DE69230105D1 - Differentielle bindungsaffinitäten und darauf beruhende dissoziationstestverfahren - Google Patents
Differentielle bindungsaffinitäten und darauf beruhende dissoziationstestverfahrenInfo
- Publication number
- DE69230105D1 DE69230105D1 DE69230105T DE69230105T DE69230105D1 DE 69230105 D1 DE69230105 D1 DE 69230105D1 DE 69230105 T DE69230105 T DE 69230105T DE 69230105 T DE69230105 T DE 69230105T DE 69230105 D1 DE69230105 D1 DE 69230105D1
- Authority
- DE
- Germany
- Prior art keywords
- receptor
- analyte
- pct
- ligand
- differential binding
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
- 238000010494 dissociation reaction Methods 0.000 title abstract 2
- 230000005593 dissociations Effects 0.000 title abstract 2
- 238000012956 testing procedure Methods 0.000 title 1
- 239000012491 analyte Substances 0.000 abstract 6
- 239000003446 ligand Substances 0.000 abstract 5
- 238000003556 assay Methods 0.000 abstract 1
- 238000011065 in-situ storage Methods 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/58—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/72—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving blood pigments, e.g. haemoglobin, bilirubin or other porphyrins; involving occult blood
- G01N33/721—Haemoglobin
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/94—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving narcotics or drugs or pharmaceuticals, neurotransmitters or associated receptors
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S435/00—Chemistry: molecular biology and microbiology
- Y10S435/975—Kit
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S436/00—Chemistry: analytical and immunological testing
- Y10S436/815—Test for named compound or class of compounds
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Immunology (AREA)
- Hematology (AREA)
- Biomedical Technology (AREA)
- Chemical & Material Sciences (AREA)
- Urology & Nephrology (AREA)
- Physics & Mathematics (AREA)
- Microbiology (AREA)
- Cell Biology (AREA)
- Food Science & Technology (AREA)
- Medicinal Chemistry (AREA)
- Biotechnology (AREA)
- Analytical Chemistry (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- General Physics & Mathematics (AREA)
- Pathology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Treating Waste Gases (AREA)
- Analysing Materials By The Use Of Radiation (AREA)
- Curing Cements, Concrete, And Artificial Stone (AREA)
- Peptides Or Proteins (AREA)
- Paper (AREA)
- Amplifiers (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US73752691A | 1991-07-29 | 1991-07-29 | |
| PCT/US1992/006249 WO1993003367A1 (en) | 1991-07-29 | 1992-07-29 | Differential binding affinities and dissociation assays based thereon |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| DE69230105D1 true DE69230105D1 (de) | 1999-11-11 |
| DE69230105T2 DE69230105T2 (de) | 2000-01-20 |
Family
ID=24964268
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE69230105T Expired - Fee Related DE69230105T2 (de) | 1991-07-29 | 1992-07-29 | Differentielle bindungsaffinitäten und darauf beruhende dissoziationstestverfahren |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US5527686A (de) |
| EP (1) | EP0600936B1 (de) |
| AT (1) | ATE185424T1 (de) |
| AU (1) | AU2402292A (de) |
| DE (1) | DE69230105T2 (de) |
| WO (1) | WO1993003367A1 (de) |
Families Citing this family (56)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5356784A (en) * | 1993-03-30 | 1994-10-18 | Terrapin Technologies, Inc. | Determination of concentration by affinity titration |
| CA2157929A1 (en) * | 1993-03-30 | 1994-10-13 | Lawrence M. Kauvar | Determination of concentration by affinity titration and competitive displacement in drug delivery |
| US5500375A (en) | 1993-04-13 | 1996-03-19 | Serex, Inc. | Integrated packaging-holder device for immunochromatographic assays in flow-through or dipstick formats |
