DK0506778T3 - Substituerede 4-phenyl-4-piperidincarboxamider med både lokal anæstetisk og analgetisk virkning samt fremgangsmåder til deres fremstilling - Google Patents

Substituerede 4-phenyl-4-piperidincarboxamider med både lokal anæstetisk og analgetisk virkning samt fremgangsmåder til deres fremstilling

Info

Publication number: DK0506778T3
Authority: DK; Denmark
Prior art keywords: preparation; well; piperidinecarboxamides; phenyl; substituted
Prior art date: 1989-12-21

Application number

DK91901571.9T

Other languages

Danish (da)

English (en)

Inventor

Anna-Lena Ask

Rune Sandberg

Original Assignee

Astra Ab

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1989-12-21

Filing date

1990-12-17

Publication date

1996-10-07

1990-12-17 Application filed by Astra Ab filed Critical Astra Ab

1996-10-07 Application granted granted Critical

1996-10-07 Publication of DK0506778T3 publication Critical patent/DK0506778T3/da

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D211/60—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D211/62—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals attached in position 4
- C07D211/64—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals attached in position 4 having an aryl radical as the second substituent in position 4
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Pain & Pain Management (AREA)
Public Health (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Biomedical Technology (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Rheumatology (AREA)
Hydrogenated Pyridines (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Plural Heterocyclic Compounds (AREA)
Cosmetics (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

DK91901571.9T 1989-12-21 1990-12-17 Substituerede 4-phenyl-4-piperidincarboxamider med både lokal anæstetisk og analgetisk virkning samt fremgangsmåder til deres fremstilling DK0506778T3 (da)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
SE8904298A SE8904298D0 (sv)	1989-12-21	1989-12-21	New compounds

Publications (1)

Publication Number	Publication Date
DK0506778T3 true DK0506778T3 (da)	1996-10-07

Family

ID=20377821

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK91901571.9T DK0506778T3 (da)	1989-12-21	1990-12-17	Substituerede 4-phenyl-4-piperidincarboxamider med både lokal anæstetisk og analgetisk virkning samt fremgangsmåder til deres fremstilling

Country Status (40)

