DK0550108T3 - Thyreoaktiv sammensætning med langvarig frigivelse - Google Patents
Thyreoaktiv sammensætning med langvarig frigivelseInfo
- Publication number
- DK0550108T3 DK0550108T3 DK92204048T DK92204048T DK0550108T3 DK 0550108 T3 DK0550108 T3 DK 0550108T3 DK 92204048 T DK92204048 T DK 92204048T DK 92204048 T DK92204048 T DK 92204048T DK 0550108 T3 DK0550108 T3 DK 0550108T3
- Authority
- DK
- Denmark
- Prior art keywords
- liothyronine
- thyroxine
- useful
- disclosed
- combination
- Prior art date
Links
- 239000000203 mixture Substances 0.000 title abstract 2
- 230000007774 longterm Effects 0.000 title 1
- AUYYCJSJGJYCDS-LBPRGKRZSA-N Thyrolar Chemical compound IC1=CC(C[C@H](N)C(O)=O)=CC(I)=C1OC1=CC=C(O)C(I)=C1 AUYYCJSJGJYCDS-LBPRGKRZSA-N 0.000 abstract 5
- XUIIKFGFIJCVMT-GFCCVEGCSA-N D-thyroxine Chemical compound IC1=CC(C[C@@H](N)C(O)=O)=CC(I)=C1OC1=CC(I)=C(O)C(I)=C1 XUIIKFGFIJCVMT-GFCCVEGCSA-N 0.000 abstract 3
- 239000002552 dosage form Substances 0.000 abstract 3
- 229940034208 thyroxine Drugs 0.000 abstract 3
- XUIIKFGFIJCVMT-UHFFFAOYSA-N thyroxine-binding globulin Natural products IC1=CC(CC([NH3+])C([O-])=O)=CC(I)=C1OC1=CC(I)=C(O)C(I)=C1 XUIIKFGFIJCVMT-UHFFFAOYSA-N 0.000 abstract 3
- 229940035722 triiodothyronine Drugs 0.000 abstract 3
- 238000002657 hormone replacement therapy Methods 0.000 abstract 2
- 238000002360 preparation method Methods 0.000 abstract 2
- 238000013268 sustained release Methods 0.000 abstract 2
- 239000012730 sustained-release form Substances 0.000 abstract 2
- 239000005495 thyroid hormone Substances 0.000 abstract 2
- 229940036555 thyroid hormone Drugs 0.000 abstract 2
- 206010020850 Hyperthyroidism Diseases 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 229940079593 drug Drugs 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 208000003532 hypothyroidism Diseases 0.000 abstract 1
- 230000002989 hypothyroidism Effects 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 239000000825 pharmaceutical preparation Substances 0.000 abstract 1
- 230000002035 prolonged effect Effects 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 230000002459 sustained effect Effects 0.000 abstract 1
- 238000002560 therapeutic procedure Methods 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
- A61K9/2806—Coating materials
- A61K9/2833—Organic macromolecular compounds
- A61K9/284—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2009—Inorganic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
- A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/10—Drugs for disorders of the endocrine system of the posterior pituitary hormones, e.g. oxytocin, ADH
- A61P5/12—Drugs for disorders of the endocrine system of the posterior pituitary hormones, e.g. oxytocin, ADH for decreasing, blocking or antagonising the activity of the posterior pituitary hormones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/14—Drugs for disorders of the endocrine system of the thyroid hormones, e.g. T3, T4
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Diabetes (AREA)
- Endocrinology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Inorganic Chemistry (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicinal Preparation (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP91203438 | 1991-12-30 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK0550108T3 true DK0550108T3 (da) | 1999-01-04 |
Family
ID=8208120
