DE9316320U1 - Cosmetic preparation in the form of lipsticks with an antiviral effect - Google Patents
Cosmetic preparation in the form of lipsticks with an antiviral effectInfo
- Publication number
- DE9316320U1 DE9316320U1 DE9316320U DE9316320U DE9316320U1 DE 9316320 U1 DE9316320 U1 DE 9316320U1 DE 9316320 U DE9316320 U DE 9316320U DE 9316320 U DE9316320 U DE 9316320U DE 9316320 U1 DE9316320 U1 DE 9316320U1
- Authority
- DE
- Germany
- Prior art keywords
- weight
- preparation
- preparation according
- amounts
- enhancer
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 238000002360 preparation method Methods 0.000 title claims description 39
- 239000002537 cosmetic Substances 0.000 title claims description 11
- 230000000840 anti-viral effect Effects 0.000 title claims description 9
- YXBUQQDFTYOHQI-UHFFFAOYSA-N Pseudohypericin Chemical compound OC1=CC(O)=C2C(=O)C3=C(O)C=C(C)C4=C3C3=C2C1=C(C(O)=CC(O)=C1C2=O)C1=C3C1=C2C(O)=CC(CO)=C14 YXBUQQDFTYOHQI-UHFFFAOYSA-N 0.000 claims description 18
- SSKVDVBQSWQEGJ-UHFFFAOYSA-N pseudohypericin Natural products C12=C(O)C=C(O)C(C(C=3C(O)=CC(O)=C4C=33)=O)=C2C3=C2C3=C4C(C)=CC(O)=C3C(=O)C3=C(O)C=C(O)C1=C32 SSKVDVBQSWQEGJ-UHFFFAOYSA-N 0.000 claims description 16
- 239000003623 enhancer Substances 0.000 claims description 12
- 235000020759 St. John’s wort extract Nutrition 0.000 claims description 9
- 239000004615 ingredient Substances 0.000 claims description 9
- 229940099416 st. john's wort extract Drugs 0.000 claims description 9
- 230000000694 effects Effects 0.000 claims description 8
- 239000004480 active ingredient Substances 0.000 claims description 7
- -1 ethoxylated sorbitan fatty acid ester Chemical class 0.000 claims description 7
- BTXNYTINYBABQR-UHFFFAOYSA-N hypericin Chemical compound C12=C(O)C=C(O)C(C(C=3C(O)=CC(C)=C4C=33)=O)=C2C3=C2C3=C4C(C)=CC(O)=C3C(=O)C3=C(O)C=C(O)C1=C32 BTXNYTINYBABQR-UHFFFAOYSA-N 0.000 claims description 7
- 229940005608 hypericin Drugs 0.000 claims description 7
- PHOKTTKFQUYZPI-UHFFFAOYSA-N hypericin Natural products Cc1cc(O)c2c3C(=O)C(=Cc4c(O)c5c(O)cc(O)c6c7C(=O)C(=Cc8c(C)c1c2c(c78)c(c34)c56)O)O PHOKTTKFQUYZPI-UHFFFAOYSA-N 0.000 claims description 7
- 239000002904 solvent Substances 0.000 claims description 6
- XQFRJNBWHJMXHO-RRKCRQDMSA-N IDUR Chemical compound C1[C@H](O)[C@@H](CO)O[C@H]1N1C(=O)NC(=O)C(I)=C1 XQFRJNBWHJMXHO-RRKCRQDMSA-N 0.000 claims description 5
- 239000003589 local anesthetic agent Substances 0.000 claims description 5
- 230000003444 anaesthetic effect Effects 0.000 claims description 4
- 239000002260 anti-inflammatory agent Substances 0.000 claims description 4
- 229940121363 anti-inflammatory agent Drugs 0.000 claims description 3
- 235000014113 dietary fatty acids Nutrition 0.000 claims description 3
- 239000000284 extract Substances 0.000 claims description 3
- 239000000194 fatty acid Substances 0.000 claims description 3
- 229930195729 fatty acid Natural products 0.000 claims description 3
- 235000010482 polyoxyethylene sorbitan monooleate Nutrition 0.000 claims description 3
- 229920000053 polysorbate 80 Polymers 0.000 claims description 3
- 150000002191 fatty alcohols Chemical class 0.000 claims description 2
- 229920000151 polyglycol Polymers 0.000 claims description 2
- 239000010695 polyglycol Substances 0.000 claims description 2
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 claims 2
- 229940049964 oleate Drugs 0.000 claims 1
- ZQPPMHVWECSIRJ-KTKRTIGZSA-N oleic acid Chemical compound CCCCCCCC\C=C/CCCCCCCC(O)=O ZQPPMHVWECSIRJ-KTKRTIGZSA-N 0.000 claims 1
- GWEVSGVZZGPLCZ-UHFFFAOYSA-N Titan oxide Chemical compound O=[Ti]=O GWEVSGVZZGPLCZ-UHFFFAOYSA-N 0.000 description 9
- ZAKOWWREFLAJOT-CEFNRUSXSA-N D-alpha-tocopherylacetate Chemical compound CC(=O)OC1=C(C)C(C)=C2O[C@@](CCC[C@H](C)CCC[C@H](C)CCCC(C)C)(C)CCC2=C1C ZAKOWWREFLAJOT-CEFNRUSXSA-N 0.000 description 4
- 239000000654 additive Substances 0.000 description 4
- ZAKOWWREFLAJOT-UHFFFAOYSA-N d-alpha-Tocopheryl acetate Natural products CC(=O)OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1C ZAKOWWREFLAJOT-UHFFFAOYSA-N 0.000 description 4
