DK0661269T3 - Substituerede heterocykliske carboxylsyreamider, deres fremstilling og anvendelse som lægemidler. - Google Patents
Substituerede heterocykliske carboxylsyreamider, deres fremstilling og anvendelse som lægemidler.Info
- Publication number
- DK0661269T3 DK0661269T3 DK94120766.4T DK94120766T DK0661269T3 DK 0661269 T3 DK0661269 T3 DK 0661269T3 DK 94120766 T DK94120766 T DK 94120766T DK 0661269 T3 DK0661269 T3 DK 0661269T3
- Authority
- DK
- Denmark
- Prior art keywords
- preparation
- drugs
- carboxylic acid
- acid amides
- substituted heterocyclic
- Prior art date
Links
- 239000003814 drug Substances 0.000 title abstract 3
- 229940079593 drug Drugs 0.000 title 1
- -1 heterocyclic carboxylic acid Chemical class 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 2
- 239000003112 inhibitor Substances 0.000 abstract 2
- 102000004079 Prolyl Hydroxylases Human genes 0.000 abstract 1
- 108010043005 Prolyl Hydroxylases Proteins 0.000 abstract 1
- 230000036570 collagen biosynthesis Effects 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 230000003176 fibrotic effect Effects 0.000 abstract 1
- 210000004185 liver Anatomy 0.000 abstract 1
- 210000004072 lung Anatomy 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D237/00—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings
- C07D237/02—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings
- C07D237/06—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
- C07D237/10—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D237/14—Oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D213/81—Amides; Imides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/89—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members with hetero atoms directly attached to the ring nitrogen atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/48—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06139—Dipeptides with the first amino acid being heterocyclic
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Dermatology (AREA)
- Heart & Thoracic Surgery (AREA)
- Urology & Nephrology (AREA)
- Cardiology (AREA)
- Pulmonology (AREA)
- Gastroenterology & Hepatology (AREA)
- Vascular Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Pyrrole Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Quinoline Compounds (AREA)
- Pyridine Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19934344958 DE4344958A1 (de) | 1993-12-30 | 1993-12-30 | Substituierte heterocyclische Carbonsäureamide, ihre Herstellung und ihre Verwendung als Arzneimittel |
| DE19944439935 DE4439935A1 (de) | 1994-11-09 | 1994-11-09 | Substituierte heterocyclische Carbonsäureamide, ihre Herstellung und ihre Verwendung als Arzneimittel |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK0661269T3 true DK0661269T3 (da) | 1997-10-13 |
Family
ID=25932646
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK94120766.4T DK0661269T3 (da) | 1993-12-30 | 1994-12-27 | Substituerede heterocykliske carboxylsyreamider, deres fremstilling og anvendelse som lægemidler. |
Country Status (22)
| Country | Link |
|---|---|
| US (1) | US5620995A (da) |
| EP (1) | EP0661269B1 (da) |
| JP (1) | JP4306812B2 (da) |
| KR (1) | KR950017970A (da) |
| CN (1) | CN1126203A (da) |
