DK0596929T3 - Amidderivater af antibiotikum A 40926 - Google Patents

Amidderivater af antibiotikum A 40926

Info

Publication number: DK0596929T3
Authority: DK; Denmark
Prior art keywords: antibiotic; amide derivatives; alkylaminocarbonyl; substituent; staplylococci
Prior art date: 1991-07-29

Application number

DK92915890.5T

Other languages

English (en)

Inventor

Adriano Malabarba

Romeo Ciabatti

Gianbattista Panzone

Alessandra Maria Marazzi

Original Assignee

Lepetit Spa

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1991-07-29

Filing date

1992-07-14

Publication date

1995-09-11

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=26128958&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DK0596929(T3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

1992-07-14 Application filed by Lepetit Spa filed Critical Lepetit Spa

1995-09-11 Application granted granted Critical

1995-09-11 Publication of DK0596929T3 publication Critical patent/DK0596929T3/da

Links

-1 Amide derivatives of antibiotic A 40926 Chemical class 0.000 title 1
125000004457 alkyl amino carbonyl group Chemical group 0.000 abstract 2
BEVDFPMXVNOQBI-AXNWEOKVSA-N (19R,22R,34S,37R,40R,52S)-64-[(2S,3R,4R,5S,6S)-3-amino-6-carboxy-4,5-dihydroxyoxan-2-yl]oxy-5,32-dichloro-2,26,31,49-tetrahydroxy-22-(methylamino)-21,35,38,54,56,59-hexaoxo-47-[(2R,3S,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-7,13,28-trioxa-20,36,39,53,55,58-hexazaundecacyclo[38.14.2.23,6.214,17.219,34.18,12.123,27.129,33.141,45.010,37.046,51]hexahexaconta-3,5,8,10,12(64),14(63),15,17(62),23(61),24,26,29(60),30,32,41,43,45(57),46(51),47,49,65-henicosaene-52-carboxylic acid Chemical class CN[C@@H]1c2ccc(O)c(Oc3cc(O)c(Cl)c(c3)[C@@H]3NC(=O)[C@@H](Cc4ccc(Oc5cc6cc(Oc7ccc(cc7Cl)C(O)C7NC(=O)[C@H](NC(=O)[C@@H]6NC3=O)c3cccc(c3)-c3c(O[C@H]6O[C@H](CO)[C@@H](O)[C@H](O)[C@@H]6O)cc(O)cc3[C@H](NC7=O)C(O)=O)c5O[C@@H]3O[C@@H]([C@@H](O)[C@H](O)[C@H]3N)C(O)=O)cc4)NC1=O)c2 BEVDFPMXVNOQBI-AXNWEOKVSA-N 0.000 abstract 1
DQJCDTNMLBYVAY-ZXXIYAEKSA-N (2S,5R,10R,13R)-16-{[(2R,3S,4R,5R)-3-{[(2S,3R,4R,5S,6R)-3-acetamido-4,5-dihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy}-5-(ethylamino)-6-hydroxy-2-(hydroxymethyl)oxan-4-yl]oxy}-5-(4-aminobutyl)-10-carbamoyl-2,13-dimethyl-4,7,12,15-tetraoxo-3,6,11,14-tetraazaheptadecan-1-oic acid Chemical compound NCCCC[C@H](C(=O)N[C@@H](C)C(O)=O)NC(=O)CC[C@H](C(N)=O)NC(=O)[C@@H](C)NC(=O)C(C)O[C@@H]1[C@@H](NCC)C(O)O[C@H](CO)[C@H]1O[C@H]1[C@H](NC(C)=O)[C@@H](O)[C@H](O)[C@@H](CO)O1 DQJCDTNMLBYVAY-ZXXIYAEKSA-N 0.000 abstract 1
102000002068 Glycopeptides Human genes 0.000 abstract 1
108010015899 Glycopeptides Proteins 0.000 abstract 1
125000004453 alkoxycarbonyl group Chemical group 0.000 abstract 1
125000003917 carbamoyl group Chemical group [H]N([H])C(*)=O 0.000 abstract 1
125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 1
150000001875 compounds Chemical class 0.000 abstract 1
230000000694 effects Effects 0.000 abstract 1
125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
125000004029 hydroxymethyl group Chemical group [H]OC([H])([H])* 0.000 abstract 1
238000000338 in vitro Methods 0.000 abstract 1
229920000768 polyamine Chemical group 0.000 abstract 1
125000001424 substituent group Chemical group 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K9/00—Peptides having up to 20 amino acids, containing saccharide radicals and having a fully defined sequence; Derivatives thereof
- C07K9/006—Peptides having up to 20 amino acids, containing saccharide radicals and having a fully defined sequence; Derivatives thereof the peptide sequence being part of a ring structure
- C07K9/008—Peptides having up to 20 amino acids, containing saccharide radicals and having a fully defined sequence; Derivatives thereof the peptide sequence being part of a ring structure directly attached to a hetero atom of the saccharide radical, e.g. actaplanin, avoparcin, ristomycin, vancomycin
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Organic Chemistry (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Veterinary Medicine (AREA)
Genetics & Genomics (AREA)
Oncology (AREA)
Pharmacology & Pharmacy (AREA)
General Chemical & Material Sciences (AREA)
Animal Behavior & Ethology (AREA)
Communicable Diseases (AREA)
Public Health (AREA)
Chemical Kinetics & Catalysis (AREA)
Biochemistry (AREA)
Biophysics (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Molecular Biology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Saccharide Compounds (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Peptides Or Proteins (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Cephalosporin Compounds (AREA)
Medicines Containing Material From Animals Or Micro-Organisms (AREA)

