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DK0608307T3 - Nye ligander til asymmetrisk dihydroxylering: flere cinchonaalkaloid-enheder fæstnet til en central heterocyklisk kerne - Google Patents

Nye ligander til asymmetrisk dihydroxylering: flere cinchonaalkaloid-enheder fæstnet til en central heterocyklisk kerne

Info

Publication number
DK0608307T3
DK0608307T3 DK92921493T DK92921493T DK0608307T3 DK 0608307 T3 DK0608307 T3 DK 0608307T3 DK 92921493 T DK92921493 T DK 92921493T DK 92921493 T DK92921493 T DK 92921493T DK 0608307 T3 DK0608307 T3 DK 0608307T3
Authority
DK
Denmark
Prior art keywords
alkaloid
asymmetric dihydroxylation
cinchonal
units attached
heterocyclic nucleus
Prior art date
Application number
DK92921493T
Other languages
Danish (da)
English (en)
Inventor
Jens Hartung
K Barry Sharpless
Original Assignee
Massachusetts Inst Technology
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Massachusetts Inst Technology filed Critical Massachusetts Inst Technology
Application granted granted Critical
Publication of DK0608307T3 publication Critical patent/DK0608307T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C67/00—Preparation of carboxylic acid esters
    • C07C67/30—Preparation of carboxylic acid esters by modifying the acid moiety of the ester, such modification not being an introduction of an ester group
    • C07C67/31—Preparation of carboxylic acid esters by modifying the acid moiety of the ester, such modification not being an introduction of an ester group by introduction of functional groups containing oxygen only in singly bound form
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C29/00—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring
    • C07C29/48—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring by oxidation reactions with formation of hydroxy groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D453/00—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids
    • C07D453/02—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids containing not further condensed quinuclidine ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D453/00—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids
    • C07D453/02—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids containing not further condensed quinuclidine ring systems
    • C07D453/04—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids containing not further condensed quinuclidine ring systems having a quinolyl-4, a substituted quinolyl-4 or a alkylenedioxy-quinolyl-4 radical linked through only one carbon atom, attached in position 2, e.g. quinine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/07—Optical isomers
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
    • C07C2601/14—The ring being saturated
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/18—Systems containing only non-condensed rings with a ring being at least seven-membered

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
DK92921493T 1991-10-10 1992-10-06 Nye ligander til asymmetrisk dihydroxylering: flere cinchonaalkaloid-enheder fæstnet til en central heterocyklisk kerne DK0608307T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US07/775,683 US5260461A (en) 1988-01-11 1991-10-10 Ligands for ADH: cinchona alkaloids and moderately sized organic substituents linked through a planar aromatic spacer group
PCT/US1992/008544 WO1993007142A1 (fr) 1991-10-10 1992-10-06 Nouveaux ligands pour dihydroxylation asymetrique: unites multiples d'alcaloides de quinquina fixees a un noyau heterocyclique central

Publications (1)

Publication Number Publication Date
DK0608307T3 true DK0608307T3 (da) 2004-06-14

Family

ID=25105173

Family Applications (1)

Application Number Title Priority Date Filing Date
DK92921493T DK0608307T3 (da) 1991-10-10 1992-10-06 Nye ligander til asymmetrisk dihydroxylering: flere cinchonaalkaloid-enheder fæstnet til en central heterocyklisk kerne

Country Status (9)

Country Link
US (1) US5260461A (fr)
EP (1) EP0608307B1 (fr)
JP (1) JP3982829B2 (fr)
AT (1) ATE258932T1 (fr)
CA (1) CA2120919C (fr)
DE (1) DE69233299T2 (fr)
DK (1) DK0608307T3 (fr)
ES (1) ES2215989T3 (fr)
WO (1) WO1993007142A1 (fr)

