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DE69108044D1 - Verfahren zur verbesserung der fliessencharakteristik von kristallinem ibuprofen. - Google Patents

Verfahren zur verbesserung der fliessencharakteristik von kristallinem ibuprofen.

Info

Publication number
DE69108044D1
DE69108044D1 DE69108044T DE69108044T DE69108044D1 DE 69108044 D1 DE69108044 D1 DE 69108044D1 DE 69108044 T DE69108044 T DE 69108044T DE 69108044 T DE69108044 T DE 69108044T DE 69108044 D1 DE69108044 D1 DE 69108044D1
Authority
DE
Germany
Prior art keywords
improving
flow characteristics
crystalline ibuprofen
ibuprofen
crystalline
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69108044T
Other languages
English (en)
Other versions
DE69108044T2 (de
Inventor
Lloyd Goddard
George Knesel
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Albemarle Corp
Original Assignee
Albemarle Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Albemarle Corp filed Critical Albemarle Corp
Publication of DE69108044D1 publication Critical patent/DE69108044D1/de
Application granted granted Critical
Publication of DE69108044T2 publication Critical patent/DE69108044T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
    • C07C51/42—Separation; Purification; Stabilisation; Use of additives
    • C07C51/43—Separation; Purification; Stabilisation; Use of additives by change of the physical state, e.g. crystallisation

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
DE69108044T 1990-11-19 1991-10-28 Verfahren zur verbesserung der fliessencharakteristik von kristallinem ibuprofen. Expired - Fee Related DE69108044T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US61534890A 1990-11-19 1990-11-19
US73491091A 1991-07-24 1991-07-24
PCT/US1991/007991 WO1992008686A1 (en) 1990-11-19 1991-10-28 Process for improving flow characteristics of crystalline ibuprofen

Publications (2)

Publication Number Publication Date
DE69108044D1 true DE69108044D1 (de) 1995-04-13
DE69108044T2 DE69108044T2 (de) 1995-07-06

Family

ID=27087485

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69108044T Expired - Fee Related DE69108044T2 (de) 1990-11-19 1991-10-28 Verfahren zur verbesserung der fliessencharakteristik von kristallinem ibuprofen.

Country Status (6)

Country Link
US (2) US5352823A (de)
EP (1) EP0558621B1 (de)
JP (1) JP3167327B2 (de)
CA (1) CA2095127C (de)
DE (1) DE69108044T2 (de)
WO (1) WO1992008686A1 (de)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AT401871B (de) * 1994-01-28 1996-12-27 Gebro Broschek Gmbh Verfahren zur herstellung von s(+)-ibuprofen- partikeln mit verbesserten fliesseigenschaften und deren verwendung zur arzneimittelherstellung
FR2857253B1 (fr) * 2003-07-07 2007-02-09 Ethypharm Sa Installation comprenant une machine de fabrication de comprimes en particulier a usage therapeuthique
CZ297830B6 (cs) * 2005-08-30 2007-04-11 I.Q.A., A. S. Zpusob výroby jemne krystalické smesi obsahující nesteroidní protizánetlivé lécivo, jemne krystalická smes pripravitelná tímto zpusobem a pevný farmaceutický prostredek tuto smes obsahující
DE102005049001A1 (de) * 2005-10-11 2007-04-12 Basf Ag Verfahren zur Herstellung von direkttablettierbaren Ibuprofen-Formulierungen
CN102311335B (zh) * 2010-06-29 2013-12-11 山东新华制药股份有限公司 高松密度布洛芬的制备工艺
JP6214156B2 (ja) * 2012-12-26 2017-10-18 三菱ケミカル株式会社 メタクリル酸の精製方法
CN110642705B (zh) * 2019-09-30 2022-04-05 福建太平洋制药有限公司 从布洛芬缓释胶囊生产过程的尾料中提取布洛芬的方法

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4107439A (en) * 1976-06-16 1978-08-15 The Upjohn Company Process for preparing arylalkanoic acid derivatives
US4135051A (en) * 1977-06-16 1979-01-16 The Upjohn Company Process for preparing arylalkanoic acid derivatives
US4476248A (en) * 1983-02-28 1984-10-09 The Upjohn Company Crystallization of ibuprofen
US4694100A (en) * 1984-07-14 1987-09-15 Nippon Petrochemicals Company, Ltd. Method for producing α-(p-isobutylphenyl)propionic acid or its alkyl esters
US4582577A (en) * 1984-12-19 1986-04-15 Monsanto Company Electrochemical carboxylation of p-isobutylacetophenone
IT1228242B (it) * 1986-11-13 1991-06-05 Ricerfarma Srl Milano Sale del diclofenac con idrossietilpirrolidina e composizioni farmaceutiche che lo contengono

Also Published As

Publication number Publication date
EP0558621A1 (de) 1993-09-08
JPH06502651A (ja) 1994-03-24
WO1992008686A1 (en) 1992-05-29
US5843863A (en) 1998-12-01
EP0558621B1 (de) 1995-03-08
CA2095127A1 (en) 1992-05-20
CA2095127C (en) 1998-06-30
US5352823A (en) 1994-10-04
DE69108044T2 (de) 1995-07-06
JP3167327B2 (ja) 2001-05-21

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee