[go: up one dir, main page]

DE69936284D1 - Vereinfachte sequenzielle chemoluminiszenz-messung - Google Patents

Vereinfachte sequenzielle chemoluminiszenz-messung

Info

Publication number
DE69936284D1
DE69936284D1 DE69936284T DE69936284T DE69936284D1 DE 69936284 D1 DE69936284 D1 DE 69936284D1 DE 69936284 T DE69936284 T DE 69936284T DE 69936284 T DE69936284 T DE 69936284T DE 69936284 D1 DE69936284 D1 DE 69936284D1
Authority
DE
Germany
Prior art keywords
detection
dna
chemoluminic
sequencial
simplified
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69936284T
Other languages
English (en)
Other versions
DE69936284T2 (de
Inventor
Hashem Akhavan-Tafti
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Lumigen Inc
Original Assignee
Lumigen Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lumigen Inc filed Critical Lumigen Inc
Application granted granted Critical
Publication of DE69936284D1 publication Critical patent/DE69936284D1/de
Publication of DE69936284T2 publication Critical patent/DE69936284T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/58—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances
    • G01N33/582—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances with fluorescent label
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/26—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving oxidoreductase
    • C12Q1/28—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving oxidoreductase involving peroxidase
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00—Chemistry: molecular biology and microbiology
    • Y10S435/973—Simultaneous determination of more than one analyte

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Immunology (AREA)
  • Urology & Nephrology (AREA)
  • Biotechnology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Microbiology (AREA)
  • Biomedical Technology (AREA)
  • Analytical Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Biochemistry (AREA)
  • Physics & Mathematics (AREA)
  • Hematology (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Genetics & Genomics (AREA)
  • Cell Biology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biophysics (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
  • Golf Clubs (AREA)
  • Reinforced Plastic Materials (AREA)
  • Ink Jet (AREA)
DE69936284T 1998-04-22 1999-04-16 Vereinfachter sequenzieller chemilumineszenz-nachweis Expired - Lifetime DE69936284T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US09/064,451 US6068979A (en) 1998-04-22 1998-04-22 Simplified sequential chemiluminescent detection
US64451 1998-04-22
PCT/US1999/006531 WO1999054503A1 (en) 1998-04-22 1999-04-16 Simplified sequential chemiluminescent detection

Publications (2)

Publication Number Publication Date
DE69936284D1 true DE69936284D1 (de) 2007-07-26
DE69936284T2 DE69936284T2 (de) 2008-03-06

Family

ID=22056080

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69936284T Expired - Lifetime DE69936284T2 (de) 1998-04-22 1999-04-16 Vereinfachter sequenzieller chemilumineszenz-nachweis

Country Status (8)

Country Link
US (1) US6068979A (de)
EP (1) EP1015641B1 (de)
JP (1) JP4156677B2 (de)
AT (1) ATE364719T1 (de)
AU (1) AU747976C (de)
CA (1) CA2294436C (de)
DE (1) DE69936284T2 (de)
WO (1) WO1999054503A1 (de)

