DK0687253T3 - New 4-Aminopyridines, Processes for their Preparation, and Medicines Containing These Compounds - Google Patents
New 4-Aminopyridines, Processes for their Preparation, and Medicines Containing These CompoundsInfo
- Publication number
- DK0687253T3 DK0687253T3 DK94909909T DK94909909T DK0687253T3 DK 0687253 T3 DK0687253 T3 DK 0687253T3 DK 94909909 T DK94909909 T DK 94909909T DK 94909909 T DK94909909 T DK 94909909T DK 0687253 T3 DK0687253 T3 DK 0687253T3
- Authority
- DK
- Denmark
- Prior art keywords
- stands
- atom
- compounds
- hydrogen
- halogen
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 title abstract 5
- 239000003814 drug Substances 0.000 title abstract 3
- 150000003928 4-aminopyridines Chemical class 0.000 title abstract 2
- 229940079593 drug Drugs 0.000 title 1
- 125000000217 alkyl group Chemical group 0.000 abstract 4
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 4
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical group [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 abstract 2
- 125000001931 aliphatic group Chemical group 0.000 abstract 2
- 125000003545 alkoxy group Chemical group 0.000 abstract 2
- 125000003710 aryl alkyl group Chemical group 0.000 abstract 2
- 125000004122 cyclic group Chemical group 0.000 abstract 2
- 125000004433 nitrogen atom Chemical group N* 0.000 abstract 2
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
- 239000005864 Sulphur Substances 0.000 abstract 1
- 125000005196 alkyl carbonyloxy group Chemical group 0.000 abstract 1
- 125000002947 alkylene group Chemical group 0.000 abstract 1
- 150000001412 amines Chemical class 0.000 abstract 1
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 abstract 1
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 1
- 125000004093 cyano group Chemical group *C#N 0.000 abstract 1
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 1
- 125000001188 haloalkyl group Chemical group 0.000 abstract 1
- 229910052736 halogen Inorganic materials 0.000 abstract 1
- 125000005843 halogen group Chemical group 0.000 abstract 1
- 150000002367 halogens Chemical class 0.000 abstract 1
- 150000004677 hydrates Chemical class 0.000 abstract 1
- 239000001257 hydrogen Substances 0.000 abstract 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 229910052757 nitrogen Inorganic materials 0.000 abstract 1
- 239000001301 oxygen Substances 0.000 abstract 1
- 229910052760 oxygen Inorganic materials 0.000 abstract 1
- 125000004430 oxygen atom Chemical group O* 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 229920006395 saturated elastomer Polymers 0.000 abstract 1
- 239000012453 solvate Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/72—Nitrogen atoms
- C07D213/74—Amino or imino radicals substituted by hydrocarbon or substituted hydrocarbon radicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Urology & Nephrology (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Vascular Medicine (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Pyridine Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
New 4-aminopyridines have general formula (I), in which R<1> stands for the groups R<6>-SO-NR<7>, R<6>-SO2-NR<7>, R<6>-NR<7>-SO-, R<6>-NR<7>-SO2-, R<6>-SO-O-, R<6>-SO2-O-, R<6>-O-SO- or R<6>-O-SO2; R<2> stands for a hydrogen or halogen atom, a cyano, alkyl, alkoxy or halogen alkyl group; X stands for an oxygen atom, a sulphur atom or the NH group; R<3> and R<4> are the same or different and stand for hydrogen atoms or alkyl groups; R<5> stands for a hydrogen atom, an alkyl group or the aralkyl group; R<6> stands for an aliphatic or cyclic, if required substituted residue; R<7> stands for a hydrogen atom or an aliphatic or cyclic, if required substituted residue; Y stands for a linear or branched alkylene chain; R<8> and R<9> are the same or different and stand for hydrogen atoms, aralkyl, cycloalkyl or alkyl groups which may be substituted once or several times by halogen, hydroxy, alkoxy, alkylcarbonyloxy, amine or carboxy, or R<8> and R<9> form together with the N atom to which they are bound a saturated ring which may contain an additional oxygen, sulphur or nitrogen atom. Also disclosed are the hydrates, solvates and physiologically acceptable salts of these compounds, their optically active forms, racemates and diastereomer mixtures, a process for preparing said compounds, medicaments containing said compounds and the use of said compounds for producing medicaments.