DK0612724T3 - Substituerede benzensulfonylurinstoffer og -thiourinstoffer, fremgangsmåde til deres fremstilling og deres anvendelse som farmaceutika - Google Patents

Substituerede benzensulfonylurinstoffer og -thiourinstoffer, fremgangsmåde til deres fremstilling og deres anvendelse som farmaceutika

Info

Publication number: DK0612724T3
Authority: DK; Denmark
Prior art keywords: alkyl; thioureas; hal; arrhythmias; pharmaceuticals
Prior art date: 1993-02-23

Application number

DK94102321.0T

Other languages

English (en)

Inventor

Heinrich Englert

Dieter Mania

Jens Hartung

Heinz Goegelein

Joachim Kaiser

Wolfgang Linz

David Wettlaufer

Original Assignee

Hoechst Ag

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1993-02-23

Filing date

1994-02-16

Publication date

1997-06-16

1994-02-16 Application filed by Hoechst Ag filed Critical Hoechst Ag

1997-06-16 Application granted granted Critical

1997-06-16 Publication of DK0612724T3 publication Critical patent/DK0612724T3/da

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
- C07C311/30—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound nitrogen atoms, not being part of nitro or nitroso groups
- C07C311/45—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound nitrogen atoms, not being part of nitro or nitroso groups at least one of the singly-bound nitrogen atoms being part of any of the groups, X being a hetero atom, Y being any atom, e.g. N-acylaminosulfonamides
- C07C311/46—Y being a hydrogen or a carbon atom
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
- C07C311/50—Compounds containing any of the groups, X being a hetero atom, Y being any atom
- C07C311/52—Y being a hetero atom
- C07C311/54—Y being a hetero atom either X or Y, but not both, being nitrogen atoms, e.g. N-sulfonylurea
- C07C311/57—Y being a hetero atom either X or Y, but not both, being nitrogen atoms, e.g. N-sulfonylurea having sulfur atoms of the sulfonylurea groups bound to carbon atoms of six-membered aromatic rings
- C07C311/58—Y being a hetero atom either X or Y, but not both, being nitrogen atoms, e.g. N-sulfonylurea having sulfur atoms of the sulfonylurea groups bound to carbon atoms of six-membered aromatic rings having nitrogen atoms of the sulfonylurea groups bound to hydrogen atoms or to acyclic carbon atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C335/00—Thioureas, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
- C07C335/40—Thioureas, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of thiourea or isothiourea groups further bound to other hetero atoms
- C07C335/42—Sulfonylthioureas; Sulfonylisothioureas

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Cardiology (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Veterinary Medicine (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Heart & Thoracic Surgery (AREA)
Chemical Kinetics & Catalysis (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Hospice & Palliative Care (AREA)
Urology & Nephrology (AREA)
Vascular Medicine (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

DK94102321.0T 1993-02-23 1994-02-16 Substituerede benzensulfonylurinstoffer og -thiourinstoffer, fremgangsmåde til deres fremstilling og deres anvendelse som farmaceutika DK0612724T3 (da)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
DE4305450		1993-02-23

Publications (1)

Publication Number	Publication Date
DK0612724T3 true DK0612724T3 (da)	1997-06-16

Family

ID=6481073

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK94102321.0T DK0612724T3 (da)	1993-02-23	1994-02-16	Substituerede benzensulfonylurinstoffer og -thiourinstoffer, fremgangsmåde til deres fremstilling og deres anvendelse som farmaceutika

Country Status (17)

Country	Link
US (6)	US5574069A (da)
EP (1)	EP0612724B1 (da)
JP (1)	JP2778450B2 (da)
AT (1)	ATE146775T1 (da)
AU (1)	AU664940B2 (da)
CA (1)	CA2116165C (da)
CY (1)	CY2034A (da)
DE (1)	DE59401361D1 (da)
DK (1)	DK0612724T3 (da)
ES (1)	ES2098069T3 (da)
FI (1)	FI114152B (da)
GR (1)	GR3022550T3 (da)
HU (1)	HU219639B (da)
NO (1)	NO300173B1 (da)
NZ (1)	NZ250925A (da)
PL (2)	PL175795B1 (da)
TW (1)	TW429245B (da)

