DK0559774T3 - Individuelle stereoisomerer af 7-/3-(1-aminoalkyl)-1-pyrrolidinal/-quinoloner og naphthyridoner som antibakterielle midler - Google Patents
Individuelle stereoisomerer af 7-/3-(1-aminoalkyl)-1-pyrrolidinal/-quinoloner og naphthyridoner som antibakterielle midlerInfo
- Publication number
- DK0559774T3 DK0559774T3 DK92901238T DK92901238T DK0559774T3 DK 0559774 T3 DK0559774 T3 DK 0559774T3 DK 92901238 T DK92901238 T DK 92901238T DK 92901238 T DK92901238 T DK 92901238T DK 0559774 T3 DK0559774 T3 DK 0559774T3
- Authority
- DK
- Denmark
- Prior art keywords
- quinolones
- aminoalkyl
- antibacterial agents
- pyrrolidinal
- naphthyridones
- Prior art date
Links
- 239000003242 anti bacterial agent Substances 0.000 title abstract 2
- 150000007660 quinolones Chemical class 0.000 title 1
- 238000002955 isolation Methods 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 238000002360 preparation method Methods 0.000 abstract 1
- 230000001225 therapeutic effect Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
- C07D207/22—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D207/24—Oxygen or sulfur atoms
- C07D207/26—2-Pyrrolidones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D207/08—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon radicals, substituted by hetero atoms, attached to ring carbon atoms
- C07D207/09—Radicals substituted by nitrogen atoms, not forming part of a nitro radical
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Communicable Diseases (AREA)
- Animal Behavior & Ethology (AREA)
- Oncology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pyrrole Compounds (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US62120190A | 1990-11-30 | 1990-11-30 | |
| US73182591A | 1991-07-15 | 1991-07-15 | |
| PCT/US1991/008419 WO1992009596A1 (fr) | 1990-11-30 | 1991-11-12 | Stereoisomeres individuels de 7-[3-(aminoalkyl)-1-pyrrolidinyl]-quinolones et de naphtyridones utilises comme agents antibacteriens |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK0559774T3 true DK0559774T3 (da) | 2000-01-31 |
Family
ID=27088892
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK92901238T DK0559774T3 (da) | 1990-11-30 | 1991-11-12 | Individuelle stereoisomerer af 7-/3-(1-aminoalkyl)-1-pyrrolidinal/-quinoloner og naphthyridoner som antibakterielle midler |
Country Status (14)
| Country | Link |
|---|---|
| EP (2) | EP0559774B1 (fr) |
| JP (1) | JPH06503565A (fr) |
| AT (1) | ATE181915T1 (fr) |
| AU (2) | AU658384B2 (fr) |
| CA (1) | CA2095338C (fr) |
| DE (1) | DE69131428T2 (fr) |
| DK (1) | DK0559774T3 (fr) |
| ES (1) | ES2137942T3 (fr) |
| GR (1) | GR3031224T3 (fr) |
| IE (1) | IE62205B1 (fr) |
| MX (1) | MX9102290A (fr) |
| NZ (1) | NZ240784A (fr) |
| PT (1) | PT99657B (fr) |
| WO (1) | WO1992009596A1 (fr) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU649893B1 (en) * | 1991-11-25 | 1994-06-02 | Warner-Lambert Company | Antibacterial agents |
| EG20543A (en) * | 1992-10-30 | 1999-07-31 | Procter & Gamble | Process for preparing of novel antimicrobial -5- (n-heterosubstituted amino) quinolones |
| AU716479B2 (en) * | 1993-05-06 | 2000-02-24 | Pharmacia & Upjohn Company | Optically active 3-(1-(alkylamino) alkyl pyrrolidines |
| US6140510A (en) * | 1993-05-06 | 2000-10-31 | Pharmacia & Upjohn Company | Optically active 3-(1-(carbamoyl))alkyl-2-oxo-pyrrolidines and optically active 3-(1-(alkylamido))alkyl-2-oxo-pyrrolidines |
| AU694427B2 (en) * | 1993-05-06 | 1998-07-23 | Pharmacia & Upjohn Company | Optically active 3-(1-(alkylamino))alkyl pyrrolidines |
