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DE69935718D1 - Antidiabetische medikamente - Google Patents

Antidiabetische medikamente

Info

Publication number
DE69935718D1
DE69935718D1 DE69935718T DE69935718T DE69935718D1 DE 69935718 D1 DE69935718 D1 DE 69935718D1 DE 69935718 T DE69935718 T DE 69935718T DE 69935718 T DE69935718 T DE 69935718T DE 69935718 D1 DE69935718 D1 DE 69935718D1
Authority
DE
Germany
Prior art keywords
substituted
group
unsubstituted
hydrogen atom
lower alkyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69935718T
Other languages
English (en)
Other versions
DE69935718T2 (de
Inventor
Junichi Shimada
Yoshihisa Ohta
Kotaro Takasaki
Miho Suda
Hideaki Kusaka
Hiroshi Yano
Satoshi Nakanishi
Yuzuru Matsuda
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
KH Neochem Co Ltd
Original Assignee
Kyowa Hakko Kogyo Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Kyowa Hakko Kogyo Co Ltd filed Critical Kyowa Hakko Kogyo Co Ltd
Application granted granted Critical
Publication of DE69935718D1 publication Critical patent/DE69935718D1/de
Publication of DE69935718T2 publication Critical patent/DE69935718T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains three hetero rings
    • C07D487/14—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Diabetes (AREA)
  • Endocrinology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Emergency Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Steroid Compounds (AREA)
DE69935718T 1998-07-02 1999-07-02 Antidiabetische medikamente Expired - Fee Related DE69935718T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP18770598 1998-07-02
JP18770598 1998-07-02
PCT/JP1999/003583 WO2000001388A1 (en) 1998-07-02 1999-07-02 Remedies for diabetes

Publications (2)

Publication Number Publication Date
DE69935718D1 true DE69935718D1 (de) 2007-05-16
DE69935718T2 DE69935718T2 (de) 2007-12-27

Family

ID=16210732

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69935718T Expired - Fee Related DE69935718T2 (de) 1998-07-02 1999-07-02 Antidiabetische medikamente

Country Status (8)