DK92915890.5T 1991-07-29 1992-07-14 Amidderivater af antibiotikum A 40926 DK0596929T3 (da)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
EP91112685		1991-07-29
EP92109906		1992-06-12

Publications (1)

Publication Number	Publication Date
DK0596929T3 true DK0596929T3 (da)	1995-09-11

Family

ID=26128958

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK92915890.5T DK0596929T3 (da)	1991-07-29	1992-07-14	Amidderivater af antibiotikum A 40926

Country Status (24)

Country	Link
EP (2)	EP0525499A1 (da)
JP (1)	JP3418762B2 (da)
KR (1)	KR100242682B1 (da)
AT (1)	ATE125551T1 (da)
AU (1)	AU666862B2 (da)
BG (1)	BG61124B2 (da)
CA (1)	CA2109601C (da)
CZ (1)	CZ285703B6 (da)
DE (1)	DE69203724T2 (da)
DK (1)	DK0596929T3 (da)
ES (1)	ES2075709T3 (da)
FI (1)	FI112662B (da)
GR (1)	GR3017897T3 (da)
HU (2)	HU223946B1 (da)
IE (1)	IE68420B1 (da)
IL (1)	IL102623A (da)
MX (1)	MX9204394A (da)
NO (1)	NO314150B1 (da)
NZ (1)	NZ243735A (da)
PL (1)	PL171813B1 (da)
RU (1)	RU2125058C1 (da)
TW (1)	TW218021B (da)
UA (1)	UA41283C2 (da)
WO (1)	WO1993003060A1 (da)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5606036A (en) *	1991-03-27	1997-02-25	Gruppo Lepetit Spa	Antibiotic A 40926 ester derivatives
US5840684A (en) *	1994-01-28	1998-11-24	Eli Lilly And Company	Glycopeptide antibiotic derivatives
MY128335A (en) *	1994-01-28	2007-01-31	Lilly Co Eli	Glycopeptide antibiotic derivatives
EP0836619B1 (en) *	1995-07-05	2004-08-25	AVENTIS BULK S.p.A.	Purification of dalbaheptide antibiotics by isoelectric focusing
IL126430A0 (en)	1996-04-23	1999-08-17	Biosearch Italia Spa	Improved chemical process for preparing amide derivatives of antibiotic a 40926
US6004959A (en) *	1996-05-30	1999-12-21	Hoechst Marion Roussel, Inc.	Alkyloxyamino substituted fluorenones and their use as protein kinase-C inhibitors
DE69908819T2 (de)	1998-12-23	2004-05-06	Theravance, Inc., South San Francisco	Glycopeptid-derivate und pharmazeutische zusammensetzungen, die sie enthalten
AR021964A1 (es) *	1998-12-23	2002-09-04	Theravance Inc	Un compuesto glicopeptidico, composiciones farmaceuticas que los contienen y uso de dichos compuestos glicopeptidicos para la manufactura de un medicamento antibacteriano.
TWI275594B (en)	2001-08-24	2007-03-11	Theravance Inc	Process for preparing vancomycin phosphonate derivatives
TWI312785B (en)	2001-08-24	2009-08-01	Theravance Inc	Process for preparing vancomycin derivatives
KR100478533B1 (ko) *	2002-07-30	2005-03-28	한국수력원자력 주식회사	레이저를 이용한 탈륨 동위원소 분리방법
MXPA05005338A (es)	2002-11-18	2005-12-14	Vicuron Pharm Inc	Metodos para administrar dalbavancin para el tratamiento de infecciones bacterianas.
US7119061B2 (en) *	2002-11-18	2006-10-10	Vicuron Pharmaceuticals, Inc.	Dalbavancin compositions for treatment of bacterial infections
US20060074014A1 (en)	2002-11-18	2006-04-06	Vicuron Pharmaceuticals Inc.	Dalbavancin compositions for treatment of bacterial infections
WO2004110473A1 (en)	2003-05-27	2004-12-23	Theravance, Inc.	Use of a polyene macrolide antifungal agent in combination with a glycopeptide antibacterial agent
ES2298821T3 (es)	2003-07-22	2008-05-16	Theravance, Inc.	Utilizacion de un agente antifungico de equinocandina en combinacion con un agente antibacteriano glicopeptidico.
US8778874B2 (en)	2004-11-29	2014-07-15	National University Corporation Nagoya University	Glycopeptide antibiotic monomer derivatives
TW200808818A (en)	2006-05-26	2008-02-16	Shionogi & Co	Glycopeptide antibiotic derivatives
JP5517153B2 (ja)	2007-12-26	2014-06-11	塩野義製薬株式会社	グリコペプチド抗生物質配糖化誘導体
WO2022148868A1 (en) *	2021-01-11	2022-07-14	Xellia Pharmaceuticals Aps	Synthesis process

