DK0599890T3 - Geneserinderivater som cholinesteraseinhibitorer - Google Patents
Geneserinderivater som cholinesteraseinhibitorerInfo
- Publication number
- DK0599890T3 DK0599890T3 DK92916772.4T DK92916772T DK0599890T3 DK 0599890 T3 DK0599890 T3 DK 0599890T3 DK 92916772 T DK92916772 T DK 92916772T DK 0599890 T3 DK0599890 T3 DK 0599890T3
- Authority
- DK
- Denmark
- Prior art keywords
- pct
- group
- sec
- geneserine
- derivatives
- Prior art date
Links
- 239000000544 cholinesterase inhibitor Substances 0.000 title abstract 2
- CNBHDDBNEKKMJH-ZFWWWQNUSA-N Eseridine Chemical class O1N(C)CC[C@@]2(C)C3=CC(OC(=O)NC)=CC=C3N(C)[C@H]21 CNBHDDBNEKKMJH-ZFWWWQNUSA-N 0.000 title 1
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 abstract 2
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 2
- 125000004178 (C1-C4) alkyl group Chemical group 0.000 abstract 1
- 125000000229 (C1-C4)alkoxy group Chemical group 0.000 abstract 1
- 125000006755 (C2-C20) alkyl group Chemical group 0.000 abstract 1
- 208000024827 Alzheimer disease Diseases 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 125000005843 halogen group Chemical group 0.000 abstract 1
- 230000004776 neurological deficiency Effects 0.000 abstract 1
- 231100000252 nontoxic Toxicity 0.000 abstract 1
- 230000003000 nontoxic effect Effects 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D498/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Veterinary Medicine (AREA)
- Neurosurgery (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biomedical Technology (AREA)
- Medicinal Chemistry (AREA)
- Neurology (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Steroid Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Pyrane Compounds (AREA)
- Saccharide Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ITMI912237A IT1251166B (it) | 1991-08-09 | 1991-08-09 | Derivati di geneserina,loro preparazione e composizioni farmaceutiche che li contengono |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK0599890T3 true DK0599890T3 (da) | 1997-10-20 |
Family
ID=11360556
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK92916772.4T DK0599890T3 (da) | 1991-08-09 | 1992-08-04 | Geneserinderivater som cholinesteraseinhibitorer |
Country Status (20)
| Country | Link |
|---|---|
| US (1) | US5538968A (fr) |
| EP (1) | EP0599890B1 (fr) |
| JP (1) | JP3172185B2 (fr) |
| KR (1) | KR100225927B1 (fr) |
| AT (1) | ATE151426T1 (fr) |
| AU (1) | AU659865B2 (fr) |
| CA (1) | CA2115250A1 (fr) |
| CZ (1) | CZ281018B6 (fr) |
| DE (1) | DE69218949T2 (fr) |
| DK (1) | DK0599890T3 (fr) |
| ES (1) | ES2101858T3 (fr) |
| FI (1) | FI107532B (fr) |
| GR (1) | GR3023838T3 (fr) |
| HK (1) | HK1006714A1 (fr) |
| HU (1) | HU222774B1 (fr) |
| IT (1) | IT1251166B (fr) |
| NO (1) | NO303175B1 (fr) |
| NZ (1) | NZ243869A (fr) |
| WO (1) | WO1993003041A1 (fr) |
| ZA (1) | ZA925903B (fr) |
