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DE69229108D1 - Oxypurin-nukleoside und seine artverwandten, und acylderivate davon, zur verbesserung der hämatopoese - Google Patents

Oxypurin-nukleoside und seine artverwandten, und acylderivate davon, zur verbesserung der hämatopoese

Info

Publication number
DE69229108D1
DE69229108D1 DE69229108T DE69229108T DE69229108D1 DE 69229108 D1 DE69229108 D1 DE 69229108D1 DE 69229108 T DE69229108 T DE 69229108T DE 69229108 T DE69229108 T DE 69229108T DE 69229108 D1 DE69229108 D1 DE 69229108D1
Authority
DE
Germany
Prior art keywords
nucleosides
acyl derivatives
oxypurin
hematopoesis
improve
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69229108T
Other languages
English (en)
Other versions
DE69229108T2 (de
Inventor
Borstel Reid Von
Michael Bamat
Bradley Hiltbrand
James Butler
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Wellstat Therapeutics Corp
Original Assignee
Pro Neuron Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pro Neuron Inc filed Critical Pro Neuron Inc
Publication of DE69229108D1 publication Critical patent/DE69229108D1/de
Application granted granted Critical
Publication of DE69229108T2 publication Critical patent/DE69229108T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A61K31/52—Purines, e.g. adenine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/74—Synthetic polymeric materials
    • A61K31/765—Polymers containing oxygen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/18—Growth factors; Growth regulators
    • A61K38/1816—Erythropoietin [EPO]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/19—Cytokines; Lymphokines; Interferons
    • A61K38/193—Colony stimulating factors [CSF]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/19—Cytokines; Lymphokines; Interferons
    • A61K38/20—Interleukins [IL]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/06—Antianaemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/08—Plasma substitutes; Perfusion solutions; Dialytics or haemodialytics; Drugs for electrolytic or acid-base disorders, e.g. hypovolemic shock
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Immunology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Virology (AREA)
  • Zoology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • AIDS & HIV (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
DE69229108T 1991-02-08 1992-02-05 Oxypurin-nukleoside und seine artverwandten, und acylderivate davon, zur verbesserung der hämatopoese Expired - Fee Related DE69229108T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US65388291A 1991-02-08 1991-02-08
PCT/US1992/000887 WO1992013561A1 (en) 1991-02-08 1992-02-05 Oxypurine nucleosides and their congeners, and acyl derivatives thereof, for improvement of hematopoiesis

Publications (2)

Publication Number Publication Date
DE69229108D1 true DE69229108D1 (de) 1999-06-10
DE69229108T2 DE69229108T2 (de) 1999-09-23

Family

ID=24622651

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69229108T Expired - Fee Related DE69229108T2 (de) 1991-02-08 1992-02-05 Oxypurin-nukleoside und seine artverwandten, und acylderivate davon, zur verbesserung der hämatopoese

Country Status (11)

Country Link
EP (1) EP0570519B1 (de)
JP (6) JP3393645B2 (de)
KR (2) KR100263943B1 (de)
AT (1) ATE179615T1 (de)
AU (1) AU663309C (de)
CA (2) CA2100655C (de)
DE (1) DE69229108T2 (de)
IL (1) IL100874A (de)
RU (1) RU2158269C2 (de)
WO (1) WO1992013561A1 (de)
ZA (1) ZA92914B (de)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE9800452D0 (sv) * 1998-02-13 1998-02-13 Medivir Ab Antivirals
US6458772B1 (en) 1909-10-07 2002-10-01 Medivir Ab Prodrugs
US6054441A (en) * 1987-10-28 2000-04-25 Pro-Neuron, Inc. Oxypurine nucleosides and their congeners, and acyl derivatives thereof, for improvement of hematopoiesis
DK0594667T3 (da) * 1991-07-05 2001-11-12 Pro Neuron Inc Behandling af kemoterapeutiske og antivirale, aktive stoffers toksiske virkning med acylerede pyrimidinnucleosider
US5641758A (en) * 1993-11-10 1997-06-24 Kluge; Michael Cytarabine derivatives, the preparation and use thereof
US5762922A (en) * 1994-01-31 1998-06-09 Ludwig Institute For Cancer Research Antioxidants and intracellular gluthathione raising agents for therapeutic treatments
CA2197205A1 (en) * 1994-08-12 1996-02-22 Reid W. Vonborstel Methods for treating sepsis or inflammatory diseases with oxypurine nucleosides
ES2239637T3 (es) * 1997-08-15 2005-10-01 Medivir Ab Derivados de guanosina 3'-fluorados para el tratamiento o profilaxis de vhb o infecciones retrovirales.
WO1999051613A1 (en) * 1998-04-03 1999-10-14 Medivir Ab Prodrugs of phosphorous-containing pharmaceuticals
GB0114286D0 (en) * 2001-06-12 2001-08-01 Hoffmann La Roche Nucleoside Derivatives
PT1567112E (pt) * 2002-11-22 2009-01-08 Smithkline Beecham Corp Novos compostos químicos
JP3929949B2 (ja) * 2003-08-08 2007-06-13 独立行政法人科学技術振興機構 酸化により機能性ユニットを放出するヌクレオシドおよびそれを含むオリゴヌクレオチドの製造法
AU2008307308C1 (en) * 2007-08-16 2014-06-05 The Government Of The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Compositions containing nucleosides and manganese and their uses
AU2016222458B2 (en) * 2007-08-16 2018-11-08 The Government Of The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Compositions containing Nucleosides and Manganese and their Uses
WO2011139881A2 (en) 2010-04-29 2011-11-10 The Henry M. Jackson Foundation For The Advancement Of Military Medicine, Inc. Compositions containing purine and pyrimidine nucleosides, peptides, and manganese and their uses
WO2014168947A2 (en) 2013-04-08 2014-10-16 The Board Of Regents Of The University Of Texas System Telomerase mediated telomere altering compounds
JP2021514985A (ja) * 2018-03-02 2021-06-17 ジャニュアリー セラピューティクス，インク． ナノ粒子組成物
US20250057849A1 (en) * 2021-12-22 2025-02-20 Cj Cheiljedang Corporation Antiviral composition comprising nucleoside analogues derived from nucleic acid and pharmaceutically acceptable salt thereof