- 206010061218 Inflammation Diseases 0.000 description 3
- YBGZDTIWKVFICR-JLHYYAGUSA-N Octyl 4-methoxycinnamic acid Chemical compound CCCCC(CC)COC(=O)\C=C\C1=CC=C(OC)C=C1 YBGZDTIWKVFICR-JLHYYAGUSA-N 0.000 description 3
- 230000000996 additive effect Effects 0.000 description 3
- 239000010642 eucalyptus oil Substances 0.000 description 3
- 229940044949 eucalyptus oil Drugs 0.000 description 3
- 230000004054 inflammatory process Effects 0.000 description 3
- DZKXJUASMGQEMA-UHFFFAOYSA-N tetradecyl tetradecanoate Chemical compound CCCCCCCCCCCCCCOC(=O)CCCCCCCCCCCCC DZKXJUASMGQEMA-UHFFFAOYSA-N 0.000 description 3
- 239000004408 titanium dioxide Substances 0.000 description 3
- 229940042585 tocopherol acetate Drugs 0.000 description 3
- DSSYKIVIOFKYAU-OIBJUYFYSA-N (S)-camphor Chemical compound C1C[C@]2(C)C(=O)C[C@H]1C2(C)C DSSYKIVIOFKYAU-OIBJUYFYSA-N 0.000 description 2
- 239000004166 Lanolin Substances 0.000 description 2
- 239000004264 Petrolatum Substances 0.000 description 2
- VYGQUTWHTHXGQB-FFHKNEKCSA-N Retinol Palmitate Chemical compound CCCCCCCCCCCCCCCC(=O)OC\C=C(/C)\C=C\C=C(/C)\C=C\C1=C(C)CCCC1(C)C VYGQUTWHTHXGQB-FFHKNEKCSA-N 0.000 description 2
- POJWUDADGALRAB-UHFFFAOYSA-N allantoin Chemical compound NC(=O)NC1NC(=O)NC1=O POJWUDADGALRAB-UHFFFAOYSA-N 0.000 description 2
- XNEFYCZVKIDDMS-UHFFFAOYSA-N avobenzone Chemical compound C1=CC(OC)=CC=C1C(=O)CC(=O)C1=CC=C(C(C)(C)C)C=C1 XNEFYCZVKIDDMS-UHFFFAOYSA-N 0.000 description 2
- 229940036350 bisabolol Drugs 0.000 description 2
- 229960000846 camphor Drugs 0.000 description 2
- 235000019388 lanolin Nutrition 0.000 description 2
- 229940039717 lanolin Drugs 0.000 description 2
- 239000000203 mixture Substances 0.000 description 2
- 239000003921 oil Substances 0.000 description 2
- 235000019198 oils Nutrition 0.000 description 2
- 229940066842 petrolatum Drugs 0.000 description 2
- 235000019271 petrolatum Nutrition 0.000 description 2
- 239000000126 substance Substances 0.000 description 2
- 230000000699 topical effect Effects 0.000 description 2
- 229940099259 vaseline Drugs 0.000 description 2
- DSEKYWAQQVUQTP-XEWMWGOFSA-N (2r,4r,4as,6as,6as,6br,8ar,12ar,14as,14bs)-2-hydroxy-4,4a,6a,6b,8a,11,11,14a-octamethyl-2,4,5,6,6a,7,8,9,10,12,12a,13,14,14b-tetradecahydro-1h-picen-3-one Chemical compound C([C@H]1[C@]2(C)CC[C@@]34C)C(C)(C)CC[C@]1(C)CC[C@]2(C)[C@H]4CC[C@@]1(C)[C@H]3C[C@@H](O)C(=O)[C@@H]1C DSEKYWAQQVUQTP-XEWMWGOFSA-N 0.000 description 1
- DSSYKIVIOFKYAU-XCBNKYQSSA-N (R)-camphor Chemical compound C1C[C@@]2(C)C(=O)C[C@@H]1C2(C)C DSSYKIVIOFKYAU-XCBNKYQSSA-N 0.000 description 1
- IIZPXYDJLKNOIY-JXPKJXOSSA-N 1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphocholine Chemical compound CCCCCCCCCCCCCCCC(=O)OC[C@H](COP([O-])(=O)OCC[N+](C)(C)C)OC(=O)CCC\C=C/C\C=C/C\C=C/C\C=C/CCCCC IIZPXYDJLKNOIY-JXPKJXOSSA-N 0.000 description 1
- TYYHDKOVFSVWON-UHFFFAOYSA-N 2-butyl-2-methoxy-1,3-diphenylpropane-1,3-dione Chemical compound C=1C=CC=CC=1C(=O)C(OC)(CCCC)C(=O)C1=CC=CC=C1 TYYHDKOVFSVWON-UHFFFAOYSA-N 0.000 description 1
- HIQIXEFWDLTDED-UHFFFAOYSA-N 4-hydroxy-1-piperidin-4-ylpyrrolidin-2-one Chemical compound O=C1CC(O)CN1C1CCNCC1 HIQIXEFWDLTDED-UHFFFAOYSA-N 0.000 description 1
- POJWUDADGALRAB-PVQJCKRUSA-N Allantoin Natural products NC(=O)N[C@@H]1NC(=O)NC1=O POJWUDADGALRAB-PVQJCKRUSA-N 0.000 description 1
- PAYRUJLWNCNPSJ-UHFFFAOYSA-N Aniline Chemical compound NC1=CC=CC=C1 PAYRUJLWNCNPSJ-UHFFFAOYSA-N 0.000 description 1
- 102000004506 Blood Proteins Human genes 0.000 description 1
- 108010017384 Blood Proteins Proteins 0.000 description 1
- NLZUEZXRPGMBCV-UHFFFAOYSA-N Butylhydroxytoluene Chemical compound CC1=CC(C(C)(C)C)=C(O)C(C(C)(C)C)=C1 NLZUEZXRPGMBCV-UHFFFAOYSA-N 0.000 description 1
- 235000007866 Chamaemelum nobile Nutrition 0.000 description 1
- 241000723346 Cinnamomum camphora Species 0.000 description 1
- 244000180278 Copernicia prunifera Species 0.000 description 1
- 235000010919 Copernicia prunifera Nutrition 0.000 description 1
