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DK0657422T3 - Naphthyloxyeddikesyrederivater som PEG2-agonister og -antagonister - Google Patents

Naphthyloxyeddikesyrederivater som PEG2-agonister og -antagonister

Info

Publication number
DK0657422T3
DK0657422T3 DK94309088T DK94309088T DK0657422T3 DK 0657422 T3 DK0657422 T3 DK 0657422T3 DK 94309088 T DK94309088 T DK 94309088T DK 94309088 T DK94309088 T DK 94309088T DK 0657422 T3 DK0657422 T3 DK 0657422T3
Authority
DK
Denmark
Prior art keywords
alkyl
agonists
acid derivatives
antagonists
peg2
Prior art date
Application number
DK94309088T
Other languages
English (en)
Inventor
Yuuki Nagao
Takayuki Maruyama
Hamanaka Nobuyuki
Original Assignee
Ono Pharmaceutical Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ono Pharmaceutical Co filed Critical Ono Pharmaceutical Co
Application granted granted Critical
Publication of DK0657422T3 publication Critical patent/DK0657422T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
    • C07C311/22—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound oxygen atoms
    • C07C311/23—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound oxygen atoms having the sulfur atoms of the sulfonamide groups bound to acyclic carbon atoms
    • C07C311/25—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound oxygen atoms having the sulfur atoms of the sulfonamide groups bound to acyclic carbon atoms of a saturated carbon skeleton containing rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
    • C07C311/01—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms
    • C07C311/12—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms of an unsaturated carbon skeleton containing rings
    • C07C311/13—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms of an unsaturated carbon skeleton containing rings the carbon skeleton containing six-membered aromatic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/18—Sulfonamides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
    • C07C311/01—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms
    • C07C311/02—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton
    • C07C311/08—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton having the nitrogen atom of at least one of the sulfonamide groups bound to a carbon atom of a six-membered aromatic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
    • C07C311/15—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings
    • C07C311/20—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the sulfonamide groups bound to a carbon atom of a ring other than a six-membered aromatic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
    • C07C311/22—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound oxygen atoms
    • C07C311/23—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound oxygen atoms having the sulfur atoms of the sulfonamide groups bound to acyclic carbon atoms
    • C07C311/27—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound oxygen atoms having the sulfur atoms of the sulfonamide groups bound to acyclic carbon atoms of an unsaturated carbon skeleton containing rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
    • C07C311/22—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound oxygen atoms
    • C07C311/28—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound oxygen atoms having the sulfur atom of at least one of the sulfonamide groups bound to a carbon atom of a ring other than a six-membered aromatic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
    • C07C311/22—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound oxygen atoms
    • C07C311/29—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound oxygen atoms having the sulfur atom of at least one of the sulfonamide groups bound to a carbon atom of a six-membered aromatic ring

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Medicinal Preparation (AREA)
DK94309088T 1993-12-09 1994-12-07 Naphthyloxyeddikesyrederivater som PEG2-agonister og -antagonister DK0657422T3 (da)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP34085493 1993-12-09

Publications (1)

Publication Number Publication Date
DK0657422T3 true DK0657422T3 (da) 1998-10-12

Family

ID=18340925

Family Applications (1)

Application Number Title Priority Date Filing Date
DK94309088T DK0657422T3 (da) 1993-12-09 1994-12-07 Naphthyloxyeddikesyrederivater som PEG2-agonister og -antagonister

Country Status (10)

