DK0656360T3 - Trifluormethylpyrroloindolcarboxylesterderivater samt fremgangsmåde til fremstilling deraf - Google Patents

Trifluormethylpyrroloindolcarboxylesterderivater samt fremgangsmåde til fremstilling deraf

Info

Publication number: DK0656360T3
Authority: DK; Denmark
Prior art keywords: trifluoromethylpyrroloindole; ester derivatives; preparation; carboxyl ester; arylsulfonyloxy
Prior art date: 1992-08-21

Application number

DK94908108T

Other languages

English (en)

Inventor

Shiro Terashima

Yasumichi Fukuda

Yasuo Oomori

Original Assignee

Sagami Chem Res

Kyorin Seiyaku Kk

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1992-08-21

Filing date

1993-08-19

Publication date

2003-03-17

1993-08-19 Application filed by Sagami Chem Res, Kyorin Seiyaku Kk filed Critical Sagami Chem Res

2003-03-17 Application granted granted Critical

2003-03-17 Publication of DK0656360T3 publication Critical patent/DK0656360T3/da

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/10—Spiro-condensed systems
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Chemical Kinetics & Catalysis (AREA)
Public Health (AREA)
General Chemical & Material Sciences (AREA)
Communicable Diseases (AREA)
Oncology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Indole Compounds (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Laminated Bodies (AREA)

DK94908108T 1992-08-21 1993-08-19 Trifluormethylpyrroloindolcarboxylesterderivater samt fremgangsmåde til fremstilling deraf DK0656360T3 (da)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
JP22286292		1992-08-21
JP20425593A JP3514490B2 (ja)	1992-08-21	1993-08-18	トリフルオロメチルピロロインドールカルボン酸エステル誘導体及びその製造方法
PCT/JP1993/001159 WO1994004535A1 (fr)	1992-08-21	1993-08-19	Derive d'ester carboxylique de trifluoromethylpyrroloindole et procede pour sa fabrication

Publications (1)

Publication Number	Publication Date
DK0656360T3 true DK0656360T3 (da)	2003-03-17

Family

ID=26514369

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK94908108T DK0656360T3 (da)	1992-08-21	1993-08-19	Trifluormethylpyrroloindolcarboxylesterderivater samt fremgangsmåde til fremstilling deraf

Country Status (13)

Country	Link
US (1)	US5629430A (da)
EP (1)	EP0656360B1 (da)
JP (1)	JP3514490B2 (da)
KR (2)	KR100312444B1 (da)
AT (1)	ATE228132T1 (da)
CA (1)	CA2142869C (da)
DE (1)	DE69332504T2 (da)
DK (1)	DK0656360T3 (da)
ES (1)	ES2188608T3 (da)
HU (1)	HU221041B1 (da)
PT (1)	PT656360E (da)
TW (1)	TW394774B (da)
WO (1)	WO1994004535A1 (da)