Country	Link
US (2)	US5227389A (fr)
EP (1)	EP0506778B1 (fr)
JP (1)	JP2656152B2 (fr)
KR (1)	KR0179382B1 (fr)
CN (1)	CN1037841C (fr)
AT (1)	ATE138650T1 (fr)
AU (1)	AU647068B2 (fr)
BG (1)	BG60912B1 (fr)
BR (1)	BR1100379A (fr)
CA (1)	CA2069608C (fr)
CZ (1)	CZ278035B6 (fr)
DE (1)	DE69027221T2 (fr)
DK (1)	DK0506778T3 (fr)
DZ (1)	DZ1468A1 (fr)
EG (1)	EG19361A (fr)
ES (1)	ES2087280T3 (fr)
FI (1)	FI100881B (fr)
HK (1)	HK22997A (fr)
HR (1)	HRP920591B1 (fr)
HU (1)	HU213110B (fr)
IE (1)	IE74855B1 (fr)
IL (1)	IL96636A (fr)
IS (1)	IS1664B (fr)
LT (1)	LT4005B (fr)
LV (2)	LV10949B (fr)
NO (1)	NO178858C (fr)
NZ (1)	NZ236293A (fr)
PL (1)	PL163591B1 (fr)
PT (1)	PT96303B (fr)
RO (1)	RO112864B1 (fr)
RU (1)	RU2039043C1 (fr)
SA (1)	SA91110209B1 (fr)
SE (1)	SE8904298D0 (fr)
SG (1)	SG46413A1 (fr)
SI (1)	SI9012346B (fr)
SK (1)	SK278283B6 (fr)
UA (1)	UA26403A (fr)
WO (1)	WO1991009845A1 (fr)
YU (1)	YU48086B (fr)
ZA (1)	ZA909903B (fr)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JP3916092B2 (ja) *	1993-09-17	2007-05-16	杏林製薬株式会社	イミダゾリジノン誘導体とその酸付加塩及び老年性痴呆症の治療薬
SE9400447D0 (sv) *	1994-02-11	1994-02-11	Astra Ab	New compounds
SE9404438D0 (sv) *	1994-12-21	1994-12-21	Astra Ab	New process
US5931809A (en)	1995-07-14	1999-08-03	Depotech Corporation	Epidural administration of therapeutic compounds with sustained rate of release
GB9600235D0 (en) *	1996-01-05	1996-03-06	Pfizer Ltd	Therapeutic agents
DE19642591A1 (de) *	1996-10-15	1998-04-16	Basf Ag	Neue Piperidin-Ketocarbonsäure-Derivate, deren Herstellung und Anwendung
TW548271B (en) *	1996-12-20	2003-08-21	Astra Pharma Inc	Novel piperidine derivatives having an exocyclic double bond with analgesic effects
SE9604786D0 (sv) *	1996-12-20	1996-12-20	Astra Pharma Inc	New compounds
RU2125878C1 (ru) *	1996-12-26	1999-02-10	Новокузнецкий научно-исследовательский химико-фармацевтический институт	Анальгетическое средство
RU2117481C1 (ru) *	1997-07-15	1998-08-20	Государственный научно-исследовательский институт органической химии и технологии	Анальгетическое средство и способ его приготовления
US7799337B2 (en)	1997-07-21	2010-09-21	Levin Bruce H	Method for directed intranasal administration of a composition
US20020102291A1 (en) *	1997-12-15	2002-08-01	Noven Pharmaceuticals, Inc.	Compositions and method for treatment of attention deficit disorder and attention deficit/hyperactivity disorder with methylphenidate
SE9803239D0 (sv) *	1998-09-24	1998-09-24	Diabact Ab	Composition for the treatment of acute pain
SE9803240D0 (sv) *	1998-09-24	1998-09-24	Diabact Ab	A pharmaceutical composition having a rapid action
AR035234A1 (es) *	2001-04-12	2004-05-05	Pharmacopeia Drug Discovery	Aril y biaril-piperidinas con actividad moduladora mch, metodo para preparar dichos compuestos, composiciones farmaceuticas, metodo para preparar las composiciones farmaceuticas y el uso de dichos compuestos para la manufactura de un medicamento
RU2203041C1 (ru) *	2001-12-27	2003-04-27	Закрытое акционерное общество "Брынцалов-А"	Спазмолитические таблетки бралангин
ATE496028T1 (de) *	2002-02-08	2011-02-15	Ono Pharmaceutical Co	Piperidinderivatverbindungen und arzneimittel, die diese verbindungen als wirkstoff enthalten
JP2006511554A (ja) *	2002-12-13	2006-04-06	スミスクラインビーチャムコーポレーション	Ｃｃｒ５アンタゴニストとしてのピペリジン誘導体
WO2008045564A2 (fr) *	2006-10-12	2008-04-17	Epix Delaware, Inc.	Composés de carboxamide et leur utilisation
CA2708364A1 (fr)	2007-12-11	2009-06-18	Efrat Ben-Zeev	Composes a base de carboxamide et leur utilisation en tant qu'agonistes du recepteur des chimiokines
US8473062B2 (en)	2008-05-01	2013-06-25	Autonomic Technologies, Inc.	Method and device for the treatment of headache
US8412336B2 (en)	2008-12-29	2013-04-02	Autonomic Technologies, Inc.	Integrated delivery and visualization tool for a neuromodulation system
US9320908B2 (en)	2009-01-15	2016-04-26	Autonomic Technologies, Inc.	Approval per use implanted neurostimulator
US8494641B2 (en)	2009-04-22	2013-07-23	Autonomic Technologies, Inc.	Implantable neurostimulator with integral hermetic electronic enclosure, circuit substrate, monolithic feed-through, lead assembly and anchoring mechanism
US20220096452A1 (en)	2019-01-22	2022-03-31	Icm (Institut Du Cerveau Et De La Moelle Épinière)	Local anesthetic for the treatment of neurological symptoms resulting from brain dysfunctions

