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DE69937272D1 - Verfahren zur herstellung eines peptids mittels eines hilfspeptids - Google Patents

Verfahren zur herstellung eines peptids mittels eines hilfspeptids

Info

Publication number
DE69937272D1
DE69937272D1 DE69937272T DE69937272T DE69937272D1 DE 69937272 D1 DE69937272 D1 DE 69937272D1 DE 69937272 T DE69937272 T DE 69937272T DE 69937272 T DE69937272 T DE 69937272T DE 69937272 D1 DE69937272 D1 DE 69937272D1
Authority
DE
Germany
Prior art keywords
peptide
target
protein
solubility
improve
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69937272T
Other languages
English (en)
Other versions
DE69937272T2 (de
Inventor
Kazuhiro Ohsuye
Masayuki Yabuta
Yuji Suzuki
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Daiichi Sankyo Co Ltd
Original Assignee
Asubio Pharma Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Asubio Pharma Co Ltd filed Critical Asubio Pharma Co Ltd
Application granted granted Critical
Publication of DE69937272D1 publication Critical patent/DE69937272D1/de
Publication of DE69937272T2 publication Critical patent/DE69937272T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/62—DNA sequences coding for fusion proteins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
    • A61P5/50—Drugs for disorders of the endocrine system of the pancreatic hormones for increasing or potentiating the activity of insulin
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/605—Glucagons
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/50—Fusion polypeptide containing protease site
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/70—Fusion polypeptide containing domain for protein-protein interaction
    • C07K2319/74—Fusion polypeptide containing domain for protein-protein interaction containing a fusion for binding to a cell surface receptor
    • C07K2319/75—Fusion polypeptide containing domain for protein-protein interaction containing a fusion for binding to a cell surface receptor containing a fusion for activation of a cell surface receptor, e.g. thrombopoeitin, NPY and other peptide hormones

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Zoology (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Diabetes (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Medicinal Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Endocrinology (AREA)
  • Plant Pathology (AREA)
  • Microbiology (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Toxicology (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Emergency Medicine (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
DE69937272T 1998-01-30 1999-01-29 Verfahren zur herstellung eines peptids mittels eines hilfspeptids Expired - Lifetime DE69937272T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP3227298 1998-01-30
JP3227298 1998-01-30
PCT/JP1999/000406 WO1999038984A1 (fr) 1998-01-30 1999-01-29 Procede de production de peptide au moyen d'un peptide accessoire

Publications (2)

Publication Number Publication Date
DE69937272D1 true DE69937272D1 (de) 2007-11-22
DE69937272T2 DE69937272T2 (de) 2008-07-10

Family

ID=12354362

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69937272T Expired - Lifetime DE69937272T2 (de) 1998-01-30 1999-01-29 Verfahren zur herstellung eines peptids mittels eines hilfspeptids

Country Status (12)

Country Link
EP (1) EP0978565B1 (de)
JP (1) JP4331270B2 (de)
KR (1) KR100627590B1 (de)
CN (1) CN1198937C (de)
AT (1) ATE375393T1 (de)
AU (1) AU765206B2 (de)
CA (1) CA2284847A1 (de)
DE (1) DE69937272T2 (de)
DK (1) DK0978565T3 (de)
IL (1) IL132030A (de)
NZ (1) NZ338004A (de)
WO (1) WO1999038984A1 (de)