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AU693283B2 (en) *	1994-11-29	1998-06-25	Kyorin Pharmaceutical Co. Ltd.	Acrylamide derivatives and process for producing the same
WO1998003509A1 (en) *	1996-07-23	1998-01-29	Kyowa Hakko Kogyo Co., Ltd.	Dc-89 derivatives
DE69828037T2 (de) *	1997-01-24	2005-11-10	Kyorin Pharmaceutical Co., Ltd.	Pyrroloindol-derivate und zwischenprodukte zu ihrer herstellung
US6310209B1 (en)	1997-12-08	2001-10-30	The Scripps Research Institute	Synthesis of CC-1065/duocarmycin analogs
CA2448319C (en) *	2001-05-31	2010-07-27	Medarex, Inc.	Cytotoxins, prodrugs, linkers and stabilizers useful therefor
JP2006505571A (ja) *	2002-10-15	2006-02-16	リゲルファーマシューテイカルズ、インコーポレイテッド	置換されたインドール及びｈｃｖ阻害剤としてのその使用
GB0403038D0 (en)	2004-02-11	2004-03-17	Novartis Ag	Organic compounds
RU2402548C2 (ru) *	2004-05-19	2010-10-27	Медарекс, Инк.	Химические линкеры и их конъюгаты
AU2005244980B2 (en) *	2004-05-19	2011-09-15	E. R. Squibb & Sons, L.L.C.	Chemical linkers and conjugates thereof
US7781478B2 (en)	2004-07-14	2010-08-24	Ptc Therapeutics, Inc.	Methods for treating hepatitis C
PL1851250T3 (pl) *	2005-02-18	2012-10-31	Squibb & Sons Llc	Ludzkie przeciwciało monoklonalne przeciwko antygenowi błony komórkowej komórek prostaty (PSMA)
US7714016B2 (en) *	2005-04-08	2010-05-11	Medarex, Inc.	Cytotoxic compounds and conjugates with cleavable substrates
ES2416136T3 (es) *	2005-09-26	2013-07-30	Medarex, Inc.	Conjugados de anticuerpo-fármaco y su uso
AU2006305842B2 (en)	2005-10-26	2011-11-03	E. R. Squibb & Sons, L.L.C.	Methods and compounds for preparing CC-1065 analogs
WO2007059404A2 (en)	2005-11-10	2007-05-24	Medarex, Inc.	Duocarmycin derivatives as novel cytotoxic compounds and conjugates
TWI412367B (zh)	2006-12-28	2013-10-21	Medarex Llc	化學鏈接劑與可裂解基質以及其之綴合物
KR20090122439A (ko)	2007-02-21	2009-11-30	메다렉스, 인코포레이티드	단일 아미노산을 갖는 화학적 링커 및 이의 접합체
US9901567B2 (en)	2007-08-01	2018-02-27	Syntarga B.V.	Substituted CC-1065 analogs and their conjugates
WO2009067489A1 (en) *	2007-11-20	2009-05-28	Lankenau Institute For Medical Research	Disulfide chemotherapeutic agents and methods of use thereof
RU2628069C2 (ru) *	2008-11-03	2017-08-14	Синтарга Б.В.	Новые аналоги сс-1065 и их конъюгаты
WO2010132771A1 (en)	2009-05-15	2010-11-18	Lankenau Institute For Medical Research	Methods and kits for measuring toxicity and oxidative stress in live cells
LT3108886T (lt)	2010-04-21	2020-08-25	Syntarga B.V.	Cc-1065 analogų ir bifunkcinių jungtukų konjugatai
CA2891280C (en)	2012-11-24	2018-03-20	Hangzhou Dac Biotech Co., Ltd.	Hydrophilic linkers and their uses for conjugation of drugs to cell binding molecules
TR201810856T4 (tr)	2014-01-10	2018-08-27	Synthon Biopharmaceuticals Bv	CYS'le bağlı antikor-ilaç konjugatlarını saflaştırmak için usul.
JP6224268B2 (ja)	2014-01-10	2017-11-01	シントン・バイオファーマシューティカルズ・ビー．ブイ．ＳｙｎｔｈｏｎＢｉｏｐｈａｒｍａｃｅｕｔｉｃａｌｓＢ．Ｖ．	子宮内膜癌の治療において使用するためのデュオカルマイシンａｄｃ
HUE029255T2 (en)	2014-01-10	2017-02-28	Synthon Biopharmaceuticals Bv	Duocarmycin adcs showing improved in vivo antitumor activity
WO2015127685A1 (en)	2014-02-28	2015-09-03	Hangzhou Dac Biotech Co., Ltd	Charged linkers and their uses for conjugation
EP3319936B1 (en)	2015-07-12	2025-12-17	Hangzhou Dac Biotech Co., Ltd.	Bridge linkers for conjugation of cell-binding molecules
US9839687B2 (en)	2015-07-15	2017-12-12	Suzhou M-Conj Biotech Co., Ltd.	Acetylenedicarboxyl linkers and their uses in specific conjugation of a cell-binding molecule
JP7138350B2 (ja)	2016-11-14	2022-09-16	ハンジョウディーエーシーバイオテックシーオー．，エルティディ．	共役連結体、該連結体を含有する細胞結合分子－薬物共役体、並びに該共役体及び連結体の使用及び製造方法
US20230348394A1 (en) *	2020-09-11	2023-11-02	The Regents Of The University Of California	Compositions and methods for treating muscular dystrophies
CN112724068A (zh) *	2020-12-30	2021-04-30	蔡桂坡	具有hdac抑制活性的吲哚类衍生物的合成方法及肿瘤应用
CN117980327A (zh)	2021-11-03	2024-05-03	杭州多禧生物科技有限公司	抗体的特异性偶联

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US4978757A (en) *	1984-02-21	1990-12-18	The Upjohn Company	1,2,8,8a-tetrahydrocyclopropa (C) pyrrolo [3,2-e)]-indol-4(5H)-ones and related compounds
JP2598116B2 (ja) *	1988-12-28	1997-04-09	協和醗酵工業株式会社	新規物質ｄｃ１１３
JP2510335B2 (ja) *	1989-07-03	1996-06-26	協和醗酵工業株式会社	Ｄｃ―８８ａ誘導体
JP3037965B2 (ja) *	1990-06-20	2000-05-08	財団法人相模中央化学研究所	２―アルコキシカルボニル―２―メチル―１―オキソ―１，２，３，６，７，８―ヘキサヒドロ―ベンゾ〔１，２―ｂ；４，３―ｂ´〕ジピロール誘導体
JPH0499774A (ja) *	1990-08-14	1992-03-31	Sagami Chem Res Center	２―エピデュオカルマイシンａおよびその製造中間体

