DE69230104D1 - Glykosidierungsverfahren - Google Patents

Glykosidierungsverfahren

Info

Publication number: DE69230104D1
Authority: DE; Germany
Prior art keywords: steroidal; activity; pyranoside; glycosylated; steroid
Prior art date: 1991-07-22
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Expired - Fee Related

Application number

DE69230104T

Other languages

English (en)

Other versions

DE69230104T2 (de

Inventor

R Erich Klemke

Masata Koreeda

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Harrier Inc

Original Assignee

Harrier Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1991-07-22

Filing date

1992-07-21

Publication date

1999-11-11

1992-07-21 Application filed by Harrier Inc filed Critical Harrier Inc

1999-11-11 Publication of DE69230104D1 publication Critical patent/DE69230104D1/de

2000-08-24 Application granted granted Critical

2000-08-24 Publication of DE69230104T2 publication Critical patent/DE69230104T2/de

2012-07-22 Anticipated expiration legal-status Critical

Status Expired - Fee Related legal-status Critical Current

Links

238000000034 method Methods 0.000 title abstract 2
238000005858 glycosidation reaction Methods 0.000 title 1
230000000694 effects Effects 0.000 abstract 4
HVYWMOMLDIMFJA-DPAQBDIFSA-N cholesterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 HVYWMOMLDIMFJA-DPAQBDIFSA-N 0.000 abstract 2
230000000144 pharmacologic effect Effects 0.000 abstract 2
229930002534 steroid glycoside Natural products 0.000 abstract 2
150000008143 steroidal glycosides Chemical class 0.000 abstract 2
230000003637 steroidlike Effects 0.000 abstract 2
150000003431 steroids Chemical class 0.000 abstract 2
DKVBOUDTNWVDEP-NJCHZNEYSA-N teicoplanin aglycone Chemical class N([C@H](C(N[C@@H](C1=CC(O)=CC(O)=C1C=1C(O)=CC=C2C=1)C(O)=O)=O)[C@H](O)C1=CC=C(C(=C1)Cl)OC=1C=C3C=C(C=1O)OC1=CC=C(C=C1Cl)C[C@H](C(=O)N1)NC([C@H](N)C=4C=C(O5)C(O)=CC=4)=O)C(=O)[C@@H]2NC(=O)[C@@H]3NC(=O)[C@@H]1C1=CC5=CC(O)=C1 DKVBOUDTNWVDEP-NJCHZNEYSA-N 0.000 abstract 2
230000003110 anti-inflammatory effect Effects 0.000 abstract 1
125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 1
239000007809 chemical reaction catalyst Substances 0.000 abstract 1
235000012000 cholesterol Nutrition 0.000 abstract 1
FSMCJUNYLQOAIM-UQBZCTSOSA-N cholesteryl beta-D-glucoside Chemical compound O([C@@H]1CC2=CC[C@H]3[C@@H]4CC[C@@H]([C@]4(CC[C@@H]3[C@@]2(C)CC1)C)[C@H](C)CCCC(C)C)[C@@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O FSMCJUNYLQOAIM-UQBZCTSOSA-N 0.000 abstract 1
125000000524 functional group Chemical group 0.000 abstract 1
229930182470 glycoside Natural products 0.000 abstract 1
150000002338 glycosides Chemical class 0.000 abstract 1
230000013595 glycosylation Effects 0.000 abstract 1
238000006206 glycosylation reaction Methods 0.000 abstract 1
229910052736 halogen Inorganic materials 0.000 abstract 1
150000002367 halogens Chemical class 0.000 abstract 1
230000004957 immunoregulator effect Effects 0.000 abstract 1
230000001506 immunosuppresive effect Effects 0.000 abstract 1
238000001727 in vivo Methods 0.000 abstract 1
230000003211 malignant effect Effects 0.000 abstract 1
RYVMUASDIZQXAA-UHFFFAOYSA-N pyranoside Natural products O1C2(OCC(C)C(OC3C(C(O)C(O)C(CO)O3)O)C2)C(C)C(C2(CCC3C4(C)CC5O)C)C1CC2C3CC=C4CC5OC(C(C1O)O)OC(CO)C1OC(C1OC2C(C(OC3C(C(O)C(O)C(CO)O3)O)C(O)C(CO)O2)O)OC(CO)C(O)C1OC1OCC(O)C(O)C1O RYVMUASDIZQXAA-UHFFFAOYSA-N 0.000 abstract 1
230000004936 stimulating effect Effects 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
- C07H15/20—Carbocyclic rings
- C07H15/24—Condensed ring systems having three or more rings
- C07H15/256—Polyterpene radicals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
- C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J17/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, having an oxygen-containing hetero ring not condensed with the cyclopenta(a)hydrophenanthrene skeleton
- C07J17/005—Glycosides
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J9/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J9/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane
- C07J9/005—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane containing a carboxylic function directly attached or attached by a chain containing only carbon atoms to the cyclopenta[a]hydrophenanthrene skeleton