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE4306506A DE4306506A1 (en) | 1993-03-03 | 1993-03-03 | Novel 4-alkylaminopyridines - processes for their preparation and medicaments containing these compounds |
| DE19934312966 DE4312966A1 (en) | 1993-04-21 | 1993-04-21 | Novel 4-aminopyridines - process for their preparation and medicaments containing these compounds |
| PCT/EP1994/000608 WO1994020467A1 (en) | 1993-03-03 | 1994-03-02 | New 4-aminopyridines, process for preparing the same and medicaments containing the same |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK0687253T3 true DK0687253T3 (en) | 1999-08-23 |
Family
ID=25923593
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK94909909T DK0687253T3 (en) | 1993-03-03 | 1994-03-02 | New 4-Aminopyridines, Processes for their Preparation, and Medicines Containing These Compounds |
Country Status (22)
| Country | Link |
|---|---|
| EP (1) | EP0687253B1 (en) |
| JP (1) | JPH08507503A (en) |
| KR (1) | KR100252551B1 (en) |
| CN (1) | CN1046710C (en) |
| AT (1) | ATE174590T1 (en) |
| AU (1) | AU682026B2 (en) |
| CA (1) | CA2156729A1 (en) |
| CZ (1) | CZ225495A3 (en) |
| DE (1) | DE59407494D1 (en) |
| DK (1) | DK0687253T3 (en) |
| ES (1) | ES2127919T3 (en) |
| FI (1) | FI954105A7 (en) |
| GR (1) | GR3029691T3 (en) |
| HU (1) | HUT72898A (en) |
| IL (1) | IL108786A (en) |
| NO (1) | NO953447L (en) |
| NZ (1) | NZ262725A (en) |
| PL (1) | PL176455B1 (en) |
| RU (1) | RU2126388C1 (en) |
| SK (1) | SK108295A3 (en) |
| TW (1) | TW257757B (en) |
| WO (1) | WO1994020467A1 (en) |
Families Citing this family (40)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE4430755A1 (en) * | 1994-08-30 | 1996-03-07 | Boehringer Mannheim Gmbh | New phosphine oxides, processes for their preparation and medicaments containing these compounds |
| IL115420A0 (en) | 1994-09-26 | 1995-12-31 | Zeneca Ltd | Aminoheterocyclic derivatives |
| US5792769A (en) * | 1995-09-29 | 1998-08-11 | 3-Dimensional Pharmaceuticals, Inc. | Guanidino protease inhibitors |
| GB9525620D0 (en) * | 1995-12-15 | 1996-02-14 | Glaxo Group Ltd | Chemical compounds |
| ES2213786T3 (en) * | 1995-12-29 | 2004-09-01 | 3-Dimensional Pharmaceuticals, Inc. | INHIBITORS OF AMIDINO-PROTEASA. |
| GB9602166D0 (en) | 1996-02-02 | 1996-04-03 | Zeneca Ltd | Aminoheterocyclic derivatives |
| AU1608397A (en) | 1996-02-02 | 1997-08-22 | Zeneca Limited | Heterocyclic compounds useful as pharmaceutical agents |
| SE9602646D0 (en) | 1996-07-04 | 1996-07-04 | Astra Ab | Pharmaceutically useful compounds |
| KR20000029984A (en) * | 1996-08-14 | 2000-05-25 | 사라 엔 람베쓰 | Substituted pyrimidine derivatives and their pharmaceutical use |
| CA2264037A1 (en) * | 1996-09-13 | 1998-03-19 | Merck & Co., Inc. | Thrombin inhibitors |
| GB9821483D0 (en) | 1998-10-03 | 1998-11-25 | Glaxo Group Ltd | Chemical compounds |
| UA56197C2 (en) | 1996-11-08 | 2003-05-15 | Зенека Лімітед | Heterocyclic derivatives |
| TW499412B (en) | 1996-11-26 | 2002-08-21 | Dimensional Pharm Inc | Aminoguanidines and alkoxyguanidines as protease inhibitors |
| US6127191A (en) * | 1996-12-03 | 2000-10-03 | 3-Dimensional Pharmaceuticals, Inc. | Aminobenzenedicarboxylic acid-based combinatorial libraries |
| AU5999698A (en) | 1997-02-13 | 1998-09-08 | Zeneca Limited | Heterocyclic compounds useful as oxido-squalene cyclase inhibitors |
