[go: up one dir, main page]

DK0527801T3 - Thiophensulfonamider, der er anvendelige som carboanhydraseinhibitorer - Google Patents

Thiophensulfonamider, der er anvendelige som carboanhydraseinhibitorer

Info

Publication number
DK0527801T3
DK0527801T3 DK91908317T DK91908317T DK0527801T3 DK 0527801 T3 DK0527801 T3 DK 0527801T3 DK 91908317 T DK91908317 T DK 91908317T DK 91908317 T DK91908317 T DK 91908317T DK 0527801 T3 DK0527801 T3 DK 0527801T3
Authority
DK
Denmark
Prior art keywords
sulfonamides useful
thiophene sulfonamides
carbohydrate inhibitors
carbohydrate
inhibitors
Prior art date
Application number
DK91908317T
Other languages
English (en)
Inventor
Thomas R Dean
Hwang-Hsing Chen
Jesse A May
Anura Pathmaciri Dantanarayana
Daniel Kuzmich
Paul W Zinke
Raymond Eugene Conrow
Michael E Deason
Mark Thomas Dupriest
Original Assignee
Alcon Lab Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Alcon Lab Inc filed Critical Alcon Lab Inc
Application granted granted Critical
Publication of DK0527801T3 publication Critical patent/DK0527801T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D333/30—Hetero atoms other than halogen
    • C07D333/34—Sulfur atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D333/38—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Heterocyclic Compounds Containing Sulfur Atoms (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Lubricants (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
DK91908317T 1990-04-09 1991-04-03 Thiophensulfonamider, der er anvendelige som carboanhydraseinhibitorer DK0527801T3 (da)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US50673090A 1990-04-09 1990-04-09
US07/618,765 US5153192A (en) 1990-04-09 1990-11-27 Thiophene sulfonamides useful as carbonic anhydrase inhibitors
PCT/US1991/002262 WO1991015486A1 (en) 1990-04-09 1991-04-03 Thiophene sulfonamides useful as carbonic anydrase inhibitors

Publications (1)

Publication Number Publication Date
DK0527801T3 true DK0527801T3 (da) 2002-11-25

Family

ID=27055558

Family Applications (1)

Application Number Title Priority Date Filing Date
DK91908317T DK0527801T3 (da) 1990-04-09 1991-04-03 Thiophensulfonamider, der er anvendelige som carboanhydraseinhibitorer

Country Status (19)

Country Link
US (2) US5153192A (da)
EP (1) EP0527801B1 (da)
JP (1) JP2562394B2 (da)
KR (1) KR100196414B1 (da)
AT (1) ATE221527T1 (da)
AU (1) AU655924B2 (da)
BR (1) BR9106330A (da)
CA (1) CA2080223C (da)
DE (3) DE10299054I1 (da)
DK (1) DK0527801T3 (da)
ES (1) ES2180530T3 (da)
FI (2) FI963424A7 (da)
IL (1) IL97800A (da)
LU (2) LU90935I2 (da)
NL (2) NL300098I2 (da)
NO (1) NO923948L (da)
NZ (1) NZ237754A (da)
WO (1) WO1991015486A1 (da)
ZA (1) ZA912580B (da)