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
SE96980C1 (fr)
US2486796A (en) *	1943-06-25	1949-11-01	Ciba Pharm Prod Inc	Esters of 1-alkyl-4-hydroxyphenylpiperidyl-4-ketones
US3334106A (en) *	1964-10-20	1967-08-01	Aldrich Chem Co Inc	N(aryl)n(hydrocarbyl)-omega-(4-phenyl-4-piperidinocarbonylheteroamine) alkanoamide
US3539580A (en) *	1967-06-26	1970-11-10	Janssen Pharm	4-aryl-4-aminoalkoxy-piperidines
CH501622A (de) *	1968-12-20	1971-01-15	Ciba Geigy Ag	Verfahren zur Herstellung von neuen Piperidinderivaten
US3737538A (en) *	1968-12-30	1973-06-05	Ciba Geigy Corp	Antitussive compositions and method with isonipecotic acid derivatives
FR2156470A2 (en) *	1971-10-21	1973-06-01	Synthelabo	1-(3,3-diphenyl-1-propyl)-4-aryl-piperidines - as analgesics spasmolytic and anti-tussive agents
ZA899436B (en) *	1988-12-12	1990-08-29	Ciba Geigy	Piperidine derivatives
US5100903A (en) *	1989-05-12	1992-03-31	Anaquest, Inc.	N-aryl-n-(1-substituted-3-alkoxy-4-piperidinyl)amides and pharmaceutical compositions and methods employing such compounds

1989
- 1989-12-21 SE SE8904298A patent/SE8904298D0/xx unknown
1990
- 1990-11-30 NZ NZ236293A patent/NZ236293A/xx unknown
- 1990-12-10 ZA ZA909903A patent/ZA909903B/xx unknown
- 1990-12-11 IL IL9663690A patent/IL96636A/en not_active IP Right Cessation
- 1990-12-12 SI SI9012346A patent/SI9012346B/sl not_active IP Right Cessation
- 1990-12-12 DZ DZ900223A patent/DZ1468A1/fr active
- 1990-12-12 YU YU234690A patent/YU48086B/sh unknown
- 1990-12-17 AU AU69783/91A patent/AU647068B2/en not_active Ceased
- 1990-12-17 EP EP91901571A patent/EP0506778B1/fr not_active Expired - Lifetime
- 1990-12-17 WO PCT/SE1990/000818 patent/WO1991009845A1/fr not_active Ceased
- 1990-12-17 UA UA5052485A patent/UA26403A/uk unknown
- 1990-12-17 IE IE453490A patent/IE74855B1/en not_active IP Right Cessation
- 1990-12-17 IS IS3659A patent/IS1664B/is unknown
- 1990-12-17 JP JP3501896A patent/JP2656152B2/ja not_active Expired - Fee Related
- 1990-12-17 AT AT91901571T patent/ATE138650T1/de not_active IP Right Cessation
- 1990-12-17 HU HU9202044A patent/HU213110B/hu unknown
- 1990-12-17 RO RO92-0832A patent/RO112864B1/ro unknown
- 1990-12-17 SG SG1996004491A patent/SG46413A1/en unknown
- 1990-12-17 DE DE69027221T patent/DE69027221T2/de not_active Expired - Fee Related
- 1990-12-17 ES ES91901571T patent/ES2087280T3/es not_active Expired - Lifetime
- 1990-12-17 KR KR1019920701484A patent/KR0179382B1/ko not_active Expired - Fee Related
- 1990-12-17 CA CA002069608A patent/CA2069608C/fr not_active Expired - Fee Related
- 1990-12-17 DK DK91901571.9T patent/DK0506778T3/da active
- 1990-12-20 PT PT96303A patent/PT96303B/pt active IP Right Grant
- 1990-12-20 EG EG74690A patent/EG19361A/xx active
- 1990-12-21 SK SK6581-90A patent/SK278283B6/sk unknown
- 1990-12-21 US US07/633,246 patent/US5227389A/en not_active Expired - Lifetime
- 1990-12-21 CN CN90106009A patent/CN1037841C/zh not_active Expired - Fee Related
- 1990-12-21 PL PL90288409A patent/PL163591B1/pl not_active IP Right Cessation
- 1990-12-21 CZ CS906581A patent/CZ278035B6/cs not_active IP Right Cessation
1991
- 1991-01-09 SA SA91110209A patent/SA91110209B1/ar unknown
1992
- 1992-06-17 NO NO922380A patent/NO178858C/no unknown
- 1992-06-17 FI FI922806A patent/FI100881B/fi not_active IP Right Cessation
- 1992-06-19 BG BG96513A patent/BG60912B1/bg unknown
- 1992-06-19 RU SU925052485A patent/RU2039043C1/ru not_active IP Right Cessation
- 1992-09-29 HR HRP-2346/90A patent/HRP920591B1/xx not_active IP Right Cessation
1993
- 1993-07-12 US US08/090,416 patent/US5360805A/en not_active Expired - Lifetime
- 1993-08-27 LV LVP-93-1042A patent/LV10949B/lv unknown
- 1993-12-30 LT LTIP1731A patent/LT4005B/lt not_active IP Right Cessation
1996
- 1996-07-17 LV LV960262A patent/LV5766B4/xx unknown
1997
- 1997-02-27 HK HK22997A patent/HK22997A/en not_active IP Right Cessation
- 1997-04-30 BR BR1100379-0A patent/BR1100379A/pt active IP Right Grant