Country Link
US (2) US5624959A (da)
EP (1) EP0657422B1 (da)
KR (1) KR100191946B1 (da)
CN (1) CN1111612A (da)
AT (1) ATE167181T1 (da)
CA (1) CA2137711A1 (da)
DE (1) DE69410956T2 (da)
DK (1) DK0657422T3 (da)
ES (1) ES2118333T3 (da)
GR (1) GR3027694T3 (da)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6197993B1 (en) 1996-07-02 2001-03-06 Ono Pharmaceutical Co., Ltd. Naphthyloxyacetic acid derivatives and a pharmaceutical composition comprising them as an active ingredient
JP3909864B2 (ja) * 1995-07-26 2007-04-25 小野薬品工業株式会社 ナフチルオキシ酢酸誘導体およびそれらを有効成分として含有する薬剤
GB9702194D0 (en) 1997-02-04 1997-03-26 Lilly Co Eli Sulphonide derivatives
WO1999011255A1 (en) * 1997-08-28 1999-03-11 Ono Pharmaceutical Co., Ltd. Peroxisome proliferator-activated receptor controllers
BR9908199A (pt) 1998-02-24 2001-04-03 Lilly Co Eli Derivados de sulfonamida
RU2267484C2 (ru) 1999-04-28 2006-01-10 Авентис Фарма Дойчланд Гмбх Производные диариловой кислоты и фармацевтическая композиция на их основе
GB0124124D0 (en) * 2001-10-08 2001-11-28 Medical Res Council Methods of treatment
US20060128810A1 (en) * 2002-10-10 2006-06-15 Kyoto University Remedies for allergic diseases
PT2799427T (pt) 2006-07-05 2018-10-16 Fibrotech Therapeutics Pty Ltd Compostos terapêuticos
DE102007013855A1 (de) 2007-03-20 2008-09-25 Merck Patent Gmbh Substituierte Tetrahydrochinoline
US20080265343A1 (en) * 2007-04-26 2008-10-30 International Business Machines Corporation Field effect transistor with inverted t shaped gate electrode and methods for fabrication thereof
KR101593708B1 (ko) * 2007-12-21 2016-02-12 피브로테크 세라퓨틱 피티와이 엘티디 항섬유증 제제의 할로겐화 유사체
CN102149676A (zh) * 2008-08-15 2011-08-10 霍夫曼-拉罗奇有限公司 单芳基氨基四氢化萘类
WO2010018113A2 (en) * 2008-08-15 2010-02-18 F. Hoffmann-La Roche Ag Bi-aryl aminotetralines
WO2010018109A2 (en) * 2008-08-15 2010-02-18 F. Hoffmann-La Roche Ag Substituted aminotetralines
EP2358677B1 (en) 2008-11-17 2014-01-08 F. Hoffmann-La Roche AG Naphthylacetic acids used as crth2 antagonists or partial agonists
MX2011005200A (es) 2008-11-17 2011-06-01 Hoffmann La Roche Acidos naftilaceticos.
MX2011005120A (es) 2008-11-17 2011-05-30 Hoffmann La Roche Acidos naftilaceticos.
EP2491030B1 (en) 2009-10-22 2015-07-15 Fibrotech Therapeutics PTY LTD Fused ring analogues of anti-fibrotic agents
US8470884B2 (en) 2011-11-09 2013-06-25 Hoffmann-La Roche Inc. Alkenyl naphthylacetic acids
CN102964279B (zh) * 2012-12-12 2014-05-07 中国药科大学 一类具有外周镇痛作用的κ阿片受体激动剂

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3623941A1 (de) * 1986-07-16 1988-01-28 Bayer Ag Substituierte amino-5,6,7,8-tetrahydronaphthyl-oxyessigsaeuren, verfahren zu deren herstellung sowie die verwendung als arzneimittel
DE3642105A1 (de) * 1986-12-10 1988-06-16 Bayer Ag Substituierte aminomethyl-5,6,7,8-tetrahydronaphtyl-oxyessigsaeuren, neue zwischenprodukte, verfahren zu ihrer herstellung sowie ihre verwendung in arzneimitteln

Also Published As

Publication number Publication date
ES2118333T3 (es) 1998-09-16
GR3027694T3 (en) 1998-11-30
EP0657422B1 (en) 1998-06-10
KR100191946B1 (ko) 1999-06-15
KR950017941A (ko) 1995-07-22
CN1111612A (zh) 1995-11-15
US5624959A (en) 1997-04-29
US5723493A (en) 1998-03-03
EP0657422A1 (en) 1995-06-14
DE69410956D1 (de) 1998-07-16
ATE167181T1 (de) 1998-06-15
CA2137711A1 (en) 1995-06-10
DE69410956T2 (de) 1999-03-25

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