| US6391880B1 (en) | 1997-02-13 | 2002-05-21 | Zeneca Limited | Heterocyclic compounds useful as oxido-squalene cyclase inhibitors |
| GB9715895D0 (en) | 1997-07-29 | 1997-10-01 | Zeneca Ltd | Heterocyclic compounds |
| JP4327915B2 (en) * | 1998-03-30 | 2009-09-09 | 株式会社デ・ウエスタン・セラピテクス研究所 | Sulfonamide derivatives |
| ATE287875T1 (en) | 1998-10-06 | 2005-02-15 | Dainippon Pharmaceutical Co | 2,3-DISUBSTITUTED PYRIDINE DERIVATIVES, METHOD FOR THE PRODUCTION THEREOF, ACTIVE INGREDIENT PREPARATIONS CONTAINING THEM AND INTERMEDIATE PRODUCTS FOR THE PRODUCTION |
| GB9902989D0 (en) | 1999-02-11 | 1999-03-31 | Zeneca Ltd | Heterocyclic derivatives |
| AR023510A1 (en) | 1999-04-21 | 2002-09-04 | Astrazeneca Ab | A TEAM OF PARTS, PHARMACEUTICAL FORMULATION AND USE OF A THROMBIN INHIBITOR. |
| JP2004505956A (en) | 2000-08-04 | 2004-02-26 | ３−ディメンショナル ファーマシューティカルズ， インコーポレイテッド | Cyclic oxyguanidine protease inhibitor |
| CA2423631C (en) * | 2000-10-04 | 2010-03-30 | Kissei Pharmaceutical Co., Ltd. | 5-amidino-2-hydroxybenzenesulfonamide derivatives, pharmaceutical compositions containing the same and intermediates for their preparation |
| US6849635B2 (en) * | 2001-05-07 | 2005-02-01 | Smithkline Beecham Corporation | Sulfonamides |
| EP1385495A4 (en) * | 2001-05-07 | 2005-12-21 | Smithkline Beecham Corp | Sulfonamides |
| DE60322544D1 (en) * | 2002-08-27 | 2008-09-11 | Merck Patent Gmbh | GLYCINAMIDE DERIVATIVES AS RAF KINASE INHIBITORS |
| BR0314126A (en) | 2002-09-20 | 2005-06-28 | Pfizer Prod Inc | Acyclic Amide and Sulphonamide Ligands for Estrogen Receptor |
| CA2543249C (en) | 2003-11-05 | 2012-08-07 | F. Hoffmann-La Roche Ag | Phenyl derivatives as ppar agonists |
| CA2679185A1 (en) * | 2007-02-28 | 2008-09-04 | Advinus Therapeutics Private Limited | 2,2,2-tri-substituted acetamide derivatives as glucokinase activators, their process and pharmaceutical application |
| RU2353619C2 (en) * | 2007-06-28 | 2009-04-27 | Общество С Ограниченной Ответственностью "Бионика" | Novel compounds possessing anticoagulant function, based on them pharmaceutical compositions for treatment of thrombotic conditions and plasma-substituting solution for correction of hypercoagulation disorders in hemodilution |
| RU2354647C2 (en) * | 2007-06-28 | 2009-05-10 | Общество С Ограниченной Ответственностью "Бионика" | New compounds with thrombin inhibiting function, and based pharmaceutical compositions |
| GB0815781D0 (en) | 2008-08-29 | 2008-10-08 | Xention Ltd | Novel potassium channel blockers |
| GB0815782D0 (en) | 2008-08-29 | 2008-10-08 | Xention Ltd | Novel potassium channel blockers |
| GB0815784D0 (en) | 2008-08-29 | 2008-10-08 | Xention Ltd | Novel potassium channel blockers |
| US8265575B2 (en) * | 2009-06-16 | 2012-09-11 | Mediatek Inc. | Methods for handling a transmitting process and communication apparatuses utilizing the same |
| US8207639B2 (en) | 2009-10-23 | 2012-06-26 | Sunonwealth Electric Machine Industry Co., Ltd. | Motor and heating dissipating fan including motor having an annular balancing member |
| RU2685261C1 (en) * | 2018-04-05 | 2019-04-17 | Общество с ограниченной ответственностью "ФК ЛАБОРАТОРИЗ" | 4-amino-1-{2-[3-methyl-5-(benzenesulfonyloxy]phenoxy]ethyl}-pyridium chloride substance, having the biologically active agent properties, influencing the mammals blood coagulability naturally running processes, anticoagulant on its basis and its obtaining method by chemical synthesis |
| CN109172573B (en) * | 2018-09-12 | 2021-01-26 | 黑龙江中桂制药有限公司 | Oral antithrombotic drug and application thereof |
| CN110669337B (en) * | 2019-07-08 | 2020-09-25 | 中国科学院长春应用化学研究所 | Aromatic diamine monomer and preparation method thereof |