Families Citing this family (82)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5585377A (en) * 1990-04-09 1996-12-17 Alcon Laboratories, Inc. Sulfonamides useful as carbonic anhydrase inhibitors
FR2662439B1 (fr) * 1990-05-23 1993-11-19 Rhone Poulenc Chimie Reactif et procede de perfluoroalkylation de substrats nucleophiles par les perfluoroalcanesulfinates de sodium en milieu oxydant.
SG84487A1 (en) 1991-04-17 2001-11-20 Merck & Co Inc Ophthalmic compositions comprising combinations of a carbonic anhydrase inhibitor and a b-adrenergic antagonist
US5932572A (en) * 1992-02-21 1999-08-03 Alcon Laboratories, Inc. Topical anti-glaucoma compositions
JP2965267B2 (ja) 1992-02-21 1999-10-18 アルコン ラボラトリーズ，インコーポレイテッド 局所用抗緑内障組成物
US5276025A (en) * 1992-09-09 1994-01-04 Merck & Co., Inc. Heterobicyclic sulfonamides
US5308842A (en) * 1992-09-09 1994-05-03 Merck & Co., Inc. Tricyclic derivatives of the thienodiazocine and thienothiadiazocine classes of compounds
WO1994006411A1 (en) * 1992-09-17 1994-03-31 Alcon Laboratories, Inc. Topical carbonic anhydrase inhibitor composition
US5344929A (en) * 1993-02-18 1994-09-06 Alcon Laboratories, Inc. Preparation of carbonic anhydrase inhibitors
US5538966A (en) * 1994-01-21 1996-07-23 Alcon Laboratories, Inc. Carbonic anhydrase inhibitors
AU1684895A (en) * 1994-01-21 1995-08-08 Alcon Laboratories, Inc. Thienothiazine sulfonamide derivatives process and intermediates for their preparation and their use as carbonic anhydrase inhibitors
US5646142A (en) * 1994-07-08 1997-07-08 Alcon Laboratories, Inc. Thiophene sulfonamides useful as carbonic anhydrase inhibitors
US6316443B1 (en) 1994-08-04 2001-11-13 Merck & Co., Inc. Ophthalmic compositions comprising combinations of a carbonic anhydrase inhibitor and a β-adrenergic antagonist
US5464831A (en) * 1994-09-09 1995-11-07 Alcon Laboratories, Inc. Thienothiadiazine sulfonamides useful as carbonic anhydrase inhibitors
US5510347A (en) * 1994-09-09 1996-04-23 Alcon Laboratories, Inc. Thienothiadiazine sulfonamides useful as carbonic anhydrase inhibitors
US5470973A (en) * 1994-10-03 1995-11-28 Alcon Laboratories, Inc. Synthesis of sulfonamide intermediates
US5620970A (en) * 1995-06-05 1997-04-15 Alcon Laboratories, Inc. Topical ophthalmic carbonic anhydrase inhibitor formulations
US6172054B1 (en) 1995-06-15 2001-01-09 Alcon Laboratories, Inc. Combination therapy for lowering and controlling intraocular pressure
WO1997002825A1 (en) * 1995-07-12 1997-01-30 Alcon Laboratories, Inc. Thiophene sulfonamides useful as carbonic anhydrase inhibitors
US6441047B2 (en) 1995-11-17 2002-08-27 Alcon Manufacturing Ltd.. Combination therapy for treating glaucoma
WO1997018812A1 (en) * 1995-11-17 1997-05-29 Alcon Laboratories, Inc. Combination therapy for treating glaucoma
EA001681B1 (ru) * 1996-02-26 2001-06-25 Эдванст Рисерч Энд Текнолоджи Инститьют Способ лечения или предупреждения макулярного отека или возрастной макулярной дистрофии
US5900427A (en) * 1996-05-03 1999-05-04 Wisconsin Alumni Research Foundation N-heteroarenesulfonyl-protected amino acid reagents for peptide synthesis
AUPO227896A0 (en) * 1996-09-13 1996-10-03 Fujisawa Pharmaceutical Co., Ltd. Novel compounds and their preparation
JP2001526231A (ja) 1997-12-23 2001-12-18 アルコン ラボラトリーズ， インコーポレーテッド 視野欠損を予防するためのブリンゾルアミドの使用