Families Citing this family (27)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE59401361D1 (de) *	1993-02-23	1997-02-06	Hoechst Ag	Substituierte Benzolsulfonylharnstoffe und -thioharnstoffe- Verfahren zu ihrer Herstellung und ihre Verwendung als Pharmazeutika
DE19503136A1 (de) *	1995-02-01	1996-08-08	Hoechst Ag	Substituierte Thiophenylsulfonylharnstoffe und -thioharnstoffe, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltendes Medikament
DE19504379A1 (de) *	1995-02-10	1996-08-14	Hoechst Ag	Substituierte Benzolsulfonylharnstoffe und -thioharnstoffe, Verfahren zu ihrer Herstellung und ihre Verwendung zur Herstellung pharmazeutischer Präparate sowie sie enthaltende pharmazeutische Präparate
DE19505397A1 (de) *	1995-02-17	1996-08-22	Hoechst Ag	Substituierte Benzolsulfonylharnstoffe und -thioharnstoffe, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltendes Medikament
HU226462B1 (en) *	1995-02-17	2008-12-29	Hoechst Ag	Substituted benzol-sulfonyl-ureas and -thioureas, process for producing them, pharmaceutical compositions containing them, and their use
ZA961314B (en) *	1995-02-21	1996-08-27	Hoechst Ag	Substituted benzenesulfonylureas and -thioreas processes for their preparation their use for the production of pharmaceutical preparations and medicaments containing them
DE19540995A1 (de) *	1995-11-03	1997-05-07	Hoechst Ag	Substituierte Sulfonimidamide, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltendes Medikament
DE19542306A1 (de) *	1995-11-14	1997-05-15	Hoechst Ag	Sulfonylamino-substituierte Benzoylguanidine, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltendes Medikament
PL316439A1 (en) *	1995-11-20	1997-05-26	Hoechst Ag	Novel substituted derivatives of benzoyloguanidine, method of obtaining them, their application in production of pharmaceutic and diagnostic agents and pharmaceutic agent as such
DE19546736A1 (de) *	1995-12-14	1997-06-19	Hoechst Ag	Substituierte Chromanylsulfonyl(thio)harnstoffe, Verfahren zu ihrer Herstellung und ihre Verwendung zur Herstellung pharmazeutischer Präparate
DE19647000A1 (de) *	1996-11-14	1998-05-20	Hoechst Ag	3-Amido-chromanylsulfonyl(thio)harnstoffe, Verfahren zu ihrer Herstellung, ihre Verwendung und sie enthaltende pharmazeutische Präparate
DE19832009A1 (de) *	1998-07-16	2000-01-20	Hoechst Marion Roussel De Gmbh	2,5-Substituierte Benzolsulfonylharnstoffe und -thioharnstoffe, Verfahren zu ihrer Herstellung, ihre Verwendung und sie enthaltende pharamazeutische Präparate
EP1117409B1 (en)	1998-09-10	2005-01-26	Aventis Pharma Deutschland GmbH	Benzenesulfonyl(thio)ureas in combination with beta-blockers for the treatment of dysfunctions of the autonomous nervous system
DE19917233A1 (de) *	1999-04-16	2000-10-19	Aventis Pharma Gmbh	Kristalline Formen des Natriumsalzes des 5-Chlor-2-methoxy-N-(2-(4-methoxy-3-methylaminothiocarbonylaminosulfonyl-phenyl)-ethyl)- benzamids
DE19923086A1 (de)	1999-05-20	2000-11-23	Aventis Pharma Gmbh	Cinnamoylaminoalkyl-substituierte Benzolsulfonamidderivate, Verfahren zu ihrer Herstellung, ihre Verwendung und sie enthaltende pharmazeutische Präparate
CN1296404C (zh)	2000-10-17	2007-01-24	旭化成株式会社	生产聚异氰酸酯组合物的方法
DE10054481A1 (de)	2000-11-03	2002-05-08	Aventis Pharma Gmbh	Acylaminoalkyl-substituierte Benzolsulfonamidderivate, ihre Herstellung, ihre Verwendung und sie enthaltende pharmazeutische Präparate
DE10054482A1 (de)	2000-11-03	2002-05-08	Aventis Pharma Gmbh	Heteroarylacryloylaminoalkyl-substituierte Benzolsulfonamidderivate, ihre Herstellung, ihre Verwendung und sie enthaltende pharmazeutische Präparate
US8472428B2 (en)	2001-02-27	2013-06-25	Verizon Data Services Llc	Methods and systems for line management
DE10129704A1 (de) *	2001-06-22	2003-01-02	Aventis Pharma Gmbh	Verwendung von Benzolsulfonyl(thio)harnstoffen in der Behandlung des septischen Schocks
US6835853B2 (en) *	2001-10-31	2004-12-28	Synthon Bv	Process for resolution of tamsulosin and compounds, compositions, and processes associated therewith
DE102004061017A1 (de) *	2004-12-18	2006-06-22	Sanofi-Aventis Deutschland Gmbh	Piperidinsulfonylharnstoffe und -thioharnstoffe, ihre Herstellung, ihre Verwendung und sie enthaltende pharmazeutische Präparate
WO2007131804A1 (en)	2006-05-17	2007-11-22	Synthon B.V.	Tablet composition with a prolonged release of tamsulosin
CA2651732C (en)	2006-05-18	2014-10-14	Mannkind Corporation	Intracellular kinase inhibitors
PT2164825E (pt) *	2007-06-05	2014-06-24	Sanofi Sa	Derivados de di(hetero)arilciclo-hexano, sua preparação, sua utilização e composições farmacêuticas compreendendo os mesmos
US8465770B2 (en) *	2008-12-24	2013-06-18	Synthon Bv	Low dose controlled release tablet
WO2010148177A2 (en) *	2009-06-17	2010-12-23	The Board Of Trustees Of The Leland Stanford Junior University	Compounds, compositions, methods of synthesis, and methods of treatment

