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DE69304573D1 - Aminsäurederivate mit antithrombotischer Wirkung - Google Patents

Aminsäurederivate mit antithrombotischer Wirkung

Info

Publication number
DE69304573D1
DE69304573D1 DE69304573T DE69304573T DE69304573D1 DE 69304573 D1 DE69304573 D1 DE 69304573D1 DE 69304573 T DE69304573 T DE 69304573T DE 69304573 T DE69304573 T DE 69304573T DE 69304573 D1 DE69304573 D1 DE 69304573D1
Authority
DE
Germany
Prior art keywords
acid derivatives
amic acid
antithrombotic effects
antithrombotic
effects
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69304573T
Other languages
English (en)
Other versions
DE69304573T2 (de
Inventor
Georg Kottirsch
Rainer Metternich
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Novartis AG
Original Assignee
Sandoz AG
Sandoz Patent GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sandoz AG, Sandoz Patent GmbH filed Critical Sandoz AG
Priority to DE69304573T priority Critical patent/DE69304573T2/de
Application granted granted Critical
Publication of DE69304573D1 publication Critical patent/DE69304573D1/de
Publication of DE69304573T2 publication Critical patent/DE69304573T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
    • C07C311/15—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings
    • C07C311/16—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the sulfonamide groups bound to hydrogen atoms or to an acyclic carbon atom
    • C07C311/19—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the sulfonamide groups bound to hydrogen atoms or to an acyclic carbon atom to an acyclic carbon atom of a hydrocarbon radical substituted by carboxyl groups
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C257/00—Compounds containing carboxyl groups, the doubly-bound oxygen atom of a carboxyl group being replaced by a doubly-bound nitrogen atom, this nitrogen atom not being further bound to an oxygen atom, e.g. imino-ethers, amidines
    • C07C257/10—Compounds containing carboxyl groups, the doubly-bound oxygen atom of a carboxyl group being replaced by a doubly-bound nitrogen atom, this nitrogen atom not being further bound to an oxygen atom, e.g. imino-ethers, amidines with replacement of the other oxygen atom of the carboxyl group by nitrogen atoms, e.g. amidines
    • C07C257/18—Compounds containing carboxyl groups, the doubly-bound oxygen atom of a carboxyl group being replaced by a doubly-bound nitrogen atom, this nitrogen atom not being further bound to an oxygen atom, e.g. imino-ethers, amidines with replacement of the other oxygen atom of the carboxyl group by nitrogen atoms, e.g. amidines having carbon atoms of amidino groups bound to carbon atoms of six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
    • C07D309/16—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D309/28—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D309/30—Oxygen atoms, e.g. delta-lactones
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2603/00—Systems containing at least three condensed rings
    • C07C2603/56—Ring systems containing bridged rings
    • C07C2603/58—Ring systems containing bridged rings containing three rings
    • C07C2603/70—Ring systems containing bridged rings containing three rings containing only six-membered rings
    • C07C2603/74—Adamantanes

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pyrane Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pyridine Compounds (AREA)
  • Materials For Medical Uses (AREA)
DE69304573T 1992-03-10 1993-03-08 Aminsäurederivate mit antithrombotischer Wirkung Expired - Fee Related DE69304573T2 (de)

Priority Applications (1)

Application Number Priority Date Filing Date Title
DE69304573T DE69304573T2 (de) 1992-03-10 1993-03-08 Aminsäurederivate mit antithrombotischer Wirkung

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE4207544 1992-03-10
DE69304573T DE69304573T2 (de) 1992-03-10 1993-03-08 Aminsäurederivate mit antithrombotischer Wirkung

Publications (2)

Publication Number Publication Date
DE69304573D1 true DE69304573D1 (de) 1996-10-17
DE69304573T2 DE69304573T2 (de) 1997-03-20

Family

ID=6453662

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69304573T Expired - Fee Related DE69304573T2 (de) 1992-03-10 1993-03-08 Aminsäurederivate mit antithrombotischer Wirkung

Country Status (26)