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK92204048T DK0550108T3 (da) | 1991-12-30 | 1992-12-22 | Thyreoaktiv sammensætning med langvarig frigivelse |
Country Status (14)
| Country | Link |
|---|---|
| US (1) | US5324522A (da) |
| EP (1) | EP0550108B1 (da) |
| JP (1) | JP3662942B2 (da) |
| KR (1) | KR100249978B1 (da) |
| AT (1) | ATE164063T1 (da) |
| AU (1) | AU660344B2 (da) |
| CA (1) | CA2086343C (da) |
| DE (1) | DE69224809T2 (da) |
| DK (1) | DK0550108T3 (da) |
| ES (1) | ES2115638T3 (da) |
| MX (1) | MX9207654A (da) |
| NO (1) | NO924985L (da) |
| NZ (1) | NZ245575A (da) |
| ZA (1) | ZA9210059B (da) |
Families Citing this family (61)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9401879D0 (en) * | 1994-02-01 | 1994-03-30 | Boots Co Plc | Therapeutic agents |
| GB9401892D0 (en) * | 1994-02-01 | 1994-03-30 | Boots Co Plc | Therapeutic agents |
| AU712217B2 (en) * | 1995-11-14 | 1999-11-04 | Abbott Gmbh & Co. Kg | Stabilized thyroid hormone preparations and methods of making same |
| US5993856A (en) * | 1997-01-24 | 1999-11-30 | Femmepharma | Pharmaceutical preparations and methods for their administration |
| US6416778B1 (en) | 1997-01-24 | 2002-07-09 | Femmepharma | Pharmaceutical preparations and methods for their regional administration |
| WO1999043307A1 (en) * | 1998-02-26 | 1999-09-02 | Prange Arthur J Jr | Thyroid hormone replacement using sustained release triiodothyronine |
| US6716452B1 (en) | 2000-08-22 | 2004-04-06 | New River Pharmaceuticals Inc. | Active agent delivery systems and methods for protecting and administering active agents |
| US6740680B1 (en) * | 1999-04-26 | 2004-05-25 | Becton Pharma, Inc. | Pharmaceutical compositions to tetrac and methods of use thereof |
| JP2002542284A (ja) * | 1999-04-26 | 2002-12-10 | ダンフォース，エリオット，ジュニア | テトラックの薬学組成物およびその使用方法 |
| US6288117B1 (en) * | 2000-03-23 | 2001-09-11 | North Shore-Long Island Jewish Research Institute | Method for treating congestive heart failure |
| WO2002008759A1 (en) * | 2000-07-26 | 2002-01-31 | Biodiagnostics, Inc. | Method for diagnosing thyroid conditions and for monitoring thyroxine therapy |
| US7163918B2 (en) * | 2000-08-22 | 2007-01-16 | New River Pharmaceuticals Inc. | Iodothyronine compositions |
| US8394813B2 (en) | 2000-11-14 | 2013-03-12 | Shire Llc | Active agent delivery systems and methods for protecting and administering active agents |
| WO2002064093A2 (en) | 2001-02-15 | 2002-08-22 | King Pharmaceuticals, Inc. | Stabilized pharmaceutical and thyroid hormone compositions and method of preparation |
| US6555581B1 (en) | 2001-02-15 | 2003-04-29 | Jones Pharma, Inc. | Levothyroxine compositions and methods |
| US20030224047A1 (en) * | 2001-02-15 | 2003-12-04 | Franz G. Andrew | Levothyroxine compositions and methods |
| US20030032675A1 (en) * | 2001-02-15 | 2003-02-13 | Franz G. Andrew | Manufacture of thyroid hormone tablets having consistent active moiety amounts |
| US20030198667A1 (en) * | 2001-08-10 | 2003-10-23 | Franz Andrew G. | Methods of producing dispersible pharmaceutical compositions |
| US20030180353A1 (en) * | 2001-08-10 | 2003-09-25 | Franz G. Andrew | Stabilized pharmaceutical compositions |
| US20030190349A1 (en) * | 2001-08-10 | 2003-10-09 | Franz G. Andrew | Methods of stabilizing pharmaceutical compositions |
| US20030198671A1 (en) * | 2001-08-10 | 2003-10-23 | Franz G. Andrew | Levothyroxine compositions having unique plasma AUC properties |