- OQEBIHBLFRADNM-UHFFFAOYSA-N D-iminoxylitol Natural products OCC1NCC(O)C1O OQEBIHBLFRADNM-UHFFFAOYSA-N 0.000 description 1
- SNPLKNRPJHDVJA-ZETCQYMHSA-N D-panthenol Chemical compound OCC(C)(C)[C@@H](O)C(=O)NCCCO SNPLKNRPJHDVJA-ZETCQYMHSA-N 0.000 description 1
- 102000004190 Enzymes Human genes 0.000 description 1
- 108090000790 Enzymes Proteins 0.000 description 1
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 1
- 241000701074 Human alphaherpesvirus 2 Species 0.000 description 1
- 244000141009 Hypericum perforatum Species 0.000 description 1
- 235000017309 Hypericum perforatum Nutrition 0.000 description 1
- 206010020751 Hypersensitivity Diseases 0.000 description 1
- 206010024561 Lip pain Diseases 0.000 description 1
- WHXSMMKQMYFTQS-UHFFFAOYSA-N Lithium Chemical compound [Li] WHXSMMKQMYFTQS-UHFFFAOYSA-N 0.000 description 1
- 244000042664 Matricaria chamomilla Species 0.000 description 1
- 235000007232 Matricaria chamomilla Nutrition 0.000 description 1
- 239000005662 Paraffin oil Substances 0.000 description 1
- 241000219000 Populus Species 0.000 description 1
- VYGQUTWHTHXGQB-UHFFFAOYSA-N Retinol hexadecanoate Natural products CCCCCCCCCCCCCCCC(=O)OCC=C(C)C=CC=C(C)C=CC1=C(C)CCCC1(C)C VYGQUTWHTHXGQB-UHFFFAOYSA-N 0.000 description 1
- 241000700584 Simplexvirus Species 0.000 description 1
- 229930182558 Sterol Natural products 0.000 description 1
- RTAQQCXQSZGOHL-UHFFFAOYSA-N Titanium Chemical compound [Ti] RTAQQCXQSZGOHL-UHFFFAOYSA-N 0.000 description 1
- 206010052428 Wound Diseases 0.000 description 1
- 208000027418 Wounds and injury Diseases 0.000 description 1
- UJNOLBSYLSYIBM-WISYIIOYSA-N [(1r,2s,5r)-5-methyl-2-propan-2-ylcyclohexyl] (2r)-2-hydroxypropanoate Chemical compound CC(C)[C@@H]1CC[C@@H](C)C[C@H]1OC(=O)[C@@H](C)O UJNOLBSYLSYIBM-WISYIIOYSA-N 0.000 description 1
- 229960000458 allantoin Drugs 0.000 description 1
- 150000001413 amino acids Chemical class 0.000 description 1
- 239000003963 antioxidant agent Substances 0.000 description 1
- 235000006708 antioxidants Nutrition 0.000 description 1
- 229960005193 avobenzone Drugs 0.000 description 1
- 235000013871 bee wax Nutrition 0.000 description 1
- 239000012166 beeswax Substances 0.000 description 1
- 230000017531 blood circulation Effects 0.000 description 1
- WTOOLIQYCQJDBG-BJILWQEISA-N but-1-ene;(e)-but-2-ene Chemical compound CCC=C.C\C=C\C WTOOLIQYCQJDBG-BJILWQEISA-N 0.000 description 1
- 229930008380 camphor Natural products 0.000 description 1
- 239000004204 candelilla wax Substances 0.000 description 1
- 235000013868 candelilla wax Nutrition 0.000 description 1
- 229940073532 candelilla wax Drugs 0.000 description 1
- 239000004203 carnauba wax Substances 0.000 description 1
- 235000013869 carnauba wax Nutrition 0.000 description 1
- 239000004359 castor oil Substances 0.000 description 1
- 235000019438 castor oil Nutrition 0.000 description 1
- 210000002808 connective tissue Anatomy 0.000 description 1
- 239000006071 cream Substances 0.000 description 1
- POULHZVOKOAJMA-UHFFFAOYSA-M dodecanoate Chemical compound CCCCCCCCCCCC([O-])=O POULHZVOKOAJMA-UHFFFAOYSA-M 0.000 description 1
- 239000000975 dye Substances 0.000 description 1
- 150000002170 ethers Chemical class 0.000 description 1
- 238000009472 formulation Methods 0.000 description 1
- FOYKKGHVWRFIBD-UHFFFAOYSA-N gamma-tocopherol acetate Natural products CC(=O)OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1 FOYKKGHVWRFIBD-UHFFFAOYSA-N 0.000 description 1
- ZEMPKEQAKRGZGQ-XOQCFJPHSA-N glycerol triricinoleate Natural products CCCCCC[C@@H](O)CC=CCCCCCCCC(=O)OC[C@@H](COC(=O)CCCCCCCC=CC[C@@H](O)CCCCCC)OC(=O)CCCCCCCC=CC[C@H](O)CCCCCC ZEMPKEQAKRGZGQ-XOQCFJPHSA-N 0.000 description 1
- 230000009931 harmful effect Effects 0.000 description 1
- 230000035876 healing Effects 0.000 description 1
- IUJAMGNYPWYUPM-UHFFFAOYSA-N hentriacontane Chemical compound CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC IUJAMGNYPWYUPM-UHFFFAOYSA-N 0.000 description 1