| AT (1) | ATE150749T1 (da) |
| AU (1) | AU697015B2 (da) |
| CA (1) | CA2138929A1 (da) |
| CZ (1) | CZ332494A3 (da) |
| DE (1) | DE59402222D1 (da) |
| DK (1) | DK0661269T3 (da) |
| ES (1) | ES2102132T3 (da) |
| GR (1) | GR3023635T3 (da) |
| HK (1) | HK1006841A1 (da) |
| IL (1) | IL112173A0 (da) |
| MY (1) | MY131657A (da) |
| NO (1) | NO302470B1 (da) |
| NZ (1) | NZ270267A (da) |
| PL (1) | PL306590A1 (da) |
| RU (1) | RU94045141A (da) |
| SG (1) | SG48088A1 (da) |
| TW (1) | TW406076B (da) |
Families Citing this family (67)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5789426A (en) * | 1995-01-20 | 1998-08-04 | Cornell Research Foundation, Inc. | Method for the treatment of fibroproliferative disorders by application of inhibitors of protein hydroxylation |
| US6046219A (en) * | 1995-01-20 | 2000-04-04 | Cornell Research Foundation, Inc. | Method for the treatment of conditions mediated by collagen formation together with cell proliferation by application of inhibitors of protein hydroxylation |
| IL135495A (en) * | 1995-09-28 | 2002-12-01 | Hoechst Ag | Intermediate compounds for the preparation of quinoline-converted amines - 2 - carboxylic acid |
| DE19650215A1 (de) * | 1996-12-04 | 1998-06-10 | Hoechst Ag | 3-Hydroxypyridin-2-carbonsäureamidester, ihre Herstellung und ihre Verwendung als Arzneimittel |
| US6200546B1 (en) * | 1997-04-22 | 2001-03-13 | The Curators Of The University Of Missouri | Gastrin receptor-avid peptide conjugates |
| DE19746287A1 (de) * | 1997-10-20 | 1999-04-22 | Hoechst Marion Roussel De Gmbh | Substituierte Isochinolin-2-Carbonsäureamide, ihre Herstellung und ihre Verwendung als Arzneimittel |
| US6306839B1 (en) | 1998-09-16 | 2001-10-23 | Dow Agrosciences Llc | 2-methoxyimino-2-(pyridinyloxymethyl) phenyl acetamides with (derivatised) hydroxyalkyl derivatives on the pyridine ring |
| US6355660B1 (en) | 1999-07-20 | 2002-03-12 | Dow Agrosciences Llc | Fungicidal heterocyclic aromatic amides and their compositions, methods of use and preparation |
| US20030018052A1 (en) | 1999-07-20 | 2003-01-23 | Ricks Michael J. | Fungicidal heterocyclic aromatic amides and their compositions, methods of use and preparation |
| WO2001005769A2 (en) | 1999-07-20 | 2001-01-25 | Dow Agrosciences Llc | Fungicidal heterocyclic aromatic amides and their compositions, methods of use and preparation |
| EP1516875A1 (en) | 1999-07-20 | 2005-03-23 | Dow AgroSciences LLC | Fungicidal heterocyclic aromatic amides and their compositions, methods of use and preparation |
| FR2803592A1 (fr) | 2000-01-06 | 2001-07-13 | Aventis Cropscience Sa | Nouveaux derives de l'acide 3-hydroxypicolinique, leur procede de preparation et compositions fongicides les contenant. |
| CN101664553B (zh) * | 2001-12-06 | 2013-08-21 | 法布罗根股份有限公司 | 低氧诱导因子(HIF)α的稳定化 |
| WO2003053997A2 (en) | 2001-12-06 | 2003-07-03 | Fibrogen, Inc. | Methods of increasing endogenous erythropoietin (epo) |
| EP2295060B1 (en) | 2001-12-06 | 2018-10-31 | Fibrogen, Inc. | Treatment or prevention of ischemic or hypoxic conditions |
| US8124582B2 (en) * | 2002-12-06 | 2012-02-28 | Fibrogen, Inc. | Treatment of diabetes |
| US7618940B2 (en) | 2002-12-06 | 2009-11-17 | Fibrogen, Inc. | Fat regulation |
