DK0581904T3 - Fremgangsmåde til inhibering af fibrose - Google Patents
Fremgangsmåde til inhibering af fibroseInfo
- Publication number
- DK0581904T3 DK0581904T3 DK92917284.9T DK92917284T DK0581904T3 DK 0581904 T3 DK0581904 T3 DK 0581904T3 DK 92917284 T DK92917284 T DK 92917284T DK 0581904 T3 DK0581904 T3 DK 0581904T3
- Authority
- DK
- Denmark
- Prior art keywords
- formula
- fibrosis
- alkyl
- hydrogen
- compound
- Prior art date
Links
- 206010016654 Fibrosis Diseases 0.000 title abstract 3
- 230000004761 fibrosis Effects 0.000 title abstract 3
- 230000002401 inhibitory effect Effects 0.000 title abstract 3
- 238000000034 method Methods 0.000 title abstract 3
- 150000001875 compounds Chemical class 0.000 abstract 3
- 125000004178 (C1-C4) alkyl group Chemical group 0.000 abstract 2
- 229910052739 hydrogen Inorganic materials 0.000 abstract 2
- 239000001257 hydrogen Substances 0.000 abstract 2
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 2
- WARCRYXKINZHGQ-UHFFFAOYSA-N benzohydrazide Chemical compound NNC(=O)C1=CC=CC=C1 WARCRYXKINZHGQ-UHFFFAOYSA-N 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 208000035475 disorder Diseases 0.000 abstract 1
- -1 hydroxy, amino Chemical group 0.000 abstract 1
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
- A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
- A61K31/17—Amides, e.g. hydroxamic acids having the group >N—C(O)—N< or >N—C(S)—N<, e.g. urea, thiourea, carmustine
- A61K31/175—Amides, e.g. hydroxamic acids having the group >N—C(O)—N< or >N—C(S)—N<, e.g. urea, thiourea, carmustine having the group, >N—C(O)—N=N— or, e.g. carbonohydrazides, carbazones, semicarbazides, semicarbazones; Thioanalogues thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
Landscapes
- Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Hematology (AREA)
- Diabetes (AREA)
- Dermatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Mechanical Treatment Of Semiconductor (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Electrical Discharge Machining, Electrochemical Machining, And Combined Machining (AREA)
- Saccharide Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US67847291A | 1991-04-01 | 1991-04-01 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK0581904T3 true DK0581904T3 (da) | 1997-12-29 |
Family
ID=24722926
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK92917284.9T DK0581904T3 (da) | 1991-04-01 | 1992-03-31 | Fremgangsmåde til inhibering af fibrose |
Country Status (11)
| Country | Link |
|---|---|
| US (2) | US5374660A (da) |
| EP (1) | EP0581904B1 (da) |
| JP (1) | JPH06506471A (da) |
| AT (1) | ATE153500T1 (da) |
| AU (1) | AU652644B2 (da) |
| CA (1) | CA2107371A1 (da) |
| DE (1) | DE69220050T2 (da) |
| DK (1) | DK0581904T3 (da) |
| ES (1) | ES2104938T3 (da) |
| GR (1) | GR3024548T3 (da) |
| WO (1) | WO1992017065A2 (da) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0581904B1 (en) * | 1991-04-01 | 1997-05-28 | Duke University | Method of inhibiting fibrosis |
| US5645839A (en) * | 1995-06-07 | 1997-07-08 | Trustees Of Boston University | Combined use of angiotensin inhibitors and nitric oxide stimulators to treat fibrosis |
| US6117445A (en) * | 1998-01-28 | 2000-09-12 | Link Technology Inc. | Methods for the prevention and treatment of fibrosis and sclerosis |