| WO2024243343A2 (en) * | 2023-05-23 | 2024-11-28 | John Karanicolas | Compounds that re-activate mutant p53 |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SU1097620A1 (en) * | 1983-02-16 | 1984-06-15 | Новокузнецкий научно-исследовательский химико-фармацевтический институт | Process for preparing diethyl-n-(6-methyl-pyridyl)-2-aminomethyl malonate |
| SU1318599A1 (en) * | 1985-06-26 | 1987-06-23 | МГУ им.М.В.Ломоносова | Method for producing 1-alkyl-2-chlorine-2-alkoxyethenylalkyl (aryl)chlorphosphines |
| DE3529529A1 (en) * | 1985-08-17 | 1987-02-19 | Boehringer Mannheim Gmbh | METHOD FOR PRODUCING A STABLE MODIFICATION OF TORASEMIDE |
| GB8819307D0 (en) * | 1988-08-13 | 1988-09-14 | Pfizer Ltd | Antiarrhythmic agents |
| JPH0256465A (en) * | 1988-08-22 | 1990-02-26 | Hamari Yakuhin Kogyo Kk | Acetamide compound |
| US4885927A (en) * | 1988-09-12 | 1989-12-12 | General Motors Corporation | Method and apparatus for press forming intricate metallic shapes such as spool valve elements |
| EP0610432A1 (en) * | 1991-10-31 | 1994-08-17 | Smithkline Beecham Corporation | C8-cyclic peptidomimetics as fibrinogen antagonists |
| WO1993010091A2 (en) * | 1991-11-14 | 1993-05-27 | Glaxo Group Limited | Piperidine acetic acid derivatives as inhibitors of fibrinogen-dependent blood platelet aggregation |
| DE4212304A1 (en) * | 1992-04-13 | 1993-10-14 | Cassella Ag | Aspartic acid derivatives, their preparation and use |
-
1994
- 1994-02-22 TW TW083101504A patent/TW257757B/zh active
- 1994-02-28 IL IL10878694A patent/IL108786A/en not_active IP Right Cessation
- 1994-03-02 EP EP94909909A patent/EP0687253B1/en not_active Expired - Lifetime
- 1994-03-02 HU HU9502568A patent/HUT72898A/en unknown
- 1994-03-02 AU AU62574/94A patent/AU682026B2/en not_active Ceased
- 1994-03-02 DE DE59407494T patent/DE59407494D1/en not_active Expired - Fee Related
- 1994-03-02 DK DK94909909T patent/DK0687253T3/en active
- 1994-03-02 NZ NZ262725A patent/NZ262725A/en unknown
- 1994-03-02 CZ CZ952254A patent/CZ225495A3/en unknown
- 1994-03-02 AT AT94909909T patent/ATE174590T1/en not_active IP Right Cessation
- 1994-03-02 JP JP6519556A patent/JPH08507503A/en active Pending
- 1994-03-02 CN CN94191554A patent/CN1046710C/en not_active Expired - Fee Related
- 1994-03-02 FI FI954105A patent/FI954105A7/en unknown
- 1994-03-02 WO PCT/EP1994/000608 patent/WO1994020467A1/en not_active Ceased
- 1994-03-02 ES ES94909909T patent/ES2127919T3/en not_active Expired - Lifetime
- 1994-03-02 KR KR1019950703694A patent/KR100252551B1/en not_active Expired - Fee Related
- 1994-03-02 CA CA002156729A patent/CA2156729A1/en not_active Abandoned
- 1994-03-02 RU RU95122612A patent/RU2126388C1/en active
- 1994-03-02 PL PL94310520A patent/PL176455B1/en unknown
- 1994-03-02 SK SK1082-95A patent/SK108295A3/en unknown
-
1995
- 1995-09-01 NO NO953447A patent/NO953447L/en unknown
-
1999
- 1999-03-16 GR GR990400775T patent/GR3029691T3/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| EP0687253B1 (en) | 1998-12-16 |
| SK108295A3 (en) | 1996-06-05 |
| HU9502568D0 (en) | 1995-11-28 |
| KR960701019A (en) | 1996-02-24 |
| IL108786A0 (en) | 1994-06-24 |
| NZ262725A (en) | 1997-05-26 |
| DE59407494D1 (en) | 1999-01-28 |
| EP0687253A1 (en) | 1995-12-20 |
| KR100252551B1 (en) | 2000-05-01 |
| ES2127919T3 (en) | 1999-05-01 |
| FI954105A0 (en) | 1995-09-01 |
| CN1119858A (en) | 1996-04-03 |
| NO953447D0 (en) | 1995-09-01 |
| AU6257494A (en) | 1994-09-26 |
| GR3029691T3 (en) | 1999-06-30 |
| PL310520A1 (en) | 1995-12-27 |
| AU682026B2 (en) | 1997-09-18 |
| PL176455B1 (en) | 1999-05-31 |
| HUT72898A (en) | 1996-06-28 |
| RU2126388C1 (en) | 1999-02-20 |
| ATE174590T1 (en) | 1999-01-15 |
| NO953447L (en) | 1995-09-01 |
| FI954105A7 (en) | 1995-09-01 |
| CN1046710C (en) | 1999-11-24 |
| CA2156729A1 (en) | 1994-09-15 |
| TW257757B (en) | 1995-09-21 |
| IL108786A (en) | 1999-04-11 |
| CZ225495A3 (en) | 1996-01-17 |
| WO1994020467A1 (en) | 1994-09-15 |
| JPH08507503A (en) | 1996-08-13 |
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