| US7226577B2 (en) * | 2003-01-13 | 2007-06-05 | Bracco Imaging, S. P. A. | Gastrin releasing peptide compounds |
| US8420050B2 (en) * | 2003-01-13 | 2013-04-16 | Bracco Imaging S.P.A. | Gastrin releasing peptide compounds |
| US8614204B2 (en) * | 2003-06-06 | 2013-12-24 | Fibrogen, Inc. | Enhanced erythropoiesis and iron metabolism |
| EP2357175A1 (en) | 2003-06-06 | 2011-08-17 | Fibrogen, Inc. | isoquinoline derivatives AND THEIR USE IN INCREASING ENDOGENEOUS ERYTHROPOIETIN |
| BRPI0413347A (pt) * | 2003-08-06 | 2006-10-10 | Senomyx Inc | novos sabores, modificadores de sabor, agentes de sabor, realçadores de sabor, agentes de sabor e/ou realçadores umami ou doces, e utilização correspondente |
| EP1866318B1 (en) | 2005-03-02 | 2011-06-22 | Fibrogen, Inc. | Thienopyridine compounds, and methods of use thereof |
| AU2006259352A1 (en) | 2005-06-15 | 2006-12-28 | Fibrogen, Inc. | Use of HIF 1alfa modulators for treatment of cancer |
| WO2007090068A2 (en) * | 2006-01-27 | 2007-08-09 | Fibrogen, Inc. | Cyanoisoquinoline compounds that stabilize hypoxia inducible factor (hif) |
| US7745461B1 (en) | 2006-02-27 | 2010-06-29 | Alcon Research, Ltd. | Method of treating dry eye disorders |
| WO2007101204A1 (en) * | 2006-02-27 | 2007-09-07 | Alcon Research, Ltd. | Method of treating glaucoma |
| US7588924B2 (en) * | 2006-03-07 | 2009-09-15 | Procter & Gamble Company | Crystal of hypoxia inducible factor 1 alpha prolyl hydroxylase |
| KR100934674B1 (ko) * | 2006-03-30 | 2009-12-31 | 엘지전자 주식회사 | 비디오 신호를 디코딩/인코딩하기 위한 방법 및 장치 |
| BRPI0710527B8 (pt) * | 2006-04-04 | 2021-05-25 | Fibrogen Inc | compostos de pirrolo- e tiazolo-piridina e composição farmacêutica que os compreende |
| NZ601731A (en) | 2006-06-26 | 2014-04-30 | Akebia Therapeutics Inc | Prolyl hydroxylase inhibitors and methods for use |
| AU2007334321B2 (en) * | 2006-12-18 | 2012-03-08 | Amgen Inc. | Azaquinolone based compounds exhibiting prolyl hydroxylase inhibitory activity, compositions, and uses thereof |
| CL2008000066A1 (es) | 2007-01-12 | 2008-08-01 | Smithkline Beecham Corp | Compuestos derivados de (5-hidroxi-3-oxo-2,3-dihidropiridazina-4-carbonil)glicina, inhibidores de hif prolil hidroxilasas; procedimiento de preparacion; composicion farmaceutica que comprende a dichos compuestos; y su uso en el tratamiento de la anem |
| US7569726B2 (en) * | 2007-04-18 | 2009-08-04 | Amgen Inc. | Indanone derivatives that inhibit prolyl hydroxylase |
| WO2008130600A2 (en) * | 2007-04-18 | 2008-10-30 | Amgen Inc. | Quinolones and azaquinolones that inhibit prolyl hydroxylase |
| US8097620B2 (en) * | 2007-05-04 | 2012-01-17 | Amgen Inc. | Diazaquinolones that inhibit prolyl hydroxylase activity |
| WO2008137060A1 (en) * | 2007-05-04 | 2008-11-13 | Amgen Inc. | Thienopyridine and thiazolopyridine derivatives that inhibit prolyl hydroxylase activity |
| US8962530B2 (en) * | 2007-06-27 | 2015-02-24 | Regents Of The University Of Colorado | Inflammatory bowel disease therapies |
| US8927591B2 (en) | 2008-11-14 | 2015-01-06 | Fibrogen, Inc. | Thiochromene derivatives as HIF hydroxylase inhibitors |
| WO2011048611A1 (en) | 2009-10-07 | 2011-04-28 | Torrent Pharmaceuticals Limited | Novel fused pyridazine derivatives |
