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DK0625989T3 - DNA-sekvenser kodende for hidtil ukendte vækst-/differentieringsfaktorer - Google Patents

DNA-sekvenser kodende for hidtil ukendte vækst-/differentieringsfaktorer

Info

Publication number
DK0625989T3
DK0625989T3 DK93903966T DK93903966T DK0625989T3 DK 0625989 T3 DK0625989 T3 DK 0625989T3 DK 93903966 T DK93903966 T DK 93903966T DK 93903966 T DK93903966 T DK 93903966T DK 0625989 T3 DK0625989 T3 DK 0625989T3
Authority
DK
Denmark
Prior art keywords
dna sequences
proteins
sequences encoding
differentiation factors
encoding novel
Prior art date
Application number
DK93903966T
Other languages
English (en)
Inventor
Helge Neidhardt
Gertrud Hoetten
Original Assignee
Bioph Biotech Entw Pharm Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bioph Biotech Entw Pharm Gmbh filed Critical Bioph Biotech Entw Pharm Gmbh
Application granted granted Critical
Publication of DK0625989T3 publication Critical patent/DK0625989T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/655—Somatostatins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/475—Growth factors; Growth regulators
    • C07K14/51—Bone morphogenetic factor; Osteogenins; Osteogenic factor; Bone-inducing factor
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Zoology (AREA)
  • Toxicology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Endocrinology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Saccharide Compounds (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
DK93903966T 1992-02-12 1993-02-12 DNA-sekvenser kodende for hidtil ukendte vækst-/differentieringsfaktorer DK0625989T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP92102324 1992-02-12
PCT/EP1993/000350 WO1993016099A2 (en) 1992-02-12 1993-02-12 Dna sequences encoding novel growth/differentiation factors

Publications (1)

Publication Number Publication Date
DK0625989T3 true DK0625989T3 (da) 2000-06-26

Family

ID=8209321

Family Applications (1)

Application Number Title Priority Date Filing Date
DK93903966T DK0625989T3 (da) 1992-02-12 1993-02-12 DNA-sekvenser kodende for hidtil ukendte vækst-/differentieringsfaktorer

Country Status (16)

Country Link
EP (1) EP0625989B1 (da)
JP (2) JP3193050B2 (da)
KR (1) KR0172186B1 (da)
AT (1) ATE188996T1 (da)
CA (1) CA2129820C (da)
CZ (2) CZ287715B6 (da)
DE (1) DE69327645T2 (da)
DK (1) DK0625989T3 (da)
ES (1) ES2141761T3 (da)
GR (1) GR3032482T3 (da)
HU (1) HU218845B (da)
NZ (1) NZ249113A (da)
PT (1) PT625989E (da)
RU (1) RU2208638C2 (da)
UA (1) UA48105C2 (da)
WO (1) WO1993016099A2 (da)