- BXWNKGSJHAJOGX-UHFFFAOYSA-N hexadecan-1-ol Chemical compound CCCCCCCCCCCCCCCCO BXWNKGSJHAJOGX-UHFFFAOYSA-N 0.000 description 1
- IPCSVZSSVZVIGE-UHFFFAOYSA-M hexadecanoate Chemical compound CCCCCCCCCCCCCCCC([O-])=O IPCSVZSSVZVIGE-UHFFFAOYSA-M 0.000 description 1
- 239000005556 hormone Substances 0.000 description 1
- 229940088597 hormone Drugs 0.000 description 1
- 208000015181 infectious disease Diseases 0.000 description 1
- 208000027866 inflammatory disease Diseases 0.000 description 1
- 229940070765 laurate Drugs 0.000 description 1
- 229940067606 lecithin Drugs 0.000 description 1
- 235000010445 lecithin Nutrition 0.000 description 1
- 239000000787 lecithin Substances 0.000 description 1
- 229910052744 lithium Inorganic materials 0.000 description 1
- 239000001525 mentha piperita l. herb oil Substances 0.000 description 1
- 210000004400 mucous membrane Anatomy 0.000 description 1
- 229940078812 myristyl myristate Drugs 0.000 description 1
- 231100000344 non-irritating Toxicity 0.000 description 1
- 235000016709 nutrition Nutrition 0.000 description 1
- ALSTYHKOOCGGFT-UHFFFAOYSA-N octadec-9-en-1-ol Chemical compound CCCCCCCCC=CCCCCCCCCO ALSTYHKOOCGGFT-UHFFFAOYSA-N 0.000 description 1
- QIQXTHQIDYTFRH-UHFFFAOYSA-N octadecanoic acid Chemical compound CCCCCCCCCCCCCCCCCC(O)=O QIQXTHQIDYTFRH-UHFFFAOYSA-N 0.000 description 1
- 229960001679 octinoxate Drugs 0.000 description 1
- 229940101267 panthenol Drugs 0.000 description 1
- 235000020957 pantothenol Nutrition 0.000 description 1
- 239000011619 pantothenol Substances 0.000 description 1
- 235000019477 peppermint oil Nutrition 0.000 description 1
- 239000000419 plant extract Substances 0.000 description 1
- 230000008092 positive effect Effects 0.000 description 1
- 239000003755 preservative agent Substances 0.000 description 1
- 230000005855 radiation Effects 0.000 description 1
- 229940108325 retinyl palmitate Drugs 0.000 description 1
- 235000019172 retinyl palmitate Nutrition 0.000 description 1
- 239000011769 retinyl palmitate Substances 0.000 description 1
- 235000003702 sterols Nutrition 0.000 description 1
- 150000003432 sterols Chemical class 0.000 description 1
- 229940088594 vitamin Drugs 0.000 description 1
- 229930003231 vitamin Natural products 0.000 description 1
- 239000011782 vitamin Substances 0.000 description 1
- 235000013343 vitamin Nutrition 0.000 description 1
- 239000001993 wax Substances 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/12—Ketones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/12—Ketones
- A61K31/122—Ketones having the oxygen directly attached to a ring, e.g. quinones, vitamin K1, anthralin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/12—Ketones
- A61K31/122—Ketones having the oxygen directly attached to a ring, e.g. quinones, vitamin K1, anthralin
- A61K31/125—Camphor; Nuclear substituted derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/38—Clusiaceae, Hypericaceae or Guttiferae (Hypericum or Mangosteen family), e.g. common St. Johnswort
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/61—Myrtaceae (Myrtle family), e.g. teatree or eucalyptus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
- A61K8/9789—Magnoliopsida [dicotyledons]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/001—Preparations for care of the lips
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Epidemiology (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Botany (AREA)
- Biotechnology (AREA)
- Engineering & Computer Science (AREA)
- Dermatology (AREA)
- Medical Informatics (AREA)
- Alternative & Traditional Medicine (AREA)
- Birds (AREA)
- Medicinal Preparation (AREA)
- Cosmetics (AREA)
Description
• ··
• ··
HMA 128 HMA128
Kosmetische Zubereitung in Form von Lippenstiften mit antiviraler WirkungCosmetic preparation in the form of lipsticks with antiviral effect
Die vorliegende Erfindung betrifft eine topische kosmetische Zubereitung in Form von Lippenstiften mit antiviraler Wirkung.The present invention relates to a topical cosmetic preparation in the form of lipsticks with antiviral action.
