[go: up one dir, main page]

DK0626859T3 - Inhibering af nitrogenoxid medieret hypotension og septisk schock med jernholdig hæmoprotein - Google Patents

Inhibering af nitrogenoxid medieret hypotension og septisk schock med jernholdig hæmoprotein

Info

Publication number
DK0626859T3
DK0626859T3 DK93905917T DK93905917T DK0626859T3 DK 0626859 T3 DK0626859 T3 DK 0626859T3 DK 93905917 T DK93905917 T DK 93905917T DK 93905917 T DK93905917 T DK 93905917T DK 0626859 T3 DK0626859 T3 DK 0626859T3
Authority
DK
Denmark
Prior art keywords
nitric oxide
septic shock
hemoprotein
ferrous
inhibition
Prior art date
Application number
DK93905917T
Other languages
English (en)
Inventor
Robert G Kilbourn
Angelo Joseph De
Joseph Bonaventura
Original Assignee
Univ Texas
Univ Duke
Apex Bioscience Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Texas, Univ Duke, Apex Bioscience Inc filed Critical Univ Texas
Application granted granted Critical
Publication of DK0626859T3 publication Critical patent/DK0626859T3/da

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/41Porphyrin- or corrin-ring-containing peptides
    • A61K38/42Haemoglobins; Myoglobins
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/12Antihypertensives
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02ATECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
DK93905917T 1992-02-19 1993-02-16 Inhibering af nitrogenoxid medieret hypotension og septisk schock med jernholdig hæmoprotein DK0626859T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US07/838,603 US5296466A (en) 1992-02-19 1992-02-19 Inhibition of nitric oxide-mediated hypotension and septic shock with iron-containing hemoprotein
PCT/US1993/001288 WO1993016721A1 (en) 1992-02-19 1993-02-16 Inhibition of nitric oxide-mediated hypotension and septic shock with iron-containing hemoprotein

Publications (1)

Publication Number Publication Date
DK0626859T3 true DK0626859T3 (da) 1998-09-21

Family

ID=25277557

Family Applications (1)

Application Number Title Priority Date Filing Date
DK93905917T DK0626859T3 (da) 1992-02-19 1993-02-16 Inhibering af nitrogenoxid medieret hypotension og septisk schock med jernholdig hæmoprotein

Country Status (11)

Country Link
US (6) US5296466A (da)
EP (1) EP0626859B1 (da)
JP (1) JPH07504193A (da)
AT (1) ATE162722T1 (da)
AU (1) AU657212B2 (da)
CA (1) CA2117380C (da)
DE (1) DE69316737T2 (da)
DK (1) DK0626859T3 (da)
ES (1) ES2115054T3 (da)
GR (1) GR3026750T3 (da)
WO (1) WO1993016721A1 (da)