Country Link
US (1) US5561112A (de)
EP (1) EP0560730B1 (de)
JP (1) JP2860222B2 (de)
KR (1) KR930019690A (de)
CN (1) CN1076200A (de)
AT (1) ATE142618T1 (de)
AU (1) AU659281B2 (de)
CA (1) CA2091292A1 (de)
CZ (1) CZ36193A3 (de)
DE (1) DE69304573T2 (de)
DK (1) DK0560730T3 (de)
ES (1) ES2090934T3 (de)
FI (1) FI931023L (de)
GR (1) GR3021030T3 (de)
HU (2) HUT63609A (de)
IL (1) IL104972A (de)
MX (1) MX9301298A (de)
MY (1) MY109060A (de)
NO (1) NO300778B1 (de)
NZ (1) NZ247084A (de)
PH (1) PH30893A (de)
RU (1) RU2106356C1 (de)
SG (1) SG47059A1 (de)
SK (1) SK17093A3 (de)
TW (1) TW256828B (de)
ZA (1) ZA931724B (de)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5753659A (en) * 1993-03-29 1998-05-19 Zeneca Limited Heterocyclic compouds
ES2159798T3 (es) * 1993-03-29 2001-10-16 Astrazeneca Ab Derivados heterociclicos como inhibidores de la agregacion plaquetaria.
US5652242A (en) * 1993-03-29 1997-07-29 Zeneca Limited Heterocyclic derivatives
EP0690847A1 (de) * 1993-03-29 1996-01-10 Zeneca Limited Heterozyklische derivate als plätchenaggregationsinhibitoren
US5750754A (en) * 1993-03-29 1998-05-12 Zeneca Limited Heterocyclic compounds
DE4310643A1 (de) * 1993-04-01 1994-10-06 Merck Patent Gmbh Cyclische Adhäsionsinhibitoren
US5463011A (en) * 1993-06-28 1995-10-31 Zeneca Limited Acid derivatives
GB9313268D0 (en) * 1993-06-28 1993-08-11 Zeneca Ltd Chemical compounds
GB9313285D0 (en) * 1993-06-28 1993-08-11 Zeneca Ltd Acid derivatives
US5811398A (en) * 1995-04-11 1998-09-22 G. D. Searle & Co. Platelet aggregation inhibitors containing C-terminal aminergic side chain amino acid residues
US5942544A (en) * 1996-02-22 1999-08-24 Dupont Pharmaceuticals Company α-branched anilines, toluenes, and analogs thereof as factor Xa inhibitors
ATE228111T1 (de) * 1996-02-22 2002-12-15 Bristol Myers Squibb Pharma Co M-amidinophenyl-analoga als faktor-xa-inhibitoren
UA63887C2 (en) * 1996-10-28 2004-02-16 Lg Chemical Ltd Selective thrombin inhibitors and a pharmaceutical composition based thereon
WO2003063910A2 (en) * 2002-01-28 2003-08-07 Novartis Ag β-HOMOLYSINE CONJUGATES AND THEIR USE AS TRANSPORT ENHANCER

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4578079A (en) * 1982-08-04 1986-03-25 La Jolla Cancer Research Foundation Tetrapeptide
CH673654A5 (de) * 1987-04-08 1990-03-30 Nippon Shinyaku Co Ltd
IT1222437B (it) * 1987-08-04 1990-09-05 Ellem Ind Farmaceutica Tripeptidi utili come immunostimolanti e nella prevenzione delle metastasi e relativo procedimento di preparazione
US4879313A (en) * 1988-07-20 1989-11-07 Mosanto Company Novel platelet-aggregation inhibitors
US5037808A (en) * 1988-07-20 1991-08-06 Monsanto Co. Indolyl platelet-aggregation inhibitors
US5039805A (en) * 1988-12-08 1991-08-13 Hoffmann-La Roche Inc. Novel benzoic and phenylacetic acid derivatives
US5273982A (en) * 1990-03-09 1993-12-28 Hoffmann-La Roche Inc. Acetic acid derivatives
CA2037153A1 (en) * 1990-03-09 1991-09-10 Leo Alig Acetic acid derivatives
US5354738A (en) * 1992-09-04 1994-10-11 G. D. Searle & Co. Platelet aggregation inhibitors

Also Published As

Publication number Publication date
HUT63609A (en) 1993-09-28
HU9300501D0 (en) 1993-05-28
CZ36193A3 (en) 1994-01-19
PH30893A (en) 1997-12-23
FI931023A0 (fi) 1993-03-08
IL104972A0 (en) 1993-07-08
KR930019690A (ko) 1993-10-18
NO300778B1 (no) 1997-07-21
AU3406993A (en) 1993-09-16
SG47059A1 (en) 1998-03-20
JPH0665175A (ja) 1994-03-08
FI931023A7 (fi) 1993-09-11
NO930830L (no) 1993-09-13
EP0560730A2 (de) 1993-09-15
NZ247084A (en) 1995-09-26
RU2106356C1 (ru) 1998-03-10
US5561112A (en) 1996-10-01
IL104972A (en) 1998-04-05
FI931023L (fi) 1993-09-11
ATE142618T1 (de) 1996-09-15
MY109060A (en) 1996-11-30
DK0560730T3 (da) 1996-10-28
MX9301298A (es) 1993-10-01
EP0560730A3 (en) 1993-12-01
DE69304573T2 (de) 1997-03-20
GR3021030T3 (en) 1996-12-31
EP0560730B1 (de) 1996-09-11
ZA931724B (en) 1994-09-10
HU210878A9 (en) 1995-09-28
TW256828B (de) 1995-09-11
CA2091292A1 (en) 1993-09-11
ES2090934T3 (es) 1996-10-16
SK17093A3 (en) 1993-10-06
CN1076200A (zh) 1993-09-15
AU659281B2 (en) 1995-05-11
JP2860222B2 (ja) 1999-02-24
NO930830D0 (no) 1993-03-08

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8327 Change in the person/name/address of the patent owner

Owner name: NOVARTIS AG, BASEL, CH

8328 Change in the person/name/address of the agent

Free format text: SPOTT WEINMILLER & PARTNER, 80336 MUENCHEN

8339 Ceased/non-payment of the annual fee