Families Citing this family (34)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE410680T1 (de) * 2001-05-26 2008-10-15 One Cell Systems Inc Sekretion von proteinen durch verkapselte zellen
US6852503B1 (en) * 2001-05-30 2005-02-08 Pierce Biotechnology, Inc. Compositions and methods for utilizing mixed substrate solutions of luminols and dioxetanes
US7166478B2 (en) * 2002-03-12 2007-01-23 Enzo Life Sciences, Inc., C/O Enzo Biochem, Inc. Labeling reagents and labeled targets, target labeling processes and other processes for using same in nucleic acid determinations and analyses
WO2003089926A2 (en) * 2002-04-19 2003-10-30 Mission Medical, Inc. Integrated automatic blood processing unit
US6897036B2 (en) 2002-06-06 2005-05-24 Lumigen, Inc. Fluorescent detection of peroxidase enzymes
DE10239821A1 (de) * 2002-08-29 2004-03-11 Roche Diagnostics Gmbh Verbesserung der Spezifität bei der Bestimmung von Antithrombin
US20040214180A1 (en) * 2003-04-28 2004-10-28 Hironori Kobayashi Method and kit for determining quantity of protein
US20040259182A1 (en) * 2003-06-17 2004-12-23 Brooks Edwards Arrays for chemiluminescent assays, methods of making the arrays and methods of detecting chemiluminescent emissions on solid supports
US20050019778A1 (en) * 2003-07-17 2005-01-27 Voyta John C. Sequential generation of multiple chemiluminescent signals on solid supports
US20050026151A1 (en) * 2003-07-17 2005-02-03 Voyta John C. Simultaneous generation of multiple chemiluminescent signals on solid supports
US20060292575A1 (en) * 2005-06-24 2006-12-28 Asiagen Corporation Novel method for diagnosing pathogens of sexually transmitted diseases
CA2619686A1 (en) * 2005-08-19 2007-02-22 Commomwealth Scientific And Industrial Research Organisation Arachnocampa luciferases
US7629125B2 (en) * 2006-11-16 2009-12-08 General Electric Company Sequential analysis of biological samples
US9201063B2 (en) * 2006-11-16 2015-12-01 General Electric Company Sequential analysis of biological samples
WO2011158203A1 (en) 2010-06-17 2011-12-22 Danisco A/S Process
KR101099508B1 (ko) 2010-06-30 2011-12-27 중앙대학교 산학협력단 과붕산염 선택성을 갖는 플루오레세인계 화합물을 포함하는 센서 및 이를 이용한 과붕산염 검출방법
JP2014531908A (ja) 2011-10-14 2014-12-04 プレジデント アンド フェローズ オブ ハーバード カレッジ 構造アッセンブリによる配列決定
ES2991004T3 (es) 2011-12-22 2024-12-02 Harvard College Métodos para la detección de analitos
EP4249605B1 (de) 2011-12-22 2024-08-28 President And Fellows Of Harvard College Verfahren zum nachweis von analyten
WO2013134442A1 (en) * 2012-03-06 2013-09-12 Advanced Cell Diagnostics, Inc. Duplex chromogenic assay for in situ detection of nucleic acids
WO2013184754A2 (en) 2012-06-05 2013-12-12 President And Fellows Of Harvard College Spatial sequencing of nucleic acids using dna origami probes
EP2971184B1 (de) 2013-03-12 2019-04-17 President and Fellows of Harvard College Verfahren zur erzeugung einer dreidimensionalen nukleinsäure mit matrix
EP2972230B1 (de) 2013-03-15 2021-07-21 Hycor Biomedical LLC Vorrichtung und zugehöriges verfahren zur durchführung von lumineszenz- und fluoreszenzmessungen in einer probe
US9322051B2 (en) 2013-10-07 2016-04-26 General Electric Company Probing of biological samples
WO2016007839A1 (en) 2014-07-11 2016-01-14 President And Fellows Of Harvard College Methods for high-throughput labelling and detection of biological features in situ using microscopy
EP3191606B1 (de) 2014-09-12 2020-05-27 Illumina, Inc. Verfahren zur erkennung der anwesenheit von polymeruntereinheiten mit chemilumineszenz
US11078528B2 (en) 2015-10-12 2021-08-03 Advanced Cell Diagnostics, Inc. In situ detection of nucleotide variants in high noise samples, and compositions and methods related thereto
JP6882282B2 (ja) 2015-11-03 2021-06-02 プレジデント アンド フェローズ オブ ハーバード カレッジ 三次元核酸含有マトリックスの立体撮像のための方法と装置
EP3449016B1 (de) 2016-04-25 2025-07-23 President and Fellows of Harvard College Hybridisierungskettenreaktionsverfahren für in-situ-moleküldetektion
CN109312287A (zh) * 2016-07-29 2019-02-05 休斯顿大学系统 检测化学发光反应的系统和方法
WO2018045186A1 (en) 2016-08-31 2018-03-08 President And Fellows Of Harvard College Methods of combining the detection of biomolecules into a single assay using fluorescent in situ sequencing
WO2020076976A1 (en) 2018-10-10 2020-04-16 Readcoor, Inc. Three-dimensional spatial molecular indexing
US20220049303A1 (en) 2020-08-17 2022-02-17 Readcoor, Llc Methods and systems for spatial mapping of genetic variants
JPWO2022244612A1 (de) * 2021-05-18 2022-11-24