| US20030194437A1 (en) * | 2001-08-14 | 2003-10-16 | Franz G. Andrew | Levothyroxine compositions having unique triiodothyronine Cmax properties |
| US20030203967A1 (en) * | 2001-08-14 | 2003-10-30 | Franz G. Andrew | Levothyroxine compositions having unique Tmax properties |
| US20030199586A1 (en) * | 2001-08-14 | 2003-10-23 | Franz G. Andrew | Unique levothyroxine aqueous materials |
| US20030199587A1 (en) * | 2001-08-14 | 2003-10-23 | Franz G. Andrew | Levothyroxine compositions having unique Cmax properties |
| US7101569B2 (en) | 2001-08-14 | 2006-09-05 | Franz G Andrew | Methods of administering levothyroxine pharmaceutical compositions |
| US20030198672A1 (en) * | 2001-08-14 | 2003-10-23 | Franz G. Andrew | Levothyroxine compositions having unique triidothyronine plasma AUC properties |
| US7169752B2 (en) * | 2003-09-30 | 2007-01-30 | New River Pharmaceuticals Inc. | Compounds and compositions for prevention of overdose of oxycodone |
| US20060014697A1 (en) * | 2001-08-22 | 2006-01-19 | Travis Mickle | Pharmaceutical compositions for prevention of overdose or abuse |
| US20030171436A1 (en) * | 2001-10-29 | 2003-09-11 | Franz G. Andrew | Levothyroxine compositions having unique triiodothyronine Tmax properties |
| MXPA04006017A (es) * | 2001-12-20 | 2005-06-08 | Femmepharma Inc | Suministro de farmacos por via vaginal. |
| EP1565171A4 (en) * | 2002-11-05 | 2010-06-30 | Shire Llc | PROGRESSIVE ABSORPTION OF MIXED FORMULATIONS OF THYROID HORMONES |
| ITMI20110713A1 (it) | 2011-04-29 | 2012-10-30 | Bracco Imaging Spa | Processo per la preparazione di un derivato solfatato di3,5-diiodo-o-[3-iodofenil]-l-tirosina |
| ITMI20022394A1 (it) | 2002-11-13 | 2004-05-14 | Bracco Spa | Uso di triiodotironina 3-solfato come farmaco ad attivita' tireomimetica e relative formulazioni farmaceutiche. |
| US9173836B2 (en) | 2003-01-02 | 2015-11-03 | FemmeParma Holding Company, Inc. | Pharmaceutical preparations for treatments of diseases and disorders of the breast |
| EP1578421A4 (en) * | 2003-01-02 | 2009-04-22 | Femmepharma Holding Co Inc | PHARMACEUTICAL PREPARATIONS FOR THE TREATMENT OF DISEASES AND BREAST CONDITIONS |
| US20040156893A1 (en) * | 2003-02-11 | 2004-08-12 | Irwin Klein | Method for treating hypothyroidism |
| US8293272B2 (en) * | 2003-05-02 | 2012-10-23 | Globopharm Pharmazeutische Produktions-Und Handelsgesellschaft M.B.H. | Solid pharmaceutical preparation containing levothyroxine and/or liothyronine salts |
| JP2007512359A (ja) * | 2003-11-19 | 2007-05-17 | メタバシス・セラピューティクス・インコーポレイテッド | 新規なリン含有甲状腺ホルモン様物質 |
| AU2006230557A1 (en) * | 2005-03-31 | 2006-10-05 | King Pharmaceuticals Research & Development, Inc. | Controlled release pharmaceutical compositions of liothyronine and methods of making and using the same |
| CA2606499C (en) | 2005-05-26 | 2017-06-13 | Metabasis Therapeutics, Inc. | Thyromimetics for the treatment of fatty liver diseases |
| RU2007148927A (ru) * | 2005-05-26 | 2009-07-10 | Метабэйзис Терапьютикс, Инк. (Us) | Новые тиреомиметики, содержащие фосфиновую кислоту |
| GB0525461D0 (en) * | 2005-12-15 | 2006-01-25 | Archimedes Dev Ltd | Pharmaceutical compositions |
| GB0608402D0 (en) * | 2006-04-28 | 2006-06-07 | Diurnal Ltd | Thyroid treatment |
| EP2043616B1 (en) | 2006-07-25 | 2016-01-27 | Lipoxen Technologies Limited | N-terminal conjugation of polysialic acid to proteins |