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE243821C (da) *
DE1185180B (de) *	1963-10-19	1965-01-14	Hoechst Ag	Verfahren zur Herstellung von Benzolsulfonylharnstoffen
DE1518874C3 (de) *	1964-10-07	1975-03-13	Farbwerke Hoechst Ag, Vormals Meister Lucius & Bruening, 6000 Frankfurt	Benzolsulfonylharnstoffe und Verfahren zu ihrer Herstellung
DE1443919C3 (de) *	1964-12-28	1973-11-29	Farbwerke Hoechst Ag, Vormals Meister Lucius & Bruening, 6000 Frankfurt	Benzolsulfonylharnstoffe, Ver fahren zu ihrer Herstellung und diese enthaltende pharmazeutische Zubereitun gen
DE1259872B (de) *	1965-03-16	1968-02-01	C. F. Boehringer & Soehne G.m. b.H., 6800 Mannheim-Waldhof	Verfahren zur Herstellung von Sulfonylurethanen bzw. deren Salzen
US3297696A (en) *	1965-05-28	1967-01-10	Sandoz Ag	6-amino-8, 9-dihydro-13bh-isoquinolo-[2, 1-c] quinazolines and intermediates therefor
GB1122830A (en) *	1965-10-09	1968-08-07	Ferranti Ltd	Improvements relating to character transmission and reproduction systems
US3917690A (en) *	1966-11-29	1975-11-04	Hoechst Ag	Benzenesulfonyl ureas and process for their manufacture
DE1568648C3 (de) *	1966-12-19	1975-03-27	Farbwerke Hoechst Ag, Vormals Meister Lucius & Bruening, 6000 Frankfurt	Benzolsulfonylharnstoffe, Verfahren zu ihrer Herstellung und diese enthaltende pharmazeutische Präparate
US3517015A (en) *	1969-03-10	1970-06-23	Sandoz Ag	Tetrahydro-isoquino(2,1-d)(1,4)benzodiazepines
US3965173A (en) *	1971-05-21	1976-06-22	Chubb Francis L	Process for preparing p-(5-chloro-2-methoxy-benzamidoethyl)-benzene sulfonamide
DE2413514C3 (de) *	1974-03-21	1982-03-04	Hoechst Ag, 6000 Frankfurt	N-Acylaminoathylbenzolsulfonyl-N'-methylharnstoffe, Verfahren zu ihrer Herstellung und deren Verwendung
US3988968A (en) *	1974-12-23	1976-11-02	Miller Fluid Power Corporation	Stop tube for cylinder assemblies
DE2600513A1 (de) *	1976-01-08	1977-07-28	Hoechst Ag	Acylamino(alkyl)benzolderivate und verfahren zu ihrer herstellung
DE3011153A1 (de) *	1980-03-22	1981-10-15	Hoechst Ag, 6000 Frankfurt	Verwendung von n-(4- spitze klammer auf 2-(5-chlor-2-methoxy-benzamido)-aethylspitze klammer zu -benzolsulfonyl)-n'-methyl-harnstoff
US5215985A (en) *	1990-07-20	1993-06-01	E. R. Squibb & Sons, Inc.	Method for treating ischemic insult to neurons employing an ATP-sensitive potassium channel blocker
DE59401361D1 (de) *	1993-02-23	1997-02-06	Hoechst Ag	Substituierte Benzolsulfonylharnstoffe und -thioharnstoffe- Verfahren zu ihrer Herstellung und ihre Verwendung als Pharmazeutika

