeletal muscle contraction |
| ATE207932T1 (de) * | 1994-07-22 | 2001-11-15 | Univ Duke | Komplexe aus porphyrin und menschlichem serumalbumin mit der fähigkeit, sauerstoff zu binden, und deren therapeutische verwendungen |
| US5684008A (en) * | 1994-11-09 | 1997-11-04 | G. D. Searle & Co. | Aminotetrazole derivatives useful as nitric oxide synthase inhibitors |
| WO1996015805A1 (en) * | 1994-11-17 | 1996-05-30 | Baxter International Inc. | Hemoglobin therapy in hemodialysis |
| US6610832B1 (en) | 1995-03-23 | 2003-08-26 | Biopure Corporation | Preserving a hemoglobin blood substitute with a transparent overwrap |
| US6271351B1 (en) | 1995-03-23 | 2001-08-07 | Biopure Corporation | Method for preserving a hemoglobin blood substitute |
| US6288027B1 (en) | 1995-03-23 | 2001-09-11 | Biopure Corporation | Preserving a hemoglobin blood substitute with a transparent overwrap |
| AU693354B2 (en) * | 1995-04-10 | 1998-06-25 | Baxter International Inc. | The use of cross-linked hemoglobin in treating subarachnoid hemorrhage |
| NZ305799A (en) * | 1995-04-20 | 1999-01-28 | Searle & Co | Cyclic amidino agents useful as nitric oxide synthase inhibitors |
| US5830917A (en) * | 1995-09-11 | 1998-11-03 | G. D. Searle & Co. | L-N6 -(1-iminoethyl) lysine derivatives useful as nitric oxide synthase inhibitors |
| US6855691B1 (en) | 1995-09-15 | 2005-02-15 | Duke University | Methods for producing and using S-nitrosohemoglobins |
| US6627738B2 (en) * | 1995-09-15 | 2003-09-30 | Duke University | No-modified hemoglobins and uses therefor |
| US6911427B1 (en) | 1995-09-15 | 2005-06-28 | Duke University | No-modified hemoglobins and uses therefore |
| US6197745B1 (en) | 1995-09-15 | 2001-03-06 | Duke University | Methods for producing nitrosated hemoglobins and therapeutic uses therefor |
| US6916471B2 (en) * | 1995-09-15 | 2005-07-12 | Duke University | Red blood cells loaded with S-nitrosothiol and uses therefor |
| US6153186A (en) | 1995-09-15 | 2000-11-28 | Duke University Medical Center | Red blood cells loaded with S-nitrosothiol and uses therefor |
| US5945408A (en) * | 1996-03-06 | 1999-08-31 | G.D. Searle & Co. | Hydroxyanidino derivatives useful as nitric oxide synthase inhibitors |
| US5981511A (en) * | 1996-03-06 | 1999-11-09 | G.D. Searle & Co. | Hydroxyamidino derivatives useful as nitric oxide synthase inhibitors |
| US5789395A (en) * | 1996-08-30 | 1998-08-04 | The Research Foundation Of State University Of New York | Method of using tetracycline compounds for inhibition of endogenous nitric oxide production |
| US5970985A (en) * | 1996-11-12 | 1999-10-26 | Baxter International, Inc. | Use of hemoglobin to treat systemic inflammatory response syndrome |
| ZA979540B (en) * | 1996-11-12 | 1998-05-12 | Baxter Int | Prophylactic use of hemoglobin to prevent sepsis. |
| US5804551A (en) * | 1996-11-12 | 1998-09-08 | Baxter International Inc. | Pretraumatic use of hemoglobin |
| DE69831248T2 (de) | 1997-02-28 | 2006-04-13 | The Regents Of The University Of California, Oakland | Verfahren und zusammensetzungen zur optimierung des sauerstofftransportes in zellfreien systemen |
| US5814601A (en) * | 1997-02-28 | 1998-09-29 | The Regents Of The University Of California | Methods and compositions for optimization of oxygen transport by cell-free systems |
| US6645138B2 (en) * | 1997-09-12 | 2003-11-11 | Uromedica, Inc. | Adjustable implantable genitourinary device |
| US5981556A (en) * | 1997-07-22 | 1999-11-09 | G.D. Searle & Co. | 1,3-diazolino and 1,3-diazolidino heterocycles as useful nitric oxide synthase inhibitors |
| US5948609A (en) * | 1997-12-03 | 1999-09-07 | Carter; Daniel C. | Oxygen-transporting albumin-based blood replacement composition and blood volume expander |
| JP2002517502A (ja) | 1998-06-10 | 2002-06-18 | ジー・ディー・サール・アンド・カンパニー | 複素二環状及び三環状一酸化窒素シンターゼ阻害剤 |
| US6448239B1 (en) | 1999-06-03 | 2002-09-10 | Trustees Of Princeton University | Peroxynitrite decomposition catalysts and methods of use thereof |
