DK0558104T3 - 1,5-Benzodiazepinderivater og deres anvendelse i lægemidler - Google Patents

1,5-Benzodiazepinderivater og deres anvendelse i lægemidler

Info

Publication number: DK0558104T3
Authority: DK; Denmark
Prior art keywords: group; phenyl; 4alkyl; substituted; bridgedcycloalkyl
Prior art date: 1992-01-21

Application number

DK93200097T

Other languages

English (en)

Inventor

Harry Finch

David Gordon Trist

Giorgio Tarzia

Aldo Feriani

Original Assignee

Glaxo Wellcome Spa

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1992-01-21

Filing date

1993-01-15

Publication date

1999-04-26

1992-01-21 Priority claimed from GB929201180A external-priority patent/GB9201180D0/en

1992-10-17 Priority claimed from GB929221847A external-priority patent/GB9221847D0/en

1993-01-15 Application filed by Glaxo Wellcome Spa filed Critical Glaxo Wellcome Spa

1999-04-26 Application granted granted Critical

1999-04-26 Publication of DK0558104T3 publication Critical patent/DK0558104T3/da

Links

ZVAPWJGRRUHKGP-UHFFFAOYSA-N 1h-1,5-benzodiazepine Chemical class N1C=CC=NC2=CC=CC=C12 ZVAPWJGRRUHKGP-UHFFFAOYSA-N 0.000 title 1
239000003814 drug Substances 0.000 title 1
125000004178 (C1-C4) alkyl group Chemical group 0.000 abstract 3
UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 3
125000005843 halogen group Chemical group 0.000 abstract 3
229910052739 hydrogen Inorganic materials 0.000 abstract 3
239000001257 hydrogen Substances 0.000 abstract 3
125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 3
125000006272 (C3-C7) cycloalkyl group Chemical group 0.000 abstract 2
108010089448 Cholecystokinin B Receptor Proteins 0.000 abstract 2
125000000217 alkyl group Chemical group 0.000 abstract 2
125000000229 (C1-C4)alkoxy group Chemical group 0.000 abstract 1
125000004454 (C1-C6) alkoxycarbonyl group Chemical group 0.000 abstract 1
125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 1
102000052874 Gastrin receptors Human genes 0.000 abstract 1
102100036016 Gastrin/cholecystokinin type B receptor Human genes 0.000 abstract 1
239000005557 antagonist Substances 0.000 abstract 1
AOXOCDRNSPFDPE-UKEONUMOSA-N chembl413654 Chemical compound C([C@H](C(=O)NCC(=O)N[C@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@H](CCSC)C(=O)N[C@H](CC(O)=O)C(=O)N[C@H](CC=1C=CC=CC=1)C(N)=O)NC(=O)[C@@H](C)NC(=O)[C@@H](CCC(O)=O)NC(=O)[C@@H](CCC(O)=O)NC(=O)[C@@H](CCC(O)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC=1C2=CC=CC=C2NC=1)NC(=O)[C@H]1N(CCC1)C(=O)CNC(=O)[C@@H](N)CCC(O)=O)C1=CC=C(O)C=C1 AOXOCDRNSPFDPE-UKEONUMOSA-N 0.000 abstract 1
150000001875 compounds Chemical class 0.000 abstract 1
125000004093 cyano group Chemical group *C#N 0.000 abstract 1
125000004356 hydroxy functional group Chemical group O* 0.000 abstract 1
-1 hydroxy, phenyl Chemical group 0.000 abstract 1
125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 abstract 1
125000000876 trifluoromethoxy group Chemical group FC(F)(F)O* 0.000 abstract 1
125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D243/00—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms
- C07D243/06—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4
- C07D243/10—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
- C07D243/12—1,5-Benzodiazepines; Hydrogenated 1,5-benzodiazepines

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Plural Heterocyclic Compounds (AREA)

DK93200097T 1992-01-21 1993-01-15 1,5-Benzodiazepinderivater og deres anvendelse i lægemidler DK0558104T3 (da)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
GB929201180A GB9201180D0 (en)	1992-01-21	1992-01-21	Chemical compounds
GB929221847A GB9221847D0 (en)	1992-10-17	1992-10-17	Chemical compounds

Publications (1)

Publication Number	Publication Date
DK0558104T3 true DK0558104T3 (da)	1999-04-26

Family

ID=26300183

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK93200097T DK0558104T3 (da)	1992-01-21	1993-01-15	1,5-Benzodiazepinderivater og deres anvendelse i lægemidler

