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DK0534445T3 - Process for the preparation of a medicament for oral or topical administration in the treatment of Leishmaniasis - Google Patents

Process for the preparation of a medicament for oral or topical administration in the treatment of Leishmaniasis

Info

Publication number
DK0534445T3
DK0534445T3 DK92116415T DK92116415T DK0534445T3 DK 0534445 T3 DK0534445 T3 DK 0534445T3 DK 92116415 T DK92116415 T DK 92116415T DK 92116415 T DK92116415 T DK 92116415T DK 0534445 T3 DK0534445 T3 DK 0534445T3
Authority
DK
Denmark
Prior art keywords
group
medicament
oral
treatment
topical administration
Prior art date
Application number
DK92116415T
Other languages
Danish (da)
Inventor
Hansjoerg Prof Dr Eibl
Clemens Dr Unger
Juergen Prof Dr Engel
Original Assignee
Max Planck Gesellschaft
Asta Medica Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Max Planck Gesellschaft, Asta Medica Ag filed Critical Max Planck Gesellschaft
Application granted granted Critical
Publication of DK0534445T3 publication Critical patent/DK0534445T3/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/66—Phosphorus compounds
    • A61K31/661—Phosphorus acids or esters thereof not having P—C bonds, e.g. fosfosal, dichlorvos, malathion or mevinphos
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/66—Phosphorus compounds
    • A61K31/683—Diesters of a phosphorus acid with two hydroxy compounds, e.g. phosphatidylinositols
    • A61K31/685—Diesters of a phosphorus acid with two hydroxy compounds, e.g. phosphatidylinositols one of the hydroxy compounds having nitrogen atoms, e.g. phosphatidylserine, lecithin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/075—Ethers or acetals
    • A61K31/08—Ethers or acetals acyclic, e.g. paraformaldehyde
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0087—Galenical forms not covered by A61K9/02 - A61K9/7023
    • A61K9/0095—Drinks; Beverages; Syrups; Compositions for reconstitution thereof, e.g. powders or tablets to be dispersed in a glass of water; Veterinary drenches
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2095—Tabletting processes; Dosage units made by direct compression of powders or specially processed granules, by eliminating solvents, by melt-extrusion, by injection molding, by 3D printing
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicinal Preparation (AREA)
  • Steroid Compounds (AREA)

Abstract

The invention relates to a medicament for oral or topical administration in the treatment of protozoal diseases, especially leishmaniasis, which contains as active ingredient one or more compounds of the general formula I <IMAGE> in which R<1> is a saturated or mono- or polyunsaturated hydrocarbon radical with 12 to 20 C atoms, and R<2>, R<3> and R<4> are, independently of one another, hydrogen, a C1-C5-alkyl group, a C3-C6-cycloalkyl group or a C1-C5-hydroxyalkyl group, it being possible for two of the radicals R<2>, R<3> and R<4> to form together a C2-C5-alkylene group which can optionally be substituted by an -O-, -S- or NR<5> group, in which R<5> is hydrogen, a C1-C5-alkyl group, a C3-C6-cycloalkyl group or a C1-C5-hydroxyalkyl group, and, where appropriate, customary pharmaceutical ancillary substances, diluents, vehicles and/or fillers.
DK92116415T 1991-09-27 1992-09-24 Process for the preparation of a medicament for oral or topical administration in the treatment of Leishmaniasis DK0534445T3 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE4132344A DE4132344A1 (en) 1991-09-27 1991-09-27 METHOD FOR PRODUCING A MEDAL FOR ORAL OR TOPICAL ADMINISTRATION IN THE TREATMENT OF LEISHMANIASIS

Publications (1)

Publication Number Publication Date
DK0534445T3 true DK0534445T3 (en) 1999-10-18

Family

ID=6441697

Family Applications (1)

Application Number Title Priority Date Filing Date
DK92116415T DK0534445T3 (en) 1991-09-27 1992-09-24 Process for the preparation of a medicament for oral or topical administration in the treatment of Leishmaniasis

Country Status (12)