| WO2002009723A2 (en) * | 2000-08-01 | 2002-02-07 | Gmp Companies, Inc. | Ammonium salts of hemoglobin allosteric effectors, and uses thereof |
| US6610702B2 (en) | 2000-08-01 | 2003-08-26 | Gmp Oxycell, Inc. | Ammonium salts of inositol hexaphosphate, and uses thereof |
| US6344473B1 (en) | 2000-08-07 | 2002-02-05 | G.D. Searle & Co. | Imidazoles useful as nitric oxide synthase inhibitors |
| US6747132B2 (en) | 2000-11-29 | 2004-06-08 | Apex Biosciences, Inc. | Methods for the synthesis of a modified hemoglobin solution |
| US6518010B2 (en) * | 2001-02-28 | 2003-02-11 | Biopure Corporation | Use of defibrinated blood for manufacture of a hemoglobin-based oxygen carrier |
| MXPA03009555A (es) | 2001-04-18 | 2004-12-06 | Northfield Lab | Sistema de recipiente flexible para almacenamiento de soluciones de hemoglobina estabilizadas. |
| FR2828206B1 (fr) * | 2001-08-03 | 2004-09-24 | Centre Nat Rech Scient | Utilisation d'inhibiteurs des lysyl oxydases pour la culture cellulaire et le genie tissulaire |
| US7109245B2 (en) * | 2001-08-15 | 2006-09-19 | The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services | Vasoconstrictor cannabinoid analogs |
| US20030153491A1 (en) * | 2002-01-11 | 2003-08-14 | Winslow Robert M. | Methods and compositions for oxygen transport comprising a high oxygen affinity modified hemoglobin |
| US20050164915A1 (en) | 2002-04-01 | 2005-07-28 | Sangart, Inc. | Compositions for oxygen transport comprising a high oxygen affinity modified hemoglobin |
| US7001715B2 (en) * | 2002-02-28 | 2006-02-21 | Biopure Corporation | Purification of red blood cells by separation and diafiltration |
| AU2003231157C1 (en) * | 2002-04-29 | 2009-02-26 | Normoxys, Inc. | Inositol pyrophosphates, and methods of use thereof |
| AU2003215035A1 (en) * | 2002-06-21 | 2004-01-06 | Hemofarm Koncern A.D. Pharmaceutical And Chemical Industry | Process for determining endotoxin level in hemoglobin solutions |
| JP3912206B2 (ja) * | 2002-07-05 | 2007-05-09 | 株式会社日立製作所 | 筒内直接燃料噴射装置用燃料ポンプ |
| US7745423B2 (en) * | 2004-07-06 | 2010-06-29 | NormOxys, Inc | Calcium/sodium salt of inositol tripyrophosphate as an allosteric effector of hemoglobin |
| US20070135389A1 (en) * | 2004-07-06 | 2007-06-14 | Claude Nicolau | Tumor eradication by inositol-tripyrophosphate |
| US20060106000A1 (en) * | 2004-07-06 | 2006-05-18 | Claude Nicolau | Use of inositol-tripyrophosphate in treating tumors and diseases |
| US20060258626A1 (en) * | 2004-07-06 | 2006-11-16 | Claude Nicolau | Use of inositol-tripyrophosphate in treating tumors and diseases |
| EP1885365A4 (en) * | 2005-05-13 | 2012-07-11 | The Feinstein Inst Medical Res | TREATMENT OF SEPSIS AND INFLAMMATION WITH ADRENEER ALPHA2A ANTAGONISTS |
| US7710624B2 (en) * | 2005-05-26 | 2010-05-04 | Inphase Technologies, Inc. | Controlling the transmission amplitude profile of a coherent light beam in a holographic memory system |
| EP1978802A2 (en) * | 2006-01-24 | 2008-10-15 | Northfield Laboratories, Inc. | Polymerized hemoglobin media and its use in isolation and transplantation of islet cells |
| US20090004159A1 (en) * | 2006-01-24 | 2009-01-01 | The Board Of Trustees Of The University Of Illinoi | Polymerized Hemoglobin Media and Its Use in Isolation and Transplantation of Islet Cells |
| EP1986694B1 (en) * | 2006-02-14 | 2015-06-10 | Novo Nordisk Health Care AG | Coupling of polypeptides at the c-terminus |
| WO2008094222A2 (en) | 2006-10-06 | 2008-08-07 | Trustees Of Princeton | Porphyrin catalysts and methods of use thereof |
| WO2008063868A2 (en) * | 2006-11-07 | 2008-05-29 | The General Hospital Corporation | Attenuation of vasoactive oxygen carrier-induced vasoconstriction |
| CN101784193A (zh) * | 2007-05-01 | 2010-07-21 | 诺尔姆奥克西斯公司 | 促红细胞生成素互补或替代 |
| US20100086530A1 (en) * | 2008-10-06 | 2010-04-08 | Martinov Norman P | Cancer-tumor necrosis by artery nutrient-oxygen blocking |
| JP6389125B2 (ja) | 2011-11-07 | 2018-09-12 | ザ ジェネラル ホスピタル コーポレイション | 赤血球の処理法 |