Es ist bekannt, daß die Verwendung von Haut- und Nährcremes, Ölen, Masken und anderen Hautpflegemitteln, die Wirkstoffe, wie Vitamine, Hormone, Phosphatide, Sterine, Fermente, Aminosäuren sowie tierische oder pflanzliche Extrakte, enthalten, in der Kosmetik von außen einen günstigen Einfluß auf den Zustand der Haut ausüben. Solche Hautpflegemittel sollen beispielsweise die Durchblutung der Haut fördern, bindegewebsfestigend und zeilerneuernd wirken, Schutz vor den schädlichen Wirkungen der UV-Strahlung bieten, den Feuchtigkeitsgehalt der Haut beeinflussen und heilend bei entzündlichen Erkrankungen sein.It is known that the use of skin and nutritional creams, oils, masks and other skin care products containing active ingredients such as vitamins, hormones, phosphatides, sterols, enzymes, amino acids and animal or plant extracts in cosmetics has a positive effect on the condition of the skin. Such skin care products are said to promote blood circulation in the skin, strengthen connective tissue and renew cells, offer protection against the harmful effects of UV radiation, influence the moisture content of the skin and have a healing effect in inflammatory diseases.
Ferner ist bekannt, daß Lippenstifte meist aus Wachsen und Ölen mit entsprechenden, für die Anwendung an Schleimhäuten gesetzlich zugelassenen Farbstoffen, Perlsubstanzen, Konservierungsmitteln, Antioxidantien und Pflegestoffen bestehen. Als Grundstoffe kommen insbesondere Bienenwachs, Carnaubawachs, Candelillawachs, Ozokerit, Hexadecanol, Lanolin, Ricinusöl, Paraffin-Öl, 9-Octadecen-l-ol zur Anwendung. Als pflegende Komponenten werden insbesondere Vitamin-A-palmitat, Vitamin-E-acetat, Allantoin, Panthenol oder auch Lecithin eingesetzt (Umbach, Kosmetik, S.103 bis 107, Stuttgart: Thieme 1988).It is also known that lipsticks mostly consist of waxes and oils with corresponding dyes, pearl substances, preservatives, antioxidants and care substances that are legally approved for use on mucous membranes. The basic ingredients used are in particular beeswax, carnauba wax, candelilla wax, ozokerite, hexadecanol, lanolin, castor oil, paraffin oil and 9-octadecen-l-ol. The care components used are in particular vitamin A palmitate, vitamin E acetate, allantoin, panthenol and lecithin (Umbach, Kosmetik, p. 103 to 107, Stuttgart: Thieme 1988).
Es ist ein sich zunehmend entwickelndes Bedürfnis der Frauen, die pflegende und kosmetische Wirksamkeit von Lippenstiften zu verbinden mit der medizinischen Behandlung, insbesondere von Infektionen und Entzündungen der Lippen.There is an increasingly developing need among women to combine the caring and cosmetic effectiveness of lipsticks with medical treatment, especially of infections and inflammations of the lips.
Zur Behandlung von Herpes ist aus der HU-PS 38.047 bekannt, daß eine kosmetische Zubereitung in Form eines Lippenstiftes für diesen Zweck geeignet sein soll. Diese Zubereitung enthält unter anderem einen Lithiumkomplex von tierischem Plasmaprotein, Phenylamine und/oder Buty lhydr oxy toluene und/oder Pfefferminzöl. For the treatment of herpes, it is known from HU-PS 38.047 that a cosmetic preparation in the form of a lipstick is said to be suitable for this purpose. This preparation contains, among other things, a lithium complex of animal plasma protein, phenylamine and/or butyl hydr oxy toluene and/or peppermint oil.
Die EP-A 87.161 beschreibt eine topische Zubereitung aus iso-Propylmyristat und 4-Alkyl-2,6-bis(tert-butyl)phenol als wirksame Bestandteile, die zur Behandlung von Blasen, Entzündungen oder Wunden verwendet werden soll, welche durch den Herpes simplex Virus hervorgerufen wurden. Eine spezielle Anwendungsform dieser Zubereitung sind unter anderem Lippenstifte.EP-A 87.161 describes a topical preparation containing isopropyl myristate and 4-alkyl-2,6-bis(tert-butyl)phenol as active ingredients, which is intended to be used for the treatment of blisters, inflammations or wounds caused by the herpes simplex virus. One special application form of this preparation is lipstick.
Es hat sich nun gezeigt, daß die genannten Zubereitungen in Form von Lippenstiften bestimmte Nachteile aufweisen. So ist insbesondere deren antivirale Aktivität eingeschränkt. Sie wirken darüber hinaus nicht oder nur unerheblich schmerzlindernd. Im allgemeinen sind diese Zubereitungen bei überempfindlichen Lippen nicht zur Behandlung von Herpes geeignet.It has now been shown that the above-mentioned preparations in the form of lipsticks have certain disadvantages. In particular, their antiviral activity is limited. In addition, they have no or only a negligible pain-relieving effect. In general, these preparations are not suitable for treating herpes in hypersensitive lips.
