DE69932246D1 - Eine methode zur modulation der effizienz der translations-termination und degradation von anormaler mrna unter einbeziehung eines überwachungs-komplexes enthaltend humanes upf1p, den eukaryotishen release faktor 1 und den eukaryotischen release faktor 3 - Google Patents
Eine methode zur modulation der effizienz der translations-termination und degradation von anormaler mrna unter einbeziehung eines überwachungs-komplexes enthaltend humanes upf1p, den eukaryotishen release faktor 1 und den eukaryotischen release faktor 3Info
- Publication number
- DE69932246D1 DE69932246D1 DE69932246T DE69932246T DE69932246D1 DE 69932246 D1 DE69932246 D1 DE 69932246D1 DE 69932246 T DE69932246 T DE 69932246T DE 69932246 T DE69932246 T DE 69932246T DE 69932246 D1 DE69932246 D1 DE 69932246D1
- Authority
- DE
- Germany
- Prior art keywords
- release factor
- translation termination
- provides
- erf3
- erf1
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 238000000034 method Methods 0.000 title abstract 4
- 230000015556 catabolic process Effects 0.000 title abstract 2
- 238000006731 degradation reaction Methods 0.000 title abstract 2
- 108020004999 messenger RNA Proteins 0.000 title abstract 2
- 101000851802 Dictyostelium discoideum Eukaryotic peptide chain release factor GTP-binding subunit Proteins 0.000 title 1
- 102100030667 Eukaryotic peptide chain release factor subunit 1 Human genes 0.000 title 1
- 101710175705 Eukaryotic peptide chain release factor subunit 1 Proteins 0.000 title 1
- 238000012544 monitoring process Methods 0.000 title 1
- 108010086507 peptide-chain-release factor 3 Proteins 0.000 abstract 8
- 125000001151 peptidyl group Chemical group 0.000 abstract 6
- 108090000623 proteins and genes Proteins 0.000 abstract 4
- 102000004169 proteins and genes Human genes 0.000 abstract 4
- 239000003795 chemical substances by application Substances 0.000 abstract 2
- 230000002950 deficient Effects 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 229940079593 drug Drugs 0.000 abstract 1
- 230000002708 enhancing effect Effects 0.000 abstract 1
- 239000013604 expression vector Substances 0.000 abstract 1
- 108020004707 nucleic acids Proteins 0.000 abstract 1
- 102000039446 nucleic acids Human genes 0.000 abstract 1
- 150000007523 nucleic acids Chemical class 0.000 abstract 1
- 230000001737 promoting effect Effects 0.000 abstract 1
- 230000001105 regulatory effect Effects 0.000 abstract 1
- 238000012216 screening Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K19/00—Hybrid peptides, i.e. peptides covalently bound to nucleic acids, or non-covalently bound protein-protein complexes
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
- C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
- C07K14/4702—Regulators; Modulating activity
- C07K14/4703—Inhibitors; Suppressors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biochemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biophysics (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Zoology (AREA)
- Diabetes (AREA)
- Gastroenterology & Hepatology (AREA)
- Hematology (AREA)
- Toxicology (AREA)
- Urology & Nephrology (AREA)
- Ophthalmology & Optometry (AREA)
- Obesity (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Peptides Or Proteins (AREA)
- Enzymes And Modification Thereof (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US8626098A | 1998-05-28 | 1998-05-28 | |
| PCT/US1999/011826 WO1999061600A2 (en) | 1998-05-28 | 1999-05-27 | A method of modulating the efficiency of translation termination and degradation of aberrant mrna involving a surveillance complex comprising human upf1p, eucaryotic release factor 1 and eucaryotic release factor 3 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DE69932246D1 true DE69932246D1 (de) | 2006-08-17 |
Family
ID=22197349
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE69932246T Expired - Lifetime DE69932246D1 (de) | 1998-05-28 | 1999-05-27 | Eine methode zur modulation der effizienz der translations-termination und degradation von anormaler mrna unter einbeziehung eines überwachungs-komplexes enthaltend humanes upf1p, den eukaryotishen release faktor 1 und den eukaryotischen release faktor 3 |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US6486305B1 (de) |
| EP (1) | EP1102838B1 (de) |
| JP (1) | JP4889150B2 (de) |
| KR (1) | KR20010082559A (de) |
| AT (1) | ATE332365T1 (de) |
| AU (1) | AU4318099A (de) |
