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DK0644777T4 - Microparticles, processes for their preparation and their use for diagnostic purposes - Google Patents

Microparticles, processes for their preparation and their use for diagnostic purposes

Info

Publication number
DK0644777T4
DK0644777T4 DK93912897T DK93912897T DK0644777T4 DK 0644777 T4 DK0644777 T4 DK 0644777T4 DK 93912897 T DK93912897 T DK 93912897T DK 93912897 T DK93912897 T DK 93912897T DK 0644777 T4 DK0644777 T4 DK 0644777T4
Authority
DK
Denmark
Prior art keywords
microparticles
processes
preparation
diagnostic purposes
contrasting agents
Prior art date
Application number
DK93912897T
Other languages
Danish (da)
Other versions
DK0644777T3 (en
Inventor
Michael Dr Stein
Werner Dr Weitschies
Thomas Dr Fritzsch
Dieter Dr Heldmann
Joachim Dr Siegert
Volkmar Dr Uhlendorf
Esther Hamacher
Frank Dr Lueders
Original Assignee
Schering Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=6461144&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DK0644777(T4) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Schering Ag filed Critical Schering Ag
Application granted granted Critical
Publication of DK0644777T3 publication Critical patent/DK0644777T3/en
Publication of DK0644777T4 publication Critical patent/DK0644777T4/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/22—Echographic preparations; Ultrasound imaging preparations ; Optoacoustic imaging preparations
    • A61K49/222—Echographic preparations; Ultrasound imaging preparations ; Optoacoustic imaging preparations characterised by a special physical form, e.g. emulsions, liposomes
    • A61K49/223—Microbubbles, hollow microspheres, free gas bubbles, gas microspheres
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo

Landscapes

  • Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Physics & Mathematics (AREA)
  • Acoustics & Sound (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Radiology & Medical Imaging (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicinal Preparation (AREA)
  • Saccharide Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Macromolecular Compounds Obtained By Forming Nitrogen-Containing Linkages In General (AREA)

Abstract

The invention concerns contrasting agents for use in ultrasonic diagnostic, the contrasting agents consisting of gas-containing microparticles with shells made of polycyanoacrylates or polyesters of $g(a)-, $g(b)-, or $g(g)-hydroxycarboxylic acids. The invention also concerns a method of producing such contrasting agents.
DK93912897T 1992-06-13 1993-06-05 Microparticles, processes for their preparation and their use for diagnostic purposes DK0644777T4 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE4219723A DE4219723A1 (en) 1992-06-13 1992-06-13 Microparticles, processes for their production and their use in diagnostics
PCT/EP1993/001425 WO1993025242A1 (en) 1992-06-13 1993-06-05 Microparticles, method of producing them and their use for diagnostic purposes

Publications (2)

Publication Number Publication Date
DK0644777T3 DK0644777T3 (en) 1998-09-23
DK0644777T4 true DK0644777T4 (en) 2004-02-23

Family

ID=6461144

Family Applications (1)

Application Number Title Priority Date Filing Date
DK93912897T DK0644777T4 (en) 1992-06-13 1993-06-05 Microparticles, processes for their preparation and their use for diagnostic purposes

Country Status (18)

