DK0563389T3 - Farmaceutisk aerosolkomposition og dens anvendelse til behandling og profylakse af virussygdomme - Google Patents
Farmaceutisk aerosolkomposition og dens anvendelse til behandling og profylakse af virussygdommeInfo
- Publication number
- DK0563389T3 DK0563389T3 DK92919013.0T DK92919013T DK0563389T3 DK 0563389 T3 DK0563389 T3 DK 0563389T3 DK 92919013 T DK92919013 T DK 92919013T DK 0563389 T3 DK0563389 T3 DK 0563389T3
- Authority
- DK
- Denmark
- Prior art keywords
- prophylaxis
- treatment
- viral diseases
- aerosol composition
- pharmaceutical aerosol
- Prior art date
Links
- 238000011321 prophylaxis Methods 0.000 title abstract 2
- 238000011282 treatment Methods 0.000 title abstract 2
- 230000003612 virological effect Effects 0.000 title abstract 2
- 201000010099 disease Diseases 0.000 title 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 title 1
- 239000000203 mixture Substances 0.000 title 1
- 239000008249 pharmaceutical aerosol Substances 0.000 title 1
- 239000013543 active substance Substances 0.000 abstract 2
- 239000007864 aqueous solution Substances 0.000 abstract 2
- 108010039627 Aprotinin Proteins 0.000 abstract 1
- 229960004405 aprotinin Drugs 0.000 abstract 1
- ZPNFWUPYTFPOJU-LPYSRVMUSA-N iniprol Chemical compound C([C@H]1C(=O)NCC(=O)NCC(=O)N[C@H]2CSSC[C@H]3C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@H](C(N[C@H](C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC=4C=CC(O)=CC=4)C(=O)N[C@@H](CC=4C=CC=CC=4)C(=O)N[C@@H](CC=4C=CC(O)=CC=4)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C)C(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CSSC[C@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](C)NC(=O)[C@H](CO)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CC=4C=CC=CC=4)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CCCCN)NC(=O)[C@H](C)NC(=O)[C@H](CCCNC(N)=N)NC2=O)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CSSC[C@H](NC(=O)[C@H](CC=2C=CC=CC=2)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H]2N(CCC2)C(=O)[C@@H](N)CCCNC(N)=N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(O)=O)C(=O)N2[C@@H](CCC2)C(=O)N2[C@@H](CCC2)C(=O)N[C@@H](CC=2C=CC(O)=CC=2)C(=O)N[C@@H]([C@@H](C)O)C(=O)NCC(=O)N2[C@@H](CCC2)C(=O)N3)C(=O)NCC(=O)NCC(=O)N[C@@H](C)C(O)=O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@H](C(=O)N[C@@H](CC=2C=CC=CC=2)C(=O)N[C@H](C(=O)N1)C(C)C)[C@@H](C)O)[C@@H](C)CC)=O)[C@@H](C)CC)C1=CC=C(O)C=C1 ZPNFWUPYTFPOJU-LPYSRVMUSA-N 0.000 abstract 1
- 239000002245 particle Substances 0.000 abstract 1
- 239000000137 peptide hydrolase inhibitor Substances 0.000 abstract 1
- 208000023504 respiratory system disease Diseases 0.000 abstract 1
- 239000007787 solid Substances 0.000 abstract 1
- 239000000126 substance Substances 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/007—Pulmonary tract; Aromatherapy
- A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
- A61K9/0075—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy for inhalation via a dry powder inhaler [DPI], e.g. comprising micronized drug mixed with lactose carrier particles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/55—Protease inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/007—Pulmonary tract; Aromatherapy
- A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
- A61K9/008—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy comprising drug dissolved or suspended in liquid propellant for inhalation via a pressurized metered dose inhaler [MDI]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Otolaryngology (AREA)