Die Aufgabe der Erfindung besteht deshalb darin, eine kosmetische Zubereitung in Form von Lippenstiften bereitzustellen, die diese Nachteile nicht aufweist, eine bessere antivirale Wirkung besitzt und reizlos auch für empfindliche Lippen verträglich ist.The object of the invention is therefore to provide a cosmetic preparation in the form of lipsticks, which does not have these disadvantages, has a better antiviral effect and is non-irritating and is also compatible with sensitive lips.
Es wurde nunmehr gefunden, daß diese Aufgabe durch eine kosmetische Zubereitung in Form von Lippenstiften auf der Basis üblicher Lippenstiftbestandteile und von Wirkstoffen gelöst wird, die dadurch gekennzeichnet ist, daß sie hypericin- und pseudohypericinreichen Johanniskraut-Extrakt oder seine wesentlichen Inhaltsstoffe, Hypericin und Pseudohypericin, als antiviralen Wirkstoff, insbesondere gegen Herpes, enthält.It has now been found that this object is achieved by a cosmetic preparation in the form of lipsticks based on conventional lipstick ingredients and active ingredients, which is characterized in that it contains hypericin- and pseudohypericin-rich St. John's wort extract or its essential ingredients, hypericin and pseudohypericin, as an antiviral active ingredient, in particular against herpes.
Mittels des erfindungsgemäßen Zusatzes an hypericin-
und pseudohypericinreichem Johanniskraut-Extrakt oder dessen wesentlichen Inhaltsstoffen, Hypericin
und Pseudohypericin, ist es möglich, unter Verwendung natürlicher Wirkstoffe kosmetische Zubereitungen in
Form von Lippenstiften zu erhalten, die eine hohe antivirale Wirkung, insbesondere gegen HSV-I- und
HSV-2-Viren, aufweisen. Sie können sowohl prophylaktisch als auch therapeutisch verwendet werden.
Unter Johanniskraut-Extrakt versteht man im Sinne dieser Erfindung einen Trockenextrakt natürlicher
Herkunft, der bezogen auf die Zubereitung in Mengen von 3 bis 15 Gew.%, vorzugsweise 3 bis 10 Gew.%,By means of the inventive addition of hypericin- and pseudohypericin-rich St. John's wort extract or its essential ingredients, hypericin and pseudohypericin, it is possible to obtain cosmetic preparations in the form of lipsticks using natural active ingredients which have a high antiviral effect, in particular against HSV-I and HSV-2 viruses. They can be used both prophylactically and therapeutically.
For the purposes of this invention, St. John's wort extract is understood to mean a dry extract of natural origin which, based on the preparation, is used in amounts of 3 to 15% by weight, preferably 3 to 10% by weight,
insbesondere 5 Gew.%, in der Zubereitung enthalten ist. Im Johanniskraut-Extrakt sind Hypericin und Pseudohypericin in Mengen von 0,3 bis 1,0 Gew.%, vorzugsweise 0,5 Gew.%, enthalten.in particular 5% by weight, is contained in the preparation. The St. John's wort extract contains hypericin and pseudohypericin in amounts of 0.3 to 1.0% by weight, preferably 0.5% by weight.
Eine bevorzugte Ausführungsform der erfindungsgemäßen Zubereitung enthält als Zusatz einen Wirkungsverstärker für den Johanniskrautextrakt bzw. dessen wesentliche Inhaltsstoffe in einer Menge von 0,5 bis 2 Gew.%, insbesondere 1 Gew.%, bezogen auf die Zubereitung. A preferred embodiment of the preparation according to the invention contains as an additive an effect enhancer for the St. John's wort extract or its essential ingredients in an amount of 0.5 to 2% by weight, in particular 1% by weight, based on the preparation.
Als Wirkungsverstärker sind besonders ethoxylierte Sorbitanfettsäureester, wie zum Beispiel Polyethoxysorbitanlaurat, Polyethoxysorbitanpalmitat, Polyethoxysorbitanstearat, Polyethoxysorbitantristearat, Polyethoxysorbitantrioleat, zu nennen. Ein bevorzugter derartiger Fettsäureester ist das unter der Bezeichnung TWEEN 80 (ICI) im Handel erhältliche Produkt, das die Wirksamkeit von Hypericin und Pseudohypericin um ein Vielfaches erhöht.Particularly suitable as effect enhancers are ethoxylated sorbitan fatty acid esters, such as polyethoxysorbitan laurate, polyethoxysorbitan palmitate, polyethoxysorbitan stearate, polyethoxysorbitan tristearate, polyethoxysorbitan trioleate. A preferred fatty acid ester of this type is the product commercially available under the name TWEEN 80 (ICI), which increases the effectiveness of hypericin and pseudohypericin many times over.
In einer weiteren bevorzugten Ausführungsform enthält die erfindungsgemäße Zubereitung als Zusatz einen Lösungsmittelverstärker mit lokalanästhetischer Wirkung, und zwar in Mengen von 1 bis 3 Gew.%, insbesondere 2 Gew.%, bezogen auf die Zubereitung. Ein derartiger Zusatz wirkt im besonderen schmerzlindernd im Hinblick auf die mit Herpes in der Regel einhergehenden schmerzhaften einzelnen Bläschen, Bläschengruppierungen und Entzündungen.In a further preferred embodiment, the preparation according to the invention contains as an additive a solvent enhancer with a local anesthetic effect, in amounts of 1 to 3% by weight, in particular 2% by weight, based on the preparation. Such an additive has a particularly pain-relieving effect with regard to the painful individual blisters, groups of blisters and inflammations that usually accompany herpes.
