DK0542802T3 - Stimulering af hårvækst med kaliumkanalåbnere og 5alfa-reduktase-inhibitorer - Google Patents
Stimulering af hårvækst med kaliumkanalåbnere og 5alfa-reduktase-inhibitorerInfo
- Publication number
- DK0542802T3 DK0542802T3 DK91913987.3T DK91913987T DK0542802T3 DK 0542802 T3 DK0542802 T3 DK 0542802T3 DK 91913987 T DK91913987 T DK 91913987T DK 0542802 T3 DK0542802 T3 DK 0542802T3
- Authority
- DK
- Denmark
- Prior art keywords
- potassium channel
- hair growth
- alpha
- reductase inhibitors
- stimulation
- Prior art date
Links
- 230000003779 hair growth Effects 0.000 title abstract 3
- 239000002677 5-alpha reductase inhibitor Substances 0.000 title abstract 2
- 229940127315 Potassium Channel Openers Drugs 0.000 title abstract 2
- 230000000638 stimulation Effects 0.000 title 1
- 201000004384 Alopecia Diseases 0.000 abstract 2
- DBEPLOCGEIEOCV-WSBQPABSSA-N finasteride Chemical compound N([C@@H]1CC2)C(=O)C=C[C@]1(C)[C@@H]1[C@@H]2[C@@H]2CC[C@H](C(=O)NC(C)(C)C)[C@@]2(C)CC1 DBEPLOCGEIEOCV-WSBQPABSSA-N 0.000 abstract 2
- 239000004036 potassium channel stimulating agent Substances 0.000 abstract 2
- JIHQDMXYYFUGFV-UHFFFAOYSA-N 1,3,5-triazine Chemical class C1=NC=NC=N1 JIHQDMXYYFUGFV-UHFFFAOYSA-N 0.000 abstract 1
- IVVNZDGDKPTYHK-JTQLQIEISA-N 1-cyano-2-[(2s)-3,3-dimethylbutan-2-yl]-3-pyridin-4-ylguanidine Chemical compound CC(C)(C)[C@H](C)N=C(NC#N)NC1=CC=NC=C1 IVVNZDGDKPTYHK-JTQLQIEISA-N 0.000 abstract 1
- FEAVXMPFTQROEI-UHFFFAOYSA-N 2h-pyrano[3,2-b]pyridine Chemical class C1=CN=C2C=CCOC2=C1 FEAVXMPFTQROEI-UHFFFAOYSA-N 0.000 abstract 1
- KYNSBQPICQTCGU-UHFFFAOYSA-N Benzopyrane Chemical compound C1=CC=C2C=CCOC2=C1 KYNSBQPICQTCGU-UHFFFAOYSA-N 0.000 abstract 1
- TVZCRIROJQEVOT-CABCVRRESA-N Cromakalim Chemical compound N1([C@@H]2C3=CC(=CC=C3OC([C@H]2O)(C)C)C#N)CCCC1=O TVZCRIROJQEVOT-CABCVRRESA-N 0.000 abstract 1
- 241000124008 Mammalia Species 0.000 abstract 1
- ZFMITUMMTDLWHR-UHFFFAOYSA-N Minoxidil Chemical compound NC1=[N+]([O-])C(N)=CC(N2CCCCC2)=N1 ZFMITUMMTDLWHR-UHFFFAOYSA-N 0.000 abstract 1
- 231100000360 alopecia Toxicity 0.000 abstract 1
- 206010068168 androgenetic alopecia Diseases 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 229950004210 cromakalim Drugs 0.000 abstract 1
- 229960003632 minoxidil Drugs 0.000 abstract 1
- 229960002310 pinacidil Drugs 0.000 abstract 1
- 230000001737 promoting effect Effects 0.000 abstract 1
- NNLBRYQGMOYARS-UHFFFAOYSA-N thiane 1-oxide Chemical compound O=S1CCCCC1 NNLBRYQGMOYARS-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q7/00—Preparations for affecting hair growth
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/565—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
- A61K8/494—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with more than one nitrogen as the only hetero atom
- A61K8/4953—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with more than one nitrogen as the only hetero atom containing pyrimidine ring derivatives, e.g. minoxidil