| DE102013014651A1 (de) * | 2013-09-03 | 2015-03-05 | Sanguibiotech Gmbh | Zubereitungen zur verbesserten Gewebe-Oxygenierung durch peritoneale Beatmung |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4061736A (en) * | 1975-02-02 | 1977-12-06 | Alza Corporation | Pharmaceutically acceptable intramolecularly cross-linked, stromal-free hemoglobin |
| US4598064A (en) * | 1984-06-27 | 1986-07-01 | University Of Iowa Research Foundation | Alpha-alpha cross-linked hemoglobins |
| US4751068A (en) * | 1984-09-10 | 1988-06-14 | Duke University | Method for catalyzing oxidation/reduction reactions of simple molecules |
| US5082642A (en) * | 1984-09-10 | 1992-01-21 | Duke University | Method for catalyzing oxidation/reduction reactions of simple molecules |
| US4584130A (en) * | 1985-03-29 | 1986-04-22 | University Of Maryland | Intramolecularly cross-linked hemoglobin and method of preparation |
| US4997812A (en) * | 1988-09-12 | 1991-03-05 | Motorola, Inc. | Superconducting thick film |
| DE3838461A1 (de) * | 1988-11-12 | 1990-05-23 | Krebsoege Gmbh Sintermetall | Pulvermetallurgischer werkstoff auf kupferbasis und dessen verwendung |
| US5059712A (en) * | 1989-09-13 | 1991-10-22 | Cornell Research Foundation, Inc. | Isolating aminoarginine and use to block nitric oxide formation in body |
| US5028627A (en) * | 1989-09-13 | 1991-07-02 | Cornell Research Foundation, Inc. | Method of using arginine derivatives to inhibit systemic hypotension associated with nitric oxide production or endothelial derived relaxing factor |
| US5216025A (en) * | 1989-09-13 | 1993-06-01 | Board Of Regents, The University Of Texas System | Nitric oxide synthesis inhibitors for potentiating the action of pressor agents in certain hypotensive patients |
| US5334706A (en) * | 1992-01-30 | 1994-08-02 | Baxter International | Administration of low dose hemoglobin to increase perfusion |
| US5296466A (en) * | 1992-02-19 | 1994-03-22 | Board Of Regents, The University Of Texas System | Inhibition of nitric oxide-mediated hypotension and septic shock with iron-containing hemoprotein |
-
1992
- 1992-02-19 US US07/838,603 patent/US5296466A/en not_active Expired - Lifetime
-
1993
- 1993-02-16 WO PCT/US1993/001288 patent/WO1993016721A1/en not_active Ceased
- 1993-02-16 AU AU36655/93A patent/AU657212B2/en not_active Ceased
- 1993-02-16 JP JP5514904A patent/JPH07504193A/ja active Pending
- 1993-02-16 CA CA002117380A patent/CA2117380C/en not_active Expired - Fee Related
- 1993-02-16 ES ES93905917T patent/ES2115054T3/es not_active Expired - Lifetime
- 1993-02-16 AT AT93905917T patent/ATE162722T1/de active
- 1993-02-16 DK DK93905917T patent/DK0626859T3/da active
- 1993-02-16 DE DE69316737T patent/DE69316737T2/de not_active Expired - Lifetime
- 1993-02-16 EP EP93905917A patent/EP0626859B1/en not_active Expired - Lifetime
-
1994
- 1994-01-18 US US08/184,637 patent/US5480866A/en not_active Expired - Lifetime
- 1994-01-18 US US08/184,255 patent/US5674836A/en not_active Expired - Lifetime
-
1997
- 1997-10-02 US US08/942,632 patent/US5900403A/en not_active Expired - Lifetime
-
1998
- 1998-04-28 GR GR980400945T patent/GR3026750T3/el unknown
- 1998-12-02 US US09/204,392 patent/US6103690A/en not_active Expired - Fee Related
-
2000
- 2000-07-13 US US09/615,353 patent/US6350729B1/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| WO1993016721A1 (en) | 1993-09-02 |
| US6350729B1 (en) | 2002-02-26 |
| CA2117380A1 (en) | 1993-09-02 |
| AU657212B2 (en) | 1995-03-02 |
| US5900403A (en) | 1999-05-04 |
| EP0626859B1 (en) | 1998-01-28 |
| US5480866A (en) | 1996-01-02 |
| EP0626859A1 (en) | 1994-12-07 |
| DE69316737D1 (de) | 1998-03-05 |
| DE69316737T2 (de) | 1998-09-17 |
| JPH07504193A (ja) | 1995-05-11 |
| ATE162722T1 (de) | 1998-02-15 |
| ES2115054T3 (es) | 1998-06-16 |
| CA2117380C (en) | 2003-04-15 |
| GR3026750T3 (en) | 1998-07-31 |
| US5296466A (en) | 1994-03-22 |
| AU3665593A (en) | 1993-09-13 |
| US6103690A (en) | 2000-08-15 |
| US5674836A (en) | 1997-10-07 |
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