Families Citing this family (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PH31122A (en) * 1993-03-31 1998-02-23 Eisai Co Ltd Nitrogen-containing fused-heterocycle compounds.
US5491237A (en) 1994-05-03 1996-02-13 Glaxo Wellcome Inc. Intermediates in pharmaceutical camptothecin preparation
US6030917A (en) 1996-07-23 2000-02-29 Symyx Technologies, Inc. Combinatorial synthesis and analysis of organometallic compounds and catalysts
US6440745B1 (en) * 1994-10-18 2002-08-27 Symyx Technologies Combinatorial synthesis and screening of organometallic compounds and catalysts
US6419881B1 (en) 1994-10-18 2002-07-16 Symyx Technologies, Inc. Combinatorial arrays of organometallic compounds and catalysts
ATE207919T1 (de) * 1995-08-03 2001-11-15 Dade Behring Inc Chinidin-konjugate und ihre anwendung in immunoassays
US5850086A (en) * 1996-06-21 1998-12-15 Regents Of The University Of Minnesota Iron complexes for bleach activation and stereospecific oxidation
US6559309B2 (en) 1996-11-01 2003-05-06 Osi Pharmaceuticals, Inc. Preparation of a camptothecin derivative by intramolecular cyclisation
EP0940170B1 (fr) * 1998-03-02 2002-09-11 Wako Pure Chemical Industries, Ltd. Composition d'oxide d'osmium micro-encapsulée
US6133485A (en) * 1998-04-15 2000-10-17 Synphar Laboratories, Inc. Asymmetric synthesis of 2-(2,4-difluorophenyl)-1-heterocycl-1-yl butan-2,3-diols
WO2000063173A1 (fr) * 1999-04-14 2000-10-26 F. Hoffmann-La Roche Ag Procede de preparation de piperidines substituees
DE19920039A1 (de) * 1999-04-25 2000-10-26 Bayer Ag Verfahren zur asymmetrischen Dihydroxylierung von Olefinen mittels Osmium-Katalysatoren
US7053236B2 (en) * 2000-04-04 2006-05-30 Brandeis University Catalytic asymmetric desymmetrization of prochiral and meso compounds
US6596870B2 (en) 2000-07-13 2003-07-22 Brandeis University Asymmetric synthetic methods based on phase transfer catalysis
US6387033B1 (en) * 2000-11-22 2002-05-14 Council Of Scientific And Industrial Research Preparation of new layered double hydroxides exchanged with osmate for asymmetric dihydroxylation of olefins to vicinal diols
US6646102B2 (en) 2001-07-05 2003-11-11 Dow Global Technologies Inc. Process for manufacturing an alpha-dihydroxy derivative and epoxy resins prepared therefrom
WO2003006151A1 (fr) * 2001-07-12 2003-01-23 Avecia Limited Catalyseur microencapsule, methodes de preparation et methodes d'utilisation associees
WO2003035253A1 (fr) * 2001-10-23 2003-05-01 Council Of Scientific And Industrial Research Procede de preparation d'osmates supportes
US6552234B1 (en) 2001-10-23 2003-04-22 Council Of Scientific And Industrial Research Process for the preparation of supported osmates
US6646168B2 (en) 2001-10-23 2003-11-11 Council Of Scientific And Industrial Research Supported osmates, process for preparation thereof, and a process for the preparation of chiral vicinal diols using supported osmate catalyst
GB0128839D0 (en) * 2001-12-01 2002-01-23 Univ Cambridge Tech Encapsulated transition metal reagents for reactions in supercritical carbon dioxide
EP1633704A2 (fr) * 2003-05-08 2006-03-15 Pfizer Inc. Produits intermediaires utiles pour la synthese d'inhibiteurs de la protease du vih et leurs procedes de preparation
KR20060070485A (ko) * 2003-06-11 2006-06-23 브랜데이스 유니버시티 프로키랄 및 메소 사이클릭 무수물의 촉매적 비대칭탈대칭화
US7531662B2 (en) * 2003-06-11 2009-05-12 Brandeis University Cinchona-alkaloid-based catalysts, and asymmetric alcoholysis of cyclic anhydrides using them
US20060074149A1 (en) * 2003-09-09 2006-04-06 Boriack Clinton J Process for manufacturing an alpha-dihydroxy derivative and epoxy resins prepared therefrom
CA2641304A1 (fr) * 2006-02-01 2007-08-09 Merck & Co., Inc. Inhibiteurs du canal potassique
US20080058533A1 (en) * 2006-08-31 2008-03-06 Alcon, Inc. Pyranoindazole cyclic carbonates and methods of use
WO2011159177A1 (fr) 2010-06-18 2011-12-22 Industrial Research Limited Aminohydroxylation améliorée d'alcènes
US20220388931A1 (en) * 2019-11-04 2022-12-08 International Flavors & Fragrances Inc. Dihydroxylation of olefins using osmate (vi) salts