| US20080153789A1 (en) * | 2006-12-26 | 2008-06-26 | Femmepharma Holding Company, Inc. | Topical administration of danazol |
| WO2008129303A2 (en) * | 2007-04-23 | 2008-10-30 | Diurnal Limited | Sustained release |
| US20110003000A1 (en) * | 2009-07-06 | 2011-01-06 | Femmepharma Holding Company, Inc. | Transvaginal Delivery of Drugs |
| CA2805958A1 (en) * | 2009-08-04 | 2011-02-10 | Haren Treasurer | Greater utility with thyroid hormone |
| EP2441450B1 (en) * | 2010-10-18 | 2017-06-14 | Blymum S.R.L. | Antioxidant composition for reducing the oxidative stress and side effects ascribable to treatment with levothyroxine |
| AU2012238665B2 (en) * | 2011-04-08 | 2016-09-29 | Bracco Imaging Spa | Process for the preparation of a sulfated derivative of 3,5-diiodo-O-[3-iodophenyl]-L-tyrosine |
| WO2013006402A1 (en) * | 2011-07-01 | 2013-01-10 | Thomas Najarian | Methods and compositions for facilitating weight loss by administration of thyroid hormones |
| US10188739B2 (en) | 2014-02-27 | 2019-01-29 | Xenetic Biosciences, Inc. | Compositions and methods for administering insulin or insulin-like protein to the brain |
| US20180064669A1 (en) * | 2016-05-03 | 2018-03-08 | Spectrix Therapeutics, LLC | Compositions and methods of providing thyroid hormone or analogs thereof |
| MX2018013410A (es) * | 2016-05-03 | 2019-06-06 | Spectrix Therapeutics Llc | Composiciones y metodos para proporcionar la hormona tiroidea o analogos de la misma. |
| WO2018094265A2 (en) | 2016-11-21 | 2018-05-24 | Viking Therapeutics, Inc. | Method of treating glycogen storage disease |
| US10695309B2 (en) | 2017-03-31 | 2020-06-30 | Western New England University | Sustained-release liothyronine formulations, method of preparation and method of use thereof |
| CN110996966A (zh) | 2017-06-05 | 2020-04-10 | 维京治疗公司 | 用于治疗纤维化的组合物 |
| KR20200138283A (ko) | 2018-03-22 | 2020-12-09 | 바이킹 테라퓨틱스 인코포레이티드 | 결정질 형태, 및 결정질 형태의 화합물을 제조하는 방법 |
| WO2020117962A1 (en) | 2018-12-05 | 2020-06-11 | Viking Therapeutics, Inc. | Compositions for the treatment of fibrosis and inflammation |
| CA3164402C (en) * | 2020-01-13 | 2025-05-06 | Amneal Complex Products Research Llc | DELAYED-RELEASE COMPOSITIONS CONTAINING LIOTHYRONIN |
Family Cites Families (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB219206A (en) * | 1923-09-15 | 1924-07-24 | John Arthur Goodall | Improvements in extincteurs or apparatus for use in the extinguishing of fires |
| US3065143A (en) * | 1960-04-19 | 1962-11-20 | Richardson Merrell Inc | Sustained release tablet |
| GB1047082A (en) * | 1963-02-01 | 1966-11-02 | Pfizer & Co C | Thyronine derivatives |
| NL297631A (da) * | 1963-06-03 | |||
| US3477954A (en) * | 1966-06-29 | 1969-11-11 | Armour Pharma | Phosphonium iodide complexes of thyroxine,methods of preparing same,and methods of preparing 3,5,3'-l-triiodothyronine therefrom |
| US3577535A (en) * | 1966-06-29 | 1971-05-04 | Armour Pharma | Treatment of thyroid hormone impairment pharmaceutical compositions containing 3,5,3' -l-triiodothyronine complexes |
| US3689669A (en) * | 1970-10-09 | 1972-09-05 | Univ Of North Carolina The | Antidepressant method and composition |
| US3928553A (en) * | 1972-03-23 | 1975-12-23 | Univ New York | Radioimmunoassay method for triiodothyronine and thyroxine |
| US4012498A (en) * | 1974-03-27 | 1977-03-15 | Sandoz, Inc. | Sustained release tablet formulations |