- Pulmonology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Immunology (AREA)
- Gastroenterology & Hepatology (AREA)
- Virology (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| SU5000531/14A RU2054180C1 (ru) | 1991-08-21 | 1991-08-21 | Способ лечения вирусных респираторных инфекций |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK0563389T3 true DK0563389T3 (da) | 1996-09-30 |
Family
ID=21584787
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK92919013.0T DK0563389T3 (da) | 1991-08-21 | 1992-08-19 | Farmaceutisk aerosolkomposition og dens anvendelse til behandling og profylakse af virussygdomme |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US5723439A (fr) |
| EP (1) | EP0563389B1 (fr) |
| JP (1) | JP2774379B2 (fr) |
| AT (1) | ATE137958T1 (fr) |
| AU (1) | AU2517792A (fr) |
| DE (1) | DE69210802T2 (fr) |
| DK (1) | DK0563389T3 (fr) |
| RU (1) | RU2054180C1 (fr) |
| WO (1) | WO1993003708A1 (fr) |
Families Citing this family (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IL99864A (en) * | 1990-10-31 | 2000-11-21 | Autoimmune Inc | Compositions for suppressing transplant rejection in mammals which contain tissue donor derived MHC antigens |
| JPH09501418A (ja) * | 1993-07-19 | 1997-02-10 | アムジエン・インコーポレーテツド | エアゾル化タンパク質の安定化 |
| DK0891426T3 (da) | 1996-03-11 | 2006-10-02 | Bayer Corp | Humant bikunin |
| RU2140273C1 (ru) * | 1996-11-06 | 1999-10-27 | Закрытое акционерное общество "АЭРОМЕД" | Способ лечения простудных заболеваний |
| DE19830694A1 (de) * | 1998-07-09 | 2000-01-13 | Bayer Ag | Substituierte Acylaminophenyl-uracile |
| JP3819239B2 (ja) * | 1998-12-22 | 2006-09-06 | バイエル アクチェンゲゼルシャフト | 粘膜線毛クリアランスの速度を促進する方法 |
| WO2002017958A1 (fr) * | 2000-08-29 | 2002-03-07 | Max-Delbrück-Centrum für Molekulare Medizin | Agent capable d'influencer l'angiogenese |
| EP1438019A1 (fr) * | 2001-10-24 | 2004-07-21 | PARI GmbH Spezialisten für effektive Inhalation | Trousse de preparation de composition pharmaceutique |
| US8084036B2 (en) | 2002-11-22 | 2011-12-27 | Nexbio, Inc. | Broad spectrum anti-viral therapeutics and prophylaxis |
| US8512710B2 (en) | 2002-11-22 | 2013-08-20 | Ansun Biopharma, Inc. | Class of therapeutic protein based molecules |
| US7807174B2 (en) | 2002-11-22 | 2010-10-05 | Nexbio, Inc. | Class of therapeutic protein based molecules |
| MD3381G2 (ro) * | 2006-06-19 | 2008-03-31 | Государственный Медицинский И Фармацевтический Университет "Nicolae Testemitanu" Республики Молдова | Metodă de tratament al parotiditei cronice la copii |
| EP2371857A1 (fr) * | 2010-04-01 | 2011-10-05 | CSL Behring GmbH | Inhibiteurs de facteur XII pour traiter la maladie de poumon interstitiel |
| RU2425691C1 (ru) * | 2010-07-15 | 2011-08-10 | ВАКЕ спол с.р.о. | Аэрозольный препарат на основе апротинина для лечения вирусных респираторных инфекций |
| EP2714716B1 (fr) * | 2011-06-02 | 2018-04-11 | Socpra Sciences Santé Et Humaines S.E.C. | Inhibiteurs de matriptase et utilisations de ceux-ci contre les infections à orthomyxoviridae |
| RU2657523C2 (ru) * | 2011-11-03 | 2018-06-14 | Олег Петрович Жирнов | Фармацевтический аэрозольный состав ингибиторов протеаз с озон-сберегающим пропеллентом и его получение |
| DE202012013134U1 (de) | 2012-11-01 | 2014-12-05 | Oleg Petrovich Zhirnov | Pharmazeutische Aerosolformulierung von Protease-Inhibitoren und deren Zubereitung |