| GB9313163D0 (en) * | 1993-06-25 | 1993-08-11 | Health Lab Service Board | Storage of antibodies |
| US5710009A (en) * | 1994-02-17 | 1998-01-20 | Serex, Inc. | Receptor:release ligand (reland) complexes and release assays using said reland and methods and kits based thereon |
| WO1996016332A1 (en) * | 1994-11-24 | 1996-05-30 | Unipath Limited | Recovery of and uses of specific binding agents |
| DE19504198A1 (de) * | 1995-02-09 | 1996-08-14 | Behringwerke Ag | Kompetitiver Immuntest unter Verwendung komplexierter Analytderivate |
| AU739280B2 (en) * | 1995-06-22 | 2001-10-11 | Serex, Inc. | Receptor: release ligand (reland) complexes and assays and kits based thereon |
| US5935790A (en) * | 1996-08-06 | 1999-08-10 | Rutgers, The State University Of New Jersey | Method for detecting a predisposition to susceptibility to toxic effects of drugs and poisons |
| US5710005A (en) * | 1996-10-29 | 1998-01-20 | Biocode, Inc. | Analyte detection with a gradient lateral flow device |
| US6710036B2 (en) | 1997-07-25 | 2004-03-23 | Avigen, Inc. | Induction of immune response to antigens expressed by recombinant adeno-associated virus |
| US6238905B1 (en) | 1997-09-12 | 2001-05-29 | University Technology Corporation | Thermophilic polymerase III holoenzyme |
| US6875606B1 (en) | 1997-10-23 | 2005-04-05 | The United States Of America As Represented By The Department Of Veterans Affairs | Human α-7 nicotinic receptor promoter |
| US6225456B1 (en) | 1998-05-07 | 2001-05-01 | University Technololy Corporation | Ras suppressor SUR-5 |
| US6506889B1 (en) | 1998-05-19 | 2003-01-14 | University Technology Corporation | Ras suppressor SUR-8 and related compositions and methods |
| US20020131972A1 (en) * | 1998-05-21 | 2002-09-19 | Daniel Sem | Multi-partite ligands and methods of identifying and using same |
| US6221349B1 (en) | 1998-10-20 | 2001-04-24 | Avigen, Inc. | Adeno-associated vectors for expression of factor VIII by target cells |
| US6200560B1 (en) | 1998-10-20 | 2001-03-13 | Avigen, Inc. | Adeno-associated virus vectors for expression of factor VIII by target cells |
| US6472222B2 (en) | 1999-02-16 | 2002-10-29 | Via Christi Research, Inc. | Method of estimating rate of nicotine metabolism in individuals |
| US6558911B1 (en) | 1999-12-10 | 2003-05-06 | Oregon Health Sciences University | Sperm quality assay |
| US6677146B1 (en) | 2000-03-28 | 2004-01-13 | Replidyne, Inc. | Thermophilic polymerase III holoenzyme |
| US6699722B2 (en) | 2000-04-14 | 2004-03-02 | A-Fem Medical Corporation | Positive detection lateral-flow apparatus and method for small and large analytes |
| US6573370B1 (en) | 2000-05-19 | 2003-06-03 | Regents Of The University Of Michigan | PON3 and uses thereof |
| US7060442B2 (en) | 2000-10-30 | 2006-06-13 | Regents Of The University Of Michigan | Modulators on Nod2 signaling |
| US6849449B2 (en) | 2001-03-01 | 2005-02-01 | Regents Of The University Of Michigan | Orphanin FQ receptor nucleic acids |
| US7653490B2 (en) * | 2001-09-10 | 2010-01-26 | Triad Liquidating Company LLC | Nuclear magnetic resonance assembly of chemical entities |
| US20030059850A1 (en) * | 2001-09-26 | 2003-03-27 | Psychiatric Genomics, Inc. | Fluorescence proximity assay |
| US7255986B2 (en) | 2002-01-31 | 2007-08-14 | The Board Of Trustees Operating Michigan State University | Compositions for the diagnosis and treatment of epizootic catarrhal enteritis in ferrets |
| US20030180797A1 (en) * | 2002-03-20 | 2003-09-25 | Lin Yu | Identification of ligands for a receptor family and related methods |
| US20040203079A1 (en) | 2003-04-09 | 2004-10-14 | Research Foundation Of The State University Of New York | Methods and kits for detecting cerebrospinal fluid in a sample |
| US20070003992A1 (en) * | 2003-04-09 | 2007-01-04 | Pentyala Srinivas N | Methods and kits for detecting cerebrospinal fluid in a sample |