Also Published As

Publication number	Publication date
US5360805A (en)	1994-11-01
LV10949A (lv)	1995-12-20
PL288409A1 (en)	1991-12-02
CN1053605A (zh)	1991-08-07
JP2656152B2 (ja)	1997-09-24
NO178858C (no)	1996-06-19
NO922380L (no)	1992-06-17
CA2069608A1 (fr)	1991-06-22
HRP920591B1 (en)	1998-12-31
HU9202044D0 (en)	1992-09-28
BG96513A (bg)	1993-12-24
SI9012346A (sl)	1998-08-31
DZ1468A1 (fr)	2004-09-13
PT96303A (pt)	1991-09-30
FI922806L (fi)	1992-06-17
IE74855B1 (en)	1997-08-13
CN1037841C (zh)	1998-03-25
PT96303B (pt)	1998-07-31
HK22997A (en)	1997-02-27
AU647068B2 (en)	1994-03-17
YU48086B (sh)	1997-01-08
JPH05502869A (ja)	1993-05-20
BR1100379A (pt)	1999-12-07
UA26403A (uk)	1999-08-30
FI100881B (fi)	1998-03-13
CZ278035B6 (en)	1993-07-14
HUT64518A (en)	1994-01-28
DE69027221D1 (de)	1996-07-04
FI922806A0 (fi)	1992-06-17
IL96636A (en)	1994-11-28
SK658190A3 (en)	1996-08-07
LV10949B (en)	1996-06-20
YU234690A (sh)	1993-10-20
ZA909903B (en)	1991-08-28
SI9012346B (sl)	1999-08-31
KR0179382B1 (ko)	1999-03-20
US5227389A (en)	1993-07-13
NO922380D0 (no)	1992-06-17
BG60912B1 (bg)	1996-06-28
CZ658190A3 (en)	1993-01-13
LV5766A4 (lv)	1996-12-20
IS3659A7 (is)	1991-06-22
SG46413A1 (en)	1998-02-20
ES2087280T3 (es)	1996-07-16
AU6978391A (en)	1991-07-24
EP0506778A1 (fr)	1992-10-07
WO1991009845A1 (fr)	1991-07-11
NZ236293A (en)	1992-10-28
KR927003531A (ko)	1992-12-18
IE904534A1 (en)	1991-07-03
HU213110B (en)	1997-02-28
CA2069608C (fr)	2001-07-10
SK278283B6 (en)	1996-08-07
SE8904298D0 (sv)	1989-12-21
LT4005B (en)	1996-07-25
IS1664B (is)	1997-07-04
LV5766B4 (lv)	1997-06-20
RO112864B1 (ro)	1998-01-30
NO178858B (no)	1996-03-11
SA91110209B1 (ar)	2004-05-08
RU2039043C1 (ru)	1995-07-09
LTIP1731A (en)	1995-07-25
PL163591B1 (pl)	1994-04-29
ATE138650T1 (de)	1996-06-15
EG19361A (en)	1994-12-30
EP0506778B1 (fr)	1996-05-29
IL96636A0 (en)	1991-09-16
HRP920591A2 (en)	1997-08-31
DE69027221T2 (de)	1996-10-10