Country Link
EP (1) EP0644777B2 (en)
JP (1) JPH07507780A (en)
KR (1) KR100254746B1 (en)
CN (1) CN1064851C (en)
AT (1) ATE163134T1 (en)
AU (1) AU686103B2 (en)
CA (1) CA2138010A1 (en)
DE (2) DE4219723A1 (en)
DK (1) DK0644777T4 (en)
ES (1) ES2115060T5 (en)
FI (1) FI945837A0 (en)
GR (1) GR3026498T3 (en)
HU (1) HU217121B (en)
IL (1) IL105891A (en)
NO (1) NO307646B1 (en)
NZ (1) NZ253115A (en)
TW (1) TW239079B (en)
WO (1) WO1993025242A1 (en)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6613306B1 (en) 1990-04-02 2003-09-02 Bracco International B.V. Ultrasound contrast agents and methods of making and using them
USRE39146E1 (en) 1990-04-02 2006-06-27 Bracco International B.V. Long-lasting aqueous dispersions or suspensions of pressure-resistant gas-filled microvesicles and methods for the preparation thereof
US7083778B2 (en) 1991-05-03 2006-08-01 Bracco International B.V. Ultrasound contrast agents and methods of making and using them
IN172208B (en) 1990-04-02 1993-05-01 Sint Sa
US6989141B2 (en) 1990-05-18 2006-01-24 Bracco International B.V. Ultrasound contrast agents and methods of making and using them
US5578292A (en) 1991-11-20 1996-11-26 Bracco International B.V. Long-lasting aqueous dispersions or suspensions of pressure-resistant gas-filled microvesicles and methods for the preparation thereof
NZ244147A (en) † 1991-09-03 1994-09-27 Hoechst Ag Echogenic particles which comprise a gas and at least one shaping substance, and their use as diagnostic agents
IL104084A (en) 1992-01-24 1996-09-12 Bracco Int Bv Long-lasting aqueous suspensions of pressure-resistant gas-filled microvesicles their preparation and contrast agents consisting of them
US5798091A (en) 1993-07-30 1998-08-25 Alliance Pharmaceutical Corp. Stabilized gas emulsion containing phospholipid for ultrasound contrast enhancement
JP3559849B2 (en) * 1993-07-30 2004-09-02 アイエムシーオーアール ファーマシューティカル カンパニー Stabilized microbubble compositions for ultrasonic technology
GB9318288D0 (en) * 1993-09-03 1993-10-20 Nycomed Imaging As Improvements in or relating to contrast agents
GB9417941D0 (en) * 1994-09-06 1994-10-26 Nycomed Imaging As Improvements in or relating to contrast agents
US5540909A (en) * 1994-09-28 1996-07-30 Alliance Pharmaceutical Corp. Harmonic ultrasound imaging with microbubbles
DE19508049C2 (en) * 1995-02-23 1997-02-06 Schering Ag Use of methylene malon diester derivatives for the production of gas-containing microparticles
DE19510690A1 (en) * 1995-03-14 1996-09-19 Schering Ag Polymeric nano- and / or microparticles, processes for their production, and use in medical diagnostics and therapy
US5804162A (en) 1995-06-07 1998-09-08 Alliance Pharmaceutical Corp. Gas emulsions stabilized with fluorinated ethers having low Ostwald coefficients
ATE266426T1 (en) * 1996-03-05 2004-05-15 Acusphere Inc MICRO-ENCAPSULED FLUORINATED GASES FOR USE AS IMAGING AGENT
US5611344A (en) * 1996-03-05 1997-03-18 Acusphere, Inc. Microencapsulated fluorinated gases for use as imaging agents
US6017310A (en) * 1996-09-07 2000-01-25 Andaris Limited Use of hollow microcapsules
US6068600A (en) * 1996-12-06 2000-05-30 Quadrant Healthcare (Uk) Limited Use of hollow microcapsules
US6045777A (en) * 1997-06-30 2000-04-04 Acusphere, Inc. Method for enhancing the echogenicity and decreasing the attenuation of microencapsulated gases
GB9800813D0 (en) 1998-01-16 1998-03-11 Andaris Ltd Improved ultrasound contrast imaging method and apparatus
DE19925311B4 (en) * 1999-05-27 2004-06-09 Schering Ag Multi-stage process for the production of gas-filled microcapsules
DE10013850A1 (en) * 2000-03-15 2001-09-20 Schering Ag Gas-filled microcapsules, useful for ultrasonic diagnosis, are prepared from functionalized poly(alkyl cyanoacrylate), allowing attachment of e.g. specific-binding agents
US8012457B2 (en) 2004-06-04 2011-09-06 Acusphere, Inc. Ultrasound contrast agent dosage formulation

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4265251A (en) * 1979-06-28 1981-05-05 Rasor Associates, Inc. Method of determining pressure within liquid containing vessel
EP0398935B1 (en) * 1988-02-05 1994-08-10 Schering Aktiengesellschaft Ultrasonic contrast agents, process for producing them and their use as diagnostic and therapeutic agents
AU636481B2 (en) * 1990-05-18 1993-04-29 Bracco International B.V. Polymeric gas or air filled microballoons usable as suspensions in liquid carriers for ultrasonic echography
NZ244147A (en) * 1991-09-03 1994-09-27 Hoechst Ag Echogenic particles which comprise a gas and at least one shaping substance, and their use as diagnostic agents

Also Published As

Publication number Publication date
CN1064851C (en) 2001-04-25
KR100254746B1 (en) 2000-08-01
IL105891A (en) 1998-10-30
GR3026498T3 (en) 1998-07-31
AU686103B2 (en) 1998-02-05
JPH07507780A (en) 1995-08-31
EP0644777B1 (en) 1998-02-11
HU9403566D0 (en) 1995-02-28
ATE163134T1 (en) 1998-02-15
TW239079B (en) 1995-01-21
FI945837A7 (en) 1994-12-12
DE59308146D1 (en) 1998-03-19
FI945837L (en) 1994-12-12
WO1993025242A1 (en) 1993-12-23
AU4323293A (en) 1994-01-04
HUT69380A (en) 1995-09-28
NO944805L (en) 1994-12-12
CN1082924A (en) 1994-03-02
CA2138010A1 (en) 1993-12-23
NO307646B1 (en) 2000-05-08
EP0644777A1 (en) 1995-03-29
DK0644777T3 (en) 1998-09-23
ES2115060T5 (en) 2004-06-16
HU217121B (en) 1999-11-29
ES2115060T3 (en) 1998-06-16
NZ253115A (en) 1996-01-26
EP0644777B2 (en) 2003-10-15
KR950701823A (en) 1995-05-17
FI945837A0 (en) 1994-12-12
IL105891A0 (en) 1993-10-20
NO944805D0 (en) 1994-12-12
DE4219723A1 (en) 1993-12-16

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