Families Citing this family (81)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5955581A (en) * 1986-11-10 1999-09-21 Biopure Corporation Method for producing a stable polymerized hemoglobin blood-substitute
US5854209A (en) * 1995-03-23 1998-12-29 Biopure Corporation Method for oxygenating tissue having reduced red blood cell flow
US6022849A (en) * 1987-05-16 2000-02-08 Baxter Biotech Technology Saarl Mutant recombinant hemoglobins containing heme pocket mutations
US6204009B1 (en) 1988-05-16 2001-03-20 BAXTER BIOTECH TECHNOLOGY SàRL Nucleic acids encoding mutant recombinant hemoglobins containing heme pocket mutations
US5478806A (en) * 1989-11-22 1995-12-26 Enzon, Inc. Enhancement of antitumor therapy with hemoglobin-based conjugates
US5374651A (en) * 1991-09-27 1994-12-20 Board Of Regents, The University Of Texas System Methods and compositions for the treatment of hypotension with arginine free essential and essential amino acids and arginine derivatives
US5334706A (en) * 1992-01-30 1994-08-02 Baxter International Administration of low dose hemoglobin to increase perfusion
US5296466A (en) * 1992-02-19 1994-03-22 Board Of Regents, The University Of Texas System Inhibition of nitric oxide-mediated hypotension and septic shock with iron-containing hemoprotein
US7063844B2 (en) 1992-12-10 2006-06-20 The Brigham And Women's Hospital, Inc. Presentation of hydrophobic antigens to T-cells by CD1 molecules
US6238676B1 (en) 1992-12-10 2001-05-29 Brigham And Women's Hospital Presentation of hydrophobic antigens to T-cells by CD1 molecules
GB9309387D0 (en) * 1993-05-06 1993-06-16 Wellcome Found Nitric oxide scavengers
US5686436A (en) * 1993-05-13 1997-11-11 Hiv Diagnostics, Inc. Multi-faceted method to repress reproduction of latent viruses in humans and animals
US5554638A (en) * 1993-05-24 1996-09-10 Duke University Methods for improving therapeutic effectiveness of agents for the treatment of solid tumors and other disorders
US5612310A (en) * 1993-05-24 1997-03-18 Duke University Methods for improving therapeutic effectiveness of agents for the treatment of solid tumors and other disorders
US5424447A (en) * 1993-07-07 1995-06-13 The Medical College Of Wisconsin Research Foundation, Inc. Heme binding compounds and use thereof
DE69431194T2 (de) * 1993-10-21 2002-12-12 G.D. Searle & Co., Chicago Amidino-derivate nützlich als no synthase-hemmer
JPH09504028A (ja) * 1993-10-21 1997-04-22 ジー.ディー.サール アンド カンパニー 酸化窒素シンターゼ抑制剤として有用なアミジノ誘導体
US5364881A (en) * 1993-11-15 1994-11-15 The Medical College Of Wisconsin Research Foundation, Inc. S-alkyl-isothioureido-amino acids and use thereof
DE4338812A1 (de) * 1993-11-15 1995-05-18 Braun Melsungen Ag Verwendung von Lösungen von vernetztem Hämoglobin zur Bekämpfung des septischen und hämorrhagischen Schocks bei Säugetieren
PT749418E (pt) * 1994-03-10 2001-01-31 Searle & Co Derivados de l-n6-(1-iminoetil)lisina uteis como inibidores de oxido nitrico sintetase
US6245758B1 (en) 1994-05-13 2001-06-12 Michael K. Stern Methods of use for peroxynitrite decomposition catalysts, pharmaceutical compositions therefor
PL317192A1 (en) * 1994-05-13 1997-03-17 Monsanto Co Methods of using pernitrite decomposition catalyst and their pharmaceutic compositions
US5767103A (en) * 1994-05-17 1998-06-16 Research Corporation Tech., Inc. Nitric oxide sequestrant
US5583101A (en) * 1994-07-15 1996-12-10 Harvard College Use of nitrogen oxide species and adducts to inhibit skeletal muscle contraction
ATE207932T1 (de) * 1994-07-22 2001-11-15 Univ Duke Komplexe aus porphyrin und menschlichem serumalbumin mit der fähigkeit, sauerstoff zu binden, und deren therapeutische verwendungen
US5684008A (en) * 1994-11-09 1997-11-04 G. D. Searle & Co. Aminotetrazole derivatives useful as nitric oxide synthase inhibitors
WO1996015805A1 (en) * 1994-11-17 1996-05-30 Baxter International Inc. Hemoglobin therapy in hemodialysis
US6610832B1 (en) 1995-03-23 2003-08-26 Biopure Corporation Preserving a hemoglobin blood substitute with a transparent overwrap
US6271351B1 (en) 1995-03-23 2001-08-07 Biopure Corporation Method for preserving a hemoglobin blood substitute
US6288027B1 (en) 1995-03-23 2001-09-11 Biopure Corporation Preserving a hemoglobin blood substitute with a transparent overwrap
AU693354B2 (en) * 1995-04-10 1998-06-25 Baxter International Inc. The use of cross-linked hemoglobin in treating subarachnoid hemorrhage
NZ305799A (en) * 1995-04-20 1999-01-28 Searle & Co Cyclic amidino agents useful as nitric oxide synthase inhibitors
US5830917A (en) * 1995-09-11 1998-11-03 G. D. Searle & Co. L-N6 -(1-iminoethyl) lysine derivatives useful as nitric oxide synthase inhibitors
US6855691B1 (en) 1995-09-15 2005-02-15 Duke University Methods for producing and using S-nitrosohemoglobins
US6627738B2 (en) * 1995-09-15 2003-09-30 Duke University No-modified hemoglobins and uses therefor
US6911427B1 (en) 1995-09-15 2005-06-28 Duke University No-modified hemoglobins and uses therefore
US6197745B1 (en) 1995-09-15 2001-03-06 Duke University Methods for producing nitrosated hemoglobins and therapeutic uses therefor
US6916471B2 (en) * 1995-09-15 2005-07-12 Duke University Red blood cells loaded with S-nitrosothiol and uses therefor
US6153186A (en) 1995-09-15 2000-11-28 Duke University Medical Center Red blood cells loaded with S-nitrosothiol and uses therefor
US5945408A (en) * 1996-03-06 1999-08-31 G.D. Searle & Co. Hydroxyanidino derivatives useful as nitric oxide synthase inhibitors