Publication	Publication Date	Title
DK0506778T3 (da)	1996-10-07	Substituerede 4-phenyl-4-piperidincarboxamider med både lokal anæstetisk og analgetisk virkning samt fremgangsmåder til deres fremstilling
NO845250L (no)	1985-07-01	Pyridin-2-etere resp. pyridin-2-tioetere med en nitrogenholdig cykloalifatisk ring, samt fremgangsmaate til deres fremstilling
NO870241L (no)	1987-03-20	Hypoglykemiske tiazolidindioner.
DK0726899T3 (da)	2000-06-26	Nye pyrazincarboxamidderivater, deres fremstilling og deres anvendelse i lægemidler
FI962445A7 (fi)	1996-06-12	Paroksetiinitabletteja ja menetelmä niiden valmistamiseksi
DK53285D0 (da)	1985-02-06	(-)-trans-4(4-fluorphenyl)-3-(4-methoxyphenoxy)-methylpiperidin, farmaceutisk acceptable syreadditionssalte heraf og farmaceutisk praeparat indeholdende samme
DK0387821T3 (da)	1994-09-19	2-Alkyl-4-arylmethylchinoliner, deres anvendelse og lægemidler fremstillet hermed
NO306718B1 (no)	1999-12-13	Nye forbindelser med analgetisk og lokalanaestetisk effekt, farmasöytisk preparat inneholdende disse forbindelsene og deres anvendelse
NO874850D0 (no)	1987-11-20	Fremgangsmaate for fremstilling av benzotiadiazinforbindelser og farmasoeytisk akseptable salter derav.
EE9400296A (et)	1996-04-15	Piperidinüültioindooli derivaadid, ravimvormid, aktiivne valuvaigisti, nende valmistamise meetodid
NO881778D0 (no)	1988-04-22	Inkastiner: nye glykopeptider med enkefalinase-hemmende virkning. fremgangsmaate til deres fremstilling og deres anvendelse som farmasoeytiske preparater.
DK222588D0 (da)	1988-04-22	5-quinoxalyl-imidazolidin-2,4-dioner, deres fremstilling og anvendelse som laegemidler
SE9401596D0 (sv)	1994-05-06	New compounds
SE8900685D0 (sv)	1989-02-28	New compounds
JO1658B1 (en)	1991-11-27	New vehicles
DK549085A (da)	1985-11-27	3-aminopropoxyphenylderivater, fremgangsmaade til fremstilling deraf og farmaceutiske praeparater, som indeholder disse derivater
JO1652B1 (en)	1991-11-27	New compounds for local anesthesia and a way to prepare them
DK98788A (da)	1988-08-27	Benzylaminoaryl-dihydropyridinlactoner, fremgangmsaade til deres fremstilling samt deres anvendelse som laegemidler
DK222886D0 (da)	1986-05-14	Propionylanilider, fremgangsmaade til fremstilling heraf og farmaceutiske praeparater indeholdende disse forbindelser