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB8608809D0 (en) *	1986-04-11	1986-05-14	Lepetit Spa	Antibiotic
GB8726859D0 (en) *	1987-11-17	1987-12-23	Lepetit Spa	22-dechlorotei-coplanins
ATE134646T1 (de) *	1988-12-27	1996-03-15	Lepetit Spa	C63-amidderivate von 34-de(acetylglucosaminyl)-34-deoxy-teicoplanine
GB2231846B (en) *	1989-05-25	1993-02-24	Hadlum Brothers Ltd	A hand held carrier
WO1992010516A1 (en) *	1990-12-05	1992-06-25	Gruppo Lepetit S.P.A.	38-decarboxy-38-hydroxymethyl derivatives of teicoplanin antibiotics, and a process for preparing them
KR100209971B1 (ko) *	1991-03-27	1999-07-15	클라우디오 쿼르타	항생제 a 40926 에스테르 유도체

1992
- 1992-07-14 KR KR1019940700273A patent/KR100242682B1/ko not_active Expired - Fee Related
- 1992-07-14 HU HU9400256A patent/HU223946B1/hu not_active IP Right Cessation
- 1992-07-14 EP EP92111932A patent/EP0525499A1/en active Pending
- 1992-07-14 CA CA002109601A patent/CA2109601C/en not_active Expired - Fee Related
- 1992-07-14 UA UA94005300A patent/UA41283C2/uk unknown
- 1992-07-14 DE DE69203724T patent/DE69203724T2/de not_active Expired - Fee Related
- 1992-07-14 EP EP92915890A patent/EP0596929B1/en not_active Expired - Lifetime
- 1992-07-14 ES ES92915890T patent/ES2075709T3/es not_active Expired - Lifetime
- 1992-07-14 DK DK92915890.5T patent/DK0596929T3/da active
- 1992-07-14 AU AU23262/92A patent/AU666862B2/en not_active Ceased
- 1992-07-14 CZ CZ94192A patent/CZ285703B6/cs not_active IP Right Cessation
- 1992-07-14 PL PL92302285A patent/PL171813B1/pl not_active IP Right Cessation
- 1992-07-14 JP JP50320293A patent/JP3418762B2/ja not_active Expired - Fee Related
- 1992-07-14 AT AT92915890T patent/ATE125551T1/de not_active IP Right Cessation
- 1992-07-14 WO PCT/EP1992/001594 patent/WO1993003060A1/en active IP Right Grant
- 1992-07-14 RU RU94013457A patent/RU2125058C1/ru not_active IP Right Cessation
- 1992-07-17 TW TW081105668A patent/TW218021B/zh not_active IP Right Cessation
- 1992-07-23 IL IL10262392A patent/IL102623A/en not_active IP Right Cessation
- 1992-07-27 MX MX9204394A patent/MX9204394A/es not_active IP Right Cessation
- 1992-07-27 NZ NZ243735A patent/NZ243735A/xx unknown
- 1992-07-28 IE IE922451A patent/IE68420B1/en not_active IP Right Cessation
1993
- 1993-12-20 NO NO19934722A patent/NO314150B1/no not_active IP Right Cessation
1994
- 1994-01-26 FI FI940394A patent/FI112662B/fi active
- 1994-02-25 BG BG098582A patent/BG61124B2/bg unknown
1995
- 1995-06-19 HU HU95P/P00252P patent/HU211347A9/hu unknown
- 1995-10-26 GR GR950402996T patent/GR3017897T3/el unknown