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4002963A (en) * 1975-05-29 1977-01-11 North Electric Company Converter circuit and method having fast responding current balance and limiting
IT1202370B (it) * 1976-07-12 1989-02-09 Hoffmann La Roche Soluzioni inietabili in cui l'atti vita' emolitica degli agenti di formazione di micelle naturali e' evitata mediante l'aggiunta di lipoidi e relativi prodotti
US4849411A (en) * 1982-11-09 1989-07-18 Scripps Clinic And Research Foundation Modulation of animal cellular responses with compositions containing 8-substituted guanine derivatives
GB2177914B (en) * 1985-06-04 1989-10-25 Chugai Pharmaceutical Co Ltd A pharmaceutical composition containing human erythropoietin and a surface active agent for nasal administration for the treatment of anemia
US4786726A (en) * 1986-01-06 1988-11-22 Blood Systems, Inc. Factor IX therapeutic blood product, means and methods of preparing same
US4962194A (en) * 1987-04-02 1990-10-09 Warner-Lambert Company Method of preparing 51,N6-disubstituted adenosines from inosines
CA1321994C (en) * 1987-10-28 1993-09-07 Reid Von Borstel Acylated uridine and cytidine and uses thereof
KR890701609A (ko) * 1987-10-28 1989-12-21 원본미기재 아실 데옥시리보뉴클레오시드 유도체 및 그의 사용
ZA892928B (en) * 1988-04-25 1991-01-30 Pro Neuron Inc Pharmaceutical compositions containing deoxyribonucleosides for wound healing
ATE111157T1 (de) * 1988-04-29 1994-09-15 Genetics Inst Lagerungsstabile zusammensetzungen von homogenem dimerem m-csf.

Also Published As

Publication number Publication date
JP3760149B2 (ja) 2006-03-29
AU1417792A (en) 1992-09-07
CA2444071A1 (en) 1992-08-20
CA2444071C (en) 2008-10-07
JP3393645B2 (ja) 2003-04-07
IL100874A (en) 1996-01-19
WO1992013561A1 (en) 1992-08-20
JP2003119152A (ja) 2003-04-23
JP2006096772A (ja) 2006-04-13
HK1003425A1 (en) 1998-10-30
KR100418483B1 (ko) 2004-02-11
JP3996352B2 (ja) 2007-10-24
ZA92914B (en) 1993-08-09
CA2100655A1 (en) 1992-08-09
KR100263943B1 (ko) 2000-08-16
DE69229108T2 (de) 1999-09-23
JPH06511473A (ja) 1994-12-22
EP0570519A4 (en) 1996-02-21
EP0570519B1 (de) 1999-05-06
AU663309C (en) 2002-08-08
JP4067926B2 (ja) 2008-03-26
CA2100655C (en) 2004-02-03
EP0570519A1 (de) 1993-11-24
AU663309B2 (en) 1995-10-05
JP2001270896A (ja) 2001-10-02
JP2003160585A (ja) 2003-06-03
JP3885006B2 (ja) 2007-02-21
IL100874A0 (en) 1992-11-15
JP2003064092A (ja) 2003-03-05
RU2158269C2 (ru) 2000-10-27
ATE179615T1 (de) 1999-05-15

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8364 No opposition during term of opposition
8327 Change in the person/name/address of the patent owner

Owner name: WELLSTAT THERAPEUTICS CORP.(N.D.GES.D. STAATES CAL

8339 Ceased/non-payment of the annual fee