Families Citing this family (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN100445394C (zh) * 1999-03-04 2008-12-24 阿斯比奥制药株式会社 控制OmpT蛋白酶切割的方法
AU7559500A (en) * 1999-10-15 2001-04-23 Shionogi & Co., Ltd. Process for producing adrenomedulin precursor
KR100407792B1 (ko) * 2000-08-02 2003-12-01 한국생명공학연구원 인간 글루카곤 유사펩타이드를 융합파트너로 이용한재조합 단백질의 제조방법
GB0121591D0 (en) 2001-09-06 2001-10-24 Chiron Spa Hybrid and tandem expression of neisserial proteins
EP1412381B1 (de) 2001-07-27 2010-06-02 Novartis Vaccines and Diagnostics S.r.l. Antikörper gegen das meningokokken adhäsin app
US8129504B2 (en) 2001-08-30 2012-03-06 Biorexis Technology, Inc. Oral delivery of modified transferrin fusion proteins
US7176278B2 (en) 2001-08-30 2007-02-13 Biorexis Technology, Inc. Modified transferrin fusion proteins
CN100491395C (zh) 2002-04-11 2009-05-27 阿斯比奥制药株式会社 修饰肽的制造方法
EP1572720A4 (de) 2002-05-24 2008-12-24 Nps Allelix Corp Verfahren zur enzymatischen herstellung von glp-2-(1-33)- und glp-2-(1-34)-peptiden
AU2003239865A1 (en) 2002-05-24 2003-12-12 Restoragen Inc. Method for universal enzymatic production of bioactive peptides
CA2485701A1 (en) * 2002-05-24 2003-12-04 Fred W. Wagner Method for enzymatic production of glp-1 (7-36) amide peptides
WO2004037859A1 (ja) * 2002-10-11 2004-05-06 Sanwa Kagaku Kenkyusho Co., Ltd. Glp-1誘導体及びその経粘膜吸収型製剤
SI2353608T1 (sl) 2002-10-11 2020-12-31 Glaxosmithkline Biologicals Sa Polipeptidna cepiva za široko zaščito proti hipervirulentnim meningokoknim linijam
WO2004078777A2 (en) * 2003-03-04 2004-09-16 Biorexis Pharmaceutical Corporation Dipeptidyl-peptidase protected proteins
CA2546319A1 (en) 2003-11-21 2005-07-28 Nps Allelix Corp. Production of glucagon like peptide 2 and analogs
US8841255B2 (en) 2005-12-20 2014-09-23 Duke University Therapeutic agents comprising fusions of vasoactive intestinal peptide and elastic peptides
US20130172274A1 (en) 2005-12-20 2013-07-04 Duke University Methods and compositions for delivering active agents with enhanced pharmacological properties
PL2038423T3 (pl) 2006-06-21 2013-05-31 Biocon Ltd Metoda wytwarzania biologicznie aktywnego polipeptydu insulinotropowego
ATE524493T1 (de) 2006-07-24 2011-09-15 Biorexis Pharmaceutical Corp Exendin-fusionsproteine
WO2008030968A2 (en) * 2006-09-06 2008-03-13 Phase Bioscience, Inc. Fusion peptide therapeutic compositions
CA2726894A1 (en) 2008-06-27 2009-12-30 Duke University Therapeutic agents comprising elastin-like peptides
WO2014077802A1 (en) * 2012-11-13 2014-05-22 Ipsen Pharma S.A.S. Purification method of a glp-1 analogue
CN104592381A (zh) * 2013-10-31 2015-05-06 江苏万邦生化医药股份有限公司 一种利拉鲁肽中间体多肽的制备方法
RU2544959C1 (ru) * 2014-04-04 2015-03-20 Александр Владимирович Бубнов Способ получения пептидов
NZ732400A (en) 2014-12-01 2021-07-30 Pfenex Inc Fusion partners for peptide production
CN105669856A (zh) * 2016-02-13 2016-06-15 王大勇 一种基因重组长效人促肾上腺皮质激素及其制备方法
HRP20240485T1 (hr) 2017-08-24 2024-07-05 Novo Nordisk A/S Pripravci glp-1 i njihova upotreba
CN111378027B (zh) * 2018-12-29 2022-04-15 万新医药科技(苏州)有限公司 一种索玛鲁肽前体的制备方法
MX2022009844A (es) 2020-02-18 2022-09-05 Novo Nordisk As Composiciones y usos del peptido similar al glucagon-1 (glp-1).

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP3531947B2 (ja) * 1991-08-19 2004-05-31 第一サントリーファーマ株式会社 ペプチドの製造方法
JP3995279B2 (ja) * 1994-09-07 2007-10-24 アスビオファーマ株式会社 蛋白の製造方法
CA2198966C (en) * 1996-03-04 2011-06-21 Yuji Suzuki Method for cleaving chimeric protein using processing enzyme

Also Published As

Publication number Publication date
EP0978565A4 (de) 2003-05-02
AU2185799A (en) 1999-08-16
EP0978565A1 (de) 2000-02-09
KR100627590B1 (ko) 2006-09-25
CN1198937C (zh) 2005-04-27
DE69937272T2 (de) 2008-07-10
WO1999038984A1 (fr) 1999-08-05
ATE375393T1 (de) 2007-10-15
NZ338004A (en) 2001-08-31
IL132030A (en) 2009-06-15
CA2284847A1 (en) 1999-08-05
DK0978565T3 (da) 2008-02-04
AU765206B2 (en) 2003-09-11
IL132030A0 (en) 2001-03-19
KR20010005859A (ko) 2001-01-15
EP0978565B1 (de) 2007-10-10
JP4331270B2 (ja) 2009-09-16
CN1255945A (zh) 2000-06-07

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8327 Change in the person/name/address of the patent owner

Owner name: DAIICHI SANKYO COMPANY, LIMITED, TOKIO, JP