Country Status (6)

Country	Link
EP (1)	EP0558104B1 (da)
AT (1)	ATE169007T1 (da)
DE (1)	DE69319945T2 (da)
DK (1)	DK0558104T3 (da)
ES (1)	ES2121925T3 (da)
SG (1)	SG52655A1 (da)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JP3621416B2 (ja) *	1993-12-28	2005-02-16	塩野義製薬株式会社	新規なベンゾジアゼピン誘導体
IL115589A0 (en)	1994-10-14	1996-01-19	Glaxo Spa	Use of cck-b antagonists in pharmaceutical compositions
GB9511220D0 (en) *	1995-06-02	1995-07-26	Glaxo Group Ltd	Solid dispersions
CU20090172A6 (es)	2009-10-09	2011-10-05	Facultad De Quimica Universidad De La Habana	Sistemas tricíclicos y tetracíclicos con actividad sobre el sistema nervioso central y vascular

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
FR2641280B1 (fr) *	1988-12-29	1994-01-21	Roussel Uclaf	Nouveaux derives de la 2,4-dioxo 2,3,4,5-tetrahydro 1h-1,5-benzodiazepine, leur procede de preparation et leur application comme medicaments

1993
- 1993-01-15 EP EP93200097A patent/EP0558104B1/en not_active Expired - Lifetime
- 1993-01-15 SG SG1996007401A patent/SG52655A1/en unknown
- 1993-01-15 ES ES93200097T patent/ES2121925T3/es not_active Expired - Lifetime
- 1993-01-15 AT AT93200097T patent/ATE169007T1/de not_active IP Right Cessation
- 1993-01-15 DK DK93200097T patent/DK0558104T3/da active
- 1993-01-15 DE DE69319945T patent/DE69319945T2/de not_active Expired - Fee Related

Also Published As

Publication number	Publication date
DE69319945D1 (de)	1998-09-03
EP0558104B1 (en)	1998-07-29
ES2121925T3 (es)	1998-12-16
SG52655A1 (en)	1998-09-28
ATE169007T1 (de)	1998-08-15
EP0558104A1 (en)	1993-09-01
DE69319945T2 (de)	1999-03-11

Publication	Publication Date	Title
CA2087672A1 (en)	1993-07-22	1,5-benzodiazepine derivatives
HU9401221D0 (en)	1994-08-29	New heterocyclic compounds
DK0842661T3 (da)	2001-09-24	Anvendelse af estrogenagonister og -antagonister til fremstilling af et lægemiddel til behandling af atherosclerose, uafhængigt af lipidsænkning
DE68906183D1 (de)	1993-06-03	2'-desoxy-5-fluoruridinderivate.
DK0410590T3 (da)	1994-10-03	Pyrimidinyl-herbicider
ATE177096T1 (de)	1999-03-15	4-substituierte 1,2,4-triazolderivate
EP0259835A3 (en)	1989-03-15	Pyridazinone derivatives
DK0539676T3 (da)	1995-08-21	Oximderivater af formylpyridylimidazolinoner, deres herbicide anvendelse og fremgangsmåder til deresfremstilling
DK0558104T3 (da)	1999-04-26	1,5-Benzodiazepinderivater og deres anvendelse i lægemidler
DE69013766D1 (de)	1994-12-08	N-Phenylpyrazol-Derivate.
DE3667788D1 (de)	1990-02-01	Diphenyletherherbizide.
ATE168686T1 (de)	1998-08-15	N,n'-disubstituierte amidderivate
DK369289D0 (da)	1989-07-26	Anvendelse af imidazopyrazolderivater som analgetica og antiinflammatoriske midler
MX9203265A (es)	1992-07-01	Compuestos inhibidores de la acil-coenzima a: colesterol acil transferasa.
MX9204939A (es)	1993-03-01	Inhibidores 5-bis-aminometilen-1,3-dioxan-4,6-diona n,n',n'-trisubstituidas, de la acil coenzima a: colesterol-aciltransferasa.
TH24858A (th)	1997-04-29	1-ไซโคลอัลคีนิลเตตระโซลิโนน
ES2087325T3 (es)	1996-07-16	Derivados de 1,2,4-triazolo(1,5-a)pirimidina, procedimiento para su preparacion, medicamentos que los contienen y su utilizacion.