| TWI718086B (zh) | 2013-01-07 | 2021-02-11 | 英屬維爾京群島商遠東超級實驗室有限公司 | 通過干擾素的經皮和/或經粘膜給藥治療骨癌、皮膚癌、皮下癌、粘膜癌和/或粘膜下癌的方法和組合物 |
| RU2711080C2 (ru) * | 2015-06-15 | 2020-01-15 | Олег Петрович Жирнов | Комбинированный аэрозольный состав на основе ингибиторов протеаз и его получение |
| RU2738885C1 (ru) * | 2020-04-30 | 2020-12-18 | Андрей Александрович Иващенко | Противо-SARS-CoV-2 вирусное средство Антипровир |
| US20220000993A1 (en) * | 2020-07-06 | 2022-01-06 | Torvald Ranta Foretagsjuridik AB | Drug for use against the novel coronavirus disease, covid-19 |
| US20240415944A1 (en) * | 2021-04-06 | 2024-12-19 | Andrey Alexandrovich Ivashchenko | Aqueous aprotinin-containing antiviral pharmaceutical composition |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BE556587A (fr) * | 1957-01-31 | 1957-04-11 | ||
| DE2654124A1 (de) * | 1976-11-29 | 1978-06-01 | Bayer Ag | Derivate des trypsin-kallikrein-inhibitors aus rinderorganen (bpti) mit proteasenhemmwirkung und antiphlogistischer wirkung, ihre herstellung und ihre verwendung als arzneimittel |
| ZA815698B (en) * | 1980-08-28 | 1983-04-27 | Lilly Co Eli | Intranasal formulation |
| DE3175003D1 (en) * | 1981-06-25 | 1986-08-28 | Serapharm Gmbh & Co Kg | Enriched plasma derivative for promoting wound sealing and wound healing |
| JPS59163313A (ja) * | 1983-03-09 | 1984-09-14 | Teijin Ltd | 経鼻投与用ペプチドホルモン類組成物 |
| US5262157A (en) * | 1987-03-26 | 1993-11-16 | Sloan-Kettering Institute For Cancer Research | Method of preventing Pneumocystis carinii pneumonia using pentamidine in an aerosol form |
| JP2656944B2 (ja) * | 1987-04-30 | 1997-09-24 | クーパー ラボラトリーズ | タンパク質性治療剤のエアロゾール化 |
| JP2804979B2 (ja) * | 1988-11-28 | 1998-09-30 | 日本ケミカルリサーチ株式会社 | エイズ治療および阻害剤 |
| FR2646354B1 (fr) * | 1989-04-27 | 1994-06-10 | Sanofi Sa | Utilisation de peptides inhibiteurs de proteases acides pour la preparation de medicaments utiles pour le traitement de maladies virales |
| CS275231B2 (en) * | 1989-09-29 | 1992-02-19 | Ustav Makormolekularni Chemie | Medicine bottle |
| DE4117078A1 (de) * | 1991-05-25 | 1992-11-26 | Boehringer Ingelheim Kg | Verfahren zur herstellung therapeutisch anwendbarer aerosole |
-
1991
- 1991-08-21 RU SU5000531/14A patent/RU2054180C1/ru active
-
1992
- 1992-08-19 US US08/039,393 patent/US5723439A/en not_active Expired - Lifetime
- 1992-08-19 AU AU25177/92A patent/AU2517792A/en not_active Abandoned
- 1992-08-19 AT AT92919013T patent/ATE137958T1/de active
- 1992-08-19 EP EP92919013A patent/EP0563389B1/fr not_active Expired - Lifetime
- 1992-08-19 DK DK92919013.0T patent/DK0563389T3/da active
- 1992-08-19 DE DE69210802T patent/DE69210802T2/de not_active Expired - Lifetime
- 1992-08-19 JP JP5504250A patent/JP2774379B2/ja not_active Expired - Lifetime
- 1992-08-19 WO PCT/RU1992/000164 patent/WO1993003708A1/fr not_active Ceased
Also Published As
| Publication number | Publication date |
|---|---|
| EP0563389B1 (fr) | 1996-05-15 |
| RU2054180C1 (ru) | 1996-02-10 |
| US5723439A (en) | 1998-03-03 |
| AU2517792A (en) | 1993-03-16 |
| JPH06506474A (ja) | 1994-07-21 |
| WO1993003708A1 (fr) | 1993-03-04 |
| DE69210802D1 (de) | 1996-06-20 |
| EP0563389A1 (fr) | 1993-10-06 |
| EP0563389A4 (en) | 1993-10-20 |
| JP2774379B2 (ja) | 1998-07-09 |
| ATE137958T1 (de) | 1996-06-15 |
| DE69210802T2 (de) | 1997-01-16 |
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