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
General Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Medicinal Chemistry (AREA)
Genetics & Genomics (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Pharmacology & Pharmacy (AREA)
Molecular Biology (AREA)
Animal Behavior & Ethology (AREA)
General Chemical & Material Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Engineering & Computer Science (AREA)
Biochemistry (AREA)
Biotechnology (AREA)
Hematology (AREA)
Oncology (AREA)
Steroid Compounds (AREA)
Saccharide Compounds (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicines Containing Material From Animals Or Micro-Organisms (AREA)

DE69230104T 1991-07-22 1992-07-21 Glykosidierungsverfahren Expired - Fee Related DE69230104T2 (de)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
US73391591A	1991-07-22	1991-07-22
US81569192A	1992-01-24	1992-01-24
PCT/US1992/006063 WO1993001821A1 (en)	1991-07-22	1992-07-21	Novel glycoside compounds and production and use thereof

Publications (2)

Publication Number	Publication Date
DE69230104D1 true DE69230104D1 (de)	1999-11-11
DE69230104T2 DE69230104T2 (de)	2000-08-24

Family

ID=27112641

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DE69230104T Expired - Fee Related DE69230104T2 (de)	1991-07-22	1992-07-21	Glykosidierungsverfahren

Country Status (10)

Country	Link
EP (1)	EP0597018B1 (de)
JP (1)	JPH06501499A (de)
CN (1)	CN1031643C (de)
AT (1)	ATE185348T1 (de)
AU (1)	AU2401192A (de)
CA (1)	CA2113819C (de)
DE (1)	DE69230104T2 (de)
IL (1)	IL102566A0 (de)
TW (1)	TW202455B (de)
WO (1)	WO1993001821A1 (de)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
CN107056878B (zh) *	2017-03-24	2019-07-05	昆明理工大学	一个d-吡喃环孕甾烷糖苷化合物及其应用
KR102124470B1 (ko) *	2019-12-13	2020-06-18	주식회사 큐라클	신규 혈관누출 차단제의 고수율 제조방법
CN116217642A (zh) *	2023-03-09	2023-06-06	西北大学	木樨榄苷类化合物及其在制备抗肿瘤药物中的应用

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
FI46067C (fi) *	1968-04-06	1972-12-11	Hoechst Ag	Menetelmä digitoksigeniiniglykosidien valmistamiseksi.
US4415731A (en) *	1981-03-30	1983-11-15	Merck & Co., Inc.	Process for the preparation of methyl 2,6-dideoxy-α-D-arabino-hexopyranoside
DE4001895A1 (de) *	1990-01-23	1991-07-25	Harrier Gmbh	Herstellung von insbesondere steroidglykosiden

1992
- 1992-07-20 IL IL102566A patent/IL102566A0/xx unknown
- 1992-07-21 CA CA002113819A patent/CA2113819C/en not_active Expired - Fee Related
- 1992-07-21 EP EP92917211A patent/EP0597018B1/de not_active Expired - Lifetime
- 1992-07-21 DE DE69230104T patent/DE69230104T2/de not_active Expired - Fee Related
- 1992-07-21 WO PCT/US1992/006063 patent/WO1993001821A1/en not_active Ceased
- 1992-07-21 AT AT92917211T patent/ATE185348T1/de not_active IP Right Cessation
- 1992-07-21 CN CN92109745A patent/CN1031643C/zh not_active Expired - Fee Related
- 1992-07-21 JP JP5503027A patent/JPH06501499A/ja active Pending
- 1992-07-21 AU AU24011/92A patent/AU2401192A/en not_active Abandoned
- 1992-08-14 TW TW081106445A patent/TW202455B/zh active