Families Citing this family (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IT1273349B (it) * | 1994-02-28 | 1997-07-08 | Getters Spa | Visualizzatore piatto ad emissione di campo contenente un getter e procedimento per il suo ottenimento |
| CN1278264A (zh) * | 1997-10-10 | 2000-12-27 | 奇斯药制品公司 | 制备具有选择性脑抗胆碱酯酶活性的金丝灵氨基羰基衍生物的方法 |
| DE19853487A1 (de) * | 1998-11-19 | 2000-05-25 | Fumapharm Ag Muri | Verwendung von Dialkylfumaraten |
| DE10000577A1 (de) * | 2000-01-10 | 2001-07-26 | Fumapharm Ag Muri | Verwendung von Fumarsäurederivaten zur Behandlung mitochondrialer Krankheiten |
| DE10101307A1 (de) * | 2001-01-12 | 2002-08-01 | Fumapharm Ag Muri | Fumarsäurederivate als NF-kappaB-Inhibitor |
| CZ304198B6 (cs) * | 2001-01-12 | 2013-12-27 | Fumapharm Ag | Amidy kyseliny fumarové |
| ATE380027T1 (de) | 2003-09-09 | 2007-12-15 | Fumapharm Ag | Verwendung von fumarsäure-derivaten zur behandlung von herzinsuffizienz und asthma |
| US7795307B2 (en) * | 2003-10-21 | 2010-09-14 | Colucid Pharmaceuticals, Inc. | Carbamoyl esters that inhibit cholinesterase and release pharmacologically active agents |
| WO2008097546A2 (fr) * | 2007-02-02 | 2008-08-14 | Colucid Pharmaceuticals, Inc. | Composés inhibiteurs de cholinestérase |
| HRP20220902T3 (hr) | 2007-02-08 | 2022-10-14 | Biogen Ma Inc. | Pripravci i njihova upotreba u liječenju multiple skleroze |
| US20100130607A1 (en) * | 2007-02-08 | 2010-05-27 | Ralf Gold | Neuroprotection in demyelinating diseases |
| CN101795683A (zh) * | 2007-07-18 | 2010-08-04 | 科露西德医药品公司 | 用于促进警醒症的方法 |
| US8593728B2 (en) * | 2009-02-19 | 2013-11-26 | Toyota Motor Engineering & Manufacturing North America, Inc. | Multilayer photonic structures |
| CA2789014C (fr) | 2010-02-09 | 2019-01-15 | Michela Gallagher | Procedes et compositions pour ameliorer la fonction cognitive |
| US20140206667A1 (en) | 2012-11-14 | 2014-07-24 | Michela Gallagher | Methods and compositions for treating schizophrenia |
| US8669281B1 (en) | 2013-03-14 | 2014-03-11 | Alkermes Pharma Ireland Limited | Prodrugs of fumarates and their use in treating various diseases |
| ES2955137T3 (es) | 2013-03-14 | 2023-11-28 | Alkermes Pharma Ireland Ltd | Profármacos de fumaratos y su uso en el tratamiento de diversas enfermedades |
| WO2014144663A1 (fr) | 2013-03-15 | 2014-09-18 | The Johns Hopkins University | Procédés et compositions pour améliorer la fonction cognitive |
| CN105142623A (zh) | 2013-03-15 | 2015-12-09 | 艾吉因生物股份有限公司 | 用于改善认知功能的方法和组合物 |
| AU2015218587B2 (en) | 2014-02-24 | 2017-04-27 | Alkermes Pharma Ireland Limited | Sulfonamide and sulfinamide prodrugs of fumarates and their use in treating various diseases |
| JP6899043B2 (ja) | 2015-05-22 | 2021-07-07 | エージンバイオ， インコーポレイテッド | レベチラセタムの持続放出性医薬組成物 |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2374908A1 (fr) * | 1976-12-21 | 1978-07-21 | Theranol Lab | Medicament constitue par l'association optimale d'une substance vagomimetique, le salicylate d'amine-oxyde d'eserine, et d'une substance potentialisant la secretion gastrique, le chlorhydrate d'acide glutamique |