Als Lösungsmittelverstärker mit lokalanästhetischer Wirksamkeit sind im besonderen Fettalkoholpolyglykolether zu erwähnen. Ein geeigneter Lösungsmittelverstärker ist das im Handel unter der Bezeichnung Dehydol KE 2567 erhältliche Produkt.Fatty alcohol polyglycol ethers are particularly worth mentioning as solvent enhancers with local anesthetic effectiveness. A suitable solvent enhancer is the product commercially available under the name Dehydol KE 2567.
Schließlich enthält die erfindungsgemäße Zubereitung in einer weiteren bevorzugten Ausführungsform ein antiphlogistisch wirkendes Mittel, und zwar in Mengen von 0,05 bis 0,1 Gew.%, insbesondere 0,07 Gew.%, bezogen auf die Zubereitung.Finally, in a further preferred embodiment, the preparation according to the invention contains an anti-inflammatory agent, in amounts of 0.05 to 0.1% by weight, in particular 0.07% by weight, based on the preparation.
Ein geeignetes antiphlogistisch wirkendes Mittel ist das aus Kamille oder den Knospen einiger Pappelarten gewonnene Oi-Bisabolol.A suitable anti-inflammatory agent is oleo-bisabolol, which is obtained from chamomile or the buds of some poplar species.
Weiterhin beinhalten die erfindungsgemäßen Zubereitungen Zusätze, wie sie üblicherweise in Formulierungen für Lippenstifte unter den folgenden CTFA-Bezeichnungen verwendet werden, wie Carnauba (Isco-Care 100, Schlickum), Myristyl Myristate (Cetiol MM, Henkel), Petrolatum (and) Lanolin Alcohol (Amerchol CAB, Nordmann), Petrolatum (Vaseline, Wagner), Octyl Methoxycinnamate (Parsol MCX, Givaudan), Butyl Methoxydibenzoylmethane (Parsol 1789, Givaudan), Titanium Dioxide (Titandioxid Kronos 117, Kronos Titan), Tocopheryl Acetate (Vitamin-E-Acetat, Hoffmann La Roche), Campher (d,l-Campher synth., Merck), Eucalyptus Oil (Eukalyptusöl DAB 10, 1/035357, Dragoco), Menthyl Lactate (Frescolat Typ ML, Haarmann & Reimer) .Furthermore, the preparations according to the invention contain additives as are usually used in formulations for lipsticks under the following CTFA names, such as Carnauba (Isco-Care 100, Schlickum), Myristyl Myristate (Cetiol MM, Henkel), Petrolatum (and) Lanolin Alcohol (Amerchol CAB, Nordmann), Petrolatum (Vaseline, Wagner), Octyl Methoxycinnamate (Parsol MCX, Givaudan), Butyl Methoxydibenzoylmethane (Parsol 1789, Givaudan), Titanium Dioxide (Titanium Dioxide Kronos 117, Kronos Titan), Tocopheryl Acetate (Vitamin E Acetate, Hoffmann La Roche), Camphor (d,l-Camphor synth., Merck), Eucalyptus Oil (Eucalyptus Oil DAB 10, 1/035357, Dragoco), Menthyl Lactate (Frescolat Type ML, Haarmann & Reimer) .
Ausschließlich zum Zwecke der Erläuterung der erfindungsgemäßen Lösung wird im folgenden ein Beispiel für eine kosmetische Zubereitung in Form von Lippenstiften aufgeführt.Solely for the purpose of explaining the solution according to the invention, an example of a cosmetic preparation in the form of lipstick is given below.
Man stellt nach der Erfindung Lippenstifte auf bekannte Weise aus einem Gemisch der folgenden Bestandteile her:According to the invention, lipsticks are produced in a known manner from a mixture of the following ingredients:
Isco-Care 100 Tex Wax MP 121 Cetiol MM
Amerchol CAB Indopol H 100 Vaseline, weiß
Tween 80
Parsol MCX Parsol 1789 Titandioxid Kronos 1171 Johanniskraut-Trocken-extrakt
Mat.-Nr. 45023 Vitamin-E-Acetat Dehydol KE 2567 d,1-Campher synth.
Eukalyptusöl DAB 1/035357Isco-Care 100 Tex Wax MP 121 Cetiol MM Amerchol CAB Indopol H 100 Vaseline, white Tween 80
Parsol MCX Parsol 1789 Titanium dioxide Kronos 1171 St. John's wort dry extract Mat. No. 45023 Vitamin E acetate Dehydol KE 2567 d,1-Camphor synth. Eucalyptus oil DAB 1/035357
Frescolat Typ ML OC-Bisabolol, links 2/012685Frescolat Type ML OC-Bisabolol, left 2/012685
100,00100.00
Das gewählte Beispiel stellt allenfalls eine typische Zubereitung dar und kann unter Zugrundelegung der
erfindungsgemaßen Lösung von jedem Fachmann leicht und in weiten Grenzen variiert werden.