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US6586388B2 (en) 1988-04-08 2003-07-01 Stryker Corporation Method of using recombinant osteogenic protein to repair bone or cartilage defects
DE19525416A1 (de) 1995-07-12 1997-01-16 Bioph Biotech Entw Pharm Gmbh Verwendung von MP52 zur Behandlung und Prävention von Erkrankungen des Nervensystems
US5807713A (en) * 1992-02-12 1998-09-15 Biopharm Gesellschaft Zur Biotechnologischen Entwicklung DNA encoding growth/differentiation factor
US6171584B1 (en) 1992-02-12 2001-01-09 Biopharm Gesellschaft Zur Biotechnologischen Entwicklung Von Pharmaka Mbh Method of treatment with growth/differentiation factors of the TGF-β family
US7067637B1 (en) 1992-02-12 2006-06-27 Biopharm Gesellschaft Zur Biotechnologischen Entwicklung Von Pharmaka Mbh Antibody or antibody fragments specific for a protein of the TGF-β family
US7025959B1 (en) 1992-02-12 2006-04-11 Biopharm Gesellschaft Zur Biotechnologischen Entwicklung Von Pharmaka Mbh MP121, a growth/differentiation factor of the TGF-β family
US6120760A (en) 1992-02-12 2000-09-19 Biopharm Gesellschaft Zur Biotechnologischen Entwicklung Growth/differentiation factors of the TGF-β family
EP1439190A1 (en) 1993-01-12 2004-07-21 The Johns Hopkins University School Of Medicine Growth differentiation factor-5
EP0804214A4 (en) * 1993-07-09 1998-05-20 Univ Johns Hopkins Med FACTOR 6 OF CELL GROWTH AND DIFFERENTIATION
JPH09503904A (ja) 1993-07-09 1997-04-22 ザ ジョーンズ ホプキンス ユニバーシティー スクール オブ メディシン 増殖分化因子−７
IL110589A0 (en) * 1993-08-10 1994-11-11 Bioph Biotech Entw Pharm Gmbh Growth/differentiation factor of the TGF- beta family
US6764994B1 (en) 1993-08-10 2004-07-20 Biopharm Gesellschaft Zur Biotechnologischen Entwicklung Von Pharmaka Mbh Growth/differential factor of the TGF-B family
RU2246315C2 (ru) * 1993-08-10 2005-02-20 Биофарм Гезелльшафт Цур Биотехнологишен Энтвиклунг Фон Фармака Мбх НОВЫЙ ФАКТОР РОСТА/ДИФФЕРЕНЦИАЦИИ TGF-β-СЕМЕЙСТВА И ФАРМАЦЕВТИЧЕСКАЯ КОМПОЗИЦИЯ
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US6027919A (en) 1993-12-07 2000-02-22 Genetics Institute, Inc. BMP-12 and BMP-13 proteins and DNA encoding them
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IL114397A0 (en) * 1994-07-01 1995-10-31 Bioph Biotech Entw Pharm Gmbh Growth/differentiation factor of the TGF-beta-family
DE69518760T2 (de) * 1994-07-13 2001-05-23 The Johns Hopkins University School Of Medicine, Baltimore Wachstumsdifferenzierungsfaktor-12
WO1996014335A1 (en) 1994-11-07 1996-05-17 The Government Of The United States Of America, Asrepresented By The Secretary, Department Of Health And Human Services Cartilage-derived morphogenetic proteins
US5846770A (en) * 1994-11-22 1998-12-08 Genetics Institute, Inc. DNA molecules encoding human chordin
PT955313E (pt) 1995-04-19 2006-07-31 Bioph Biotech Entw Pharm Gmbh Nova proteina e processo para a sua producao
AP856A (en) * 1995-04-19 2000-07-12 Biopharm Gmbh A novel homodimer protein used in pharmaceutical preparation for treating cartlage and bone diseases.
US5635372A (en) * 1995-05-18 1997-06-03 Genetics Institute, Inc. BMP-15 compositions
HU222664B1 (hu) 1995-06-05 2003-09-29 Genetics Institute, Llc Csont morfogenetikus protein (BMP) alkalmazása csont és ín vagy szalag funkcionális összeköttetésének regenerálására
US5902785A (en) * 1995-06-06 1999-05-11 Genetics Institute, Inc. Cartilage induction by bone morphogenetic proteins
ZA966489B (en) * 1995-08-03 1997-02-26 Bioph Biotech Entw Pharm Gmbh New protein human MP52 Arg.
US5700774A (en) * 1996-03-26 1997-12-23 Genetics Institute, Inc. Compositions comprising bone morphogenic proteins and truncated parathyroid hormone related peptide, and methods of inducing cartilage by administration of same
JPH1080273A (ja) * 1996-05-13 1998-03-31 Hoechst Yakuhin Kogyo Kk Ｍｐ５２に対するモノクローナル抗体
US5965403A (en) 1996-09-18 1999-10-12 Genetics Institute, Inc. Nucleic acids encoding bone morphogenic protein-16 (BMP-16)
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US7041641B2 (en) 1997-03-20 2006-05-09 Stryker Corporation Osteogenic devices and methods of use thereof for repair of endochondral bone and osteochondral defects
US20010016646A1 (en) 1998-03-20 2001-08-23 David C. Rueger Osteogenic devices and methods of use thereof for repair of endochondral bone, osteochondral and chondral defects
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US7147839B2 (en) 1998-05-29 2006-12-12 Curis, Inc. Methods for evaluating tissue morphogenesis and activity
US6727224B1 (en) 1999-02-01 2004-04-27 Genetics Institute, Llc. Methods and compositions for healing and repair of articular cartilage
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US8546334B2 (en) 2001-11-19 2013-10-01 Scil Technology Gmbh Device having osteoinductive and osteoconductive properties
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US7344716B2 (en) 2003-05-13 2008-03-18 Depuy Spine, Inc. Transdiscal administration of specific inhibitors of pro-inflammatory cytokines
US7429378B2 (en) 2003-05-13 2008-09-30 Depuy Spine, Inc. Transdiscal administration of high affinity anti-MMP inhibitors
US8273347B2 (en) 2003-05-13 2012-09-25 Depuy Spine, Inc. Autologous treatment of degenerated disc with cells
US7553827B2 (en) 2003-08-13 2009-06-30 Depuy Spine, Inc. Transdiscal administration of cycline compounds
US8361467B2 (en) 2003-07-30 2013-01-29 Depuy Spine, Inc. Trans-capsular administration of high specificity cytokine inhibitors into orthopedic joints
JP5392981B2 (ja) 2003-09-12 2014-01-22 ワイス・エルエルシー 骨形成蛋白の送達のための注入可能なリン酸カルシウム固体ロッドおよびペースト
US8895540B2 (en) 2003-11-26 2014-11-25 DePuy Synthes Products, LLC Local intraosseous administration of bone forming agents and anti-resorptive agents, and devices therefor
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US7575751B2 (en) 2004-04-27 2009-08-18 Research Development Foundation Activin-A mutants
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US7473678B2 (en) 2004-10-14 2009-01-06 Biomimetic Therapeutics, Inc. Platelet-derived growth factor compositions and methods of use thereof
US8147860B2 (en) 2005-12-06 2012-04-03 Etex Corporation Porous calcium phosphate bone material
ES2427993T3 (es) 2006-02-09 2013-11-05 Biomimetic Therapeutics, Llc Composiciones y métodos para el tratamiento de hueso
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US8524265B2 (en) 2006-08-17 2013-09-03 Warsaw Orthopedic, Inc. Medical implant sheets useful for tissue regeneration
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ES2447516T3 (es) 2006-12-21 2014-03-12 Stryker Corporation Formulaciones de liberación sostenida que comprenden cristales BMP-7
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CA2042577A1 (en) * 1989-10-17 1991-04-18 Hermann Oppermann Osteogenic devices
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Also Published As