US5981511A (en) * 1996-03-06 1999-11-09 G.D. Searle & Co. Hydroxyamidino derivatives useful as nitric oxide synthase inhibitors
US5789395A (en) * 1996-08-30 1998-08-04 The Research Foundation Of State University Of New York Method of using tetracycline compounds for inhibition of endogenous nitric oxide production
US5970985A (en) * 1996-11-12 1999-10-26 Baxter International, Inc. Use of hemoglobin to treat systemic inflammatory response syndrome
ZA979540B (en) * 1996-11-12 1998-05-12 Baxter Int Prophylactic use of hemoglobin to prevent sepsis.
US5804551A (en) * 1996-11-12 1998-09-08 Baxter International Inc. Pretraumatic use of hemoglobin
DE69831248T2 (de) 1997-02-28 2006-04-13 The Regents Of The University Of California, Oakland Verfahren und zusammensetzungen zur optimierung des sauerstofftransportes in zellfreien systemen
US5814601A (en) * 1997-02-28 1998-09-29 The Regents Of The University Of California Methods and compositions for optimization of oxygen transport by cell-free systems
US6645138B2 (en) * 1997-09-12 2003-11-11 Uromedica, Inc. Adjustable implantable genitourinary device
US5981556A (en) * 1997-07-22 1999-11-09 G.D. Searle & Co. 1,3-diazolino and 1,3-diazolidino heterocycles as useful nitric oxide synthase inhibitors
US5948609A (en) * 1997-12-03 1999-09-07 Carter; Daniel C. Oxygen-transporting albumin-based blood replacement composition and blood volume expander
JP2002517502A (ja) 1998-06-10 2002-06-18 ジー・ディー・サール・アンド・カンパニー 複素二環状及び三環状一酸化窒素シンターゼ阻害剤
US6448239B1 (en) 1999-06-03 2002-09-10 Trustees Of Princeton University Peroxynitrite decomposition catalysts and methods of use thereof
WO2002009723A2 (en) * 2000-08-01 2002-02-07 Gmp Companies, Inc. Ammonium salts of hemoglobin allosteric effectors, and uses thereof
US6610702B2 (en) 2000-08-01 2003-08-26 Gmp Oxycell, Inc. Ammonium salts of inositol hexaphosphate, and uses thereof
US6344473B1 (en) 2000-08-07 2002-02-05 G.D. Searle & Co. Imidazoles useful as nitric oxide synthase inhibitors
US6747132B2 (en) 2000-11-29 2004-06-08 Apex Biosciences, Inc. Methods for the synthesis of a modified hemoglobin solution
US6518010B2 (en) * 2001-02-28 2003-02-11 Biopure Corporation Use of defibrinated blood for manufacture of a hemoglobin-based oxygen carrier
MXPA03009555A (es) 2001-04-18 2004-12-06 Northfield Lab Sistema de recipiente flexible para almacenamiento de soluciones de hemoglobina estabilizadas.
FR2828206B1 (fr) * 2001-08-03 2004-09-24 Centre Nat Rech Scient Utilisation d'inhibiteurs des lysyl oxydases pour la culture cellulaire et le genie tissulaire
US7109245B2 (en) * 2001-08-15 2006-09-19 The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services Vasoconstrictor cannabinoid analogs
US20030153491A1 (en) * 2002-01-11 2003-08-14 Winslow Robert M. Methods and compositions for oxygen transport comprising a high oxygen affinity modified hemoglobin
US20050164915A1 (en) 2002-04-01 2005-07-28 Sangart, Inc. Compositions for oxygen transport comprising a high oxygen affinity modified hemoglobin
US7001715B2 (en) * 2002-02-28 2006-02-21 Biopure Corporation Purification of red blood cells by separation and diafiltration
AU2003231157C1 (en) * 2002-04-29 2009-02-26 Normoxys, Inc. Inositol pyrophosphates, and methods of use thereof
AU2003215035A1 (en) * 2002-06-21 2004-01-06 Hemofarm Koncern A.D. Pharmaceutical And Chemical Industry Process for determining endotoxin level in hemoglobin solutions
JP3912206B2 (ja) * 2002-07-05 2007-05-09 株式会社日立製作所 筒内直接燃料噴射装置用燃料ポンプ
US7745423B2 (en) * 2004-07-06 2010-06-29 NormOxys, Inc Calcium/sodium salt of inositol tripyrophosphate as an allosteric effector of hemoglobin
US20070135389A1 (en) * 2004-07-06 2007-06-14 Claude Nicolau Tumor eradication by inositol-tripyrophosphate
US20060106000A1 (en) * 2004-07-06 2006-05-18 Claude Nicolau Use of inositol-tripyrophosphate in treating tumors and diseases
US20060258626A1 (en) * 2004-07-06 2006-11-16 Claude Nicolau Use of inositol-tripyrophosphate in treating tumors and diseases
EP1885365A4 (en) * 2005-05-13 2012-07-11 The Feinstein Inst Medical Res TREATMENT OF SEPSIS AND INFLAMMATION WITH ADRENEER ALPHA2A ANTAGONISTS
US7710624B2 (en) * 2005-05-26 2010-05-04 Inphase Technologies, Inc. Controlling the transmission amplitude profile of a coherent light beam in a holographic memory system
EP1978802A2 (en) * 2006-01-24 2008-10-15 Northfield Laboratories, Inc. Polymerized hemoglobin media and its use in isolation and transplantation of islet cells
US20090004159A1 (en) * 2006-01-24 2009-01-01 The Board Of Trustees Of The University Of Illinoi Polymerized Hemoglobin Media and Its Use in Isolation and Transplantation of Islet Cells
EP1986694B1 (en) * 2006-02-14 2015-06-10 Novo Nordisk Health Care AG Coupling of polypeptides at the c-terminus
WO2008094222A2 (en) 2006-10-06 2008-08-07 Trustees Of Princeton Porphyrin catalysts and methods of use thereof
WO2008063868A2 (en) * 2006-11-07 2008-05-29 The General Hospital Corporation Attenuation of vasoactive oxygen carrier-induced vasoconstriction
CN101784193A (zh) * 2007-05-01 2010-07-21 诺尔姆奥克西斯公司 促红细胞生成素互补或替代
US20100086530A1 (en) * 2008-10-06 2010-04-08 Martinov Norman P Cancer-tumor necrosis by artery nutrient-oxygen blocking
JP6389125B2 (ja) 2011-11-07 2018-09-12 ザ ジェネラル ホスピタル コーポレイション 赤血球の処理法
DE102013014651A1 (de) * 2013-09-03 2015-03-05 Sanguibiotech Gmbh Zubereitungen zur verbesserten Gewebe-Oxygenierung durch peritoneale Beatmung