US6156785A (en) * 1998-01-23 2000-12-05 Merck Sharp & Dohme B.V. Method for increasing oxygen tension in the optic nerve and retina
EP1058546A4 (en) * 1998-03-06 2004-07-28 Univ Texas COMPILATIONS AND METHODS FOR THE TREATMENT OF MACULA DISEASES
US5948801A (en) * 1998-03-09 1999-09-07 Alcon Laboratories, Inc. Treatment of retinal edema with brinzolamide
US6960579B1 (en) * 1998-05-19 2005-11-01 Alcon Manufacturing, Ltd. Serotonergic 5HT7 receptor compounds for treating ocular and CNS disorders
ATE409491T1 (de) * 2000-01-18 2008-10-15 Merck & Co Inc Orhthalmologische zusammenstellungen zur behandlung von ocularer hypertension
US6548535B2 (en) 2000-01-18 2003-04-15 Merck & Co., Inc. Method for treating ocular hypertension
AU784462B2 (en) * 2000-03-31 2006-04-06 Purdue Research Foundation Phosphoramidate prodrugs
JP2004522711A (ja) * 2000-11-16 2004-07-29 アルコン マニュファクチャリング，リミティド 眼内圧の低下および制御のための組み合わせ治療
US20040067992A1 (en) * 2001-08-10 2004-04-08 Pharmacia Corporation Compositions of a cyclooxygenase-2 selective inhibitor and a carbonic anhydrase inhibitor for the treatment of neoplasia
US20040254230A1 (en) * 2001-12-03 2004-12-16 Ogidigben Miller J. Method for treating ocular hypertension
WO2003077845A2 (en) * 2002-03-15 2003-09-25 Merck & Co., Inc. Compositions and methods for treating glaucoma and ocular hypertension
AU2003233731A1 (en) * 2002-06-06 2003-12-22 Xavier Billot 1,5-disubstituted imidazolidin-2-one derivatives for use as ep4 receptor agonists in the treatment of eye and bone diseases
US20050256117A1 (en) * 2002-06-14 2005-11-17 Meng Hsin Chen Ophthalmic compositions for treating ocular hypertension
JP2005532361A (ja) * 2002-06-17 2005-10-27 メルク　エンド　カムパニー　インコーポレーテッド 高眼圧症の治療用の眼科用組成物
JP2005533055A (ja) * 2002-06-17 2005-11-04 メルク　エンド　カムパニー　インコーポレーテッド 新規マキシｋチャンネルブロッカー、その使用方法および製造方法
WO2003105868A1 (en) * 2002-06-17 2003-12-24 Merck & Co., Inc. Novel maxi-k channel blockers, methods of use and process for making the same
CA2495917A1 (en) * 2002-08-28 2004-03-11 Merck Frosst Canada & Co. Oxazolidin-2-one and thiazolidin-2-one derivatives for use as ep4 receptor agonists in the treatment of glaucoma
JP2006505572A (ja) * 2002-10-25 2006-02-16 メルク フロスト カナダ アンド カンパニー Ｅｐ４受容体アゴニストとしての２−ピロリドン
KR100503618B1 (ko) * 2002-11-07 2005-07-26 안헌상 케이크용 장식용품
US20040216749A1 (en) * 2003-01-23 2004-11-04 Hosheng Tu Vasomodulation during glaucoma surgery
JP2006524239A (ja) * 2003-03-27 2006-10-26 メルク　エンド　カムパニー　インコーポレーテッド 高眼圧症を治療するための眼用組成物
US6949518B1 (en) 2003-06-25 2005-09-27 Pao-Hsien Chu Methods for treating macular degeneration with topiramate
US20050119262A1 (en) * 2003-08-21 2005-06-02 Pharmacia Corporation Method for preventing or treating an optic neuropathy with a cox-2 inhibitor and an intraocular pressure reducing agent
KR100537781B1 (ko) * 2004-06-02 2005-12-20 안헌상 케이크 장식용품의 제조방법 및 그 물품
PT1905452E (pt) 2005-07-12 2013-07-16 Kowa Co Agente para a prevenção ou tratamento do glaucoma
JP4831668B2 (ja) * 2006-02-16 2011-12-07 独立行政法人産業技術総合研究所 新規なチアジノインドール化合物およびその製造方法
LT5504B (lt) 2006-08-02 2008-06-25 Biotechnologijos Institutas Benzimidazo[1,2-c][1,2,3]tiadiazolo sulfonamidai - karboanhidrazių slopikliai ir tarpiniai junginiai jiems gauti
EP2106260B8 (en) 2007-01-25 2018-04-04 Naia Metabolic, Inc. Insulin sensitisers and methods of treatment