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/63—Steroids; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/74—Biological properties of particular ingredients
- A61K2800/78—Enzyme modulators, e.g. Enzyme agonists
- A61K2800/782—Enzyme inhibitors; Enzyme antagonists
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Birds (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Dermatology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Cosmetics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US56577790A | 1990-08-10 | 1990-08-10 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK0542802T3 true DK0542802T3 (da) | 1996-07-22 |
Family
ID=24260045
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK91913987.3T DK0542802T3 (da) | 1990-08-10 | 1991-07-29 | Stimulering af hårvækst med kaliumkanalåbnere og 5alfa-reduktase-inhibitorer |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US5578599A (fr) |
| EP (1) | EP0542802B1 (fr) |
| JP (1) | JP3004718B2 (fr) |
| KR (1) | KR100192734B1 (fr) |
| AT (1) | ATE134877T1 (fr) |
| AU (1) | AU646069B2 (fr) |
| CA (1) | CA2085605C (fr) |
| DE (1) | DE69117762T2 (fr) |
| DK (1) | DK0542802T3 (fr) |
| ES (1) | ES2084175T3 (fr) |
| GR (1) | GR3019789T3 (fr) |
| WO (1) | WO1992002225A1 (fr) |
Families Citing this family (32)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5516768A (en) * | 1990-03-16 | 1996-05-14 | Smithkline Beecham Corporation | Uncompetitive inhibition of steroid and 5α-reductose |
| GB2274060A (en) * | 1993-01-07 | 1994-07-13 | Merck & Co Inc | Treatment of patterned alopecia with 17ß-acyl-4-aza-5-androst-1-ene-3-ones and minoxidil |
| AU6083494A (en) * | 1993-01-07 | 1994-08-15 | Merck & Co., Inc. | Combination method for treating patterned alopecia with 17beta -n-substituted-carbamoyl-4-aza-5alpha-androst-1-en-3- ones and minoxidil |
| US5407944A (en) * | 1993-02-19 | 1995-04-18 | Goldman; Boris E. | Compositions and methods for promoting hair growth |
| ATE158301T1 (de) * | 1993-06-28 | 1997-10-15 | Merck & Co Inc | 4-aza-pregnan-5-alpha-reductase isozym 1 inhibitoren |
| TW382595B (en) * | 1993-10-15 | 2000-02-21 | Merck & Co Inc | Pharmaceutical composition for use in arresting and reversing androgenic alopecia |
| US5547957A (en) | 1993-10-15 | 1996-08-20 | Merck & Co., Inc. | Method of treating androgenic alopecia with 5-α reductase inhibitors |
| WO1995013815A1 (fr) * | 1993-11-18 | 1995-05-26 | Merck & Co., Inc. | Procede combine pour le traitement de l'alopecie hippocratique |
| FR2717381B1 (fr) * | 1994-03-15 | 1996-04-19 | Oreal | Compositions à base d'alpha-pyrones pour induire et stimuler la croissance des cheveux et/ou freiner leur chute et utilisation. |
| US5886005A (en) * | 1995-01-17 | 1999-03-23 | Merck & Co., Inc. | 4-Aza-19-norandrostane derivatives |
| EP0862436A1 (fr) * | 1995-10-19 | 1998-09-09 | Merck & Co., Inc. | Inhibiteurs de 5-alpha-reductase a 6-aza-steroides a substitution en position 16 |
| JPH10203933A (ja) * | 1997-01-27 | 1998-08-04 | Kao Corp | 養毛・育毛料 |
| US6013668A (en) | 1997-08-13 | 2000-01-11 | Bristol-Myers Squibb Company | Enantiomers of 4-[[(cyanoimino) [(1,2,2-trimethylpropyl) amino]methyl]amino]benzonitrile |
