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DK0542969T3 - Biodegradable particle forming vector and process for its preparation - Google Patents

Biodegradable particle forming vector and process for its preparation

Info

Publication number
DK0542969T3
DK0542969T3 DK92911799.2T DK92911799T DK0542969T3 DK 0542969 T3 DK0542969 T3 DK 0542969T3 DK 92911799 T DK92911799 T DK 92911799T DK 0542969 T3 DK0542969 T3 DK 0542969T3
Authority
DK
Denmark
Prior art keywords
preparation
particle forming
forming vector
linked
biodegradable particle
Prior art date
Application number
DK92911799.2T
Other languages
Danish (da)
Inventor
Daniel Samain
Miguel Ignacio De
Jaouad Meniali
Karim Ioualalen
Li Ding
Monique Cervilla
Valerie Rieumajou
Pascal Delrieu
Laurent Imbertie
Original Assignee
Biovector Therapeutics Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Biovector Therapeutics Sa filed Critical Biovector Therapeutics Sa
Application granted granted Critical
Publication of DK0542969T3 publication Critical patent/DK0542969T3/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/51—Nanocapsules; Nanoparticles
    • A61K9/5107—Excipients; Inactive ingredients
    • A61K9/5123—Organic compounds, e.g. fats, sugars
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/167—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction with an outer layer or coating comprising drug; with chemically bound drugs or non-active substances on their surface
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/51—Nanocapsules; Nanoparticles
    • A61K9/5107—Excipients; Inactive ingredients
    • A61K9/513—Organic macromolecular compounds; Dendrimers
    • A61K9/5161—Polysaccharides, e.g. alginate, chitosan, cellulose derivatives; Cyclodextrin

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Optics & Photonics (AREA)
  • Nanotechnology (AREA)
  • Biomedical Technology (AREA)
  • Physics & Mathematics (AREA)
  • Dispersion Chemistry (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Medicinal Preparation (AREA)
  • Biological Depolymerization Polymers (AREA)
  • Materials For Medical Uses (AREA)
  • Physical Or Chemical Processes And Apparatus (AREA)
  • Manufacturing Of Micro-Capsules (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Wrappers (AREA)
  • Laminated Bodies (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Immobilizing And Processing Of Enzymes And Microorganisms (AREA)

Abstract

A biodegradable particulate vector is disclosed and is characterized in that it comprises: a nucleus consisting of a cross-linked polysaccharide or oligosaccharide matrix to which ionic ligands are attached; a first semi-permeable lipid layer linked to the nucleus by covalent bonds; a second layer of amphiphilic compounds linked to the first lipid layer by hydrophobic interactions. A method for synthesis of said vector is also disclosed.
DK92911799.2T 1991-06-04 1992-06-04 Biodegradable particle forming vector and process for its preparation DK0542969T3 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR9106743A FR2677249B1 (en) 1991-06-04 1991-06-04 BIODEGRADABLE PARTICULATE VECTOR AND SYNTHESIS METHOD.

Publications (1)

Publication Number Publication Date
DK0542969T3 true DK0542969T3 (en) 1997-11-03

Family

ID=9413451

Family Applications (1)

Application Number Title Priority Date Filing Date
DK92911799.2T DK0542969T3 (en) 1991-06-04 1992-06-04 Biodegradable particle forming vector and process for its preparation

Country Status (11)

Country Link
EP (1) EP0542969B1 (en)
JP (1) JPH06500570A (en)
KR (1) KR100258521B1 (en)
AT (1) ATE152619T1 (en)
CA (1) CA2088759A1 (en)
DE (1) DE69219561T2 (en)
DK (1) DK0542969T3 (en)
ES (1) ES2103032T3 (en)
FR (1) FR2677249B1 (en)
GR (1) GR3024217T3 (en)
WO (1) WO1992021329A1 (en)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2114184T3 (en) * 1993-02-12 1998-05-16 Mayo Foundation COMPOSITION BASED ON CONDENSED PHASE MICROPARTICLES AND PROCEDURE.
US5654006A (en) * 1993-02-12 1997-08-05 Mayo Foundation For Medical Education And Research Condensed-phase microparticle composition and method
FR2702160B1 (en) * 1993-03-02 1995-06-02 Biovecteurs As Synthetic particulate vectors and method of preparation.
FR2704145B1 (en) * 1993-04-21 1995-07-21 Pasteur Institut Particulate vector and pharmaceutical composition containing it.
FR2754828B1 (en) * 1996-10-23 1998-12-24 Univ Toulouse ARTIFICIAL MEMBRANE STRUCTURE, METHOD AND POLYMER FOR PREPARING IT, METHOD FOR PREPARING THIS POLYMER, PARTICLE AND FILM COMPRISING THIS STRUCTURE
FR2757876B1 (en) * 1996-12-27 1999-04-09 Biovector Therapeutics Sa CONJUGATES OF A PARTICULATE VECTOR AND OLIGONUCLEOTIDES, THEIR PREPARATION METHOD AND THE PHARMACEUTICAL COMPOSITIONS CONTAINING THEM
FR2765496B1 (en) * 1997-07-03 1999-09-24 Rosanne Raynal MICROBALLS CALLED CAPSULES WITH POLYMERIC CORES CAPABLE OF CARRYING MOLECULES, ACTIVE INGREDIENTS AND / OR CELLS.
BRPI0801929A2 (en) * 2008-05-13 2010-01-12 Santana Cristiano Alberto Ribeiro A process and pharmaceutical composition comprising supramolecular nanoparticle plant proteolytic enzymes for the treatment of peyronie disease, collagen and fibrotic pathologies and their use.
US8716219B2 (en) * 2009-07-07 2014-05-06 Sabanci University Crosslinked protein nanocrystals, crosslinked protein nanoaggregates and method of preparation thereof
PT2506859T (en) * 2009-12-04 2016-08-12 Magle Ab Microspheres of hydrolysed starch with endogenous, charged ligands
KR102004232B1 (en) * 2011-09-29 2019-07-26 다우 글로벌 테크놀로지스 엘엘씨 In-situ method for preparing hydrolyzed acyl halide compound
WO2014026284A1 (en) * 2012-08-14 2014-02-20 Froese Aaron Internal structured self assembling liposomes

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2631826B1 (en) * 1988-05-27 1992-06-19 Centre Nat Rech Scient PARTICULATE VECTOR USEFUL IN PARTICULAR FOR THE TRANSPORT OF BIOLOGICALLY ACTIVATED MOLECULES AND METHOD FOR THE PREPARATION THEREOF
FR2646777B1 (en) * 1989-05-12 1993-09-03 Bio Serae Lab PROCESS FOR PREPARING AN ANTIMICROBIAL PARTICULATE PRODUCT, ANTIMICROBIAL PRODUCT OBTAINED AND APPLICATIONS

Also Published As

Publication number Publication date
CA2088759A1 (en) 1992-12-05
FR2677249A1 (en) 1992-12-11
EP0542969A1 (en) 1993-05-26
ATE152619T1 (en) 1997-05-15
KR930701158A (en) 1993-06-11
KR100258521B1 (en) 2000-08-01
DE69219561T2 (en) 1997-11-13
GR3024217T3 (en) 1997-10-31
WO1992021329A1 (en) 1992-12-10
ES2103032T3 (en) 1997-08-16
JPH06500570A (en) 1994-01-20
DE69219561D1 (en) 1997-06-12
FR2677249B1 (en) 1995-03-17
EP0542969B1 (en) 1997-05-07

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