WO2008120099A1 (en) * 2007-03-30 2008-10-09 Pfizer Inc. Thieno [3, 2-e] [1, 2] thiazine derivative as inhibitor of carbonic anhydrase
EP1985618A1 (en) * 2007-04-27 2008-10-29 Duke Chem, S. A. Process for the preparation of brinzolamide and intermediates thereof
US20110015158A1 (en) 2007-12-11 2011-01-20 Viamet Pharmaceuticals, Inc. Metalloenzyme inhibitors using metal binding moieties in combination with targeting moieties
ITMI20081084A1 (it) * 2008-06-16 2009-12-17 Phf Sa Processo per la preparazione di brinzolamide
US8332007B2 (en) * 2009-01-12 2012-12-11 The Board Of Trustees Of The University Of Illinois Quantitative three-dimensional mapping of oxygen tension
WO2010103115A1 (en) * 2009-03-13 2010-09-16 Azad Pharmaceutical Ingredients Ag Process for preparing brinzolamide
US10206813B2 (en) 2009-05-18 2019-02-19 Dose Medical Corporation Implants with controlled drug delivery features and methods of using same
US12478503B2 (en) 2009-05-18 2025-11-25 Glaukos Corporation Implants with controlled drug delivery features and methods of using same
EP2348026A1 (en) * 2009-12-22 2011-07-27 Duke Chem, S. A. Process for the preparation of brinzolamide and intermediates thereof
EP2394637A1 (en) 2010-05-21 2011-12-14 Zaklady Farmaceutyczne Polpharma SA Process for obtaining sterile brinzolamide suspensions
TW201210584A (en) 2010-08-18 2012-03-16 Alcon Res Ltd Bradykinin receptor agonists and uses thereof to treat ocular hypertension and glaucoma
US20110021974A1 (en) * 2010-10-05 2011-01-27 Shantha Totada R Retinitis pigmentosa treatment and prophalaxis
WO2012053011A2 (en) 2010-10-18 2012-04-26 Usv Limited Ophthalmic compositions comprising brinzolamide
EP2755549A1 (en) 2011-09-13 2014-07-23 Dose Medical Corporation Intraocular physiological sensor
JP5836851B2 (ja) * 2012-03-12 2015-12-24 株式会社トクヤマ ブリンゾラミドの製造方法
EP2638909A1 (en) 2012-03-15 2013-09-18 Azad Pharmaceutical Ingredients AG Process for preparing sterile Brinzolamide
JP5881514B2 (ja) * 2012-04-09 2016-03-09 株式会社トクヤマ アミン誘導体の製造方法
JP5914246B2 (ja) * 2012-08-10 2016-05-11 株式会社トクヤマ ブリンゾラミドの精製方法
CN102936236A (zh) * 2012-11-13 2013-02-20 江苏吉贝尔药业有限公司 一种布林佐胺中间体(3-乙酰基-5-氯-2-(苄基巯基)噻酚)的制备方法
US9730638B2 (en) 2013-03-13 2017-08-15 Glaukos Corporation Intraocular physiological sensor
US9801813B2 (en) 2013-10-17 2017-10-31 Sentiss Pharma Private Limited Preservative-free ophthalmic pharmaceutical formulation
US10463674B2 (en) 2013-11-08 2019-11-05 Sentiss Pharma Private Limited Process for manufacturing sterile ophthalmic pharmaceutical suspensions
US9820991B2 (en) 2013-11-08 2017-11-21 Sentiss Pharma Private Limited Pharmaceutical composition comprising brinzolamide
EP3096740B1 (en) * 2014-01-24 2020-09-30 Sentiss Pharma Private Limited Pharmaceutical composition comprising brinzolamide
UA124698C2 (uk) 2014-10-20 2021-11-03 Сентіс Фарма Прайвет Лімітед Офтальмологічний розчин
JP6192878B1 (ja) * 2015-12-10 2017-09-06 千寿製薬株式会社 眼科用医薬製品
WO2018118947A1 (en) 2016-12-21 2018-06-28 Biotheryx, Inc. Thienopyrrole derivatives for use in targeting proteins, compositions, methods, and uses thereof
JP2021521240A (ja) 2018-04-25 2021-08-26 シルパ メディケア リミテッドＳｈｉｌｐａ Ｍｅｄｉｃａｒｅ Ｌｉｍｉｔｅｄ ブリンゾラミドの眼科用組成物
WO2024236599A1 (en) 2023-05-16 2024-11-21 Micro Labs Limited Ophthalmic solution of brinzolamide