1993
- 1993-08-18 JP JP20425593A patent/JP3514490B2/ja not_active Expired - Fee Related
- 1993-08-19 KR KR1019950700666A patent/KR100312444B1/ko not_active Expired - Fee Related
- 1993-08-19 DK DK94908108T patent/DK0656360T3/da active
- 1993-08-19 PT PT94908108T patent/PT656360E/pt unknown
- 1993-08-19 EP EP94908108A patent/EP0656360B1/en not_active Expired - Lifetime
- 1993-08-19 AT AT94908108T patent/ATE228132T1/de not_active IP Right Cessation
- 1993-08-19 US US08/381,981 patent/US5629430A/en not_active Expired - Fee Related
- 1993-08-19 ES ES94908108T patent/ES2188608T3/es not_active Expired - Lifetime
- 1993-08-19 WO PCT/JP1993/001159 patent/WO1994004535A1/ja not_active Ceased
- 1993-08-19 CA CA002142869A patent/CA2142869C/en not_active Expired - Fee Related
- 1993-08-19 DE DE69332504T patent/DE69332504T2/de not_active Expired - Fee Related
- 1993-08-19 HU HU9500494A patent/HU221041B1/hu not_active IP Right Cessation
- 1993-10-04 TW TW082108171A patent/TW394774B/zh not_active IP Right Cessation
2001
- 2001-04-13 KR KR1020017004709A patent/KR100312445B1/ko not_active Expired - Fee Related

Also Published As

Publication number	Publication date
AU689443B2 (en)	1998-04-02
AU4761893A (en)	1994-03-15
DE69332504D1 (de)	2003-01-02
CA2142869C (en)	2002-01-01
TW394774B (en)	2000-06-21
KR100312444B1 (ko)	2002-02-28
EP0656360B1 (en)	2002-11-20
EP0656360A4 (en)	1995-08-30
PT656360E (pt)	2003-02-28
CA2142869A1 (en)	1994-03-03
HU9500494D0 (en)	1995-04-28
US5629430A (en)	1997-05-13
HU221041B1 (hu)	2002-07-29
KR100312445B1 (ko)	2001-11-09
EP0656360A1 (en)	1995-06-07
ES2188608T3 (es)	2003-07-01
HUT71493A (en)	1995-11-28
JPH06116269A (ja)	1994-04-26
WO1994004535A1 (fr)	1994-03-03
JP3514490B2 (ja)	2004-03-31
DE69332504T2 (de)	2003-10-02
ATE228132T1 (de)	2002-12-15

Publication	Publication Date	Title
DK0656360T3 (da)	2003-03-17	Trifluormethylpyrroloindolcarboxylesterderivater samt fremgangsmåde til fremstilling deraf
DE69032981D1 (de)	1999-04-08	N-Heteroarylamidederivate als Inhibitoren von Acyl-Coenzym A: Cholesterol-Acyl-Transferase
DE69420068D1 (de)	1999-09-23	1H-Indol-3-Acetamid-Derivate als sPLA2-Inhibitoren
ATE132150T1 (de)	1996-01-15	3-alkenyl-1-azabicyclo(3.2.0)hept-2-en-2- carbonsäure-verbindungen
DK0520406T3 (da)	1998-12-14	Diastereomert salt af optisk aktiv quinolinmevalonsyre
EP1004573A4 (en)	2000-10-18	ARYLOXYANILINE DERIVATIVES
DE69017174D1 (de)	1995-03-30	Substituierte Oxophtalazinyl-Essigsäuren und deren Analogen.
NO20014119D0 (no)	2001-08-24	Medikament inneholdende et sulfopyranosylacylglycerolderivat
AU539568B2 (en)	1984-10-04	2-(4-(diphenylmethylene)-1-piperidinyl)acetic acid derivatives
EP0878196A4 (en)	2001-04-11	INHIBITORS OF KAINIC ACID NEUROTOXICITY AND PYRIDOTHIAZINE DERIVATIVES
DK0571243T3 (da)	1995-12-04	Thiochromanderivater, fremgangsmåder til fremstilling heraf samt farmaceutiske midler indeholdende d isse
NO903058D0 (no)	1990-07-09	Farmasoeytisk preparat med forbedret absorberbarhet.
CO4890844A1 (es)	2000-02-28	Nuevos retinoides
DK0654473T3 (da)	2000-03-20	Cyclopropanderivater og antivirale midler med indhold deraf
EP0657443A4 (en)	1995-09-06	OPTICALLY ACTIVE CARBOXAMIDE DERIVATIVES.
DE69123757D1 (de)	1997-01-30	Epoxysuccinamidsäurederivat
NO175255C (no)	1994-09-21	Analogifremgangsmåte for fremstilling av terapeutisk aktive alkylestere av 2-(4-(2-piperidino-etoksy)-benzoyl)-benzosyre med forgrenet kjede
DE3265110D1 (en)	1985-09-05	New compound having antiinflammatory, analgesic and mucoregulating activity, process for its production and relative pharmaceutical compositions
ATE120731T1 (de)	1995-04-15	Optisch aktives derivat der d-2-(6-methoxy-2- naphthyl)-propionsäure und es enthaltende pharmazeutische zusammensetzungen.
ES2042727T3 (es)	1993-12-16	Acidos 1,3,4,9-tetrahidropirano(3,4-b)indol-1-acetico.
ES2080445T3 (es)	1996-02-01	Derivados de ursano, su preparacion y formulaciones farmaceuticas de los mismos.
ITMI931848A1 (it)	1995-02-25	Glicoconiugati anfifilici sintetici attivi sul sistema nervoso centrale, procedimento per la loro preparazione e relative
DK0573360T3 (da)	1999-05-25	Pyrrolothienopyrazinforbindelser som 5-HT3-receptorantagonister