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4061736A (en) * 1975-02-02 1977-12-06 Alza Corporation Pharmaceutically acceptable intramolecularly cross-linked, stromal-free hemoglobin
US4598064A (en) * 1984-06-27 1986-07-01 University Of Iowa Research Foundation Alpha-alpha cross-linked hemoglobins
US4751068A (en) * 1984-09-10 1988-06-14 Duke University Method for catalyzing oxidation/reduction reactions of simple molecules
US5082642A (en) * 1984-09-10 1992-01-21 Duke University Method for catalyzing oxidation/reduction reactions of simple molecules
US4584130A (en) * 1985-03-29 1986-04-22 University Of Maryland Intramolecularly cross-linked hemoglobin and method of preparation
US4997812A (en) * 1988-09-12 1991-03-05 Motorola, Inc. Superconducting thick film
DE3838461A1 (de) * 1988-11-12 1990-05-23 Krebsoege Gmbh Sintermetall Pulvermetallurgischer werkstoff auf kupferbasis und dessen verwendung
US5059712A (en) * 1989-09-13 1991-10-22 Cornell Research Foundation, Inc. Isolating aminoarginine and use to block nitric oxide formation in body
US5028627A (en) * 1989-09-13 1991-07-02 Cornell Research Foundation, Inc. Method of using arginine derivatives to inhibit systemic hypotension associated with nitric oxide production or endothelial derived relaxing factor
US5216025A (en) * 1989-09-13 1993-06-01 Board Of Regents, The University Of Texas System Nitric oxide synthesis inhibitors for potentiating the action of pressor agents in certain hypotensive patients
US5334706A (en) * 1992-01-30 1994-08-02 Baxter International Administration of low dose hemoglobin to increase perfusion
US5296466A (en) * 1992-02-19 1994-03-22 Board Of Regents, The University Of Texas System Inhibition of nitric oxide-mediated hypotension and septic shock with iron-containing hemoprotein