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA661731A (en) * 1963-04-23 Siedel Walter Substituted thiophene-3,5-disulfonamides and a process for preparing them
DE1096916B (de) * 1957-12-17 1961-01-12 Hoechst Ag Verfahren zur Herstellung von Thiophen-3, 5-disulfonamiden
GB1516024A (en) * 1977-04-20 1978-06-28 Pfizer Ltd Thiophene-2,5-disulphonamides
US4746745A (en) * 1980-07-09 1988-05-24 Maren Thomas H 1,3,4-thiadiazoline-5-sulfonamides
US4797413A (en) * 1986-05-14 1989-01-10 Merck & Co., Inc. Thieno thiopyran sulfonamide derivatives, pharmaceutical compositions and use
US4731368A (en) * 1986-12-08 1988-03-15 Merck & Co., Inc. Thienopyridine sulfonamides and their ophthalmological formulation
US4847289A (en) * 1987-06-08 1989-07-11 Merck & Co., Inc. Thiophene sulfonamide antiglaucoma agents
US5093332A (en) * 1990-10-01 1992-03-03 Merck & Co., Inc. Substituted thieno(2,3-b)(1,4)thiazine-6-sulfonamides as antiglaucoma agents

Also Published As

Publication number Publication date
FI924553A0 (fi) 1992-10-08
FI924553A7 (fi) 1992-10-08
US5240923A (en) 1993-08-31
KR100196414B1 (ko) 1999-06-15
NL300098I1 (nl) 2002-11-01
WO1991015486A1 (en) 1991-10-17
IL97800A (en) 1997-08-14
ES2180530T3 (es) 2003-02-16
CA2080223C (en) 2000-11-07
NZ237754A (en) 1992-08-26
CA2080223A1 (en) 1991-10-10
NO923948L (no) 1992-12-08
IL97800A0 (en) 1992-06-21
EP0527801A4 (en) 1993-03-10
KR930700490A (ko) 1993-03-15
BR9106330A (pt) 1993-04-20
LU91555I2 (fr) 2009-06-22
JP2562394B2 (ja) 1996-12-11
EP0527801B1 (en) 2002-07-31
AU7746791A (en) 1991-10-30
DE10299054I1 (de) 2006-06-08
DE69133080T2 (de) 2003-03-27
HK1014186A1 (en) 1999-09-24
FI963424A0 (fi) 1996-09-02
ZA912580B (en) 1992-01-29
EP0527801A1 (en) 1993-02-24
FI963424L (fi) 1996-09-02
NL300389I1 (nl) 2009-07-01
DE69133080D1 (de) 2002-09-05
FI924553L (fi) 1992-10-08
FI963424A7 (fi) 1996-09-02
DE122009000026I1 (de) 2010-01-28
NL300098I2 (nl) 2003-01-06
LU90935I2 (en) 2002-09-05
US5153192A (en) 1992-10-06
ATE221527T1 (de) 2002-08-15
AU655924B2 (en) 1995-01-19
NO923948D0 (no) 1992-10-09
JPH05508832A (ja) 1993-12-09