| CZ138297A3 (en) * | 1994-11-18 | 1997-10-15 | Pharmacia & Upjohn | Novel physically stable form of solid fluoroquinolone |
| EP0898477B1 (fr) * | 1996-05-10 | 2002-12-18 | PHARMACIA & UPJOHN COMPANY | Administration topique de premafloxacine dans le traitement de maladies bacteriennes systemiques |
| US5929086A (en) * | 1996-05-10 | 1999-07-27 | Pharmacia & Upjohn Company | Topical administration of antimicrobial agents for the treatment of systemic bacterial diseases |
| KR100395779B1 (ko) * | 2001-05-25 | 2003-08-21 | 한국화학연구원 | 임의적으로 베타-위치가 치환된 알파-아릴알킬기의 제거를통해 3급 아미드 화합물로부터 2급 아미드 화합물을제조하는 방법 |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IL79189A (en) * | 1985-06-26 | 1990-07-12 | Daiichi Seiyaku Co | Quinoline and/or naphthyridine-4-oxo-3-carboxylic acid derivatives,process for their preparation and pharmaceutical compositions comprising them |
| US4780468A (en) * | 1987-08-07 | 1988-10-25 | Warner-Lambert Company | 8-trifluoromethyl quinolones as antibacterial agents |
| CA2012681A1 (fr) * | 1989-03-31 | 1990-09-30 | Masayasu Okuhira | Derives de la quinolone, procedes de preparation et agents antibacteriens les renfermant |
| US5157128A (en) * | 1990-11-30 | 1992-10-20 | Warner-Lambert Company | Certain optically active substituted α,α-dialkyl-pyrrolidine-3-methamines useful as intermediates |
| KR950014567B1 (ko) * | 1991-08-01 | 1995-12-08 | 주식회사대웅제약 | 신규한 퀴놀론 카르복실산 유도체 |
-
1991
- 1991-11-12 DK DK92901238T patent/DK0559774T3/da active
- 1991-11-12 AU AU90574/91A patent/AU658384B2/en not_active Ceased
- 1991-11-12 EP EP92901238A patent/EP0559774B1/fr not_active Expired - Lifetime
- 1991-11-12 WO PCT/US1991/008419 patent/WO1992009596A1/fr not_active Ceased
- 1991-11-12 EP EP98120700A patent/EP0909759A3/fr not_active Withdrawn
- 1991-11-12 JP JP4502273A patent/JPH06503565A/ja active Pending
- 1991-11-12 CA CA002095338A patent/CA2095338C/fr not_active Expired - Fee Related
- 1991-11-12 ES ES92901238T patent/ES2137942T3/es not_active Expired - Lifetime
- 1991-11-12 DE DE69131428T patent/DE69131428T2/de not_active Expired - Fee Related
- 1991-11-12 AT AT92901238T patent/ATE181915T1/de not_active IP Right Cessation
- 1991-11-28 NZ NZ240784A patent/NZ240784A/en not_active IP Right Cessation
- 1991-11-29 IE IE416091A patent/IE62205B1/en not_active IP Right Cessation
- 1991-11-29 MX MX9102290A patent/MX9102290A/es not_active IP Right Cessation
- 1991-11-29 PT PT99657A patent/PT99657B/pt not_active IP Right Cessation
-
1995
- 1995-06-29 AU AU23344/95A patent/AU678715B2/en not_active Ceased
-
1999
- 1999-09-16 GR GR990402315T patent/GR3031224T3/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| DE69131428D1 (de) | 1999-08-12 |
| IE62205B1 (en) | 1994-12-28 |
| AU678715B2 (en) | 1997-06-05 |
| PT99657B (pt) | 1999-05-31 |
| EP0559774B1 (fr) | 1999-07-07 |
| ATE181915T1 (de) | 1999-07-15 |
| CA2095338A1 (fr) | 1992-05-31 |
| NZ240784A (en) | 1997-06-24 |
| AU658384B2 (en) | 1995-04-13 |
| IE914160A1 (en) | 1992-06-03 |
| EP0909759A3 (fr) | 2000-04-26 |
| MX9102290A (es) | 1992-07-08 |
| AU9057491A (en) | 1992-06-25 |
| ES2137942T3 (es) | 2000-01-01 |
| EP0909759A2 (fr) | 1999-04-21 |
| GR3031224T3 (en) | 1999-12-31 |
| CA2095338C (fr) | 2002-04-09 |
| WO1992009596A1 (fr) | 1992-06-11 |
| EP0559774A1 (fr) | 1993-09-15 |
| JPH06503565A (ja) | 1994-04-21 |
| DE69131428T2 (de) | 2000-01-05 |
| AU2334495A (en) | 1995-09-07 |
| PT99657A (pt) | 1992-12-31 |
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