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3869462A (en) * 1968-07-02 1975-03-04 Hoffmann La Roche Processes and intermediates for quinine, quinidine, isomers and derivatives thereof
US3557117A (en) * 1968-12-24 1971-01-19 Pennwalt Corp Tetrahydro - 4 - quinazolinones substituted in the 3-position by heterocyclic group
US3792053A (en) * 1970-07-15 1974-02-12 American Home Prod 3-(1,2,3,4-tetrahydroisoquinolinomethyl)-3-quinuclidinol
US3813384A (en) * 1972-01-17 1974-05-28 Asta Werke Ag Chem Fab Basically substituted benzyl phthalazone derivatives,acid salts thereof and process for the production thereof
US4393253A (en) * 1980-11-24 1983-07-12 Exxon Research & Engineering Co. Hydroxylation of olefins
EP0077202B1 (fr) * 1981-10-09 1986-04-09 Exxon Research And Engineering Company Procédé d'hydroxylation d'oléfines utilisant des catalyseurs comprenant un composé osmium-halogène
EP0098701A1 (fr) * 1982-07-01 1984-01-18 Exxon Research And Engineering Company Procédé pour l'hydroxylation des oléfines en présence d'un catalyseur à l'oxyde d'osmium et d'un co-catalyseur au sel d'un acide carboxylique
US4482763A (en) * 1982-07-19 1984-11-13 Exxon Research & Engineering Co. Process for hydroxylating olefins in the presence of an osmium containing catalyst and organic halogenated hydrocarbon co-catalyst
US4496778A (en) * 1983-10-03 1985-01-29 Exxon Research & Engineering Co. Process for the hydroxylation of olefins using molecular oxygen, an osmium containing catalyst, a copper Co-catalyst, and an aromatic amine based promoter
US4496779A (en) * 1984-04-26 1985-01-29 Exxon Research & Engineering Co. Process for the hydroxylation of olefins using molecular oxygen, an osmium containing catalyst, a copper co-catalyst, and a cycloaliphatic amine based promoter
WO1989002428A1 (fr) * 1987-09-18 1989-03-23 Ici Australia Operations Proprietary Limited Procede enantioselectif
US4871855A (en) * 1988-01-11 1989-10-03 Massachusetts Institute Of Technology Ligand-accelerated catalytic asymmetric dihydroxylation using dihydroquinidine and dihydroquinidine esters as ligands
US5126494A (en) * 1988-01-11 1992-06-30 Massachusetts Institute Of Technology Methods for catalytic asymmetric dihydroxylation of olefins
US4965364A (en) * 1988-02-23 1990-10-23 Massachusetts Institute Of Technology Ligand-accelerated catalytic asymmetric dihydroxylation
DE68924418T2 (de) * 1988-01-11 1996-03-28 Massachusetts Inst Technology Durch komplexmittel beschleunigte katalytische asymmetrische dihydroxylierung.

Also Published As

Publication number Publication date
EP0608307B1 (fr) 2004-02-04
ATE258932T1 (de) 2004-02-15
ES2215989T3 (es) 2004-10-16
DE69233299D1 (de) 2004-03-11
US5260461A (en) 1993-11-09
JPH07500323A (ja) 1995-01-12
DE69233299T2 (de) 2004-09-16
WO1993007142A1 (fr) 1993-04-15
EP0608307A1 (fr) 1994-08-03
CA2120919C (fr) 2003-07-01
CA2120919A1 (fr) 1993-04-15
JP3982829B2 (ja) 2007-09-26

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