Also Published As

Publication number	Publication date
AU2401192A (en)	1993-02-23
ATE185348T1 (de)	1999-10-15
TW202455B (de)	1993-03-21
EP0597018A1 (de)	1994-05-18
JPH06501499A (ja)	1994-02-17
CN1073179A (zh)	1993-06-16
WO1993001821A1 (en)	1993-02-04
CA2113819C (en)	2009-01-06
IL102566A0 (en)	1993-01-14
CA2113819A1 (en)	1993-02-04
DE69230104T2 (de)	2000-08-24
EP0597018B1 (de)	1999-10-06
CN1031643C (zh)	1996-04-24
EP0597018A4 (de)	1996-02-07

Similar Documents

Publication	Publication Date	Title
MX9303712A (es)	1994-05-31	Proceso de anomerizacion para producir un sulfonato de ribofuranosilo enriquecido con alfa-anomero.
EP0941733A3 (de)	1999-12-01	Verfahren zur hemmung der Leaderless-Proteinausscheidung mittels Herzglykosiden, deren Aglykone, oder Derivate
GB2396103A (en)	2004-06-16	A seating system and a passanger accomodation unit for a vehicle
AR001045A1 (es)	1997-09-24	Procedimiento para purificar y aislar 2'-desoxi-2',2'-difluoronucleosidos enriquecidos en beta anomeros
DE69607444D1 (de)	2000-05-04	Befeuchtigungsvorrichtung für eine Flugzeugkabine
DE59708788D1 (de)	2003-01-09	Beleuchtungssystem in Passagierkabinen, insbesondere für Passagierflugzeuge
ES2012494B3 (es)	1990-04-01	Pala en material compuesto, para estructura bilarguero y bicaja y revestimientos estratificados en sandwich de nidos de abejas y su procedimiento de fabricacion.
DE68904601D1 (de)	1993-03-11	Faserverstaerktes spant, insbesondere eines luftfahrzeugrumpfs, und sein herstellungsverfahren.
FR2701786B1 (fr)	1995-09-22	Cellule photovoltauique, son procede de realisation et panneau solaire comportant de telles cellules.
AU2365488A (en)	1989-04-20	Reinforced honeycomb core sandwich panels and method for making same
CA2105112A1 (en)	1994-03-02	A process for anomerizing nucleosides
BR8501750A (pt)	1986-04-22	Estrutura para comutacao por teclado de membrana
ES2092231T3 (es)	1996-11-16	Escudos termicos.
DE69230104D1 (de)	1999-11-11	Glykosidierungsverfahren
KR100192005B1 (en)	1999-06-15	Production of glycoside, particularly steroidal gycoside
HK1005615B (en)	1999-01-15	Convertible aircraft passenger seating
ATE235883T1 (de)	2003-04-15	Zusammensetzung für dermatologische zubereitung
EP0576227A3 (de)	1994-02-09	2'-Desoxy-2',2'-Difluoro(2,6,8-substituierte)Purinnukleoside mit antiviraler und anti-Krebs Aktivität und Zwischenprodukten
AU3193095A (en)	1996-03-07	Ganglioside gm3 analog having sialic acid residue fluorinated at the 9-position and intermediate therefor
JPS6485099A (en)	1989-03-30	Method for manufacturing 9d- hydroxy-4-androstene-3, 17- dione and mycobacterium rhoseum for use in performing said method
DK320685A (da)	1986-01-15	Fremstilling af glycosider ud fra glycosylfluorider
IE780610L (en)	1978-09-30	Dimeric indole-dihydroindoles
DE58900124D1 (de)	1991-07-04	Plattenfoermiges bauelement in sandwichbauweise.
PL321281A1 (en)	1997-11-24	Method of and apparatus for forming a middle layer of a "honeycomb" type structural member for panels incorporating a "honeycomb" type structural member
NZ238054A (en)	1993-04-28	Avermectin derivatives having an alkyleneoxy or an ethoxymethoxy spacer between the disaccharide and the aglycone; pesticidal compositions

Legal Events

Date	Code	Title
2000-05-11	8332	No legal effect for de
2000-06-21	8370	Indication related to discontinuation of the patent is to be deleted
2000-10-26	8364	No opposition during term of opposition
2010-05-20	8339	Ceased/non-payment of the annual fee