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DE69927685D1 - Verfahren zum screenen von verbindungen mit bioaktivität in organgeweben - Google Patents

Verfahren zum screenen von verbindungen mit bioaktivität in organgeweben

Info

Publication number
DE69927685D1
DE69927685D1 DE69927685T DE69927685T DE69927685D1 DE 69927685 D1 DE69927685 D1 DE 69927685D1 DE 69927685 T DE69927685 T DE 69927685T DE 69927685 T DE69927685 T DE 69927685T DE 69927685 D1 DE69927685 D1 DE 69927685D1
Authority
DE
Germany
Prior art keywords
bioactivity
screening compounds
organic woven
compound
woven
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69927685T
Other languages
English (en)
Other versions
DE69927685T2 (de
Inventor
H Vandenburgh
F Valentini
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Individual
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of DE69927685D1 publication Critical patent/DE69927685D1/de
Application granted granted Critical
Publication of DE69927685T2 publication Critical patent/DE69927685T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • G01N33/5082—Supracellular entities, e.g. tissue, organisms
    • G01N33/5088—Supracellular entities, e.g. tissue, organisms of vertebrates
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2500/00—Screening for compounds of potential therapeutic value

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Immunology (AREA)
  • Hematology (AREA)
  • Cell Biology (AREA)
  • Chemical & Material Sciences (AREA)
  • Urology & Nephrology (AREA)
  • Molecular Biology (AREA)
  • Toxicology (AREA)
  • Physics & Mathematics (AREA)
  • Biotechnology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Microbiology (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
DE69927685T 1998-02-18 1999-02-18 Verfahren zum screenen von verbindungen mit bioaktivität in organgeweben Expired - Lifetime DE69927685T2 (de)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US7505498P 1998-02-18 1998-02-18
US75054 1998-02-18
US8637098P 1998-05-22 1998-05-22
US86370 1998-05-22
PCT/US1999/003459 WO1999042604A1 (en) 1998-02-18 1999-02-18 Methods of screening compounds for bioactivity in organized tissue

Publications (2)

Publication Number Publication Date
DE69927685D1 true DE69927685D1 (de) 2006-02-23
DE69927685T2 DE69927685T2 (de) 2006-07-13

Family

ID=26756388

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69927685T Expired - Lifetime DE69927685T2 (de) 1998-02-18 1999-02-18 Verfahren zum screenen von verbindungen mit bioaktivität in organgeweben

Country Status (6)

Country Link
US (3) US20020106627A1 (de)
EP (1) EP1088096B1 (de)
AT (1) ATE306559T1 (de)
AU (1) AU2685699A (de)
DE (1) DE69927685T2 (de)
WO (1) WO1999042604A1 (de)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2003068979A2 (en) * 2001-08-06 2003-08-21 Vanderbilt University System and methods for discriminating an agent
DE102014003465A1 (de) 2014-03-11 2015-09-17 NeuroProof GmbH Gewinnung von Gehirnregion-spezifischen neuronalen Kulturen aus dreidimensionalen Gewebekulturen von Stammzellen
EP3525584B1 (de) * 2016-10-14 2023-05-03 Wake Forest University Health Sciences Multiorgan- körper-auf-einem-chip -vorrichtung unter verwendung eines gemeinsamen mediums
EP3746785A4 (de) 2018-02-02 2022-05-11 Wake Forest University Health Sciences, Inc. Mit einer immuntherapie verwandte organoide und verfahren zur herstellung und verwendung davon

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5863531A (en) * 1986-04-18 1999-01-26 Advanced Tissue Sciences, Inc. In vitro preparation of tubular tissue structures by stromal cell culture on a three-dimensional framework
US5153136A (en) * 1988-07-22 1992-10-06 Vandenburgh Herman H Apparatus for growing tissue specimens in vitro
US4940853A (en) * 1988-07-22 1990-07-10 Vandenburgh Herman H Method for growing tissue specimens in vitro
US5521087A (en) * 1989-05-10 1996-05-28 Massachusetts Institute Of Technology Method for producing oriented connective tissue cells in a ligament configuration
US5340736A (en) * 1991-05-13 1994-08-23 The President & Fellows Of Harvard College ATP-dependent protease and use of inhibitors for same in the treatment of cachexia and muscle wasting
US5661133B1 (en) * 1991-11-12 1999-06-01 Univ Michigan Collateral blood vessel formation in cardiac muscle by injecting a dna sequence encoding an angiogenic protein
US5618718A (en) * 1994-12-30 1997-04-08 Universite Laval Production of a contractile smooth muscle
US5869041A (en) * 1996-01-12 1999-02-09 The Miriam Hospital Delivery of bioactive compounds to an organism
US5888982A (en) * 1996-04-01 1999-03-30 President And Fellows Of Harvard College Regulation of vascular smooth muscle cell heme oxygenase-1
US6008010A (en) * 1996-11-01 1999-12-28 University Of Pittsburgh Method and apparatus for holding cells
US6114164A (en) * 1998-12-07 2000-09-05 The Regents Of The University Of Michigan System and method for emulating an in vivo environment of a muscle tissue specimen

Also Published As

Publication number Publication date
US20020106627A1 (en) 2002-08-08
EP1088096A4 (de) 2002-02-06
US20100190165A1 (en) 2010-07-29
US20030027202A1 (en) 2003-02-06
ATE306559T1 (de) 2005-10-15
AU2685699A (en) 1999-09-06
WO1999042604A1 (en) 1999-08-26
EP1088096B1 (de) 2005-10-12
WO1999042604A8 (en) 1999-10-28
EP1088096A1 (de) 2001-04-04
DE69927685T2 (de) 2006-07-13

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