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DK0471660T3 - Protein C for the treatment of pain - Google Patents

Protein C for the treatment of pain

Info

Publication number
DK0471660T3
DK0471660T3 DK91890012.7T DK91890012T DK0471660T3 DK 0471660 T3 DK0471660 T3 DK 0471660T3 DK 91890012 T DK91890012 T DK 91890012T DK 0471660 T3 DK0471660 T3 DK 0471660T3
Authority
DK
Denmark
Prior art keywords
protein
pain
treatment
compsn
prepare
Prior art date
Application number
DK91890012.7T
Other languages
Danish (da)
Inventor
Johann Dr Eibl
Ludwig Prof Dr Pichler
Hans-Peter Doz Dr Schwarz
Original Assignee
Immuno Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Immuno Ag filed Critical Immuno Ag
Application granted granted Critical
Publication of DK0471660T3 publication Critical patent/DK0471660T3/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/40—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against enzymes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/14—Vasoprotectives; Antihaemorrhoidals; Drugs for varicose therapy; Capillary stabilisers
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6424—Serine endopeptidases (3.4.21)
    • C12N9/6464—Protein C (3.4.21.69)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
    • C12Y304/21—Serine endopeptidases (3.4.21)
    • C12Y304/21069—Protein C activated (3.4.21.69)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Biomedical Technology (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Biochemistry (AREA)
  • Wood Science & Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pain & Pain Management (AREA)
  • Immunology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Vascular Medicine (AREA)
  • Biophysics (AREA)
  • Rheumatology (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Urology & Nephrology (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)

Abstract

The use of opt. activated protein C (I) to prepare a compsn. for normalising increased vascular permeabilty and to inhibit permeability defects of the vascular wall is new. Also new is the use of (I) to prepare a compsn. for stimulating the beta-adrenergic receptors.
DK91890012.7T 1990-08-16 1991-01-28 Protein C for the treatment of pain DK0471660T3 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
AT0169790A AT402260B (en) 1990-08-16 1990-08-16 PROTEIN C-CONTAINING PHARMACEUTICAL PREPARATION

Publications (1)

Publication Number Publication Date
DK0471660T3 true DK0471660T3 (en) 1995-12-18

Family

ID=3519039

Family Applications (3)

Application Number Title Priority Date Filing Date
DK92117248.2T DK0533209T3 (en) 1990-08-16 1991-01-28 Pharmaceutical preparation containing protein C as beta-sympathomimetic.
DK92117249.0T DK0533210T3 (en) 1990-08-16 1991-01-28 Protein C-containing pharmaceutical preparations as agents for inflammation.
DK91890012.7T DK0471660T3 (en) 1990-08-16 1991-01-28 Protein C for the treatment of pain

Family Applications Before (2)

Application Number Title Priority Date Filing Date
DK92117248.2T DK0533209T3 (en) 1990-08-16 1991-01-28 Pharmaceutical preparation containing protein C as beta-sympathomimetic.
DK92117249.0T DK0533210T3 (en) 1990-08-16 1991-01-28 Protein C-containing pharmaceutical preparations as agents for inflammation.

Country Status (12)

Country Link
EP (3) EP0533209B1 (en)
JP (1) JP2530770B2 (en)
AT (6) AT402260B (en)
CA (1) CA2041380C (en)
CZ (1) CZ280004B6 (en)
DE (3) DE59106292D1 (en)
DK (3) DK0533209T3 (en)
ES (3) ES2103861T3 (en)
HR (1) HRP921237A2 (en)
HU (1) HUT60147A (en)
RU (1) RU2066550C1 (en)
YU (1) YU77591A (en)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5571786A (en) * 1990-08-16 1996-11-05 Immuno Aktiengesellschaft Use of protein C or the activation peptide of protein C for preparing a pharmaceutical preparation
AT397615B (en) * 1991-05-14 1994-05-25 Immuno Ag MEDICINAL PRODUCT PROTEIN C
DE4320294A1 (en) * 1993-06-18 1994-12-22 Immuno Ag Use of human protein C to prevent and treat platelet deposits
EP0733371B1 (en) * 1995-03-21 2002-06-19 Baxter Aktiengesellschaft Agent for the subcutaneous application of protein C
DE19608218A1 (en) * 1995-03-21 1996-09-26 Immuno Ag Agent for subcutaneous administration of protein C.
US20080293631A1 (en) * 2005-01-07 2008-11-27 Christopher John Jackson Treatment for Autoimmune and Inflammatory Conditions
CN104394883B (en) 2012-07-04 2017-05-31 悉尼大学 Treatment of Inflammatory Skin Conditions
EP3137102B1 (en) 2014-04-16 2021-07-14 ZZ Biotech LLC Apc for use in the treatment of abnormal cutaneous scarring
US20170035862A1 (en) 2014-04-16 2017-02-09 Zz Biotech Llc Use of APC analogue for wound healing

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2739050B2 (en) * 1988-01-28 1998-04-08 ヘキスト薬品工業株式会社 Anticoagulant
US5093117A (en) * 1989-01-24 1992-03-03 Baxter International Inc. Compositions and method for the treatment or prophylaxis of sepsis or septic shock

Also Published As

Publication number Publication date
ATA20392A (en) 1997-07-15
AT403439B (en) 1998-02-25
ATA20492A (en) 1997-10-15
CA2041380A1 (en) 1992-02-17
EP0533209A1 (en) 1993-03-24
ATE126699T1 (en) 1995-09-15
EP0471660B1 (en) 1995-08-23
ATE152354T1 (en) 1997-05-15
JPH04230633A (en) 1992-08-19
DK0533209T3 (en) 1997-09-22
DE59108638D1 (en) 1997-04-30
DK0533210T3 (en) 1997-11-03
YU77591A (en) 1995-10-24
ES2080289T3 (en) 1996-02-01
HU911348D0 (en) 1991-10-28
CZ280004B6 (en) 1995-09-13
EP0471660A3 (en) 1992-04-15
ATA169790A (en) 1996-08-15
CA2041380C (en) 1997-10-07
EP0533209B1 (en) 1997-03-26
JP2530770B2 (en) 1996-09-04
ES2102435T3 (en) 1997-08-01
AT403763B (en) 1998-05-25
EP0533210B1 (en) 1997-05-02
HUT60147A (en) 1992-08-28
HRP921237A2 (en) 1995-10-31
AT402260B (en) 1997-03-25
DE59106292D1 (en) 1995-09-28
RU2066550C1 (en) 1996-09-20
EP0533210A1 (en) 1993-03-24
CS121391A3 (en) 1992-02-19
EP0471660A2 (en) 1992-02-19
ATE150649T1 (en) 1997-04-15
ES2103861T3 (en) 1997-10-01
DE59108697D1 (en) 1997-06-05

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Legal Events

Date Code Title Description
AHB Application shelved due to non-payment