| TWI500623B (zh) | 2009-10-13 | 2015-09-21 | Torrent Pharmaceuticals Ltd | 新穎稠合噻唑及噁唑嘧啶酮 |
| IN2012DN04940A (da) * | 2009-11-06 | 2015-09-25 | Aerpio Therapeutics Inc | |
| US8541430B2 (en) | 2009-11-27 | 2013-09-24 | Torrent Pharmaceuticals Limited | Fused thiazolo and oxazolo pyrimidinones |
| KR20110123657A (ko) * | 2010-05-07 | 2011-11-15 | 에스케이케미칼주식회사 | 피콜린아마이드 및 피리미딘-4-카복사미드 화합물, 이의 제조방법 및 이를 함유하는 약제학적 조성물 |
| AR085013A1 (es) * | 2011-01-26 | 2013-08-07 | Sanofi Aventis | Derivados de acido 3-heteroaroilamino-propionico sustituidos y su uso como sustancias farmaceuticas |
| EP2670750B1 (en) | 2011-02-02 | 2016-09-14 | Fibrogen, Inc. | Naphthyridine derivatives as inhibitors of hypoxia inducible factor |
| EP2717870B1 (en) | 2011-06-06 | 2017-09-27 | Akebia Therapeutics Inc. | Composition for stabilizing hypoxia inducible factor-2 alpha useful for treating cancer |
| NO2686520T3 (da) | 2011-06-06 | 2018-03-17 | ||
| EP2834220B1 (en) | 2012-03-09 | 2016-11-09 | Fibrogen, Inc. | 4-hydroxy-isoquinoline compounds as hif hydroxylase inhibitors |
| MX350922B (es) | 2012-07-16 | 2017-09-25 | Fibrogen Inc | Proceso para elaborar compuestos de isoquinolina. |
| SG10201700873UA (en) | 2012-07-16 | 2017-04-27 | Fibrogen Inc | Crystalline forms of the prolyl hydroxylase inhibitor [(4-hydroxy-1-methyl-7-phenoxy-isoquinoline-3-carbonyl)-amino]-acetic acid |
| US8883823B2 (en) | 2012-07-16 | 2014-11-11 | Fibrogen, Inc. | Crystalline forms of a prolyl hydroxylase inhibitor |
| AP2015008502A0 (en) | 2012-12-24 | 2015-06-30 | Cadila Healthcare Ltd | Novel quinolone derivatives |
| WO2014116849A1 (en) | 2013-01-24 | 2014-07-31 | Fibrogen, Inc. | Crystalline forms of {[1-cyano-5-(4-chlorophenoxy)-4-hydroxy-isoquinoline-3-carbonyl]-amino}-acetic acid |
| MX378150B (es) | 2013-06-13 | 2025-03-10 | Akebia Therapeutics Inc | Composiciones y metodos para tratar anemia. |
| KR102381295B1 (ko) | 2013-11-15 | 2022-03-31 | 아케비아 테라퓨틱스 인코포레이티드 | ｛[5-(3-클로로페닐)-3-하이드록시피리딘-2-카보닐]아미노｝아세트산의 고체형, 이의 조성물 및 용도 |
| BR112017015852A2 (pt) | 2015-01-23 | 2018-03-27 | Akebia Therapeutics Inc | forma de cristal, sal hemicálcico, sal hemicálcico di-hidratado, sal monossódico hidratado, sal bissódico monoidratado, sal monossódico anidro e método para preparar o composto 1 |
| CN106146395B (zh) * | 2015-03-27 | 2019-01-01 | 沈阳三生制药有限责任公司 | 3-羟基吡啶化合物、其制备方法及其制药用途 |
| CR20210248A (es) | 2015-04-01 | 2021-06-01 | Akebia Therapeutics Inc | FORMULACIONES QUE COMPRENDEN COMPUESTOS INHIBIDORES DE PROLILHIDROXILASA DE HIF Y SUS SALES ACEPTABLES (Divionales 2017-0450) |
| AU2018264313B2 (en) | 2017-05-09 | 2020-06-04 | Kind Pharmaceutical | Indolizine derivatives and application thereof in medicine |
| CN107417605A (zh) * | 2017-08-02 | 2017-12-01 | 江苏艾立康药业股份有限公司 | 作用于脯氨酰羟化酶的吡啶衍生化合物 |
| CN112088155A (zh) | 2018-05-09 | 2020-12-15 | 阿克比治疗有限公司 | 用于制备2-[[5-(3-氯苯基)-3-羟基吡啶-2-羰基]氨基]乙酸的方法 |
| KR20210013095A (ko) * | 2018-05-24 | 2021-02-03 | 쑤저우 선카디아 바이오파마수티컬즈 컴퍼니 리미티드 | 알키닐 피리딘 프롤릴 히드록실라제 억제제의 제조 방법 |
| EP3994124A1 (en) * | 2019-07-05 | 2022-05-11 | Syngenta Crop Protection AG | Microbiocidal picolinamide derivatives |
| US11524939B2 (en) | 2019-11-13 | 2022-12-13 | Akebia Therapeutics, Inc. | Solid forms of {[5-(3-chlorophenyl)-3-hydroxypyridine-2-carbonyl]amino} acetic acid |