1994
- 1994-02-16 DE DE59401361T patent/DE59401361D1/de not_active Expired - Lifetime
- 1994-02-16 DK DK94102321.0T patent/DK0612724T3/da active
- 1994-02-16 AT AT94102321T patent/ATE146775T1/de active
- 1994-02-16 EP EP94102321A patent/EP0612724B1/de not_active Expired - Lifetime
- 1994-02-16 ES ES94102321T patent/ES2098069T3/es not_active Expired - Lifetime
- 1994-02-21 AU AU55279/94A patent/AU664940B2/en not_active Expired
- 1994-02-21 FI FI940810A patent/FI114152B/fi not_active IP Right Cessation
- 1994-02-21 NZ NZ250925A patent/NZ250925A/en not_active IP Right Cessation
- 1994-02-22 JP JP6024119A patent/JP2778450B2/ja not_active Expired - Lifetime
- 1994-02-22 PL PL94302325A patent/PL175795B1/pl unknown
- 1994-02-22 NO NO940600A patent/NO300173B1/no not_active IP Right Cessation
- 1994-02-22 PL PL94326170A patent/PL179268B1/pl unknown
- 1994-02-22 CA CA002116165A patent/CA2116165C/en not_active Expired - Lifetime
- 1994-02-23 HU HU9400525A patent/HU219639B/hu unknown
- 1994-03-25 TW TW083102607A patent/TW429245B/zh not_active IP Right Cessation
1995
- 1995-02-23 US US08/393,027 patent/US5574069A/en not_active Expired - Lifetime
1996
- 1996-09-03 US US08/707,103 patent/US5698596A/en not_active Expired - Lifetime
- 1996-11-07 US US08/744,314 patent/US5776980A/en not_active Expired - Lifetime
1997
- 1997-02-12 GR GR970400240T patent/GR3022550T3/el unknown
1998
- 1998-02-20 CY CY203498A patent/CY2034A/xx unknown
- 1998-05-19 US US09/081,143 patent/US6090981A/en not_active Expired - Lifetime
2000
- 2000-01-24 US US09/490,078 patent/US6335467B1/en not_active Expired - Lifetime
2001
- 2001-11-29 US US09/995,782 patent/US6506937B2/en not_active Expired - Fee Related

Also Published As

Publication number	Publication date
FI114152B (fi)	2004-08-31
AU5527994A (en)	1994-09-01
NO940600L (no)	1994-08-24
ES2098069T3 (es)	1997-04-16
CA2116165A1 (en)	1994-08-24
HU9400525D0 (en)	1994-05-30
JPH07304728A (ja)	1995-11-21
EP0612724B1 (de)	1996-12-27
HU219639B (hu)	2001-06-28
US6506937B2 (en)	2003-01-14
EP0612724A1 (de)	1994-08-31
NZ250925A (en)	1995-09-26
HUT71104A (en)	1995-11-28
GR3022550T3 (en)	1997-05-31
DE59401361D1 (de)	1997-02-06
US5698596A (en)	1997-12-16
US20020058838A1 (en)	2002-05-16
PL175795B1 (pl)	1999-02-26
US5776980A (en)	1998-07-07
US5574069A (en)	1996-11-12
NO300173B1 (no)	1997-04-21
US6090981A (en)	2000-07-18
HK1006166A1 (en)	1999-02-12
ATE146775T1 (de)	1997-01-15
PL302325A1 (en)	1994-09-05
JP2778450B2 (ja)	1998-07-23
FI940810L (fi)	1994-08-24
PL179268B1 (pl)	2000-08-31
NO940600D0 (no)	1994-02-22
CA2116165C (en)	2006-02-21
AU664940B2 (en)	1995-12-07
FI940810A0 (fi)	1994-02-21
US6335467B1 (en)	2002-01-01
TW429245B (en)	2001-04-11
CY2034A (en)	1998-02-20

Publication	Publication Date	Title
DK0612724T3 (da)	1997-06-16	Substituerede benzensulfonylurinstoffer og -thiourinstoffer, fremgangsmåde til deres fremstilling og deres anvendelse som farmaceutika
BR9813668A (pt)	2000-10-17	Composto, uso do mesmo, processo para prepará-lo, formulação farmacêutica, e, processo de profilaxia ou tratamento de uma arritmia
NO944699D0 (no)	1994-12-06	Aminosubstituerte benzensulfornylurinstoffer og -tiourinstoffer, fremgangsmåte for deres fremstilling og deres anvendelse som farmasöytika
NO302750B1 (no)	1998-04-20	Substituerte benzensulfonylurinstoffer og -tiourinstoffer, og deres anvendelse for fremstilling av legemidler
ES2037666T3 (es)	1993-07-01	Utilizacion de las fenil-naftiridinas.
HK10292A (en)	1992-01-31	Intermediates for agriculturally useful acrylic acid derivatives
EP0217747A3 (en)	1988-07-27	Nematocidal agents
KR930005621A (ko)	1993-04-20	고혈압 치료용 제약 조성물
NO970964L (no)	1997-09-05	Ortosubstituerte benzoylguanidiner, fremgangsmåter for deres fremstilling, deres anvendelse som medikament eller diagnostikum samt medikamenter inneholdende forbindelsene
DE3462030D1 (en)	1987-02-19	Derivatives of beta-û2-(halogenobenzyl)-phenoxy¨- ethylamine,process for their preparation and their therapeutical use.
KR890014101A (ko)	1989-10-21	동맥경화증 치료제
TH13552A (th)	1993-12-15	อนุพันธุ์ต่าง ๆ ของเบนโซฟิโนน