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4931223A (en) * 1986-07-24 1990-06-05 Tropix, Inc. Methods of using chemiluminescent 1,2-dioxetanes
US5656207A (en) * 1989-06-24 1997-08-12 Gen Probe Incorporated Detecting or quantifying multiple analytes using labelling techniques
ATE174914T1 (de) * 1990-08-30 1999-01-15 Tropix Inc Chemolumineszente 3-(substituierte adamant-2'- ylidene)1,2-dioxetane
AU679008B2 (en) * 1993-05-06 1997-06-19 Chiron Diagnostics Corporation Mixed luminescent conjugate test assays
US5686258A (en) * 1993-05-17 1997-11-11 Lumigen, Inc. Chemiluminescent detection of hydrolytic enzymes using an acridan
US5451347A (en) * 1993-06-24 1995-09-19 Lumigen, Inc. Methods and compositions providing enhanced chemiluminescence from chemiluminescent compounds using dicationic surfactants
KR0148439B1 (ko) * 1994-03-11 1998-11-02 마사까쓰 마쓰모또 1,2-디옥세탄 유도체
US5744320A (en) * 1995-06-07 1998-04-28 Promega Corporation Quenching reagents and assays for enzyme-mediated luminescence
US6602657B1 (en) * 1995-12-28 2003-08-05 Tropix, Inc. Multiple reporter gene assay

Also Published As

Publication number Publication date
AU3546299A (en) 1999-11-08
DE69936284T2 (de) 2008-03-06
WO1999054503A1 (en) 1999-10-28
AU747976B2 (en) 2002-05-30
ATE364719T1 (de) 2007-07-15
EP1015641B1 (de) 2007-06-13
JP4156677B2 (ja) 2008-09-24
EP1015641A4 (de) 2003-04-16
JP2002511770A (ja) 2002-04-16
CA2294436C (en) 2009-04-14
AU747976C (en) 2002-12-05
WO1999054503B1 (en) 1999-11-25
EP1015641A1 (de) 2000-07-05
CA2294436A1 (en) 1999-10-28
US6068979A (en) 2000-05-30

Similar Documents

Publication Publication Date Title
DE69936284D1 (de) Vereinfachte sequenzielle chemoluminiszenz-messung
EP1304566A4 (de) Biosensor
DE60012946D1 (de) Interferenzreduzierter wegwerfbarer sensor und herstellungsverfahren
SE9601318D0 (sv) Method for nucleic acid analysis
EP1318399A3 (de) Passive Probefeststellung zum Beginn einer Analyse
HUP9801679A2 (hu) Eljárás és hatóanyag többváltozós, többmintás elektro-kemilumineszcencia teszthez
DE69941367D1 (de) Multienzym-nachweisverfahren
BRPI9816332B8 (pt) tira de teste de biossensor eletroquímico aperfeiçoada
ATE247830T1 (de) Verbesserungen in oder in bezug auf spezifische bindungsassays
IL157380A0 (en) Mediator stabilized reagent compositions and methods for their use in electrochemical analyte detection assays
DK1368488T3 (da) Sensorindretning, indretning og fremgangsmåde til aomperometrisk og/eller potentiometrisk, farmakologisk testning af aktive steder og/eller aktive stoffer
CA2510377A1 (en) Use of nicotinamide n-methyltransferase as a marker for colorectal cancer
Hirtz et al. Absolute quantification of 35 plasma biomarkers in human saliva using targeted MS
ATE384952T1 (de) Enzymhemmungsimmunverfahren
DE60029413D1 (de) Enzymatische messung von mycophenolsäure
Gu et al. Serum level of interleukin‐35 as a potential prognostic factor for gastric cancer
WO2004050911A3 (en) Method for lowering both sequence variations and increase of base lines effects in diagnostic hybridisation assay, assay for performing such a method and probe for use in the assay
SG148027A1 (en) Methods for identifying combinations of entities as therapeutics
ATE184055T1 (de) Verfahren zum sensitiven nachweis von reverser transcriptase
WO2003089896A3 (en) Rapid assay, method and system for detecting biowarfare agents
NO994705L (no) Preparering av blodpröver for deteksjon av homocystein og/eller folat
AU2003260530A1 (en) Method for detecting a risk of acid related disease in an individual
NO20052553L (no) Cobalaminanalyse.
ATE208811T1 (de) Peroxydase/goldkolloid/oxidase-biosensoren zur mediatorlosen glukosebestimmung
WO2003006947A3 (en) Cell-screening assay and composition

Legal Events

Date Code Title Description
8364 No opposition during term of opposition