| CA (1) | CA2329267C (de) |
| DE (1) | DE69932246D1 (de) |
| MX (1) | MXPA00011760A (de) |
| WO (1) | WO1999061600A2 (de) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20030032158A1 (en) * | 1998-05-28 | 2003-02-13 | University Of Medicine And Dentistry Of New Jersey | Method of modulating the efficiency of translation termination and degradation of aberrant mRNA involving a surveillance complex comprising human Upf1p,eucaryotic release factor 1 and eucaryotic release factor 3 |
| ATE367399T1 (de) * | 1998-07-22 | 2007-08-15 | Univ New Jersey Med | Rna helicasen die die termination der translation beeinflussen |
| US6630294B1 (en) | 1998-07-22 | 2003-10-07 | University Of Medicine And Dentistry Of New Jersey | Subfamily of RNA helicases which are modulators of the fidelity of translation termination and uses thereof |
| US6458538B1 (en) * | 1999-12-14 | 2002-10-01 | Ptc Therapeutics, Inc. | Methods of assaying for compounds that inhibit premature translation termination and nonsense-mediated RNA decay |
| US20040161765A1 (en) * | 2001-04-13 | 2004-08-19 | Dietz Harry C. | Methods and compositions for identifying disease genes using nonsense-mediated decay inhibition |
| US20040072201A1 (en) * | 2002-04-16 | 2004-04-15 | Dietz Harry C. | Methods of identifying compounds that inhibit nonstop degradation of mRNA |
| US7291461B2 (en) * | 2002-06-21 | 2007-11-06 | Ptc Therapeutics, Inc. | Methods for identifying small molecules that modulate premature translation termination and nonsense mRNA decay |
| WO2004037976A2 (en) * | 2002-08-22 | 2004-05-06 | University Of Rochester | NONSENSE-MEDIATED mRNA DECAY |
| WO2005086768A2 (en) * | 2004-03-11 | 2005-09-22 | Albert Einstein College Of Medicine Of Yeshiva University | Enhanced production of functional proteins from defective genes |
| EP2251437B1 (de) * | 2009-05-13 | 2013-12-04 | Hannelore Breitenbach-Koller | Verfahren zur Identifizierung von Verbindungen, die die translationale Aktivität von ribosomalen Proteinen in differentieller mRNA-Expression steuern |
| CN113908589B (zh) * | 2021-10-08 | 2022-09-27 | 天津工业大学 | 一种表面印迹抗体的疏水电荷诱导模式膜层析介质及其制备方法 |
| KR102864696B1 (ko) * | 2021-11-08 | 2025-09-29 | 한양대학교 산학협력단 | Upf1 단백질 또는 upf1 단백질 유래 폴리펩티드의 암의 예방 또는 치료 용도 |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH09504176A (ja) | 1993-10-25 | 1997-04-28 | ライボジーン、インコーポレイテッド | 抗真菌剤の選抜法 |
| US5874231A (en) | 1994-08-22 | 1999-02-23 | Mcgill University | Methods of screening for non-hormone compounds which effect modulation of polypeptide translation |
| US5679566A (en) | 1995-01-20 | 1997-10-21 | University Of Massachusetts Medical Center | Yeast NMD2 gene |
| JP2002515855A (ja) * | 1995-10-06 | 2002-05-28 | ユニヴァーシティー オブ メディシン アンド デンティストリー オブ ニュージャージー | ペプチジル転移反応中心のターゲッティングに関与するタンパク、および対応する治療薬剤並びに治療方法 |
| US5840702A (en) | 1996-03-22 | 1998-11-24 | Uab Research Foundation | Cystic fibrosis treatment |
| JP2000511410A (ja) | 1996-04-29 | 2000-09-05 | ザ ジョーンズ ホプキンス ユニバーシティー スクール オブ メディシン | ナンセンス介在ｒｎａ崩壊の哺乳動物の調節因子 |
-
1999
- 1999-05-27 AU AU43180/99A patent/AU4318099A/en not_active Abandoned
- 1999-05-27 DE DE69932246T patent/DE69932246D1/de not_active Expired - Lifetime
- 1999-05-27 AT AT99953357T patent/ATE332365T1/de not_active IP Right Cessation
- 1999-05-27 EP EP99953357A patent/EP1102838B1/de not_active Expired - Lifetime
- 1999-05-27 CA CA2329267A patent/CA2329267C/en not_active Expired - Fee Related
- 1999-05-27 WO PCT/US1999/011826 patent/WO1999061600A2/en not_active Ceased
- 1999-05-27 MX MXPA00011760A patent/MXPA00011760A/es unknown
- 1999-05-27 KR KR1020007013415A patent/KR20010082559A/ko not_active Withdrawn
- 1999-05-27 JP JP2000550985A patent/JP4889150B2/ja not_active Expired - Fee Related
-
2000
- 2000-08-16 US US09/639,987 patent/US6486305B1/en not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| CA2329267A1 (en) | 1999-12-02 |
| CA2329267C (en) | 2013-01-22 |
| JP2002516091A (ja) | 2002-06-04 |
| EP1102838B1 (de) | 2006-07-05 |
| US6486305B1 (en) | 2002-11-26 |
| WO1999061600A3 (en) | 2000-02-10 |
| KR20010082559A (ko) | 2001-08-30 |
| WO1999061600A9 (en) | 2000-07-06 |
| JP4889150B2 (ja) | 2012-03-07 |
| EP1102838A2 (de) | 2001-05-30 |
| AU4318099A (en) | 1999-12-13 |
| ATE332365T1 (de) | 2006-07-15 |
| WO1999061600A2 (en) | 1999-12-02 |
| MXPA00011760A (es) | 2002-10-17 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| 8332 | No legal effect for de |