Also Published As

Publication number	Publication date
DE69203724D1 (de)	1995-08-31
GR3017897T3 (en)	1996-01-31
CZ285703B6 (cs)	1999-10-13
DE69203724T2 (de)	1996-01-18
CZ19294A3 (en)	1994-11-16
JPH06509347A (ja)	1994-10-20
EP0525499A1 (en)	1993-02-03
HUT66080A (en)	1994-09-28
AU666862B2 (en)	1996-02-29
MX9204394A (es)	1993-01-29
IE922451A1 (en)	1993-02-10
WO1993003060A1 (en)	1993-02-18
CA2109601A1 (en)	1993-02-18
UA41283C2 (uk)	2001-09-17
ATE125551T1 (de)	1995-08-15
KR100242682B1 (ko)	2000-02-01
NO934722D0 (no)	1993-12-20
CA2109601C (en)	2002-07-02
EP0596929A1 (en)	1994-05-18
NO314150B1 (no)	2003-02-03
IE68420B1 (en)	1996-06-12
BG61124B2 (bg)	1996-11-29
NO934722L (no)	1994-02-14
AU2326292A (en)	1993-03-02
FI112662B (fi)	2003-12-31
RU2125058C1 (ru)	1999-01-20
HU223946B1 (hu)	2005-03-29
TW218021B (da)	1993-12-21
JP3418762B2 (ja)	2003-06-23
ES2075709T3 (es)	1995-10-01
IL102623A0 (en)	1993-01-14
NZ243735A (en)	1995-01-27
FI940394L (fi)	1994-01-26
IL102623A (en)	1996-10-16
HU9400256D0 (en)	1994-05-30
EP0596929B1 (en)	1995-07-26
HU211347A9 (en)	1995-11-28
FI940394A0 (fi)	1994-01-26
PL171813B1 (pl)	1997-06-30

Publication	Publication Date	Title
DK0596929T3 (da)	1995-09-11	Amidderivater af antibiotikum A 40926
ATE282630T1 (de)	2004-12-15	Dolastatin-derivate
ATE190983T1 (de)	2000-04-15	Neue tetrapeptidderivate
NO2006018I1 (no)	2006-12-27	Entekavir:(2-amino-1,9-dihydro-9Ä(1S,3R,4S)-4hydroksy-3-(hydroksymetyl)-2-metylencyklopentylÜ-6H-purin-6-on og hydrater derav, saerlig monohydrat
DK0706393T3 (da)	2000-04-03	Immun-undertrykkende og antiallergiske forbindelser, f.eks. N-(3-oxohexanoyl)homoserin-lacton
ATE157368T1 (de)	1997-09-15	6-0-methylerythromycin a-derivat
RU94013457A (ru)	1995-09-10	Амидные производные антибиотика а 40926
KR930700485A (ko)	1993-03-15	피리미딘 뉴클레오시드 유도체
ATE110382T1 (de)	1994-09-15	Oxetanocin.
DK0451547T3 (da)	1993-12-29	1,4,8-triazacyclotridecanderivater med prolylendopeptidase inhiberende aktivitet
BG102647A (en)	1999-04-30	Acyclic nucleoside derivatives
ES2169220T3 (es)	2002-07-01	Derivados de vitamina d3 con sustituyentes en la posicion 2.
DE69423339D1 (de)	2000-04-13	Epoxycyclohexendionderivat
ATE90685T1 (de)	1993-07-15	Disaccharidderivate.
FI963568A0 (fi)	1996-09-10	Peptidijohdannaisia
DE69017763D1 (de)	1995-04-20	Angolamycin-Derivate.