| US8003765B2 (en) | 2003-04-09 | 2011-08-23 | Stony Brook Anaesthesiology, University Faculty Practice Corporation | Methods, antibodies and kits for detecting cerebrospinal fluid in a sample |
| US7173010B2 (en) | 2003-05-19 | 2007-02-06 | Regents Of The University Of Michigan | Orphanin FQ receptor |
| US7655833B2 (en) | 2003-05-29 | 2010-02-02 | Brookhaven Science Associates, Llc | ADS genes for reducing saturated fatty acid levels in seed oils |
| US8007725B2 (en) | 2003-11-07 | 2011-08-30 | Princeton Biochemicals, Inc. | Electrophoresis apparatus having valve system |
| US7432057B2 (en) | 2004-01-30 | 2008-10-07 | Michigan State University | Genetic test for PSE-susceptible turkeys |
| US7858323B2 (en) | 2004-06-09 | 2010-12-28 | The Regents Of The University Of Michigan | Phage microarray profiling of the humoral response to disease |
| US8563328B2 (en) * | 2004-07-26 | 2013-10-22 | University Of Louisville Research Foundation, Inc. | Fiber-optic biosensor and biosensing methods |
| US7229782B1 (en) | 2004-08-03 | 2007-06-12 | Labone, Inc. | Antibodies specific to multiple beta blockers and methods for their use |
| US20100256062A1 (en) | 2004-12-06 | 2010-10-07 | Howard Tommy E | Allelic Variants of Human Factor VIII |
| WO2006088976A2 (en) * | 2005-02-16 | 2006-08-24 | University Of Louisville Research Foundation, Inc. | Fiber-optic biosensor and biosensing methods |
| WO2007057428A1 (en) * | 2005-11-17 | 2007-05-24 | Epfl - Ecole Polytechnique Federale De Lausanne | Chromophore containing ligands for characterisation of receptors for binding and activation |
| US20120149884A1 (en) * | 2006-11-22 | 2012-06-14 | 3M Innovative Properties Company | Specific antibody selection by selective elution conditions |
| CA2705486C (en) | 2007-11-19 | 2019-04-02 | Celera Corporation | Lung cancer markers and uses thereof |
| CA2807645C (en) | 2009-08-07 | 2021-09-07 | Affinimark Technologies, Inc. | Device and methods for the immunological identification of cerebrospinal fluid |
| US20110177107A1 (en) | 2010-01-14 | 2011-07-21 | Haplomics, Inc. | Predicting and reducing alloimmunogenicity of protein therapeutics |
| EP3450979A3 (de) | 2010-03-17 | 2019-04-24 | The Regents of The University of Michigan | Verwendung von phagenepitopen zur profilierung einer immunreaktion |
| US8956859B1 (en) | 2010-08-13 | 2015-02-17 | Aviex Technologies Llc | Compositions and methods for determining successful immunization by one or more vaccines |
| WO2012129128A1 (en) * | 2011-03-18 | 2012-09-27 | Biotium, Inc. | Fluorescent dyes, fluorescent dye kits, and methods of preparing labeled molecules |
| CN102809650B (zh) * | 2012-08-29 | 2015-02-11 | 沃克(天津)生物科技有限公司 | 生物素化牛丙种球蛋白-链霉亲和素酶标板及其制备方法 |
| US10272163B2 (en) | 2012-12-07 | 2019-04-30 | The Regents Of The University Of California | Factor VIII mutation repair and tolerance induction |
| CN104034893B (zh) * | 2013-03-08 | 2016-04-20 | 北京普析通用仪器有限责任公司 | 一种基于胶乳的三聚氰胺快速检测方法及试剂盒 |
| JP2017521654A (ja) | 2014-06-27 | 2017-08-03 | アボット・ラボラトリーズAbbott Laboratories | ヒトペギウイルス2(HPgV−2)を検出するための組成物および方法 |
| WO2017142956A1 (en) * | 2016-02-16 | 2017-08-24 | Walkill Concepts, Inc. | Methods, compositions and devices for improving the sensitivity of assays |
| CN106053788A (zh) * | 2016-07-21 | 2016-10-26 | 苏州博源医疗科技有限公司 | 一种可替宁均相酶免疫检测试剂及其制备和检测方法 |
| WO2020078999A1 (en) | 2018-10-15 | 2020-04-23 | F. Hoffmann-La Roche Ag | Immunoassay for measuring c-peptide |
Family Cites Families (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3817837A (en) * | 1971-05-14 | 1974-06-18 | Syva Corp | Enzyme amplification assay |
| US3875011A (en) * | 1972-11-06 | 1975-04-01 | Syva Co | Enzyme immunoassays with glucose-6-phosphate dehydrogenase |
