DK0540614T3 - 3-(1-substitueret pyrazoyl)-2-oxindolderivater - Google Patents
3-(1-substitueret pyrazoyl)-2-oxindolderivaterInfo
- Publication number
- DK0540614T3 DK0540614T3 DK91913692.9T DK91913692T DK0540614T3 DK 0540614 T3 DK0540614 T3 DK 0540614T3 DK 91913692 T DK91913692 T DK 91913692T DK 0540614 T3 DK0540614 T3 DK 0540614T3
- Authority
- DK
- Denmark
- Prior art keywords
- pyrazoyl
- substituted
- oxindole derivatives
- biosynthesis
- interleukin
- Prior art date
Links
- 102000000589 Interleukin-1 Human genes 0.000 abstract 3
- 108010002352 Interleukin-1 Proteins 0.000 abstract 3
- 230000015572 biosynthetic process Effects 0.000 abstract 3
- 150000001875 compounds Chemical class 0.000 abstract 3
- YIBNHAJFJUQSRA-YNNPMVKQSA-N prostaglandin H2 Chemical compound C1[C@@H]2OO[C@H]1[C@H](/C=C/[C@@H](O)CCCCC)[C@H]2C\C=C/CCCC(O)=O YIBNHAJFJUQSRA-YNNPMVKQSA-N 0.000 abstract 3
- 208000037976 chronic inflammation Diseases 0.000 abstract 2
- 208000037893 chronic inflammatory disorder Diseases 0.000 abstract 2
- 239000003112 inhibitor Substances 0.000 abstract 2
- 238000000034 method Methods 0.000 abstract 2
- 102000001381 Arachidonate 5-Lipoxygenase Human genes 0.000 abstract 1
- 108010093579 Arachidonate 5-lipoxygenase Proteins 0.000 abstract 1
- 241000124008 Mammalia Species 0.000 abstract 1
- 230000000202 analgesic effect Effects 0.000 abstract 1
- 239000000730 antalgic agent Substances 0.000 abstract 1
- 239000002260 anti-inflammatory agent Substances 0.000 abstract 1
- 229940121363 anti-inflammatory agent Drugs 0.000 abstract 1
- 230000003110 anti-inflammatory effect Effects 0.000 abstract 1
- 229940124346 antiarthritic agent Drugs 0.000 abstract 1
- 239000003435 antirheumatic agent Substances 0.000 abstract 1
- 230000002401 inhibitory effect Effects 0.000 abstract 1
- 239000000543 intermediate Substances 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/415—1,2-Diazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pain & Pain Management (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Rheumatology (AREA)
- Immunology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US07/557,265 US5064851A (en) | 1990-07-24 | 1990-07-24 | 3-(1-substituted-pyrazoyl)-2-oxindole derivatives, compositions and use |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK0540614T3 true DK0540614T3 (da) | 1996-09-09 |
Family
ID=24224706
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK91913692.9T DK0540614T3 (da) | 1990-07-24 | 1991-06-12 | 3-(1-substitueret pyrazoyl)-2-oxindolderivater |
Country Status (13)
| Country | Link |
|---|---|
| US (1) | US5064851A (da) |
| EP (1) | EP0540614B1 (da) |
| JP (1) | JP2504659B2 (da) |
| AT (1) | ATE141601T1 (da) |
| CA (1) | CA2086432C (da) |
| DE (1) | DE69121571T2 (da) |
| DK (1) | DK0540614T3 (da) |
| ES (1) | ES2090345T3 (da) |
| FI (1) | FI107609B (da) |
| GR (1) | GR3021291T3 (da) |
| IE (1) | IE74689B1 (da) |
| PT (1) | PT98404B (da) |
| WO (1) | WO1992001684A1 (da) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5698399A (en) * | 1996-04-05 | 1997-12-16 | Duff; Gordon W. | Detecting genetic predisposition for osteoporosis |
| ID21775A (id) * | 1996-10-25 | 1999-07-22 | Yoshitomi Pharmaceutical | Senyawa-senyawa 1-fenilpirazol dan penggunaan farmasinya |
| AU723895B2 (en) * | 1997-01-29 | 2000-09-07 | Pfizer Inc. | Sulfonyl urea derivatives and their use in the control of interleukin-1 activity |