| IT1199076B (it) * | 1984-03-01 | 1988-12-30 | Consiglio Nazionale Ricerche | Derivati della fisostigmina con proprieta'di inibizione della aceticolinesterasi e relativo procedimento di produzione |
| IT1225462B (it) * | 1987-04-03 | 1990-11-14 | Mediolanum Farmaceutici Srl | Sali organici di derivati della fisostigmina |
-
1991
- 1991-08-09 IT ITMI912237A patent/IT1251166B/it active IP Right Grant
-
1992
- 1992-08-04 HU HU9400353A patent/HU222774B1/hu not_active IP Right Cessation
- 1992-08-04 EP EP92916772A patent/EP0599890B1/fr not_active Expired - Lifetime
- 1992-08-04 DK DK92916772.4T patent/DK0599890T3/da active
- 1992-08-04 CZ CZ94262A patent/CZ281018B6/cs not_active IP Right Cessation
- 1992-08-04 ES ES92916772T patent/ES2101858T3/es not_active Expired - Lifetime
- 1992-08-04 CA CA002115250A patent/CA2115250A1/fr not_active Abandoned
- 1992-08-04 WO PCT/EP1992/001762 patent/WO1993003041A1/fr not_active Ceased
- 1992-08-04 HK HK98106098A patent/HK1006714A1/en not_active IP Right Cessation
- 1992-08-04 AT AT92916772T patent/ATE151426T1/de not_active IP Right Cessation
- 1992-08-04 US US08/193,154 patent/US5538968A/en not_active Expired - Fee Related
- 1992-08-04 DE DE69218949T patent/DE69218949T2/de not_active Expired - Fee Related
- 1992-08-04 AU AU23876/92A patent/AU659865B2/en not_active Ceased
- 1992-08-04 KR KR1019940700410A patent/KR100225927B1/ko not_active Expired - Fee Related
- 1992-08-04 JP JP50327893A patent/JP3172185B2/ja not_active Expired - Fee Related
- 1992-08-06 ZA ZA925903A patent/ZA925903B/xx unknown
- 1992-08-06 NZ NZ243869A patent/NZ243869A/en unknown
-
1994
- 1994-02-08 FI FI940573A patent/FI107532B/fi active
- 1994-02-08 NO NO940415A patent/NO303175B1/no unknown
-
1997
- 1997-06-19 GR GR970401476T patent/GR3023838T3/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| JP3172185B2 (ja) | 2001-06-04 |
| HU222774B1 (hu) | 2003-10-28 |
| FI940573A0 (fi) | 1994-02-08 |
| JPH06509572A (ja) | 1994-10-27 |
| ES2101858T3 (es) | 1997-07-16 |
| US5538968A (en) | 1996-07-23 |
| CZ281018B6 (cs) | 1996-05-15 |
| WO1993003041A1 (fr) | 1993-02-18 |
| NO940415D0 (no) | 1994-02-08 |
| ITMI912237A0 (it) | 1991-08-09 |
| NO940415L (no) | 1994-04-06 |
| ITMI912237A1 (it) | 1993-02-09 |
| NZ243869A (en) | 1994-03-25 |
| HU9400353D0 (en) | 1994-06-28 |
| AU659865B2 (en) | 1995-06-01 |
| FI940573L (fi) | 1994-03-28 |
| AU2387692A (en) | 1993-03-02 |
| GR3023838T3 (en) | 1997-09-30 |
| HK1006714A1 (en) | 1999-03-12 |
| ZA925903B (en) | 1993-04-28 |
| KR100225927B1 (ko) | 1999-10-15 |
| EP0599890B1 (fr) | 1997-04-09 |
| HUT70414A (en) | 1995-10-30 |
| NO303175B1 (no) | 1998-06-08 |
| FI107532B (fi) | 2001-08-31 |
| DE69218949D1 (de) | 1997-05-15 |
| EP0599890A1 (fr) | 1994-06-08 |
| IT1251166B (it) | 1995-05-04 |
| CA2115250A1 (fr) | 1993-02-18 |
| ATE151426T1 (de) | 1997-04-15 |
| CZ26294A3 (en) | 1994-07-13 |
| DE69218949T2 (de) | 1997-09-18 |
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