| US3917582A (en) * | 1973-06-13 | 1975-11-04 | Syva Corp | Isothiocyanate and thiourea derivatives of benzoyl ecgonine conjugated to polypeptides |
| US4383031A (en) * | 1975-04-28 | 1983-05-10 | Miles Laboratories, Inc. | Homogeneous chemiluminescent specific binding assay |
| US4069105A (en) * | 1977-03-03 | 1978-01-17 | Syva Company | Lidocaine antigens and antibodies |
| US4115535A (en) * | 1977-06-22 | 1978-09-19 | General Electric Company | Diagnostic method employing a mixture of normally separable protein-coated particles |
| US4318707A (en) * | 1978-11-24 | 1982-03-09 | Syva Company | Macromolecular fluorescent quencher particle in specific receptor assays |
| US4323507A (en) * | 1979-02-12 | 1982-04-06 | Syva Company | Valproate conjugation using dicarbonyls |
| US4341866A (en) * | 1980-06-02 | 1982-07-27 | Syva Company | Antienzyme termination in enzyme immunoassays |
| US4590278A (en) * | 1981-01-29 | 1986-05-20 | Philip Morris Incorporated | Nicotine analogs |
| US4480042A (en) * | 1981-10-28 | 1984-10-30 | E. I. Du Pont De Nemours And Company | Covalently bonded high refractive index particle reagents and their use in light scattering immunoassays |
| US4504413A (en) * | 1982-04-02 | 1985-03-12 | Syva Company | Acetaminophen analogs, antigens, and antibodies |
| US4434236A (en) * | 1982-10-20 | 1984-02-28 | E. I. Du Pont De Nemours & Co. | Immunoassay wherein labeled antibody is displaced from immobilized analyte-analogue |
| US4551426A (en) * | 1983-10-03 | 1985-11-05 | E. I. Du Pont De Nemours And Company | Heterogeneous immunoassay for digoxin using ouabain as a separation means |
| US4766064A (en) * | 1984-05-07 | 1988-08-23 | Allied Corporation | Displacement polynucleotide assay employing polyether and diagnostic kit |
| US4977077A (en) * | 1984-10-24 | 1990-12-11 | Bioprobe International | Integrated solid-phase immunoassay |
| JPH0750114B2 (ja) * | 1986-03-17 | 1995-05-31 | 富士写真フイルム株式会社 | 免疫分析器具を用いる分析方法 |
| US5137808A (en) * | 1987-04-07 | 1992-08-11 | Syntex (U.S.A.) Inc. | Immunoassay device |
| US5009998A (en) * | 1987-06-26 | 1991-04-23 | E. I. Du Pont De Nemours And Company | Method for performing heterogeneous immunoassay |
| US5028535A (en) * | 1989-01-10 | 1991-07-02 | Biosite Diagnostics, Inc. | Threshold ligand-receptor assay |
| JPH02213766A (ja) * | 1989-02-15 | 1990-08-24 | Mochida Pharmaceut Co Ltd | 免疫測定用試薬および免疫測定器具 |
| DE3922960A1 (de) * | 1989-07-12 | 1991-01-17 | Boehringer Mannheim Gmbh | Verfahren zur bestimmung eines analyten |
| US5183740A (en) * | 1990-02-23 | 1993-02-02 | The United States Of America As Represented By The Secretary Of The Navy | Flow immunosensor method and apparatus |
| US5164504A (en) * | 1991-01-16 | 1992-11-17 | Abbott Laboratories | Haptens, tracers, immunogens and antibodies for immunoassays for cotinine derivatives |
-
1992
- 1992-07-29 AT AT92916797T patent/ATE185424T1/de not_active IP Right Cessation
- 1992-07-29 WO PCT/US1992/006249 patent/WO1993003367A1/en not_active Ceased
- 1992-07-29 AU AU24022/92A patent/AU2402292A/en not_active Abandoned
- 1992-07-29 EP EP92916797A patent/EP0600936B1/de not_active Expired - Lifetime
- 1992-07-29 DE DE69230105T patent/DE69230105T2/de not_active Expired - Fee Related
- 1992-07-29 US US08/196,092 patent/US5527686A/en not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| ATE185424T1 (de) | 1999-10-15 |
| US5527686A (en) | 1996-06-18 |
| WO1993003367A1 (en) | 1993-02-18 |
| DE69230105T2 (de) | 2000-01-20 |
| EP0600936A4 (en) | 1996-08-28 |
| EP0600936B1 (de) | 1999-10-06 |
| EP0600936A1 (de) | 1994-06-15 |
| AU2402292A (en) | 1993-03-02 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| 8364 | No opposition during term of opposition | ||
| 8328 | Change in the person/name/address of the agent |
Representative=s name: VONNEMANN, KLOIBER & KOLLEGEN, 80796 MUENCHEN |
|
| 8339 | Ceased/non-payment of the annual fee |