| US3939259A (en) * | 1974-05-24 | 1976-02-17 | Anthony Pescetti | Coating composition and therapeutic preparation incorporating same |
| US4357469A (en) * | 1979-06-14 | 1982-11-02 | Forest Laboratories, Inc. | Carrier base material for prolonged release therapeutic compositions |
| US4369172A (en) * | 1981-12-18 | 1983-01-18 | Forest Laboratories Inc. | Prolonged release therapeutic compositions based on hydroxypropylmethylcellulose |
| US4389393A (en) * | 1982-03-26 | 1983-06-21 | Forest Laboratories, Inc. | Sustained release therapeutic compositions based on high molecular weight hydroxypropylmethylcellulose |
| US4680323A (en) * | 1983-12-01 | 1987-07-14 | Hans Lowey | Method and composition for the preparation of controlled long-acting pharmaceuticals for oral administration |
| DE3571924D1 (en) * | 1984-04-11 | 1989-09-07 | Thiemann Arzneimittel Gmbh | Dosage units for controlled release of active material |
| CN1011118B (zh) * | 1986-06-13 | 1991-01-09 | 天津医学院附属医院 | 治疗白内障的眼药水的制药方法 |
| US4970075A (en) * | 1986-07-18 | 1990-11-13 | Euroceltique, S.A. | Controlled release bases for pharmaceuticals |
| US4851232A (en) * | 1987-02-13 | 1989-07-25 | Alza Corporation | Drug delivery system with means for obtaining desirable in vivo release rate pattern |
| US4915954A (en) * | 1987-09-03 | 1990-04-10 | Alza Corporation | Dosage form for delivering a drug at two different rates |
| US5032406A (en) * | 1989-02-21 | 1991-07-16 | Norwich Eaton Pharmaceuticals, Inc. | Dual-action tablet |
| US5133974A (en) * | 1989-05-05 | 1992-07-28 | Kv Pharmaceutical Company | Extended release pharmaceutical formulations |
-
1992
- 1992-12-22 DK DK92204048T patent/DK0550108T3/da active
- 1992-12-22 AT AT92204048T patent/ATE164063T1/de active
- 1992-12-22 DE DE69224809T patent/DE69224809T2/de not_active Expired - Lifetime
- 1992-12-22 EP EP92204048A patent/EP0550108B1/en not_active Expired - Lifetime
- 1992-12-22 ES ES92204048T patent/ES2115638T3/es not_active Expired - Lifetime
- 1992-12-22 NO NO92924985A patent/NO924985L/no unknown
- 1992-12-23 NZ NZ245575A patent/NZ245575A/en not_active IP Right Cessation
- 1992-12-24 AU AU30444/92A patent/AU660344B2/en not_active Expired
- 1992-12-28 US US07/997,474 patent/US5324522A/en not_active Expired - Lifetime
- 1992-12-28 ZA ZA9210059A patent/ZA9210059B/xx unknown
- 1992-12-28 JP JP34844792A patent/JP3662942B2/ja not_active Expired - Lifetime
- 1992-12-29 CA CA002086343A patent/CA2086343C/en not_active Expired - Lifetime
- 1992-12-29 KR KR1019920025966A patent/KR100249978B1/ko not_active Expired - Fee Related
- 1992-12-30 MX MX9207654A patent/MX9207654A/es unknown
Also Published As
| Publication number | Publication date |
|---|---|
| AU660344B2 (en) | 1995-06-22 |
| NZ245575A (en) | 1995-03-28 |
| JP3662942B2 (ja) | 2005-06-22 |
| CA2086343A1 (en) | 1993-07-01 |
| ATE164063T1 (de) | 1998-04-15 |
| DE69224809T2 (de) | 1998-07-09 |
| ES2115638T3 (es) | 1998-07-01 |
| KR100249978B1 (ko) | 2000-04-01 |
| EP0550108A1 (en) | 1993-07-07 |
| ZA9210059B (en) | 1993-08-03 |
| MX9207654A (es) | 1994-05-31 |
| DE69224809D1 (de) | 1998-04-23 |
| EP0550108B1 (en) | 1998-03-18 |
| JPH05255081A (ja) | 1993-10-05 |
| NO924985L (no) | 1993-07-01 |
| US5324522A (en) | 1994-06-28 |
| NO924985D0 (no) | 1992-12-22 |
| AU3044492A (en) | 1993-07-01 |
| CA2086343C (en) | 2004-03-09 |
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