Publication number Publication date
ATE188996T1 (de) 2000-02-15
EP0625989A1 (en) 1994-11-30
RU2208638C2 (ru) 2003-07-20
KR0172186B1 (ko) 1999-02-01
AU666170B2 (en) 1996-02-01
JPH09182593A (ja) 1997-07-15
CA2129820A1 (en) 1993-08-19
KR950700331A (ko) 1995-01-16
JP3493105B2 (ja) 2004-02-03
CZ287810B6 (cs) 2001-02-14
NZ249113A (en) 1996-07-26
HUT67683A (en) 1995-04-28
WO1993016099A3 (en) 1993-09-30
EP0625989B1 (en) 2000-01-19
CZ287715B6 (en) 2001-01-17
CZ194294A3 (en) 1995-10-18
CA2129820C (en) 2003-06-17
RU94046367A (ru) 1997-03-27
DE69327645T2 (de) 2000-09-07
JP3193050B2 (ja) 2001-07-30
GR3032482T3 (en) 2000-05-31
HU9402143D0 (en) 1994-09-28
PT625989E (pt) 2000-06-30
HU218845B (hu) 2000-12-28
DE69327645D1 (de) 2000-02-24
AU3497193A (en) 1993-09-03
ES2141761T3 (es) 2000-04-01
JPH07503847A (ja) 1995-04-27
UA48105C2 (uk) 2002-08-15
WO1993016099A2 (en) 1993-08-19

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