Also Published As

Publication number Publication date
WO1993016721A1 (en) 1993-09-02
US6350729B1 (en) 2002-02-26
CA2117380A1 (en) 1993-09-02
AU657212B2 (en) 1995-03-02
US5900403A (en) 1999-05-04
EP0626859B1 (en) 1998-01-28
US5480866A (en) 1996-01-02
EP0626859A1 (en) 1994-12-07
DE69316737D1 (de) 1998-03-05
DE69316737T2 (de) 1998-09-17
JPH07504193A (ja) 1995-05-11
ATE162722T1 (de) 1998-02-15
ES2115054T3 (es) 1998-06-16
CA2117380C (en) 2003-04-15
GR3026750T3 (en) 1998-07-31
US5296466A (en) 1994-03-22
AU3665593A (en) 1993-09-13
US6103690A (en) 2000-08-15
US5674836A (en) 1997-10-07

Similar Documents

Publication Publication Date Title
DK0626859T3 (da) Inhibering af nitrogenoxid medieret hypotension og septisk schock med jernholdig hæmoprotein
EP1306377A3 (en) Pyridyl-oxazoles and their use as cytokines inhibitors
FI942112L (fi) AIDS:n hoidossa käyttökelpoisia HIV-proteaasi-inhibiittoreita
DK0534396T3 (da) 2-Substituerede indan-2-carboxyalkylderivater med hæmmende virkning på enkefalinase og ACE
DK0534363T3 (da) 2-substituerede indan-2-mercaptoacetylamid-forbindelse med inhiberende virkning på enkephalinase og ACE.
DE69225426D1 (de) Neue Thrombin-Inhibitoren
ES8602768A1 (es) Un procedimiento para la preparacion de nuevas n-(heterociclil biciclo)-4-piperidinaminas.
FI935585A0 (fi) Pyrrolopyrimidiner
DE60234778D1 (de) Verwendung von il-18-hemmern zur behandlung oder prävention von sepsis
NL194717B (nl) Blokkeermiddelen van EDRF-effect of -vorming ter behandeling van shock.
ATE161013T1 (de) Verfahren zum reinigen von 20 cs)-camptothecin
DE3888225D1 (de) Bindung reiner Metallfilme an Keramik.
ATE107506T1 (de) Antiretroviraler castanosperminester.
CA1270834C (en) DIHYDROBENZOPYRAN SUBSTITUTES
IL107736A0 (en) Triphostins and pharmaceutical compositions containing them
ZA945246B (en) Novel 9-N-Bicyclic nucleoside agents useful as selective inhibitors of proinflammatory cytokines
DE69128624D1 (de) Verfahren zum Herstellen von normal kornorientiertem Stahl mit hohem Silizium- und niedrigem Kohlenstoffgehalt
DE69210503D1 (de) Verfahren zur Herstellung von kornorientiertem Siliziumstahlblech mit niedrigem Eisenverlust
ATE178486T1 (de) Verwendung von kardiotonischen mitteln und inhibitoren der stickstoffoxidsynthese zur linderung von pathologisch verringertem blutdruck
KR900009169A (ko) 세경 금속관의 굽힘 가공 장치
BG34037A3 (bg) Метод за получаване на субституирани n-метиленови производни на тиенамицина
DE69218535D1 (de) Verfahren zur Herstellung von kornorientierten Siliziumstahlblechen
FR2656528B1 (fr) Formule combinee de cimetidine-pirenzepine pour le traitement des ulceres simples de l'estomac et des erosions et procede de traitement.
DE58902675D1 (de) Verfahren zur steigerung des anteils an siliciumtetrachlorid.
KR950700896A (ko) 신규의 심장 보호제(Novel Cardioprotective Agents)