| US6458835B2 (en) | 1997-08-13 | 2002-10-01 | Bristol-Myers Squibb Company | Method of inhibiting or treating chemotherapy-induced hair loss |
| AUPO983897A0 (en) | 1997-10-17 | 1997-11-06 | Soltec Research Pty Ltd | Topical antifungal composition |
| AUPP310798A0 (en) * | 1998-04-22 | 1998-05-14 | Soltec Research Pty Ltd | Vehicle system for a composition comprising a piperidinopyrimidine derivative |
| GB9909792D0 (en) | 1998-12-04 | 1999-06-23 | Cambridge Bioclinical Limited | Potassium channel activators and their use |
| US20050153940A1 (en) * | 2000-01-26 | 2005-07-14 | Cedars-Sinai Medical Center | Method for using potassium channel activation for delivering a medicant to an abnormal brain region and/or a malignant tumor |
| US7018979B1 (en) | 2000-01-26 | 2006-03-28 | Cedars-Sinai Medical Center | Method for using potassium channel agonists for delivering a medicant to an abnormal brain region and/or a malignant tumor |
| US6596266B2 (en) | 2000-02-18 | 2003-07-22 | Natural Science, Inc. | Compositions containing minoxidil and saw palmetto for treating baldness |
| KR20020005332A (ko) * | 2000-07-10 | 2002-01-17 | 정상훈 | 탈모증 치료용 키트 |
| DE10036799A1 (de) * | 2000-07-28 | 2002-02-07 | Beiersdorf Ag | Neues Mittel zur Behandlung der Haare und der Kopfhaut |
| SE0100374D0 (sv) * | 2001-02-07 | 2001-02-07 | Pharmacia Ab | Novel compositions of potassium channel openers and protein kinase c inhibitors and use thereof |
| RU2181584C1 (ru) * | 2001-04-25 | 2002-04-27 | Московская медицинская академия им. И.М. Сеченова | Стимулятор роста волос |
| US7211561B2 (en) * | 2001-10-12 | 2007-05-01 | Cedars-Sinai Medical Center | Method for inducing selective cell death of malignant cells by activation of calcium-activated potassium channels (KCa) |
| SE0104421D0 (sv) * | 2001-12-21 | 2001-12-21 | Ponsus Pharma Ab | New composition |
| EP1850852A4 (fr) * | 2005-02-22 | 2009-11-18 | Cedars Sinai Medical Center | Utilisation du sildenafil, du vardenafil et d'autres inhibiteurs de la 5-phosphodiesterase pour augmenter la permeabilite d'une barriere sang /cerveau anormale |
| US7914548B2 (en) * | 2006-04-17 | 2011-03-29 | Ustuner E Tuncay | Prevention or treatment of male pattern baldness method and device |
| EP2343061A1 (fr) | 2009-12-28 | 2011-07-13 | Lipofoods, S.L. | Utilisation d'extrait d'huile de pin et compositions le contenant |
| KR101205209B1 (ko) * | 2011-04-25 | 2012-11-27 | 박준형 | 탈모방지 및 발모촉진용 외용제 조성물 |
| WO2015155609A2 (fr) * | 2014-04-11 | 2015-10-15 | Bcs Business Consulting Services Pte Ltd | Composition d'embellissement des sourcils et des cils |
| MX390288B (es) * | 2018-02-06 | 2025-03-20 | Centro Int De Cosmiatria S A P I De C V | Formulación y método para el tratamiento de la alopecia androgénica. |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4139619A (en) * | 1976-05-24 | 1979-02-13 | The Upjohn Company | 6-Amino-4-(substituted amino)-1,2-dihydro-1-hydroxy-2-iminopyrimidine, topical compositions and process for hair growth |