Similar Documents

Publication Publication Date Title
DK0527801T3 (da) Thiophensulfonamider, der er anvendelige som carboanhydraseinhibitorer
FI925615A0 (fi) Stabiliserade farmaceutiska kompositioner, som innehaoller en hmg-coa-reduktas-inhibitorfoerening
MX9200180A (es) DERIVADOS DE LA 5H-PIRROL (3,4-b) PIRAZINA OPTICAMENTE ACTIVOS, PROCEDIMIENTO PARA SU PREPARACION Y COMPOSICION FARMACEUTICA QUE LOS CONTIENE.
MX9704037A (es) 1,1-dioxidos de 1,2,5-tiadiazolidin-3-ona 2-substituida y composiciones y metodo de uso de los mismos.
KR910019620A (ko) 15-케토-프로스타글란딘 화합물을 사용한 췌장 질병의 치료
DK0479093T3 (da) Oligosaccharidderivater og deres anvendelse som lægemidler
NO911459D0 (no) Anvendelse av metallion-komplekser som belegginhibitorer.
MX9704034A (es) Derivados y composiciones de 1,1-dioxido de 2-arilcarboniloximetil-1,2,5-tiadiazolidin-3-ona substituido y metodo de uso.
DK436784A (da) Beta-butyrolacton-derivater, fremgangsmaade til deres fremstilling samt immunomodulerende midler indeholdende disse derivater som aktive bestanddele
ITMI912745A0 (it) Derivati 5h-benzodiazepinici, composizioni farmaceutiche che li contengono e procedimento per la loro preparazione.
DK0521353T3 (da) Lægemiddel med antineoplastisk virkning, der som virksomt stof indeholder octadecyl-(2-(N-metylpiperidino)-ethyl)-phosphat og fremgangsmåde til fremstilling deraf
DK0457215T3 (da) 3-deamino-4-desoxy-4-amino-8-fluoranthracycliner samt fremgangsmåder til fremstilling deraf
DK256689D0 (da) 1,2-dithiol-3-thion-s-oxid-forbindelser til anven delse som laegemidler
DK484784D0 (da) Hidtil ukendte 2-tolylmorpholinderivater, der er nyttige som farmaceutiske midler
LV10921A (lv) Jaunas farmaceitiskas kompozicijas
FI970318A0 (fi) Antiproliferatiivisina aineina ja Garft-inhibiitoreina käyttökelpoisia yhdisteitä
FI924088A0 (fi) Anvaendning av prostaglandin f3a som oegontryck saenkande medel.
NO901892D0 (no) Fremgangsmaate for fremstilling av (2,1-c)(1,3)-benzodiazepiner og deres anvendelse som medikamenter.
SE8503513D0 (sv) Farmaceutiska och kosmetiska kompositioner, vilka som verksam bestandsdel innehaller acetyl-10-triacetoxi-1,8,9-antracen
IT8022188A0 (it) Derivati nicotinici di glucosamina, procedimento per la preparazione e relative composizioni farmaceutiche.
ITMI931684A0 (it) Procedimento per la preparazione di derivati del 5,4- diidrocarbostirile
ITMI911535A1 (it) Derivati di una pirrolo-piridina, un procedimento per la loro preparazione e composizioni terapeutiche che li contengono.
IT8920570A0 (it) Procedimento di preparazione di derivati eterociclici.
SE8206217D0 (sv) N-substituerade ergolin- och 9,10-didehydro-ergolin-8-karboxamid- och -8-aminometyl-derivat, deras framstellning och farmaceutiska kompositioner derav
FI842101A7 (fi) Farmaseuttinen silmälääkekoostumus kohonneen silmänsisäisen paineen paikalliseen käsittelyyn.