| PT1734970E (pt) | 2004-03-12 | 2015-03-11 | Intercept Pharmaceuticals Inc | Tratamento de fibrose utilizando ligandos de rfx |
| AT509045B1 (de) | 2010-01-29 | 2011-06-15 | Planta Naturstoffe Vertriebsges M B H | Verbindungen zur behandlung von asthma bronchiale |
| PT2953948T (pt) | 2013-02-07 | 2017-12-12 | Scifluor Life Sciences Inc | Antagonistas de integrina fluorada |
| CA2976634C (en) | 2015-02-19 | 2023-10-17 | Scifluor Life Sciences, Inc | Fluorinated tetrahydronaphthyridinyl nonanoic acid derivatives and uses thereof |
| JP2018514568A (ja) | 2015-04-30 | 2018-06-07 | サイフルーア ライフ サイエンシズ インコーポレイテッド | テトラヒドロナフチリジニルプロピオン酸誘導体およびその使用法 |
| US10118929B2 (en) | 2016-04-27 | 2018-11-06 | Scifluor Life Sciences, Inc. | Nonanoic and decanoic acid derivatives and uses thereof |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB828344A (en) * | 1957-01-30 | 1960-02-17 | Ici Ltd | Veterinary compositions containing acid hydrazides |
| JPS5119135A (en) * | 1974-08-05 | 1976-02-16 | Itsuo Takeshita | Kohakusenzaino seiho |
| US4321273A (en) * | 1978-03-01 | 1982-03-23 | Ryuichi Sato | Germanium-containing organic polymer and its use in the treatment of pulmonary fibrosis |
| US4382941A (en) * | 1980-11-26 | 1983-05-10 | Sicardi Susana M | Bishydrazide quaternary salts and pharmaceutical compositions thereof |
| HU207051B (en) * | 1987-12-30 | 1993-03-01 | Chinoin Gyogyszer Es Vegyeszet | Process for producing 4-chloro-3-sulfamoylbenzoic acid hydrazides and pharmaceutical compositions comprising such compounds |
| EP0581904B1 (en) * | 1991-04-01 | 1997-05-28 | Duke University | Method of inhibiting fibrosis |
-
1992
- 1992-03-31 EP EP92917284A patent/EP0581904B1/en not_active Expired - Lifetime
- 1992-03-31 AT AT92917284T patent/ATE153500T1/de not_active IP Right Cessation
- 1992-03-31 ES ES92917284T patent/ES2104938T3/es not_active Expired - Lifetime
- 1992-03-31 CA CA002107371A patent/CA2107371A1/en not_active Abandoned
- 1992-03-31 JP JP4510233A patent/JPH06506471A/ja active Pending
- 1992-03-31 WO PCT/US1992/002618 patent/WO1992017065A2/en not_active Ceased
- 1992-03-31 DE DE69220050T patent/DE69220050T2/de not_active Expired - Fee Related
- 1992-03-31 AU AU18763/92A patent/AU652644B2/en not_active Ceased
- 1992-03-31 DK DK92917284.9T patent/DK0581904T3/da active
-
1993
- 1993-02-16 US US08/017,795 patent/US5374660A/en not_active Expired - Lifetime
-
1994
- 1994-12-07 US US08/351,484 patent/US5571846A/en not_active Expired - Fee Related
-
1997
- 1997-08-27 GR GR970402158T patent/GR3024548T3/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| ES2104938T3 (es) | 1997-10-16 |
| JPH06506471A (ja) | 1994-07-21 |
| ATE153500T1 (de) | 1997-06-15 |
| EP0581904B1 (en) | 1997-05-28 |
| GR3024548T3 (en) | 1997-12-31 |
| WO1992017065A2 (en) | 1992-10-15 |
| DE69220050D1 (de) | 1997-07-03 |
| DE69220050T2 (de) | 1998-01-22 |
| US5374660A (en) | 1994-12-20 |
| EP0581904A1 (en) | 1994-02-09 |
| AU652644B2 (en) | 1994-09-01 |
| CA2107371A1 (en) | 1992-10-02 |
| EP0581904A4 (en) | 1994-05-25 |
| US5571846A (en) | 1996-11-05 |
| AU1876392A (en) | 1992-11-02 |
| WO1992017065A3 (en) | 1992-11-26 |
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