Der Anspruch aus der beschriebenen Erfindung wird ausdrücklich auch auf diese möglichen Variationen der
Grundrezeptur erhoben.The example chosen represents at most a typical preparation and can be easily and widely varied by any person skilled in the art on the basis of the solution according to the invention.
The claim arising from the invention described is expressly also made to these possible variations of the basic recipe.
Claims (12)
Priority Applications (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE9316320U DE9316320U1 (en) | 1993-10-20 | 1993-10-20 | Cosmetic preparation in the form of lipsticks with an antiviral effect |
| PCT/EP1994/003445 WO1995011035A1 (en) | 1993-10-20 | 1994-10-20 | Cosmetic preparation with anti-viral action for topical application |
| DE9421714U DE9421714U1 (en) | 1993-10-20 | 1994-10-20 | Cosmetic preparation with an antiviral effect for topical use |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE9316320U DE9316320U1 (en) | 1993-10-20 | 1993-10-20 | Cosmetic preparation in the form of lipsticks with an antiviral effect |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DE9316320U1 true DE9316320U1 (en) | 1994-01-20 |
Family
ID=6899888
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE9316320U Expired - Lifetime DE9316320U1 (en) | 1993-10-20 | 1993-10-20 | Cosmetic preparation in the form of lipsticks with an antiviral effect |
Country Status (2)
| Country | Link |
|---|---|
| DE (1) | DE9316320U1 (en) |
| WO (1) | WO1995011035A1 (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2013171056A3 (en) * | 2012-05-14 | 2014-06-26 | Beiersdorf Ag | Flavoured lip butter |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DK1131063T3 (en) * | 1998-11-25 | 2003-07-21 | Universitaetsklinikum Freiburg | Hyperforin ointment or cream |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0256452A2 (en) * | 1986-08-08 | 1988-02-24 | Yeda Research And Development Company Limited | Antiviral pharmaceutical compositions containing hypericin or pseudohypericin |
| WO1990000596A1 (en) * | 1988-07-07 | 1990-01-25 | The Trustees Of The University Of Pennsylvania | Method of modulating virus-host cell interactions using carbohydrates and carbohydrate derivatives |
| DE3841562A1 (en) * | 1988-12-09 | 1990-06-13 | Roth Carl Gmbh & Co | Pharmaceutical composition and its use |
| DE3912433A1 (en) * | 1989-04-15 | 1990-10-18 | Gustav Dr Klein | Homogeneous aq. soln. of hypericin or derivs. prodn. - by dissolving solid in organic solvent then dilution to predetermined active ingredient content |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4898891A (en) * | 1987-08-07 | 1990-02-06 | Yeda Research And Development Company Ltd. | Antiviral compositions |
-
1993
- 1993-10-20 DE DE9316320U patent/DE9316320U1/en not_active Expired - Lifetime
-
1994
- 1994-10-20 WO PCT/EP1994/003445 patent/WO1995011035A1/en not_active Ceased
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0256452A2 (en) * | 1986-08-08 | 1988-02-24 | Yeda Research And Development Company Limited | Antiviral pharmaceutical compositions containing hypericin or pseudohypericin |
| WO1990000596A1 (en) * | 1988-07-07 | 1990-01-25 | The Trustees Of The University Of Pennsylvania | Method of modulating virus-host cell interactions using carbohydrates and carbohydrate derivatives |
| DE3841562A1 (en) * | 1988-12-09 | 1990-06-13 | Roth Carl Gmbh & Co | Pharmaceutical composition and its use |
| DE3912433A1 (en) * | 1989-04-15 | 1990-10-18 | Gustav Dr Klein | Homogeneous aq. soln. of hypericin or derivs. prodn. - by dissolving solid in organic solvent then dilution to predetermined active ingredient content |
Non-Patent Citations (9)
| Title |
|---|
| Chemical Abstracts: Vol.66,1967,Ref.88613y * |
| et.al.:Studies of the mechanisms of action of the antiretroviral agents hypericin and pseudohypericin.In:Proc.Natl.Acad.Sci.USA, Vol.86,Aug.1989,S.5963-5967 * |
| GAD,LAVIE * |
| GAD,LAVIE,et.al.:Studies of the mechanisms of action of the antiretroviral agents hypericin and pseudohypericin.In:Proc.Natl.Acad.Sci.USA, Vol.86,Aug.1989,S.5963-5967 |
| JANISTYN,H.:Handbuch der Kosmetika und Riech- stoffe.In:Alfred Hüthig Verlag,B.1,3.Aufl., 1978,S.486,S.503 * |
| MERUELO,D.:Therapeutic agents with dramatic antiretroviral activity and little toxicity at effective doses: Aromatic polycyclic diones hypericin and pseudohypericin.In:Proc.Natl.Acad. Sci.USA,Vol.85,July 1988,S.5230-5234 * |
| NOWAK,G.A.:Die kosmetischen Präparate.In: Verlag für chemische Industrie H.Ziolkowsky KG, Augsburg,Bd.1,3.Aufl.1982,S.247-249 * |
| Vol.113,1990,Ref.204470q * |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2013171056A3 (en) * | 2012-05-14 | 2014-06-26 | Beiersdorf Ag | Flavoured lip butter |
Also Published As
| Publication number | Publication date |
|---|---|
| WO1995011035A1 (en) | 1995-04-27 |
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