| EP1270565B1 (en) * | 1997-01-29 | 2004-06-30 | Pfizer Inc. | 4-Substituted furan-2-sulfonamide and its use in the preparation of sulfonyl urea derivatives |
| EP1068187A1 (en) * | 1998-04-08 | 2001-01-17 | Abbott Laboratories | Pyrazole inhibitors of cytokine production |
| MXPA02007068A (es) * | 2000-01-20 | 2004-02-26 | Nortel Networks Ltd | Estructura de marco adaptable para un sistema hibrido cdma/tdma. |
| MX2011011517A (es) | 2009-04-29 | 2012-06-19 | Amarin Corp Plc | Composiciones farmaceuticas que comprenden epa y un agente cardiovascular y metodos para utilizar el mismo. |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3259622A (en) * | 1962-09-07 | 1966-07-05 | Merck & Co Inc | 1-benzyl-3-indolyl-alpha-haloalkyl and alkylidenyl acetic acids |
| DE3310891A1 (de) * | 1983-03-25 | 1984-09-27 | Boehringer Mannheim Gmbh, 6800 Mannheim | Neue indolinon-(2)-derivate, verfahren zu ihrer herstellung, diese verbindungen enthaltende arzneimittel und zwischenprodukte |
| US4556672A (en) * | 1984-03-19 | 1985-12-03 | Pfizer Inc. | 3-Substituted 2-oxindole-1-carboxamides as analgesic and anti-inflammatory agents |
| US4569942A (en) * | 1984-05-04 | 1986-02-11 | Pfizer Inc. | N,3-Disubstituted 2-oxindole-1-carboxamides as analgesic and antiinflammatory agents |
| US4861794A (en) * | 1988-04-13 | 1989-08-29 | Pfizer Inc. | 3-substituted-2-oxindole-1-carboxamides as inhibitors of interleukin-1 biosynthesis |
| US5047554A (en) * | 1989-04-18 | 1991-09-10 | Pfizer Inc. | 3-substituted-2-oxindole derivatives |
-
1990
- 1990-07-24 US US07/557,265 patent/US5064851A/en not_active Expired - Lifetime
-
1991
- 1991-06-12 ES ES91913692T patent/ES2090345T3/es not_active Expired - Lifetime
- 1991-06-12 JP JP3513041A patent/JP2504659B2/ja not_active Expired - Fee Related
- 1991-06-12 EP EP91913692A patent/EP0540614B1/en not_active Expired - Lifetime
- 1991-06-12 AT AT91913692T patent/ATE141601T1/de not_active IP Right Cessation
- 1991-06-12 DE DE69121571T patent/DE69121571T2/de not_active Expired - Fee Related
- 1991-06-12 WO PCT/US1991/004043 patent/WO1992001684A1/en not_active Ceased
- 1991-06-12 CA CA002086432A patent/CA2086432C/en not_active Expired - Fee Related
- 1991-06-12 DK DK91913692.9T patent/DK0540614T3/da active
- 1991-07-22 PT PT98404A patent/PT98404B/pt not_active IP Right Cessation
- 1991-07-23 IE IE257491A patent/IE74689B1/en not_active IP Right Cessation
-
1993
- 1993-01-22 FI FI930263A patent/FI107609B/fi not_active IP Right Cessation
-
1996
- 1996-10-09 GR GR960402662T patent/GR3021291T3/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| DE69121571T2 (de) | 1997-01-09 |
| EP0540614B1 (en) | 1996-08-21 |
| CA2086432C (en) | 1997-12-16 |
| DE69121571D1 (de) | 1996-09-26 |
| ATE141601T1 (de) | 1996-09-15 |
| ES2090345T3 (es) | 1996-10-16 |
| EP0540614A1 (en) | 1993-05-12 |
| JP2504659B2 (ja) | 1996-06-05 |
| JPH05504773A (ja) | 1993-07-22 |
| FI107609B (fi) | 2001-09-14 |
| WO1992001684A1 (en) | 1992-02-06 |
| PT98404B (pt) | 1999-01-29 |
| US5064851A (en) | 1991-11-12 |
| GR3021291T3 (en) | 1997-01-31 |
| CA2086432A1 (en) | 1992-01-25 |
| IE912574A1 (en) | 1992-01-29 |
| FI930263L (fi) | 1993-01-22 |
| FI930263A0 (fi) | 1993-01-22 |
| IE74689B1 (en) | 1997-07-30 |
| PT98404A (pt) | 1992-05-29 |
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