| CN112979541B (zh) * | 2019-12-17 | 2022-11-11 | 浙江大学 | 一种基于n-(3-羟基吡啶-2-羰基)甘氨酸的抗肿瘤药物增敏剂及其应用 |
| US20230295110A1 (en) * | 2020-08-14 | 2023-09-21 | Akebia Therapeutics, Inc. | Phd inhibitor compounds, compositions, and methods of use |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE4015255A1 (de) * | 1990-05-12 | 1991-11-14 | Hoechst Ag | Oxalyl-aminosaeurederivate, verfahren zu ihrer herstellung und ihrer verwendung als arzneimittel zur inhibierung der prolyl-hydroxylase |
| US5192773A (en) * | 1990-07-02 | 1993-03-09 | Vertex Pharmaceuticals, Inc. | Immunosuppressive compounds |
| TW352384B (en) * | 1992-03-24 | 1999-02-11 | Hoechst Ag | Sulfonamido- or sulfonamidocarbonylpyridine-2-carboxamides, process for their preparation and their use as pharmaceuticals |
-
1994
- 1994-12-22 TW TW083112023A patent/TW406076B/zh not_active IP Right Cessation
- 1994-12-22 CA CA002138929A patent/CA2138929A1/en not_active Abandoned
- 1994-12-22 NZ NZ270267A patent/NZ270267A/en unknown
- 1994-12-27 AT AT94120766T patent/ATE150749T1/de active
- 1994-12-27 DE DE59402222T patent/DE59402222D1/de not_active Expired - Lifetime
- 1994-12-27 ES ES94120766T patent/ES2102132T3/es not_active Expired - Lifetime
- 1994-12-27 SG SG1996006937A patent/SG48088A1/en unknown
- 1994-12-27 EP EP94120766A patent/EP0661269B1/de not_active Expired - Lifetime
- 1994-12-27 DK DK94120766.4T patent/DK0661269T3/da active
- 1994-12-28 US US08/365,411 patent/US5620995A/en not_active Expired - Lifetime
- 1994-12-28 MY MYPI94003526A patent/MY131657A/en unknown
- 1994-12-28 JP JP32690394A patent/JP4306812B2/ja not_active Expired - Lifetime
- 1994-12-28 IL IL11217394A patent/IL112173A0/xx unknown
- 1994-12-28 CZ CZ943324A patent/CZ332494A3/cs unknown
- 1994-12-29 PL PL94306590A patent/PL306590A1/xx unknown
- 1994-12-29 RU RU94045141/04A patent/RU94045141A/ru unknown
- 1994-12-29 AU AU81790/94A patent/AU697015B2/en not_active Ceased
- 1994-12-29 NO NO945084A patent/NO302470B1/no not_active IP Right Cessation
- 1994-12-30 KR KR1019940040786A patent/KR950017970A/ko not_active Ceased
- 1994-12-30 CN CN94113548A patent/CN1126203A/zh active Pending
-
1997
- 1997-05-30 GR GR970401281T patent/GR3023635T3/el unknown
-
1998
- 1998-06-22 HK HK98105871A patent/HK1006841A1/xx not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| GR3023635T3 (en) | 1997-08-29 |
| JPH07242635A (ja) | 1995-09-19 |
| RU94045141A (ru) | 1996-10-10 |
| CN1126203A (zh) | 1996-07-10 |
| ATE150749T1 (de) | 1997-04-15 |
| CZ332494A3 (en) | 1996-07-17 |
| MY131657A (en) | 2007-08-30 |
| JP4306812B2 (ja) | 2009-08-05 |
| NO302470B1 (no) | 1998-03-09 |
| AU697015B2 (en) | 1998-09-24 |
| SG48088A1 (en) | 1998-04-17 |
| US5620995A (en) | 1997-04-15 |
| IL112173A0 (en) | 1995-03-15 |
| EP0661269B1 (de) | 1997-03-26 |
| DE59402222D1 (de) | 1997-04-30 |
| HK1006841A1 (en) | 1999-03-19 |
| NZ270267A (en) | 1997-03-24 |
| ES2102132T3 (es) | 1997-07-16 |
| TW406076B (en) | 2000-09-21 |
| NO945084D0 (no) | 1994-12-29 |
| EP0661269A1 (de) | 1995-07-05 |
| NO945084L (no) | 1995-07-03 |
| CA2138929A1 (en) | 1995-07-01 |
| AU8179094A (en) | 1995-07-06 |
| KR950017970A (ko) | 1995-07-22 |
| PL306590A1 (en) | 1995-07-10 |
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