Country Link
US (1) US5980915A (en)
EP (1) EP0534445B1 (en)
JP (2) JP3587862B2 (en)
KR (2) KR100270255B1 (en)
AT (1) ATE177950T1 (en)
BR (1) BR9203768A (en)
DE (2) DE4132344A1 (en)
DK (1) DK0534445T3 (en)
ES (1) ES2132101T3 (en)
GR (1) GR3030016T3 (en)
MX (1) MX9205466A (en)
SG (1) SG49692A1 (en)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6254879B1 (en) * 1991-09-27 2001-07-03 Max-Planck-Gessellschaft zun Förderung der Wissenschaften e.V. Methods of treating protozoal diseases
US5681829A (en) * 1992-10-08 1997-10-28 Shaman Pharmaceuticals, Inc. Class of phosphocholine derivatives having antifungal activity
DE4305553A1 (en) * 1992-12-18 1994-06-23 Rhone Poulenc Rorer Gmbh Topical pharmaceutical or cosmetic compsn - contg. N-acyl-alkanolamine and phosphatidyl-ethanolamine derivs., e.g. for protecting skin against light or treating insect stings
RU2190390C2 (en) * 1998-01-22 2002-10-10 Центарис АГ Solid pharmaceutical composition for oral administration in treatment of leishmaniasis and method of its production, pharmaceutical combination for treatment of leishmaniasis in mammals and method of treatment (versions)
SK284839B6 (en) * 1998-01-22 2005-12-01 Zentaris Gmbh The use of miltefosine for the manufacture of a medicament and a pharmaceutical combination for the treatment of leishmanosis
DE19835611A1 (en) 1998-08-06 2000-02-10 Max Planck Gesellschaft Novel phospholipids with synthetic, unsaturated alkyl and acyl chains
DE10015814A1 (en) * 2000-03-30 2001-10-11 Max Planck Gesellschaft Medicines to stimulate leukopoiesis, treat tumors and protozoan diseases and process for its manufacture
DE10025124B4 (en) * 2000-05-20 2015-07-16 Beiersdorf Ag Combinations of glycerol monoalkyl ethers and aryl-substituted alcohols
DE10025122A1 (en) * 2000-05-20 2001-11-22 Beiersdorf Ag Combinations of Clycerol monoalkyl ethers and fatty acid glycerides
BG64968B1 (en) * 2000-08-07 2006-11-30 Asta Medica Aktiengesellschaft Solid pharmaceutical compositions containing miltefosine for oral administration in the treatment of leishmaniasis
DE10203195A1 (en) * 2002-01-25 2003-08-07 Zentaris Ag Use of alkylphosphocholines in the preventive treatment of protozoal diseases
US7887817B2 (en) 2002-01-25 2011-02-15 Aeterna Zentaris Gmbh Process for preventing protozoal diseases
CA2503058A1 (en) * 2002-10-30 2004-05-21 Theodora Calogeropoulou Antiprotozoal ring-substituted phospholipids
US20070167408A1 (en) * 2005-12-19 2007-07-19 Zentaris Gmbh Novel alkyl phospholipid derivatives with reduced cytotoxicity and uses thereof
EP1800684A1 (en) * 2005-12-20 2007-06-27 Zentaris GmbH Novel alkyl phospholipid derivatives and uses thereof
KR101378005B1 (en) * 2005-12-19 2014-03-27 아에테르나 젠타리스 게엠베하 Alkyl phospholipid derivatives with reduced cytotoxicity and uses thereof
DE102007014375A1 (en) * 2007-03-26 2008-10-02 MAX-PLANCK-Gesellschaft zur Förderung der Wissenschaften e.V. oleylphosphocholine
CA2767460A1 (en) 2009-07-09 2011-01-13 Expergen Drug Development Gmbh Liquid pharmaceutical form of alkylphosphocholine and method of preparing same
PT2642981T (en) * 2010-11-22 2017-06-16 Oblita Therapeutics Bvba Solid dosage forms of oleyl phosphocholine
EA202092369A1 (en) * 2018-04-10 2021-01-26 Селлектар Байосайенсиз, Инк. PHOSPHOLIPID-FLAVAGLIN CONJUGATES AND METHODS FOR THEIR APPLICATION FOR TARGETED CANCER THERAPY
EP4041718A4 (en) 2019-10-10 2023-12-20 Cellectar Biosciences, Inc. Phospholipid-flavagline conjugates and methods of using the same for targeted cancer therapy
JP7738404B2 (en) * 2021-04-26 2025-09-12 株式会社アルビオン Oil-in-water emulsion composition
CN119798052B (en) * 2025-01-02 2025-11-04 万华化学集团股份有限公司 A nonionic surfactant, its preparation method and application

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5984824A (en) * 1982-11-08 1984-05-16 Takeda Chem Ind Ltd Antitumor agent
IE59778B1 (en) * 1985-12-04 1994-04-06 Max Planck Gesellschaft Medicament with anti-tumour action containing hexadecylphosphocholine
US5087721A (en) * 1987-10-23 1992-02-11 The University Of Michigan Radioiodinated phosphate esters
DE58904595D1 (en) * 1988-04-19 1993-07-15 Hafslund Nycomed Pharma NEW ALKYLPHOSPHONOSERINE, METHOD FOR THE PRODUCTION THEREOF AND PHARMACEUTICAL AGENT CONTAINING IT.

Also Published As

Publication number Publication date
HK1004472A1 (en) 1998-11-27
KR100283783B1 (en) 2001-02-15
ATE177950T1 (en) 1999-04-15
KR930005622A (en) 1993-04-20
US5980915A (en) 1999-11-09
GR3030016T3 (en) 1999-07-30
EP0534445A1 (en) 1993-03-31
BR9203768A (en) 1993-04-20
KR100270255B1 (en) 2002-09-04
DE4132344A1 (en) 1993-04-01
SG49692A1 (en) 1998-06-15
JPH06263643A (en) 1994-09-20
MX9205466A (en) 1993-05-01
JP3587862B2 (en) 2004-11-10
EP0534445B1 (en) 1999-03-24
DE59209663D1 (en) 1999-04-29
ES2132101T3 (en) 1999-08-16
JP2004315540A (en) 2004-11-11

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