| US4596812A (en) * | 1976-05-24 | 1986-06-24 | The Upjohn Company | Methods and solutions for treating male pattern alopecia |
| DE3486090T2 (de) * | 1983-12-12 | 1993-08-05 | Kaszynski Edwin G | Haarwuchsmodifikation. |
| US4684635A (en) * | 1984-05-11 | 1987-08-04 | Norman Orentreich | Compositions and methods for inhibiting the action of androgens |
| EP0232311B1 (fr) * | 1985-07-18 | 1993-05-12 | PROCTOR, Peter H. | Composition topique et procede destines a stimuler la croissance des cheveux |
| DE3615396A1 (de) * | 1986-05-07 | 1987-11-12 | Wella Ag | Mittel zur behandlung der haare und der kopfhaut |
| US5026691A (en) * | 1987-03-30 | 1991-06-25 | The Upjohn Company | Combination of minoxidil and an antiinflammatory agent for treating patterned alopecia |
| WO1988007361A1 (fr) * | 1987-03-30 | 1988-10-06 | The Upjohn Company | Combinaison de minoxydil et d'un agent anti-inflammatoire pour le traitement de l'alopecie typique des personnes de sexe masculin |
| EP0285382B1 (fr) * | 1987-04-03 | 1994-04-13 | Merck & Co. Inc. | Traitement d'alopécia androgénique avec 17-bêta-n-monosubstitué-carbamoyl-4-aza-5-alpha-androst-1-en-3-ones |
| JPH01305017A (ja) * | 1988-05-31 | 1989-12-08 | Yakurigaku Chuo Kenkyusho:Kk | 脱毛症治療剤 |
| WO1990006100A1 (fr) * | 1988-12-02 | 1990-06-14 | The Upjohn Company | Compositions a base de minoxidil et de substances vasoconstrictives pour le traitement de l'alopecie |
-
1991
- 1991-07-29 KR KR1019930700375A patent/KR100192734B1/ko not_active Expired - Fee Related
- 1991-07-29 DE DE69117762T patent/DE69117762T2/de not_active Expired - Fee Related
- 1991-07-29 JP JP3513370A patent/JP3004718B2/ja not_active Expired - Fee Related
- 1991-07-29 ES ES91913987T patent/ES2084175T3/es not_active Expired - Lifetime
- 1991-07-29 CA CA002085605A patent/CA2085605C/fr not_active Expired - Fee Related
- 1991-07-29 AU AU83010/91A patent/AU646069B2/en not_active Ceased
- 1991-07-29 AT AT91913987T patent/ATE134877T1/de not_active IP Right Cessation
- 1991-07-29 DK DK91913987.3T patent/DK0542802T3/da active
- 1991-07-29 WO PCT/US1991/005170 patent/WO1992002225A1/fr not_active Ceased
- 1991-07-29 EP EP91913987A patent/EP0542802B1/fr not_active Expired - Lifetime
-
1995
- 1995-01-20 US US08/376,468 patent/US5578599A/en not_active Expired - Fee Related
-
1996
- 1996-04-29 GR GR960401169T patent/GR3019789T3/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| AU646069B2 (en) | 1994-02-03 |
| EP0542802A1 (fr) | 1993-05-26 |
| US5578599A (en) | 1996-11-26 |
| AU8301091A (en) | 1992-03-02 |
| EP0542802B1 (fr) | 1996-03-06 |
| CA2085605A1 (fr) | 1992-02-11 |
| WO1992002225A1 (fr) | 1992-02-20 |
| KR100192734B1 (ko) | 1999-06-15 |
| DE69117762D1 (de) | 1996-04-11 |
| ATE134877T1 (de) | 1996-03-15 |
| DE69117762T2 (de) | 1996-08-08 |
| ES2084175T3 (es) | 1996-05-01 |
| JP3004718B2 (ja) | 2000-01-31 |
| GR3019789T3 (en) | 1996-07-31 |
| CA2085605C (fr) | 2003-03-11 |
| JPH06500081A (ja) | 1994-01-06 |
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