Country Link
US (1) US6489331B1 (de)
EP (1) EP1092435B1 (de)
AT (1) ATE358484T1 (de)
AU (1) AU4396899A (de)
CA (1) CA2336412C (de)
DE (1) DE69935718T2 (de)
ES (1) ES2284256T3 (de)
WO (1) WO2000001388A1 (de)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1187354C (zh) 1999-11-12 2005-02-02 拜奥根有限公司 腺苷受体拮抗剂以及制造和使用它们的方法
NZ527917A (en) 1999-11-12 2005-03-24 Biogen Inc Polycycoalkylpurines as adenosine receptor antagonists
EP1251130B1 (de) * 1999-12-24 2005-02-16 Kyowa Hakko Kogyo Co., Ltd. Kondensierte purinderivate
EP1347981B1 (de) 2000-12-01 2008-05-07 Biogen Idec MA Inc. Kondensierte purinderivate als a1-adenosinrezeptorantagonisten
EP1490065B1 (de) 2002-03-22 2007-06-13 Janssen Pharmaceutica N.V. Benzylimidazolyl substituierte 2-chinolon und chinazolinon derivate zur verwendung als farnesyl transferase inhibitoren
EP1514942A4 (de) * 2002-05-17 2007-05-16 Kyowa Hakko Kogyo Kk Verfahren zur suche nach einer substanz mit antidiabetischer wirkung
JPWO2003097064A1 (ja) * 2002-05-17 2005-09-15 協和醗酵工業株式会社 糖尿病治療剤
WO2004011469A1 (ja) * 2002-07-26 2004-02-05 Kyowa Hakko Kogyo Co., Ltd. 細胞分化誘導剤
KR101003877B1 (ko) 2002-09-19 2010-12-30 교린 세이야꾸 가부시키 가이샤 아미노알코올 유도체와 그 부가염 및 면역 억제제
JPWO2004096812A1 (ja) * 2003-04-25 2006-07-13 協和醗酵工業株式会社 縮合ピリミジン誘導体
PT1772145E (pt) 2004-07-16 2011-05-27 Kyorin Seiyaku Kk Processo de utiliza??o eficaz de um medicamento e processo respeitante ? preven??o de efeitos secund?rios
BRPI0516337A (pt) * 2004-10-12 2008-04-29 Kyorin Seiyaku Kk processo para a produção de 2- amino-2-[4-(3-benziloxifeniltio) -2- (clorofenil} etil] - 1,3 - hidrocloreto de propanediol e hidratos dos mesmos e produtos intermerdiários para a produção dos mesmos
PL1932522T3 (pl) * 2005-10-07 2012-09-28 Kyorin Seiyaku Kk Środek terapeutyczny do leczenia choroby wątroby zawierający jako składnik czynny pochodną 2-amino-1,3-propanodiolu
TWI389683B (zh) * 2006-02-06 2013-03-21 Kyorin Seiyaku Kk A therapeutic agent for an inflammatory bowel disease or an inflammatory bowel disease treatment using a 2-amino-1,3-propanediol derivative as an active ingredient
BRPI0713561A2 (pt) * 2006-06-23 2012-03-13 Incyte Corporation composto ou um sal ou pró-droga farmaceuticamente aceitável do mesmo, composição, e, métodos de modulação do receptor e de tratamento de uma doença
AR061625A1 (es) 2006-06-23 2008-09-10 Incyte Corp Derivados de purinona como agonistas de hm74a
US7462624B2 (en) 2006-06-23 2008-12-09 Incyte Corporation Purinone derivatives as HM74a agonists
EP2058317B1 (de) * 2006-08-08 2013-10-16 Kyorin Pharmaceutical Co., Ltd. Aminophosphorsäureesterderivat und s1p-rezeptor-modulator, der dieses als wirkstoff enthält
EP2053038B1 (de) * 2006-08-08 2016-10-05 Kyorin Pharmaceutical Co., Ltd. Aminoalkoholderivat und dieses als wirkstoff enthaltendes immunosuppressivum
JP4337898B2 (ja) * 2007-03-29 2009-09-30 セイコーエプソン株式会社 半導体装置
WO2009099174A1 (ja) 2008-02-07 2009-08-13 Kyorin Pharmaceutical Co., Ltd. アミノアルコール誘導体を有効成分とする炎症性腸疾患の治療剤又は予防剤
EP2145621A1 (de) * 2008-07-16 2010-01-20 Stephan Lück Verhinderung der Dehydrierung und Reduzierung der gluconeogenetischen Verluste von Aminosäuren durch Propan-1,2,3-Triol
CN103492359B (zh) * 2011-04-02 2015-11-25 中国人民解放军军事医学科学院毒物药物研究所 氨基苯丙醇类化合物及其用于制备免疫抑制剂的用途

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2028235C (en) 1989-10-20 1997-01-21 Fumio Suzuki Condensed purine derivatives
GB9015914D0 (en) * 1990-07-19 1990-09-05 Wellcome Found Heterocyclic compounds
JP3204880B2 (ja) 1995-07-25 2001-09-04 株式会社バーテックススタンダード デジタルフィルタ
WO1998015555A1 (en) 1996-10-07 1998-04-16 Kyowa Hakko Kogyo Co., Ltd. Fused purine derivatives
JP4354016B2 (ja) * 1996-11-29 2009-10-28 株式会社メディサイエンスプラニング 新規プリン誘導体およびこれを含む医薬組成物

Also Published As

Publication number Publication date
EP1092435A1 (de) 2001-04-18
ES2284256T3 (es) 2007-11-01
WO2000001388A1 (en) 2000-01-13
US6489331B1 (en) 2002-12-03
ATE358484T1 (de) 2007-04-15
CA2336412A1 (en) 2000-01-13
DE69935718T2 (de) 2007-12-27
EP1092435B1 (de) 2007-04-04
AU4396899A (en) 2000-01-24
CA2336412C (en) 2007-11-27
EP1092435A4 (de) 2004-03-17

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee